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ONTOLOGY REPORT - ANNOTATIONS


Term:multicellular organism aging
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Accession:GO:0010259 term browser browse the term
Definition:An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).


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multicellular organism aging term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan IEP RGD PMID:19729050 RGD:2315752 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Cisd2 CDGSH iron sulfur domain 2 ISO (MGI:MGI:3845412|PMID:19451219) RGD PMID:19451219 MGI:MGI:3845412 NCBI chr 2:240,586,754...240,611,560
Ensembl chr 2:240,586,754...240,611,560
JBrowse link
G Comp cartilage oligomeric matrix protein ISO
IEA
MGI:MGI:2180787 (MGI:MGI:5824640|PMID:27498005)
GO_REF:0000107
RGD
Ensembl
PMID:27498005 GO_REF:0000107, MGI:MGI:5824640 NCBI chr16:20,798,437...20,807,070
Ensembl chr16:20,798,437...20,807,070
JBrowse link
G Cryaa crystallin, alpha A IEP RGD PMID:19120020 RGD:13503352 NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187
JBrowse link
G Cryab crystallin, alpha B IEP RGD PMID:19120020 RGD:13503352 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Ctsl cathepsin L IEP kidney RGD PMID:16865413 RGD:2315581 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Dbh dopamine beta-hydroxylase IEP RGD PMID:18522866 RGD:5129682 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Ddc dopa decarboxylase IEP RGD PMID:17112516 RGD:5129108 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Edn1 endothelin 1 IEP arteries RGD PMID:20522806 RGD:4144863 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO MGI:MGI:2183944 (MGI:MGI:3696605|PMID:17183314) RGD PMID:17183314 MGI:MGI:3696605 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IEP RGD PMID:11171671 RGD:5685607 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Helt helt bHLH transcription factor ISO MGI:MGI:3703237 (MGI:MGI:3702791|PMID:16968817) RGD PMID:16968817 MGI:MGI:3702791 NCBI chr16:49,185,560...49,187,293
Ensembl chr16:49,185,560...49,187,293
JBrowse link
G Hyal2 hyaluronidase 2 ISO
IEA
MGI:MGI:3836764 (MGI:MGI:3836537|PMID:18772348)
GO_REF:0000107
RGD
Ensembl
PMID:18772348 GO_REF:0000107, MGI:MGI:3836537 NCBI chr 8:116,324,062...116,328,978
Ensembl chr 8:116,324,040...116,328,978
JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 ISO MGI:MGI:4346527 (MGI:MGI:5319010|PMID:22474353) RGD PMID:22474353 MGI:MGI:5319010 NCBI chr 2:26,471,173...26,471,587
Ensembl chr 2:26,471,173...26,471,584
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 ISO MGI:MGI:5292676 (MGI:MGI:5287526|PMID:21820362) RGD PMID:21820362 MGI:MGI:5287526 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
JBrowse link
G Pmp22 peripheral myelin protein 22 ISO MGI:MGI:2447704 (MGI:MGI:5311965|PMID:22337502) RGD PMID:22337502 MGI:MGI:5311965 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Rnf165 ring finger protein 165 ISO MGI:MGI:5516581 (MGI:MGI:5499270|PMID:23610558) RGD PMID:23610558 MGI:MGI:5499270 NCBI chr18:73,831,289...73,873,246
Ensembl chr18:73,831,326...73,873,280
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator ISO MGI:MGI:5442171 (MGI:MGI:5441703|PMID:21685914) RGD PMID:21685914 MGI:MGI:5441703 NCBI chr20:47,494,270...47,563,222
Ensembl chr20:47,494,270...47,563,222
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 ISO MGI:MGI:3652355 (MGI:MGI:3629369|PMID:16705175) RGD PMID:16705175 MGI:MGI:3629369 NCBI chr 2:148,718,279...148,722,263
Ensembl chr 2:148,718,280...148,722,263
JBrowse link
G Slc1a2 solute carrier family 1 member 2 ISO MGI:MGI:2449707 (MGI:MGI:892703|PMID:9180080) RGD PMID:9180080 MGI:MGI:892703 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Terc telomerase RNA component ISO MGI:MGI:109635 (MGI:MGI:3050262|PMID:15235603) RGD PMID:15235603 MGI:MGI:3050262 NCBI chr 2:116,432,723...116,433,110
Ensembl chr 2:116,432,691...116,433,110
JBrowse link
G Th tyrosine hydroxylase IEP RGD PMID:17112516 RGD:5129108 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tp63 tumor protein p63 ISO MGI:MGI:2385473 (MGI:MGI:3588617|PMID:16107615) RGD PMID:16107615 MGI:MGI:3588617 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Wrn WRN RecQ like helicase ISO
IBA
MGI:MGI:109558 (MGI:MGI:3050262|PMID:15235603)
PMID:21873635
(PMID:16673358)
RGD PMID:15235603, PMID:16673358, PMID:21873635 MGI:MGI:3050262, RGD:13792537 NCBI chr16:62,483,773...62,619,018
Ensembl chr16:62,483,761...62,615,375
JBrowse link
determination of adult lifespan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankle1 ankyrin repeat and LEM domain containing 1 NOT ISO (MGI:MGI:5800654|PMID:27010503) RGD PMID:27010503 MGI:MGI:5800654 NCBI chr16:19,799,943...19,826,057
Ensembl chr16:19,800,463...19,803,796
JBrowse link
G Atm ATM serine/threonine kinase ISO MGI:MGI:3605986|MGI:MGI:894697 (MGI:MGI:3836659|PMID:19061978) RGD PMID:19061978 MGI:MGI:3836659 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atn1 atrophin 1 ISO MGI:MGI:4360645 (MGI:MGI:4359552|PMID:19681162) RGD PMID:19681162 MGI:MGI:4359552 NCBI chr 4:157,267,394...157,281,199
Ensembl chr 4:157,267,901...157,274,755
Ensembl chr 9:157,267,901...157,274,755
JBrowse link
G Bbc3 Bcl-2 binding component 3 ISO UniProtKB:P02340 (MGI:MGI:4944151|PMID:20818388) RGD PMID:20818388 MGI:MGI:4944151 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Cfh complement factor H ISO (MGI:MGI:5883383|PMID:28057640) RGD PMID:28057640 MGI:MGI:5883383 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Cgas cyclic GMP-AMP synthase ISO MGI:MGI:1328317 (MGI:MGI:5699498|PMID:26371324) RGD PMID:26371324 MGI:MGI:5699498 NCBI chr 8:85,789,515...85,804,008
Ensembl chr 8:85,789,763...85,803,433
JBrowse link
G Coq7 coenzyme Q7, hydroxylase ISO
IBA
MGI:MGI:2157003 (MGI:MGI:4359329|PMID:19478076)
PMID:21873635
RGD PMID:19478076, PMID:21873635 MGI:MGI:4359329, RGD:13792537 NCBI chr 1:188,176,060...188,190,874
Ensembl chr 1:188,174,874...188,190,860
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease ISO MGI:MGI:3043589 (MGI:MGI:3041918|PMID:15082767) RGD PMID:15082767 MGI:MGI:3041918 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955
JBrowse link
G Gba glucosylceramidase beta ISO (MGI:MGI:3795074|PMID:18346921) RGD PMID:18346921 MGI:MGI:3795074 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Ghrhr growth hormone releasing hormone receptor ISO MGI:MGI:1856425 (MGI:MGI:2135699|PMID:11371619) RGD PMID:11371619 MGI:MGI:2135699 NCBI chr 4:85,587,321...85,602,389
Ensembl chr 4:85,588,595...85,601,666
JBrowse link
G Hdac9 histone deacetylase 9 ISO MGI:MGI:1890508 (MGI:MGI:5139938|PMID:21746928) RGD PMID:21746928 MGI:MGI:5139938 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Htt huntingtin ISO MGI:MGI:2177757|MGI:MGI:2177767|MGI:MGI:2177768 (MGI:MGI:1926691|PMID:11062468), (MGI:MGI:1929816|PMID:11152661) RGD PMID:11062468, PMID:11152661 MGI:MGI:1926691, MGI:MGI:1929816 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase ISO MGI:MGI:1890508 (MGI:MGI:5500993|PMID:23686339) RGD PMID:23686339 MGI:MGI:5500993 NCBI chr 5:169,475,270...169,482,031
Ensembl chr 5:169,475,270...169,482,030
JBrowse link
G Ide insulin degrading enzyme ISO (PMID:18448515) RGD PMID:18448515 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO
IEA
MGI:MGI:2386884 (MGI:MGI:1266928|PMID:9620849)
GO_REF:0000107
RGD
Ensembl
PMID:9620849 GO_REF:0000107, MGI:MGI:1266928 NCBI chr 9:94,745,220...94,850,778
Ensembl chr 9:94,745,217...94,850,771
JBrowse link
G Lep leptin ISO MGI:MGI:1328317 (MGI:MGI:5829115|PMID:28069950) RGD PMID:28069950 MGI:MGI:5829115 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO (PMID:19692353) RGD PMID:19692353 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Msh2 mutS homolog 2 ISO
IEA
MGI:MGI:1858055 (MGI:MGI:1351797|PMID:10545954)
GO_REF:0000107
RGD
Ensembl
PMID:10545954 GO_REF:0000107, MGI:MGI:1351797 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Msh6 mutS homolog 6 ISO MGI:MGI:1858014|MGI:MGI:2151803 (MGI:MGI:1100204|PMID:9390556), (MGI:MGI:1351797|PMID:10545954) RGD PMID:9390556, PMID:10545954 MGI:MGI:1100204, MGI:MGI:1351797 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
JBrowse link
G Pou1f1 POU class 1 homeobox 1 ISO MGI:MGI:1856024|MGI:MGI:1856025 (MGI:MGI:2135699|PMID:11371619) RGD PMID:11371619 MGI:MGI:2135699 NCBI chr11:2,645,659...2,662,581
Ensembl chr11:2,645,865...2,662,579
JBrowse link
G Prdm2 PR/SET domain 2 ISO
IEA
MGI:MGI:2388354 (MGI:MGI:2149923|PMID:11544182)
GO_REF:0000107
RGD
Ensembl
PMID:11544182 GO_REF:0000107, MGI:MGI:2149923 NCBI chr 5:161,769,587...161,879,150
Ensembl chr 5:161,770,653...161,879,133
JBrowse link
G Rad54b RAD54 homolog B ISO MGI:MGI:107202|MGI:MGI:894697 (MGI:MGI:3836659|PMID:19061978) RGD PMID:19061978 MGI:MGI:3836659 NCBI chr 5:25,140,531...25,214,469
Ensembl chr 5:25,146,949...25,214,376
JBrowse link
G Rad54l RAD54 like ISO MGI:MGI:107202|MGI:MGI:3605986 (MGI:MGI:3836659|PMID:19061978) RGD PMID:19061978 MGI:MGI:3836659 NCBI chr 5:134,948,511...134,978,125
Ensembl chr 5:134,948,512...134,978,125
JBrowse link
G Suv39h1 suppressor of variegation 3-9 homolog 1 ISO MGI:MGI:1890508 (MGI:MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:MGI:5913114 NCBI chr  X:146,532,002...146,533,538 JBrowse link
G Tfcp2l1 transcription factor CP2-like 1 ISO MGI:MGI:3707684 (MGI:MGI:3703120|PMID:17079272) RGD PMID:17079272 MGI:MGI:3703120 NCBI chr13:34,610,689...34,671,617
Ensembl chr13:34,610,684...34,670,124
JBrowse link
G Tp53 tumor protein p53 ISO (MGI:MGI:4944151|PMID:20818388) RGD PMID:20818388 MGI:MGI:4944151 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trex1 three prime repair exonuclease 1 ISO MGI:MGI:104663|MGI:MGI:2442261|MGI:MGI:3052754 (MGI:MGI:3052278|PMID:15254239), (MGI:MGI:5699498|PMID:26371324), (MGI:MGI:5829115|PMID:28069950) RGD PMID:15254239, PMID:26371324, PMID:28069950 MGI:MGI:3052278, MGI:MGI:5699498, MGI:MGI:5829115 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 ISO MGI:MGI:1099440|MGI:MGI:1888594|MGI:MGI:1931221|MGI:MGI:2180033 (MGI:MGI:2178865|PMID:11923874), (MGI:MGI:3583382|PMID:15980864), (MGI:MGI:3789238|PMID:16079796), (MGI:MGI:3797328|PMID:18443001), (MGI:MGI:5139938|PMID:21746928), (MGI:MGI:5500993|PMID:23686339), (MGI:MGI:5824440|PMID:27799555), (MGI:MGI:5913114|PMID:23695662) RGD PMID:11923874, PMID:15980864, PMID:16079796, PMID:18443001, PMID:21746928, PMID:23686339, PMID:23695662, PMID:27799555 MGI:MGI:2178865, MGI:MGI:3583382, MGI:MGI:3789238, MGI:MGI:3797328, MGI:MGI:5139938, MGI:MGI:5500993, MGI:MGI:5824440, MGI:MGI:5913114 NCBI chr 5:139,982,404...140,015,541
Ensembl chr 5:139,983,680...140,015,541
JBrowse link
reproductive senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inhbb inhibin subunit beta B IEP RGD PMID:17636211 RGD:9743910 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Jmjd1c jumonji domain containing 1C ISO MGI:MGI:5544070 (MGI:MGI:5529185|PMID:24006281) RGD PMID:24006281 MGI:MGI:5529185 NCBI chr20:22,751,743...22,914,080
Ensembl chr20:22,751,743...22,882,672
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    multicellular organismal process 9055
      multicellular organism development 5735
        multicellular organism aging 54
          determination of adult lifespan + 28
          menopause 0
          reproductive senescence 2
Path 2
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        multicellular organism development 5735
          multicellular organism aging 54
            determination of adult lifespan + 28
            menopause 0
            reproductive senescence 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.