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ONTOLOGY REPORT - ANNOTATIONS


Term:NAD biosynthetic process
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Accession:GO:0009435 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
Synonyms:exact_synonym: NAD anabolism;   NAD biosynthesis;   NAD formation;   NAD synthesis;   NADH biosynthesis;   NADH biosynthetic process;   nicotinamide adenine dinucleotide biosynthesis;   nicotinamide adenine dinucleotide biosynthetic process;   oxidized NAD biosynthesis;   oxidized NAD biosynthetic process;   oxidized nicotinamide adenine dinucleotide biosynthesis;   oxidized nicotinamide adenine dinucleotide biosynthetic process;   reduced NAD biosynthesis;   reduced NAD biosynthetic process;   reduced nicotinamide adenine dinucleotide biosynthesis;   reduced nicotinamide adenine dinucleotide biosynthetic process
 alt_id: GO:0006736


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NAD biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFMID arylformamidase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:78,185,102...78,207,702
Ensembl chr17:78,187,317...78,207,701
JBrowse link
G ASPDH aspartate dehydrogenase domain containing IEA UniProt
InterPro
GO_REF:0000002, GO_REF:0000041 NCBI chr19:50,511,600...50,514,684
Ensembl chr19:50,511,600...50,514,690
JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IMP (PMID:28792876) UniProtKB PMID:28792876 NCBI chr 2:42,767,087...42,801,002
Ensembl chr 2:42,767,089...42,792,593
JBrowse link
G KYNU kynureninase IMP
IEA
(PMID:28792876) UniProtKB
InterPro
PMID:28792876 GO_REF:0000002 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
G NADSYN1 NAD synthetase 1 IEA
IBA
(PMID:21873635) InterPro
GO_Central
UniProt
PMID:21873635 GO_REF:0000002, GO_REF:0000041 NCBI chr11:71,453,203...71,501,816
Ensembl chr11:71,453,109...71,524,107
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase IEA UniProt GO_REF:0000041 NCBI chr 7:106,248,298...106,284,983
Ensembl chr 7:106,248,298...106,286,326
JBrowse link
G NAPRT nicotinate phosphoribosyltransferase IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr 8:143,574,585...143,578,349
Ensembl chr 8:143,574,785...143,578,649
JBrowse link
G NMNAT1 nicotinamide nucleotide adenylyltransferase 1 IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr 1:9,942,923...9,996,884
Ensembl chr 1:9,943,428...9,985,501
JBrowse link
G NMNAT2 nicotinamide nucleotide adenylyltransferase 2 IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr 1:183,248,237...183,418,380
Ensembl chr 1:183,248,237...183,418,380
JBrowse link
G NMNAT3 nicotinamide nucleotide adenylyltransferase 3 IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr 3:139,560,180...139,678,050
Ensembl chr 3:139,560,180...139,678,017
JBrowse link
G NMRK1 nicotinamide riboside kinase 1 IEA UniProt GO_REF:0000041 NCBI chr 9:75,060,577...75,088,319
Ensembl chr 9:75,060,573...75,088,217
JBrowse link
G NMRK2 nicotinamide riboside kinase 2 IEA UniProt GO_REF:0000041 NCBI chr19:3,933,069...3,942,416
Ensembl chr19:3,933,103...3,942,416
JBrowse link
G QPRT quinolinate phosphoribosyltransferase IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr16:29,670,588...29,698,699
Ensembl chr16:29,663,279...29,698,699
JBrowse link
'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFMID arylformamidase IEA UniProt GO_REF:0000104 NCBI chr17:78,185,102...78,207,702
Ensembl chr17:78,187,317...78,207,701
JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:42,767,087...42,801,002
Ensembl chr 2:42,767,089...42,792,593
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:39,934,955...40,016,391
Ensembl chr 8:39,934,614...40,016,391
JBrowse link
G KMO kynurenine 3-monooxygenase IEA UniProt GO_REF:0000104 NCBI chr 1:241,531,883...241,595,642
Ensembl chr 1:241,532,134...241,595,642
JBrowse link
G KYNU kynureninase IEA UniProt GO_REF:0000104 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
NAD biosynthesis via nicotinamide riboside salvage pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NAMPT nicotinamide phosphoribosyltransferase TAS Reactome Reactome:R-HSA-197264 NCBI chr 7:106,248,298...106,284,983
Ensembl chr 7:106,248,298...106,286,326
JBrowse link
G NAPRT nicotinate phosphoribosyltransferase TAS Reactome Reactome:R-HSA-197264 NCBI chr 8:143,574,585...143,578,349
Ensembl chr 8:143,574,785...143,578,649
JBrowse link
G NAXD NAD(P)HX dehydratase TAS Reactome Reactome:R-HSA-197264 NCBI chr13:110,615,460...110,639,996
Ensembl chr13:110,615,460...110,639,993
JBrowse link
G NAXE NAD(P)HX epimerase TAS Reactome Reactome:R-HSA-197264 NCBI chr 1:156,591,776...156,599,818
Ensembl chr 1:156,591,762...156,594,299
JBrowse link
G NNMT nicotinamide N-methyltransferase TAS Reactome Reactome:R-HSA-197264 NCBI chr11:114,257,806...114,313,536
Ensembl chr11:114,257,787...114,313,536
Ensembl chr11:114,257,787...114,313,536
JBrowse link
G NUDT12 nudix hydrolase 12 TAS Reactome Reactome:R-HSA-197264 NCBI chr 5:103,548,855...103,562,805
Ensembl chr 5:103,548,855...103,562,790
JBrowse link
G PARP10 poly(ADP-ribose) polymerase family member 10 TAS Reactome Reactome:R-HSA-197264 NCBI chr 8:143,977,158...143,986,460
Ensembl chr 8:143,977,153...144,012,772
JBrowse link
G PARP16 poly(ADP-ribose) polymerase family member 16 TAS Reactome Reactome:R-HSA-197264 NCBI chr15:65,231,691...65,286,891
Ensembl chr15:65,234,460...65,300,618
JBrowse link
G PARP9 poly(ADP-ribose) polymerase family member 9 TAS Reactome Reactome:R-HSA-197264 NCBI chr 3:122,527,924...122,564,784
Ensembl chr 3:122,527,924...122,564,577
JBrowse link
G PTGIS prostaglandin I2 synthase TAS Reactome Reactome:R-HSA-197264 NCBI chr20:49,503,874...49,568,137
Ensembl chr20:49,503,874...49,568,137
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 TAS Reactome Reactome:R-HSA-197264 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RNLS renalase, FAD dependent amine oxidase TAS Reactome Reactome:R-HSA-197264 NCBI chr10:88,176,052...88,584,480
Ensembl chr10:88,273,864...88,584,530
JBrowse link
G SLC22A13 solute carrier family 22 member 13 TAS Reactome Reactome:R-HSA-197264 NCBI chr 3:38,265,812...38,278,757
Ensembl chr 3:38,265,812...38,278,757
JBrowse link
G SLC5A8 solute carrier family 5 member 8 TAS Reactome Reactome:R-HSA-197264 NCBI chr12:101,155,493...101,210,238
Ensembl chr12:101,155,493...101,210,238
JBrowse link
NAD salvage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NAPRT nicotinate phosphoribosyltransferase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:143,574,585...143,578,349
Ensembl chr 8:143,574,785...143,578,649
JBrowse link
regulation of 'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACMSD aminocarboxymuconate semialdehyde decarboxylase TAS (PMID:12140278), (PMID:19843166) ParkinsonsUK-UCL PMID:12140278, PMID:19843166 NCBI chr 2:134,838,319...134,902,906
Ensembl chr 2:134,838,616...134,902,034
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18626
    metabolic process 12276
      biosynthetic process 6519
        cellular biosynthetic process 6329
          cellular nitrogen compound biosynthetic process 5143
            pyridine-containing compound biosynthetic process 38
              pyridine nucleotide biosynthetic process 33
                nicotinamide nucleotide biosynthetic process 33
                  NAD biosynthetic process 29
                    'de novo' NAD biosynthetic process + 7
                    NAD biosynthesis via nicotinamide riboside salvage pathway 14
                    NAD salvage 1
Path 2
Term Annotations click to browse term
  biological_process 18626
    metabolic process 12276
      cellular metabolic process 11259
        cellular aromatic compound metabolic process 6222
          nucleobase-containing compound metabolic process 5971
            nucleobase-containing small molecule metabolic process 668
              nucleoside phosphate metabolic process 577
                nucleotide metabolic process 569
                  nucleotide biosynthetic process 285
                    pyridine nucleotide biosynthetic process 33
                      nicotinamide nucleotide biosynthetic process 33
                        NAD biosynthetic process 29
                          'de novo' NAD biosynthetic process + 7
                          NAD biosynthesis via nicotinamide riboside salvage pathway 14
                          NAD salvage 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.