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ONTOLOGY REPORT - ANNOTATIONS


Term:nucleobase metabolic process
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Accession:GO:0009112 term browser browse the term
Definition:The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.
Synonyms:exact_synonym: nucleobase metabolism


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'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase JBrowse link 6 26,657,507 26,680,459 RGD:5132591
RGD:13792537
RGD:1624291
G Cmpk1 cytidine/uridine monophosphate kinase 1 JBrowse link 5 133,759,722 133,786,452 RGD:1600115
G Cps1 carbamoyl-phosphate synthase 1 JBrowse link 9 74,113,437 74,236,274 RGD:1600115
G Dhodh dihydroorotate dehydrogenase (quinone) JBrowse link 19 42,066,103 42,087,906 RGD:5132591
RGD:13792537
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
G Umps uridine monophosphate synthetase JBrowse link 11 70,034,181 70,044,590 RGD:1600115
adenine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase JBrowse link 11 31,780,477 31,805,728 RGD:13792537
adenine metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ak1 adenylate kinase 1 JBrowse link 3 11,652,143 11,659,135 RGD:5490217
G Ak2 adenylate kinase 2 JBrowse link 5 147,185,474 147,204,050 RGD:5490217
G Aprt adenine phosphoribosyl transferase JBrowse link 19 55,387,288 55,389,256 RGD:1624291
G Hprt1 hypoxanthine phosphoribosyltransferase 1 JBrowse link X 158,196,640 158,228,815 RGD:1624291
adenine salvage term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aprt adenine phosphoribosyl transferase JBrowse link 19 55,387,288 55,389,256 RGD:1624291
RGD:13792537
G Hprt1 hypoxanthine phosphoribosyltransferase 1 JBrowse link X 158,196,640 158,228,815 RGD:1624291
RGD:13792537
G LOC103689983 hypoxanthine-guanine phosphoribosyltransferase JBrowse link X 158,623,231 158,655,277 RGD:13792537
cytosine metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:1624291
G Tet2 tet methylcytosine dioxygenase 2 JBrowse link 2 238,719,389 238,802,975 RGD:1624291
guanine catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gda guanine deaminase JBrowse link 1 238,982,542 239,057,663 RGD:1600115
guanine metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gda guanine deaminase JBrowse link 1 238,982,542 239,057,663 RGD:13792537
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:9588315
guanine salvage term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hprt1 hypoxanthine phosphoribosyltransferase 1 JBrowse link X 158,196,640 158,228,815 RGD:1624291
RGD:13792537
RGD:1600115
G LOC103689983 hypoxanthine-guanine phosphoribosyltransferase JBrowse link X 158,623,231 158,655,277 RGD:1600115
RGD:13792537
G Prtfdc1 phosphoribosyl transferase domain containing 1 JBrowse link 17 87,926,242 88,037,040 RGD:1624291
hypoxanthine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ada adenosine deaminase JBrowse link 3 160,115,840 160,139,947 RGD:1624291
G Prps1 phosphoribosyl pyrophosphate synthetase 1 JBrowse link X 111,798,233 111,820,270 RGD:1624291
hypoxanthine metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hprt1 hypoxanthine phosphoribosyltransferase 1 JBrowse link X 158,196,640 158,228,815 RGD:1580844
RGD:13792537
RGD:1624291
G LOC103689983 hypoxanthine-guanine phosphoribosyltransferase JBrowse link X 158,623,231 158,655,277 RGD:13792537
hypoxanthine oxidation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:13210503
hypoxanthine salvage term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ada adenosine deaminase JBrowse link 3 160,115,840 160,139,947 RGD:13792537
G Hprt1 hypoxanthine phosphoribosyltransferase 1 JBrowse link X 158,196,640 158,228,815 RGD:1624291
RGD:1600115
G LOC103689983 hypoxanthine-guanine phosphoribosyltransferase JBrowse link X 158,623,231 158,655,277 RGD:1600115
purine nucleobase biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppat phosphoribosyl pyrophosphate amidotransferase JBrowse link 14 33,580,541 33,614,919 RGD:1600115
G Shmt1 serine hydroxymethyltransferase 1 JBrowse link 10 47,030,813 47,059,216 RGD:1624291
RGD:13792537
G Shmt2 serine hydroxymethyltransferase 2 JBrowse link 7 70,824,718 70,829,822 RGD:13792537
purine nucleobase catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dpyd dihydropyrimidine dehydrogenase JBrowse link 2 221,823,692 222,694,627 RGD:1624291
RGD:1600115
G Uox urate oxidase JBrowse link 2 252,452,282 252,488,497 RGD:730101
purine nucleobase metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acp3 acid phosphatase 3 JBrowse link 8 112,838,574 112,884,062 RGD:1600115
RGD:1624291
G Gmpr guanosine monophosphate reductase JBrowse link 17 19,543,274 19,580,929 RGD:1600115
G Gmpr2 guanosine monophosphate reductase 2 JBrowse link 15 34,352,857 34,362,074 RGD:1600115
G Prps1 phosphoribosyl pyrophosphate synthetase 1 JBrowse link X 111,798,233 111,820,270 RGD:1624291
G RGD1309350 similar to transthyretin (4L369) JBrowse link 1 213,577,202 213,580,598 RGD:13792537
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:13792537
pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctps1 CTP synthase 1 JBrowse link 5 139,475,934 139,505,065 RGD:13792537
G Ctps2 CTP synthase 2 JBrowse link X 33,383,087 33,522,852 RGD:13792537
G Umps uridine monophosphate synthetase JBrowse link 11 70,034,181 70,044,590 RGD:13792537
pyrimidine nucleobase catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crmp1 collapsin response mediator protein 1 JBrowse link 14 78,266,931 78,312,777 RGD:13792537
G Dpyd dihydropyrimidine dehydrogenase JBrowse link 2 221,823,692 222,694,627 RGD:1599794
RGD:1624291
G Dpys dihydropyrimidinase JBrowse link 7 78,769,918 78,847,941 RGD:1624291
RGD:13792537
G Dpysl2 dihydropyrimidinase-like 2 JBrowse link 15 43,475,640 43,581,725 RGD:13792537
G Dpysl3 dihydropyrimidinase-like 3 JBrowse link 18 37,716,371 37,819,347 RGD:13792537
G Dpysl4 dihydropyrimidinase-like 4 JBrowse link 1 211,423,022 211,438,533 RGD:13792537
G Dpysl5 dihydropyrimidinase-like 5 JBrowse link 6 26,939,696 27,024,129 RGD:13792537
G LOC103692570 dihydropyrimidinase-related protein 5-like JBrowse link 6 26,423,841 26,446,080 RGD:13792537
pyrimidine nucleobase metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rrm1 ribonucleotide reductase catalytic subunit M1 JBrowse link 1 167,538,387 167,562,688 RGD:5133695
G Rrm2 ribonucleotide reductase regulatory subunit M2 JBrowse link 6 43,884,627 43,890,818 RGD:5133695
G Tymp thymidine phosphorylase JBrowse link 7 130,342,481 130,347,845 RGD:1600115
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:5133447
thymine catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 JBrowse link 6 108,146,552 108,167,185 RGD:1599052
RGD:13792537
RGD:1600115
RGD:1624291
G Dpyd dihydropyrimidine dehydrogenase JBrowse link 2 221,823,692 222,694,627 RGD:1624291
RGD:13792537
RGD:1600115
G Dpys dihydropyrimidinase JBrowse link 7 78,769,918 78,847,941 RGD:1624990
thymine metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 JBrowse link 6 108,146,552 108,167,185 RGD:1599052
uracil catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dpyd dihydropyrimidine dehydrogenase JBrowse link 2 221,823,692 222,694,627 RGD:1600115
RGD:13792537
RGD:1624291
G Dpys dihydropyrimidinase JBrowse link 7 78,769,918 78,847,941 RGD:1624990
RGD:1624291
uracil metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dpyd dihydropyrimidine dehydrogenase JBrowse link 2 221,823,692 222,694,627 RGD:1624989
G Dpys dihydropyrimidinase JBrowse link 7 78,769,918 78,847,941 RGD:1624989
RGD:1624990
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:5133426
xanthine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ada adenosine deaminase JBrowse link 3 160,115,840 160,139,947 RGD:1624291
xanthine catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aox1 aldehyde oxidase 1 JBrowse link 9 64,929,682 65,007,872 RGD:13792537
G Aox2 aldehyde oxidase 2 JBrowse link 9 65,175,455 65,265,149 RGD:13792537
G Aox3 aldehyde oxidase 3 JBrowse link 9 65,013,831 65,099,433 RGD:13792537
G Aox4 aldehyde oxidase 4 JBrowse link 9 65,110,330 65,167,188 RGD:13792537
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:8553512
RGD:13792537
RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      nitrogen compound metabolic process 10193
        organonitrogen compound metabolic process 7095
          nucleobase metabolic process 48
            nucleobase biosynthetic process + 18
            nucleobase catabolic process + 16
            purine nucleobase metabolic process + 26
            pyrimidine nucleobase metabolic process + 23
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      cellular metabolic process 10918
        cellular aromatic compound metabolic process 5567
          nucleobase-containing compound metabolic process 5344
            nucleobase-containing small molecule metabolic process 582
              nucleobase metabolic process 48
                nucleobase biosynthetic process + 18
                nucleobase catabolic process + 16
                purine nucleobase metabolic process + 26
                pyrimidine nucleobase metabolic process + 23
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.