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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cell fate commitment
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Accession:GO:0010454 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


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negative regulation of cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Glis1 GLIS family zinc finger 1 JBrowse link 5 127,043,344 127,233,395 RGD:1624291
G Nanog Nanog homeobox JBrowse link 4 155,531,906 155,539,268 RGD:1624291
G Nkx6-2 NK6 homeobox 2 JBrowse link 1 211,922,389 211,923,929 RGD:1624291
G Sostdc1 sclerostin domain containing 1 JBrowse link 6 55,812,820 55,816,994 RGD:1624291
G Spdef SAM pointed domain containing ets transcription factor JBrowse link 20 7,292,823 7,308,053 RGD:1624291
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
negative regulation of cell fate determination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:1624291
RGD:1600115
negative regulation of cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:1624291
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fzd7 frizzled class receptor 7 JBrowse link 9 66,305,731 66,308,550 RGD:1624291
negative regulation of endodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:1624291
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1624291
G Mesp1 mesoderm posterior bHLH transcription factor 1 JBrowse link 1 141,532,390 141,533,908 RGD:1624291
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
negative regulation of retinal cone cell fate commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casz1 castor zinc finger 1 JBrowse link 5 165,625,119 165,777,053 RGD:1624291
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase-like 3 JBrowse link 4 113,866,782 113,883,713 RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    cellular process 18362
      negative regulation of cellular process 5082
        negative regulation of cell differentiation 820
          negative regulation of cell fate commitment 16
            negative regulation of T-helper 17 cell lineage commitment 3
            negative regulation of anterior neural cell fate commitment of the neural plate + 0
            negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
            negative regulation of cell fate determination + 1
            negative regulation of cell fate specification + 6
            negative regulation of establishment or maintenance of neuroblast polarity 0
            negative regulation of mating type switching 0
            negative regulation of retinal cone cell fate commitment + 1
            negative regulation of sevenless signaling pathway 0
            negative regulation of trichome patterning 0
            negative regulation of venous endothelial cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 19578
    cellular process 18362
      cellular developmental process 4347
        cell differentiation 4249
          cell fate commitment 288
            regulation of cell fate commitment 36
              negative regulation of cell fate commitment 16
                negative regulation of T-helper 17 cell lineage commitment 3
                negative regulation of anterior neural cell fate commitment of the neural plate + 0
                negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
                negative regulation of cell fate determination + 1
                negative regulation of cell fate specification + 6
                negative regulation of establishment or maintenance of neuroblast polarity 0
                negative regulation of mating type switching 0
                negative regulation of retinal cone cell fate commitment + 1
                negative regulation of sevenless signaling pathway 0
                negative regulation of trichome patterning 0
                negative regulation of venous endothelial cell fate commitment + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.