ONTOLOGY REPORT - ANNOTATIONS


Term:multicellular organism aging
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Accession:GO:0010259 term browser browse the term
Definition:An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).


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multicellular organism aging term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acan aggrecan JBrowse link 1 140,762,758 140,824,441 RGD:2315752
G Cisd2 CDGSH iron sulfur domain 2 JBrowse link 2 240,586,754 240,611,560 RGD:1624291
RGD:1600115
G Comp cartilage oligomeric matrix protein JBrowse link 16 20,798,437 20,807,070 RGD:1624291
RGD:1600115
G Cryaa crystallin, alpha A JBrowse link 20 10,438,444 10,442,189 RGD:13503352
G Cryab crystallin, alpha B JBrowse link 8 55,178,543 55,182,546 RGD:13503352
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:2315581
G Dbh dopamine beta-hydroxylase JBrowse link 3 5,709,236 5,731,895 RGD:5129682
G Ddc dopa decarboxylase JBrowse link 14 91,905,919 91,996,816 RGD:5129108
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:4144863
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:1624291
RGD:1600115
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:5685607
G Helt helt bHLH transcription factor JBrowse link 16 49,185,560 49,187,293 RGD:1624291
RGD:1600115
G Hyal2 hyaluronidase 2 JBrowse link 8 116,324,062 116,328,978 RGD:1624291
RGD:1600115
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 JBrowse link 2 26,471,173 26,471,587 RGD:1624291
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 JBrowse link 3 22,998,900 23,020,441 RGD:1624291
RGD:1600115
G Pmp22 peripheral myelin protein 22 JBrowse link 10 49,538,588 49,568,583 RGD:1624291
G Rnf165 ring finger protein 165 JBrowse link 18 73,831,289 73,873,246 RGD:1624291
RGD:1600115
G Sec63 SEC63 homolog, protein translocation regulator JBrowse link 20 47,494,270 47,563,222 RGD:1624291
RGD:1600115
G Serp1 stress-associated endoplasmic reticulum protein 1 JBrowse link 2 148,718,279 148,722,263 RGD:1624291
RGD:1600115
G Slc1a2 solute carrier family 1 member 2 JBrowse link 3 92,518,679 92,665,731 RGD:1624291
G Terc telomerase RNA component JBrowse link 2 116,432,723 116,433,110 RGD:1624291
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:5129108
G Tp63 tumor protein p63 JBrowse link 11 78,234,853 78,456,559 RGD:1624291
RGD:1600115
G Wrn Werner syndrome RecQ like helicase JBrowse link 16 62,483,773 62,619,018 RGD:1624291
RGD:13792537
determination of adult lifespan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ankle1 ankyrin repeat and LEM domain containing 1 JBrowse link 16 19,799,943 19,826,057 RGD:1624291
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
RGD:1600115
G Atn1 atrophin 1 JBrowse link 4 157,267,394 157,281,199 RGD:1624291
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:1624291
G Cgas cyclic GMP-AMP synthase JBrowse link 8 85,789,515 85,804,008 RGD:1624291
G Coq7 coenzyme Q7, hydroxylase JBrowse link 1 188,176,060 188,190,874 RGD:1624291
RGD:13792537
G Ercc5 ERCC excision repair 5, endonuclease JBrowse link 9 50,928,847 50,970,962 RGD:1624291
G Ghrhr growth hormone releasing hormone receptor JBrowse link 4 85,587,321 85,602,389 RGD:1624291
RGD:1600115
G Hdac9 histone deacetylase 9 JBrowse link 6 53,487,367 54,358,694 RGD:1624291
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1624291
G Icmt isoprenylcysteine carboxyl methyltransferase JBrowse link 5 169,475,270 169,482,031 RGD:1624291
G Ide insulin degrading enzyme JBrowse link 1 255,914,465 256,014,168 RGD:1624291
RGD:1600115
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:1624291
RGD:1600115
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1600115
RGD:1624291
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:1600115
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1624291
RGD:1600115
G Msh6 mutS homolog 6 JBrowse link 6 11,644,565 11,662,389 RGD:1624291
RGD:1600115
G Pou1f1 POU class 1 homeobox 1 JBrowse link 11 2,645,659 2,662,581 RGD:1624291
RGD:1600115
G Prdm2 PR/SET domain 2 JBrowse link 5 161,769,587 161,879,150 RGD:1624291
RGD:1600115
G Rad54b RAD54 homolog B JBrowse link 5 25,140,531 25,214,469 RGD:1624291
RGD:1600115
G Rad54l RAD54 like JBrowse link 5 134,948,511 134,978,125 RGD:1624291
RGD:1600115
G Suv39h1 suppressor of variegation 3-9 homolog 1 JBrowse link X 146,532,002 146,533,538 RGD:1624291
G Tfcp2l1 transcription factor CP2-like 1 JBrowse link 13 34,610,689 34,671,617 RGD:1624291
RGD:1600115
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
RGD:1600115
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:1624291
RGD:1600115
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:1624291
RGD:1600115
reproductive senescence term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Inhbb inhibin subunit beta B JBrowse link 13 35,436,532 35,442,222 RGD:9743910
G Jmjd1c jumonji domain containing 1C JBrowse link 20 22,751,743 22,914,080 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17896
    multicellular organismal process 8524
      multicellular organism development 5425
        multicellular organism aging 52
          determination of adult lifespan + 26
          menopause 0
          reproductive senescence 2
Path 2
Term Annotations click to browse term
  biological_process 17896
    developmental process 6323
      anatomical structure development 5930
        multicellular organism development 5425
          multicellular organism aging 52
            determination of adult lifespan + 26
            menopause 0
            reproductive senescence 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.