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ONTOLOGY REPORT - ANNOTATIONS


Term:apoptotic mitochondrial changes
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Accession:GO:0008637 term browser browse the term
Definition:The morphological and physiological alterations undergone by mitochondria during apoptosis.
Comment:This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it.


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apoptotic mitochondrial changes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07014739.1 RGD:13792537
G Aifm2 apoptosis inducing factor, mitochondria associated 2 JBrowse link 20 31,329,047 31,353,548 RGD:1624291
RGD:13792537
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
G Aldh2 aldehyde dehydrogenase 2 family member JBrowse link 12 40,466,418 40,498,813 RGD:15036798
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 JBrowse link 1 197,855,912 197,875,038 RGD:1624291
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
RGD:1600115
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:1624291
RGD:13792537
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:1624291
RGD:13792537
G Cd24 CD24 molecule JBrowse link 20 48,335,540 48,340,847 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Dap3 death associated protein 3 JBrowse link 2 188,225,607 188,255,324 RGD:1624291
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:13792537
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:1624291
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:1624291
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:10402841
RGD:13792537
G Jtb jumping translocation breakpoint JBrowse link 2 189,591,707 189,595,926 RGD:1624291
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:1624291
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:1624291
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 JBrowse link 9 69,919,863 69,953,182 RGD:1624291
RGD:1600115
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase JBrowse link X 15,462,621 15,467,890 RGD:1624291
G Ppif peptidylprolyl isomerase F JBrowse link 16 1,979,191 1,985,912 RGD:1624291
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:1624291
G Rnf7 ring finger protein 7 JBrowse link 8 104,326,719 104,336,098 RGD:1624291
G Slc25a4 solute carrier family 25 member 4 JBrowse link 16 49,266,903 49,270,698 RGD:1624291
RGD:1600115
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:1624291
mitochondrial fragmentation involved in apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg3 autophagy related 3 JBrowse link 11 60,585,192 60,613,706 RGD:1624291
RGD:1600115
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
RGD:1600115
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:1624291
G Ccar2 cell cycle and apoptosis regulator 2 JBrowse link 15 51,818,887 51,834,443 RGD:1624291
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:12738363
RGD:13792537
RGD:1624291
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:1600115
RGD:1624291
G Fis1 fission, mitochondrial 1 JBrowse link 12 22,750,485 22,765,324 RGD:2314538
RGD:13792537
RGD:1624291
RGD:1600115
G Mff mitochondrial fission factor JBrowse link 9 88,490,280 88,518,517 RGD:1624291
G Nptx1 neuronal pentraxin 1 JBrowse link 10 108,682,637 108,691,592 RGD:6903322
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta JBrowse link 18 36,985,709 37,421,383 RGD:2314538
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:13432138
G Vps35 VPS35 retromer complex component JBrowse link 19 27,464,937 27,500,636 RGD:1624291
mitochondrial outer membrane permeabilization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:1624291
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 JBrowse link 1 263,913,901 263,920,989 RGD:1600115
RGD:8553738
RGD:1624291
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:1624291
RGD:13792537
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:13792537
G Eya2 EYA transcriptional coactivator and phosphatase 2 JBrowse link 3 162,285,275 162,470,642 RGD:1624291
G LOC102548901 protein Bop-like JBrowse link 12 6,230,524 6,231,398 RGD:1624291
G Rhot1 ras homolog family member T1 JBrowse link 10 67,559,277 67,640,622 RGD:1624291
G Rhot2 ras homolog family member T2 JBrowse link 10 15,205,943 15,211,739 RGD:1624291
RGD:1600115
negative regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa2 acetyl-CoA acyltransferase 2 JBrowse link 18 70,733,872 70,762,395 RGD:1624291
RGD:1600115
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:11561965
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:1600115
RGD:1624291
G Slc25a4 solute carrier family 25 member 4 JBrowse link 16 49,266,903 49,270,698 RGD:9681467
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa2 acetyl-CoA acyltransferase 2 JBrowse link 18 70,733,872 70,762,395 RGD:1600115
RGD:1624291
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:1624291
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
G Ier3 immediate early response 3 JBrowse link 20 3,438,798 3,440,002 RGD:1624291
G Mpv17l MPV17 mitochondrial inner membrane protein like JBrowse link 10 3,321,488 3,359,219 RGD:1624291
G Slc25a5 solute carrier family 25 member 5 JBrowse link X 123,404,570 123,407,637 RGD:1624291
RGD:1600115
G Slc35f6 solute carrier family 35, member F6 JBrowse link 6 27,095,144 27,106,982 RGD:1624291
RGD:1600115
G Tmem14a transmembrane protein 14A JBrowse link 9
9
27,333,956
27,334,103
27,345,612
27,351,302
RGD:1624291
RGD:13792537
negative regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
RGD:1600115
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5510006
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:1624291
G Bcl2l2 Bcl2-like 2 JBrowse link 15 33,543,774 33,549,165 RGD:14394498
G Fxn frataxin JBrowse link 1 242,123,975 242,152,834 RGD:1624291
RGD:1600115
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:1624291
RGD:1600115
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:1624291
G Higd1a HIG1 hypoxia inducible domain family, member 1A JBrowse link 8 130,482,492 130,491,888 RGD:1624291
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
RGD:1600115
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:1624291
RGD:1600115
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:12738362
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:10047155
RGD:1624291
G Opa1 OPA1, mitochondrial dynamin like GTPase JBrowse link 11 74,717,600 74,793,902 RGD:1624291
RGD:1600115
G Pam16 presequence translocase associated motor 16 JBrowse link 10 11,146,359 11,153,936 RGD:13462066
G Parl presenilin associated, rhomboid-like JBrowse link 11 84,517,368 84,544,463 RGD:1600115
RGD:1624291
G Ppif peptidylprolyl isomerase F JBrowse link 16 1,979,191 1,985,912 RGD:1624291
RGD:1600115
G Prelid1 PRELI domain containing 1 JBrowse link 17 9,834,245 9,837,285 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1600115
RGD:1624291
G Psmd10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 112,323,188 112,328,642 RGD:1624291
RGD:1600115
G Triap1 TP53 regulated inhibitor of apoptosis 1 JBrowse link 12 46,987,404 46,989,906 RGD:1624291
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:1624291
RGD:1600115
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
G Stpg1 sperm-tail PG-rich repeat containing 1 JBrowse link 5 153,834,263 153,888,510 RGD:1624291
RGD:13792537
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp5if1 ATP synthase inhibitory factor subunit 1 JBrowse link 5 150,719,570 150,723,287 RGD:1624291
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 JBrowse link 20 13,665,046 13,666,845 RGD:1624291
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:1624291
RGD:1600115
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
RGD:1600115
G Hip1r huntingtin interacting protein 1 related JBrowse link 12 38,024,517 38,053,184 RGD:1624291
G Siva1 SIVA1, apoptosis-inducing factor JBrowse link 6 137,209,999 137,214,379 RGD:1624291
G Zfp13 zinc finger protein 13 JBrowse link 10 12,908,643 12,916,784 RGD:1624291
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:1624291
RGD:13792537
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 JBrowse link 2 250,709,812 250,744,216 RGD:1624291
RGD:1600115
positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC130253.1 RGD:13792537
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1624291
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:2317097
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:1624291
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:13792537
RGD:1624291
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:1624291
RGD:13792537
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:1624291
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:1624291
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:1624291
G Cideb cell death-inducing DFFA-like effector b JBrowse link 15 34,439,844 34,444,244 RGD:1624291
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:1624291
G Fam162a family with sequence similarity 162, member A JBrowse link 11 67,618,683 67,646,253 RGD:1624291
RGD:13792537
RGD:1600115
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:8553942
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:1624291
G Mff mitochondrial fission factor JBrowse link 9 88,490,280 88,518,517 RGD:1624291
G Mllt11 MLLT11, transcription factor 7 cofactor JBrowse link 2 196,392,936 196,402,106 RGD:1624291
RGD:13792537
RGD:1600115
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:1624291
RGD:1600115
G Moap1 modulator of apoptosis 1 JBrowse link 6 126,620,597 126,622,532 RGD:1624291
G Pdcd5 programmed cell death 5 JBrowse link 1 91,173,473 91,178,801 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6482750
G Plaur plasminogen activator, urokinase receptor JBrowse link 1 81,328,171 81,344,954 RGD:1624291
RGD:1600115
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
G Ppif peptidylprolyl isomerase F JBrowse link 16 1,979,191 1,985,912 RGD:1624291
RGD:1600115
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G RGD1306484 similar to growth and transformation-dependent protein JBrowse link 10 37,582,678 37,583,232 RGD:13792537
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Wdr35 WD repeat domain 35 JBrowse link 6 34,094,291 34,152,048 RGD:11553920
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
RGD:1600115
G Moap1 modulator of apoptosis 1 JBrowse link 6 126,620,597 126,622,532 RGD:1624291
regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:1624291
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:1624291
RGD:1600115
G Mtch2 mitochondrial carrier 2 JBrowse link 3 79,678,141 79,695,356 RGD:1624291
G Naif1 nuclear apoptosis inducing factor 1 JBrowse link 3 11,476,330 11,482,629 RGD:1624291
G Them4 thioesterase superfamily member 4 JBrowse link 2 195,554,092 195,576,710 RGD:1624291
RGD:1600115
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
G Tmem102 transmembrane protein 102 JBrowse link 10 56,410,898 56,413,154 RGD:1624291
regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plscr3 phospholipid scramblase 3 JBrowse link 10 56,452,632 56,458,390 RGD:1624291
RGD:1600115
release of cytochrome c from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7a ATPase copper transporting alpha JBrowse link X 77,076,085 77,193,644 RGD:1624291
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1624291
RGD:13792537
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:2313987
RGD:1624291
RGD:1600115
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:14394498
RGD:13792537
RGD:1624291
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:1624291
RGD:13792537
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:8554139
RGD:1600115
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:1624291
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:2313987
RGD:1624291
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
G Cck cholecystokinin JBrowse link 8 130,120,525 130,127,515 RGD:625521
G Dnm1l dynamin 1-like JBrowse link 11 88,830,968 88,882,271 RGD:1624291
G Fis1 fission, mitochondrial 1 JBrowse link 12 22,750,485 22,765,324 RGD:1624291
G Ggct gamma-glutamyl cyclotransferase JBrowse link 4 85,186,644 85,192,857 RGD:1624291
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:2290592
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:2298783
G Mff mitochondrial fission factor JBrowse link 9 88,490,280 88,518,517 RGD:1624291
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:1624291
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:1624291
G Timm50 translocase of inner mitochondrial membrane 50 JBrowse link 1 85,470,810 85,480,813 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:1624291
release of matrix enzymes from mitochondria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18617
      cell death 2138
        programmed cell death 1953
          apoptotic process 1907
            apoptotic mitochondrial changes 118
              mitochondrial fragmentation involved in apoptotic process 12
              regulation of mitochondrial membrane permeability involved in apoptotic process + 42
              release of cytochrome c from mitochondria + 63
              release of matrix enzymes from mitochondria 1
Path 2
Term Annotations click to browse term
  biological_process 19858
    cellular process 18617
      cellular component organization or biogenesis 6706
        cellular component organization 6456
          organelle organization 4029
            mitochondrion organization 534
              apoptotic mitochondrial changes 118
                mitochondrial fragmentation involved in apoptotic process 12
                regulation of mitochondrial membrane permeability involved in apoptotic process + 42
                release of cytochrome c from mitochondria + 63
                release of matrix enzymes from mitochondria 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.