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Term:epsilon DNA polymerase complex
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Accession:GO:0008622 term browser browse the term
Definition:A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.

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epsilon DNA polymerase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07027368.1 RGD:13792537
G AABR07052692.1 RGD:13792537
G LOC100362333 DNA-directed DNA polymerase epsilon 3 JBrowse link 7 118,816,053 118,816,725 RGD:1600115
G Pole DNA polymerase epsilon, catalytic subunit JBrowse link 12 52,403,533 52,452,075 RGD:13792537
G Pole2 DNA polymerase epsilon 2, accessory subunit JBrowse link 6 91,494,348 91,532,355 RGD:13792537
G Pole3 DNA polymerase epsilon 3, accessory subunit JBrowse link 5 78,380,813 78,384,047 RGD:1624291
G Pole4 DNA polymerase epsilon 4, accessory subunit JBrowse link 4 113,491,644 113,497,455 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19951
    intracellular 13934
      DNA polymerase complex 23
        epsilon DNA polymerase complex 7
Path 2
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  cellular_component 19951
    cellular anatomical entity 19598
      organelle 12670
        intracellular organelle 12137
          intracellular membrane-bounded organelle 10066
            nucleus 6843
              nuclear lumen 4008
                nuclear chromosome 658
                  epsilon DNA polymerase complex 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.