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ONTOLOGY REPORT - ANNOTATIONS


Term:dosage compensation by inactivation of X chromosome
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Accession:GO:0009048 term browser browse the term
Definition:Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.
Synonyms:exact_synonym: X chromosome inactivation
 broad_synonym: chromosome inactivation
 related_synonym: Barr body formation
 xref: Wikipedia:X-inactivation


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dosage compensation by inactivation of X chromosome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated ISO
IEA
IBA
(MGI:MGI:2389513|PMID:12419249)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:12419249, PMID:21873635 GO_REF:0000107, MGI:MGI:2389513, RGD:13792537 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 ISO (MGI:MGI:3694307|PMID:16789828) RGD PMID:16789828 MGI:MGI:3694307 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
JBrowse link
G Exosc10 exosome component 10 ISO (MGI:MGI:3694307|PMID:16789828) RGD PMID:16789828 MGI:MGI:3694307 NCBI chr 5:165,374,964...165,398,195
Ensembl chr 5:165,374,951...165,398,217
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U ISO (MGI:MGI:4831049|PMID:20833368) RGD PMID:20833368 MGI:MGI:4831049 NCBI chr13:96,222,093...96,238,845
Ensembl chr13:96,225,912...96,238,572
JBrowse link
G Lrif1 ligand dependent nuclear receptor interacting factor 1 ISS
ISO
IEA
GO_REF:0000024
(PMID:23542155)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:23542155 GO_REF:0000024, GO_REF:0000107 NCBI chr 2:209,358,668...209,448,123
Ensembl chr 2:209,358,760...209,448,123
JBrowse link
G Mettl3 methyltransferase-like 3 ISO (PMID:27602518) RGD PMID:27602518 NCBI chr15:28,710,299...28,721,491
Ensembl chr15:28,710,300...28,721,127
JBrowse link
G Rbm15 RNA binding motif protein 15 ISO (PMID:27602518) RGD PMID:27602518 NCBI chr 2:210,079,678...210,090,200
Ensembl chr 2:210,081,770...210,088,949
JBrowse link
G Rbm15b RNA binding motif protein 15B ISO (PMID:27602518) RGD PMID:27602518 NCBI chr 8:115,618,242...115,623,068
Ensembl chr 8:115,618,555...115,621,394
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 ISO MGI:MGI:3586547 (MGI:MGI:3821390|PMID:18425126), (MGI:MGI:5532809|PMID:23754746)
(PMID:23542155)
RGD PMID:18425126, PMID:23542155, PMID:23754746 MGI:MGI:3821390, MGI:MGI:5532809 NCBI chr 9:119,675,750...119,818,620
Ensembl chr 9:119,676,628...119,818,310
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase ISO (MGI:MGI:3694307|PMID:16789828) RGD PMID:16789828 MGI:MGI:3694307 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link
G Ythdc1 YTH domain containing 1 ISS
ISO
GO_REF:0000024
(PMID:27602518)
UniProt
RGD
PMID:27602518 GO_REF:0000024 NCBI chr14:22,971,834...23,002,326
Ensembl chr14:22,971,836...23,002,011
JBrowse link
inactivation of paternal X chromosome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prdm14 PR/SET domain 14 ISO MGI:MGI:3805889 (MGI:MGI:5548017|PMID:24268575) RGD PMID:24268575 MGI:MGI:5548017 NCBI chr 5:5,710,076...5,730,560
Ensembl chr 5:5,710,392...5,730,560
JBrowse link
inactivation of X chromosome by DNA methylation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt3b DNA methyltransferase 3 beta ISO MGI:MGI:3047834 (MGI:MGI:5532809|PMID:23754746) RGD PMID:23754746 MGI:MGI:5532809 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 ISO MGI:MGI:3586547 (MGI:MGI:3821390|PMID:18425126) RGD PMID:18425126 MGI:MGI:3821390 NCBI chr 9:119,675,750...119,818,620
Ensembl chr 9:119,676,628...119,818,310
JBrowse link
inactivation of X chromosome by genetic imprinting term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcgf3 polycomb group ring finger 3 ISO (MGI:MGI:5908473|PMID:28596365) RGD PMID:28596365 MGI:MGI:5908473 NCBI chr14:2,247,805...2,297,155
Ensembl chr14:2,247,808...2,297,155
JBrowse link
G Pcgf5 polycomb group ring finger 5 ISO
IBA
(MGI:MGI:5908473|PMID:28596365)
PMID:21873635
RGD PMID:28596365, PMID:21873635 MGI:MGI:5908473, RGD:13792537 NCBI chr 1:254,974,688...255,090,925
Ensembl chr 1:254,974,789...255,086,207
JBrowse link
inactivation of X chromosome by heterochromatin assembly term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 ISO (MGI:MGI:5532809|PMID:23754746) RGD PMID:23754746 MGI:MGI:5532809 NCBI chr 9:119,675,750...119,818,620
Ensembl chr 9:119,676,628...119,818,310
JBrowse link
random inactivation of X chromosome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdyl chromodomain Y-like ISO
ISS
(MGI:MGI:5551942|PMID:24144980)
GO_REF:0000024
RGD
UniProt
PMID:24144980 GO_REF:0000024, MGI:MGI:5551942 NCBI chr17:29,672,925...29,895,416
Ensembl chr17:29,674,164...29,895,386
JBrowse link
G LOC100910646 E3 ubiquitin-protein ligase RLIM-like ISO (MGI:MGI:4418586|PMID:19945382) RGD PMID:19945382 MGI:MGI:4418586 NCBI chr  X:73,757,664...73,778,757 JBrowse link
G NEWGENE_1559832 ring finger protein, LIM domain interacting IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:74,838,159...74,859,561
Ensembl chr  X:73,762,691...73,778,674
Ensembl chr  X:73,762,691...73,778,674
JBrowse link
G Rlim ring finger protein, LIM domain interacting ISO
IBA
(PMID:19945382)
PMID:21873635
RGD PMID:19945382, PMID:21873635 RGD:13792537 NCBI chr  X:73,757,664...73,778,763
Ensembl chr  X:73,762,691...73,778,674
Ensembl chr  X:73,762,691...73,778,674
JBrowse link
regulation of dosage compensation by inactivation of X chromosome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftx FTX transcript, XIST regulator ISO (MGI:MGI:4936795|PMID:21118898), (MGI:MGI:5581575|PMID:24613346) RGD PMID:21118898, PMID:24613346 MGI:MGI:4936795, MGI:MGI:5581575 NCBI chr  X:74,440,265...74,484,164 JBrowse link
G Jpx JPX transcript, XIST activator ISO MGI:MGI:4887255 (MGI:MGI:4881359|PMID:21029862), (MGI:MGI:5581575|PMID:24613346) RGD PMID:21029862, PMID:24613346 MGI:MGI:4881359, MGI:MGI:5581575 NCBI chr  X:74,360,739...74,410,973 JBrowse link
G LOC100910646 E3 ubiquitin-protein ligase RLIM-like ISO (MGI:MGI:5581575|PMID:24613346) RGD PMID:24613346 MGI:MGI:5581575 NCBI chr  X:73,757,664...73,778,757 JBrowse link
G NEWGENE_1559832 ring finger protein, LIM domain interacting IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:74,838,159...74,859,561
Ensembl chr  X:73,762,691...73,778,674
Ensembl chr  X:73,762,691...73,778,674
JBrowse link
G Rlim ring finger protein, LIM domain interacting IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:73,757,664...73,778,763
Ensembl chr  X:73,762,691...73,778,674
Ensembl chr  X:73,762,691...73,778,674
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    regulation of biological process 13071
      regulation of metabolic process 7007
        regulation of macromolecule metabolic process 6492
          regulation of gene expression 4799
            regulation of gene expression, epigenetic 153
              dosage compensation 23
                dosage compensation by inactivation of X chromosome 21
                  inactivation of X chromosome by DNA methylation 2
                  inactivation of X chromosome by genetic imprinting + 2
                  inactivation of X chromosome by heterochromatin assembly 1
                  inactivation of paternal X chromosome + 1
                  negative regulation of dosage compensation by inactivation of X chromosome 0
                  positive regulation of dosage compensation by inactivation of X chromosome 0
                  random inactivation of X chromosome 4
                  regulation of dosage compensation by inactivation of X chromosome + 5
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of metabolic process 7007
          regulation of macromolecule metabolic process 6492
            regulation of gene expression 4799
              regulation of gene expression, epigenetic 153
                dosage compensation 23
                  dosage compensation by inactivation of X chromosome 21
                    inactivation of X chromosome by DNA methylation 2
                    inactivation of X chromosome by genetic imprinting + 2
                    inactivation of X chromosome by heterochromatin assembly 1
                    inactivation of paternal X chromosome + 1
                    negative regulation of dosage compensation by inactivation of X chromosome 0
                    positive regulation of dosage compensation by inactivation of X chromosome 0
                    random inactivation of X chromosome 4
                    regulation of dosage compensation by inactivation of X chromosome + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.