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ONTOLOGY REPORT - ANNOTATIONS


Term:intrinsic apoptotic signaling pathway in response to DNA damage
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Accession:GO:0008630 term browser browse the term
Definition:A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
Synonyms:related_synonym: DNA damage response, signal transduction resulting in induction of apoptosis


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intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC098008.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:167,765,040...167,765,552 JBrowse link
G Atad5 ATPase family, AAA domain containing 5 ISO MGI:MGI:1328356|MGI:MGI:88138 (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Atm ATM serine/threonine kinase ISO
IBA
MGI:MGI:109337|MGI:MGI:1933746 (MGI:MGI:1926715|PMID:11040211), (MGI:MGI:3652689|PMID:16777961), (MGI:MGI:3714678|PMID:17476307)
PMID:21873635
RGD PMID:11040211, PMID:16777961, PMID:17476307, PMID:21873635 MGI:MGI:1926715, MGI:MGI:3652689, MGI:MGI:3714678, RGD:13792537 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bad BCL2-associated agonist of cell death ISO MGI:MGI:3029528 (MGI:MGI:3029504|PMID:12431371), (MGI:MGI:3057092|PMID:15231831) RGD PMID:12431371, PMID:15231831 MGI:MGI:3029504, MGI:MGI:3057092 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 ISO
IBA
MGI:MGI:1197519|MGI:MGI:99702 (MGI:MGI:3581932|PMID:15967824), (MGI:MGI:3689797|PMID:15901672)
PMID:21873635
RGD PMID:15901672, PMID:15967824, PMID:21873635 MGI:MGI:3581932, MGI:MGI:3689797, RGD:13792537 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
MGI:MGI:1097161|MGI:MGI:1197519|MGI:MGI:1857429 (MGI:MGI:2675761|PMID:12952892), (MGI:MGI:3581932|PMID:15967824), (MGI:MGI:3689797|PMID:15901672)
Ensembl
RGD
PMID:12952892, PMID:15901672, PMID:15967824, PMID:21873635 GO_REF:0000107, MGI:MGI:2675761, MGI:MGI:3581932, MGI:MGI:3689797, RGD:13792537 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO
IBA
IEA
MGI:MGI:2442925 (MGI:MGI:3584078|PMID:15983387)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:15983387, PMID:21873635 GO_REF:0000107, MGI:MGI:3584078, RGD:13792537 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 ISO
IBA
MGI:MGI:2158303 (MGI:MGI:2677658|PMID:14517295)
PMID:21873635
RGD PMID:14517295, PMID:21873635 MGI:MGI:2677658, RGD:13792537 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l10 BCL2 like 10 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744
JBrowse link
G Bcl2l11 BCL2 like 11 ISO (PMID:11546872)
MGI:MGI:1097161|MGI:MGI:99702 (MGI:MGI:3581932|PMID:15967824)
RGD PMID:11546872, PMID:15967824 MGI:MGI:3581932 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl2l2 Bcl2-like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Bok BCL2 family apoptosis regulator BOK IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Brca1 BRCA1, DNA repair associated ISO
IEA
(PMID:14654789)
GO_REF:0000107
RGD
Ensembl
PMID:14654789 GO_REF:0000107 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brca2 BRCA2, DNA repair associated ISO MGI:MGI:107202 (MGI:MGI:3714678|PMID:17476307) RGD PMID:17476307 MGI:MGI:3714678 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Casp2 caspase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp9 caspase 9 ISO
IBA
(PMID:15657060)
PMID:21873635
RGD PMID:15657060, PMID:21873635 RGD:13792537 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Chek2 checkpoint kinase 2 ISO (PMID:12402044), (PMID:12717439), (PMID:18644861) RGD PMID:12402044, PMID:12717439, PMID:18644861 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Crip1 cysteine rich protein 1 ISO
IBA
ISS
(PMID:20415737)
PMID:21873635
RGD PMID:20415737, PMID:21873635, PMID:20415737 RGD:13792537, RGD:8553326 NCBI chr 6:137,959,171...137,967,042
Ensembl chr 6:137,959,171...137,967,042
JBrowse link
G E2f1 E2F transcription factor 1 ISO
ISS
(PMID:12717439)
GO_REF:0000024
RGD
UniProt
PMID:12717439 GO_REF:0000024 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein ISO (MGI:MGI:1350723|PMID:10594026) RGD PMID:10594026 MGI:MGI:1350723 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Epha2 Eph receptor A2 ISO (PMID:18339848) RGD PMID:18339848 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor ISO MGI:MGI:1932102 (MGI:MGI:1913261|PMID:11005836) RGD PMID:11005836 MGI:MGI:1913261 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Fnip2 folliculin interacting protein 2 ISO
ISS
(MGI:MGI:5284752|PMID:19137017)
GO_REF:0000024
RGD
UniProt
PMID:19137017 GO_REF:0000024, MGI:MGI:5284752 NCBI chr 2:178,223,561...178,334,925
Ensembl chr 2:178,225,915...178,334,900
JBrowse link
G Hic1 HIC ZBTB transcriptional repressor 1 ISO (PMID:16269335)
(MGI:MGI:5297787|PMID:16269335)
RGD PMID:16269335 MGI:MGI:5297787 NCBI chr10:62,007,150...62,010,774
Ensembl chr10:62,007,150...62,009,582
JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:11854317 RGD:625692 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Htra2 HtrA serine peptidase 2 ISO (PMID:11602612) RGD PMID:11602612 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Ier3 immediate early response 3 ISO (MGI:MGI:3775338|PMID:11753682) RGD PMID:11753682 MGI:MGI:3775338 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon ISO (PMID:20188669) RGD PMID:20188669 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G LOC100912068 hypermethylated in cancer 1 protein-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:62,480,601...62,483,619
Ensembl chr10:62,480,767...62,483,342
JBrowse link
G Mael maelstrom spermatogenic transposon silencer ISO MGI:MGI:3795667 (MGI:MGI:3813746|PMID:18694567) RGD PMID:18694567 MGI:MGI:3813746 NCBI chr13:84,412,569...84,452,140
Ensembl chr13:84,383,670...84,452,181
JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase ISO MGI:MGI:2183491 (MGI:MGI:2678630|PMID:14562041) RGD PMID:14562041 MGI:MGI:2678630 NCBI chr 4:147,744,673...147,756,462
Ensembl chr 4:147,746,186...147,756,294
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member ISO
IBA
(MGI:MGI:3689797|PMID:15901672)
PMID:21873635
RGD PMID:15901672, PMID:21873635 MGI:MGI:3689797, RGD:13792537 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mlh1 mutL homolog 1 ISO
IEA
MGI:MGI:1857946 (MGI:MGI:2678630|PMID:14562041)
GO_REF:0000107
RGD
Ensembl
PMID:14562041 GO_REF:0000107, MGI:MGI:2678630 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Moap1 modulator of apoptosis 1 ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:126,620,597...126,622,532
Ensembl chr 6:126,620,602...126,622,532
JBrowse link
G Msh2 mutS homolog 2 ISO MGI:MGI:1858055|MGI:MGI:2680817 (MGI:MGI:1334080|PMID:10097137), (MGI:MGI:3029112|PMID:14744764) RGD PMID:10097137, PMID:14744764 MGI:MGI:1334080, MGI:MGI:3029112 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Msh6 mutS homolog 6 ISO
IBA
MGI:MGI:1858014 (MGI:MGI:3053495|PMID:15324697)
PMID:21873635
RGD PMID:15324697, PMID:21873635 MGI:MGI:3053495, RGD:13792537 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO MGI:MGI:2447604 (MGI:MGI:2677658|PMID:14517295) RGD PMID:14517295 MGI:MGI:2677658 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 ISO MGI:MGI:97583 (MGI:MGI:3709926|PMID:17242187) RGD PMID:17242187 MGI:MGI:3709926 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO
IEA
MGI:MGI:104798|MGI:MGI:2149414 (MGI:MGI:3709926|PMID:17242187)
GO_REF:0000107
RGD
Ensembl
PMID:17242187 GO_REF:0000107, MGI:MGI:3709926 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO MGI:MGI:2678372 (MGI:MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:MGI:2675761 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pml PML nuclear body scaffold ISO
IBA
(PMID:12402044)
PMID:21873635
MGI:MGI:104662|MGI:MGI:2429949 (MGI:MGI:1306978|PMID:9806545), (MGI:MGI:3580934|PMID:15626733)
RGD PMID:9806545, PMID:12402044, PMID:15626733, PMID:21873635 MGI:MGI:1306978, MGI:MGI:3580934, RGD:13792537 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Polb DNA polymerase beta ISO (MGI:MGI:1334987|PMID:10197627) RGD PMID:10197627 MGI:MGI:1334987 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO
IBA
MGI:MGI:1857113 (MGI:MGI:2450507|PMID:12604618)
PMID:21873635
RGD PMID:12604618, PMID:21873635 MGI:MGI:2450507, RGD:13792537 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Sfn stratifin ISO (PMID:11574543) RGD PMID:11574543 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:5297787|PMID:16269335) RGD PMID:16269335 MGI:MGI:5297787 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sod2 superoxide dismutase 2 ISO MGI:MGI:1857480 (MGI:MGI:3691744|PMID:15642323) RGD PMID:15642323 MGI:MGI:3691744 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor ISO (MGI:MGI:3709926|PMID:17242187) RGD PMID:17242187 MGI:MGI:3709926 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO
IEA
(MGI:MGI:3709926|PMID:17242187)
GO_REF:0000107
RGD
Ensembl
PMID:17242187 GO_REF:0000107, MGI:MGI:3709926 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO
IBA
(MGI:MGI:3709926|PMID:17242187)
PMID:21873635
RGD PMID:17242187, PMID:21873635 MGI:MGI:3709926, RGD:13792537 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase ISO (PMID:20188669) RGD PMID:20188669 NCBI chr 5:56,554,956...56,566,503
Ensembl chr 5:56,554,969...56,567,320
JBrowse link
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats ISO MGI:MGI:3043446 (MGI:MGI:3056865|PMID:15271982) RGD PMID:15271982 MGI:MGI:3056865 NCBI chr 8:65,686,586...65,774,940
Ensembl chr 8:65,686,648...65,774,989
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor ISO MGI:MGI:1857939 (MGI:MGI:1913261|PMID:11005836) RGD PMID:11005836 MGI:MGI:1913261 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aen apoptosis enhancing nuclease ISO
IBA
ISS
(PMID:18264133)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:18264133, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745
JBrowse link
G Atad5 ATPase family, AAA domain containing 5 ISO MGI:MGI:1336991|MGI:MGI:98834 (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Bag6 BAG cochaperone 6 ISO
ISS
(PMID:17403783)
GO_REF:0000024
RGD
UniProt
PMID:17403783 GO_REF:0000024 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Bbc3 Bcl-2 binding component 3 ISO MGI:MGI:2681654 (MGI:MGI:3603103|PMID:16151013) RGD PMID:16151013 MGI:MGI:3603103 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl3 BCL3, transcription coactivator ISO (PMID:16384933) RGD PMID:16384933 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Brca2 BRCA2, DNA repair associated IEA
ISO
GO_REF:0000107
MGI:MGI:2429691|MGI:MGI:3052655|MGI:MGI:98834 (MGI:MGI:3579926|PMID:15735671), (MGI:MGI:3714678|PMID:17476307)
Ensembl
RGD
PMID:15735671, PMID:17476307 GO_REF:0000107, MGI:MGI:3579926, MGI:MGI:3714678 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Cdip1 cell death-inducing p53 target 1 ISO (PMID:17599062) RGD PMID:17599062 NCBI chr10:10,966,819...10,989,937
Ensembl chr10:10,967,658...10,989,936
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO MGI:MGI:1933751 (MGI:MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:MGI:2675761 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek2 checkpoint kinase 2 ISO MGI:MGI:2386905 (MGI:MGI:1354114|PMID:10710310) RGD PMID:10710310 MGI:MGI:1354114 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5298149|PMID:21896779)
Ensembl
UniProt
RGD
PMID:21896779 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5298149 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 ISO (PMID:17349958) RGD PMID:17349958 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729
JBrowse link
G Ep300 E1A binding protein p300 ISO (PMID:17403783) RGD PMID:17403783 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 ISO
IBA
IEA
MGI:MGI:1314872|MGI:MGI:98834 (MGI:MGI:3619785|PMID:16537918)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:16537918, PMID:21873635 GO_REF:0000107, MGI:MGI:3619785, RGD:13792537 NCBI chr 2:206,224,015...206,274,910
Ensembl chr 2:206,224,015...206,274,079
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 ISO
IBA
MGI:MGI:1314872|MGI:MGI:98834 (MGI:MGI:3619785|PMID:16537918)
PMID:21873635
RGD PMID:16537918, PMID:21873635 MGI:MGI:3619785, RGD:13792537 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
JBrowse link
G Msh2 mutS homolog 2 ISO
IBA
IEA
MGI:MGI:98834 (MGI:MGI:1334080|PMID:10097137)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:10097137, PMID:21873635 GO_REF:0000107, MGI:MGI:1334080, RGD:13792537 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator ISO MGI:MGI:3784016 (MGI:MGI:3784021|PMID:11896600) RGD PMID:11896600 MGI:MGI:3784021 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 ISO
IBA
ISS
(PMID:19203586)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:19203586, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO (MGI:MGI:1858284|PMID:10807576) RGD PMID:10807576 MGI:MGI:1858284 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Pml PML nuclear body scaffold ISO (MGI:MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:MGI:3580934 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:134,804,128...134,941,912
Ensembl chr 6:134,804,141...134,939,358
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rps27l ribosomal protein S27-like ISO (PMID:17057733), (PMID:18056458) RGD PMID:17057733, PMID:18056458 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090
JBrowse link
G Shisa5 shisa family member 5 ISO
IEA
(MGI:MGI:2183272|PMID:12135983)
GO_REF:0000107
RGD
Ensembl
PMID:12135983 GO_REF:0000107, MGI:MGI:2183272 NCBI chr 8:117,780,992...117,795,923
Ensembl chr 8:117,780,891...117,795,919
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:20100829)
GO_REF:0000107
RGD
Ensembl
PMID:20100829 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Snw1 SNW domain containing 1 ISO (PMID:21460037) RGD PMID:21460037 NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782
JBrowse link
G Tmem109 transmembrane protein 109 ISO
IBA
MGI:MGI:4453832 (MGI:MGI:4437179|PMID:20060811)
PMID:21873635
RGD PMID:20060811, PMID:21873635 MGI:MGI:4437179, RGD:13792537 NCBI chr 1:226,925,114...226,935,710
Ensembl chr 1:226,925,117...226,935,689
JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase ISO (MGI:MGI:3578084|PMID:15735665) RGD PMID:15735665 MGI:MGI:3578084 NCBI chr 5:56,554,956...56,566,503
Ensembl chr 5:56,554,969...56,567,320
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:14654789), (PMID:14744935), (PMID:16213212), (PMID:17403783)
MGI:MGI:109337|MGI:MGI:1096393|MGI:MGI:1336991|MGI:MGI:1857263|MGI:MGI:1926340|MGI:MGI:2442925 (MGI:MGI:2183272|PMID:12135983), (MGI:MGI:2675761|PMID:12952892), (MGI:MGI:3584078|PMID:15983387), (MGI:MGI:3652689|PMID:16777961), (MGI:MGI:3690827|PMID:16286009), (MGI:MGI:3714678|PMID:17476307), (MGI:MGI:4944151|PMID:20818388), (MGI:MGI:5882892|PMID:16213212)
RGD PMID:12135983, PMID:12952892, PMID:14654789, PMID:14744935, PMID:15983387, PMID:16213212, PMID:16286009, PMID:16777961, PMID:17403783, PMID:17476307, PMID:20818388 MGI:MGI:2183272, MGI:MGI:2675761, MGI:MGI:3584078, MGI:MGI:3652689, MGI:MGI:3690827, MGI:MGI:3714678, MGI:MGI:4944151, MGI:MGI:5882892 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp63 tumor protein p63 ISO MGI:MGI:1934269 (MGI:MGI:3693137|PMID:17122775) RGD PMID:17122775 MGI:MGI:3693137 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tp73 tumor protein p73 ISO (PMID:18174154), (PMID:19490146) RGD PMID:18174154, PMID:19490146 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Usp28 ubiquitin specific peptidase 28 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:16901786)
Ensembl
UniProt
RGD
PMID:16901786 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:53,295,188...53,355,572
Ensembl chr 8:53,295,222...53,355,572
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 ISO (PMID:20388803) RGD PMID:20388803 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Atad5 ATPase family, AAA domain containing 5 ISO (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Bcl2l1 Bcl2-like 1 ISO (PMID:16608847) RGD PMID:16608847 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist ISO MGI:MGI:5428930 (MGI:MGI:5662300|PMID:26219591) RGD PMID:26219591 MGI:MGI:5662300 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Ccar2 cell cycle and apoptosis regulator 2 ISO (PMID:23352644) RGD PMID:23352644 NCBI chr15:51,818,887...51,834,443
Ensembl chr15:51,818,897...51,834,030
JBrowse link
G Clu clusterin ISO
ISS
IEA
(PMID:16113678)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:16113678 GO_REF:0000024, GO_REF:0000107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO (PMID:20388803) RGD PMID:20388803 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Ddias DNA damage-induced apoptosis suppressor ISO (PMID:24214091) RGD PMID:24214091 NCBI chr 1:157,675,754...157,700,064
Ensembl chr 1:157,675,765...157,700,064
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO (PMID:14561758) RGD PMID:14561758 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
G Snai1 snail family transcriptional repressor 1 ISO (PMID:15314165) RGD PMID:15314165 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 ISO (PMID:15314165) RGD PMID:15314165 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Tmem161a transmembrane protein 161A ISO (PMID:16551573) RGD PMID:16551573 NCBI chr16:20,985,841...20,996,351
Ensembl chr16:20,986,687...20,994,379
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 ISO (PMID:11598139) RGD PMID:11598139 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Trim32 tripartite motif-containing 32 ISO (PMID:18632609) RGD PMID:18632609 NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
JBrowse link
G Usp47 ubiquitin specific peptidase 47 ISO MGI:MGI:4130032 (MGI:MGI:4839431|PMID:19966869) RGD PMID:19966869 MGI:MGI:4839431 NCBI chr 1:176,854,589...176,937,763
Ensembl chr 1:176,854,653...176,937,763
JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 ISO (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Bcl2l12 BCL2 like 12 ISO (MGI:MGI:4834958|PMID:20837658) RGD PMID:20837658 MGI:MGI:4834958 NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO
IEA
(PMID:17045821)
GO_REF:0000107
(MGI:MGI:3690285|PMID:17045821)
RGD
Ensembl
PMID:17045821 GO_REF:0000107, MGI:MGI:3690285 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd74 CD74 molecule ISO
IBA
ISS
(MGI:MGI:3690285|PMID:17045821)
PMID:21873635
GO_REF:0000024
(PMID:17045821)
RGD
BHF-UCL
PMID:17045821, PMID:21873635 GO_REF:0000024, MGI:MGI:3690285, RGD:13792537 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 ISO (MGI:MGI:5438719|PMID:22768269) RGD PMID:22768269 MGI:MGI:5438719 NCBI chr 3:113,400,395...113,405,869
Ensembl chr 3:113,401,734...113,405,829
JBrowse link
G Kdm1a lysine demethylase 1A ISO (PMID:17805299) RGD PMID:17805299 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 ISO
ISS
(PMID:29295817)
GO_REF:0000024
RGD
UniProt
PMID:29295817 GO_REF:0000024 NCBI chr 3:46,284,961...46,325,230
Ensembl chr 3:46,286,712...46,324,057
JBrowse link
G Mif macrophage migration inhibitory factor ISO (PMID:17045821) RGD PMID:17045821 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Muc1 mucin 1, cell surface associated ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:2152474|PMID:11672522) RGD PMID:11672522 MGI:MGI:2152474 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 ISO (PMID:15735003) RGD PMID:15735003 NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897
Ensembl chr12:46,987,404...46,989,897
JBrowse link
G Zfp385a zinc finger protein 385A ISO (PMID:17719541) RGD PMID:17719541 NCBI chr 7:144,939,616...144,966,364
Ensembl chr 7:144,939,619...144,966,370
JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbh1 F-box DNA helicase 1 ISO (PMID:23361013) RGD PMID:23361013 NCBI chr17:70,399,093...70,437,151
Ensembl chr17:70,399,049...70,437,144
JBrowse link
G Mtch2 mitochondrial carrier 2 ISO MGI:MGI:2449949|MGI:MGI:5566664 (MGI:MGI:5662300|PMID:26219591) RGD PMID:26219591 MGI:MGI:5662300 NCBI chr 3:79,678,141...79,695,356
Ensembl chr 3:79,678,201...79,694,006
JBrowse link
G Nacc2 NACC family member 2 ISO
IEA
(PMID:22926524)
GO_REF:0000107
RGD
Ensembl
PMID:22926524 GO_REF:0000107 NCBI chr 3:3,508,084...3,574,787
Ensembl chr 3:3,510,041...3,574,787
JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 ISO (MGI:MGI:5009403|PMID:16816390) RGD PMID:16816390 MGI:MGI:5009403 NCBI chr 7:11,414,565...11,428,090
Ensembl chr 7:11,414,446...11,428,552
JBrowse link
G Plscr1 phospholipid scramblase 1 ISO
IEA
(MGI:MGI:5284813|PMID:12509439)
GO_REF:0000107
RGD
Ensembl
PMID:12509439 GO_REF:0000107, MGI:MGI:5284813 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Rad9a RAD9 checkpoint clamp component A ISO MGI:MGI:2442925 (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr 1:219,443,347...219,450,574
Ensembl chr 1:219,444,092...219,450,451
JBrowse link
G Rps3 ribosomal protein S3 ISO (PMID:22510408) RGD PMID:22510408 NCBI chr 1:164,435,868...164,441,167
Ensembl chr 1:164,435,878...164,441,167
JBrowse link
G Skil SKI-like proto-oncogene ISO MGI:MGI:2387096 (MGI:MGI:1858539|PMID:10811619) RGD PMID:10811619 MGI:MGI:1858539 NCBI chr 2:115,862,932...115,891,304
Ensembl chr 2:115,866,701...115,891,097
JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl26 ribosomal protein L26 ISO (PMID:16213212)
(MGI:MGI:5882892|PMID:16213212)
RGD PMID:16213212 MGI:MGI:5882892 NCBI chr10:55,492,417...55,495,547
Ensembl chr10:55,492,404...55,496,012
JBrowse link
G Steap3 STEAP3 metalloreductase ISO MGI:MGI:4398911 (MGI:MGI:4367682|PMID:18617898) RGD PMID:18617898 MGI:MGI:4367682 NCBI chr13:36,257,220...36,274,144
Ensembl chr13:36,257,112...36,290,531
JBrowse link
G Tp73 tumor protein p73 ISO MGI:MGI:2442925|MGI:MGI:98834 (MGI:MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:MGI:3584078 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpk heterogeneous nuclear ribonucleoprotein K ISO (MGI:MGI:4881379|PMID:20673990) RGD PMID:20673990 MGI:MGI:4881379 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      signal transduction 7015
        intracellular signal transduction 2615
          intrinsic apoptotic signaling pathway 303
            intrinsic apoptotic signaling pathway in response to DNA damage 110
              intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 44
              negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 26
              positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 11
              regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 38
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            apoptotic signaling pathway 635
              intrinsic apoptotic signaling pathway 303
                intrinsic apoptotic signaling pathway in response to DNA damage 110
                  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 44
                  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 26
                  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 11
                  regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 38
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.