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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of gene expression
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Accession:GO:0010468 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
Comment:This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
Synonyms:narrow_synonym: regulation of protein expression
 related_synonym: regulation of gene product expression
 xref: Wikipedia:Regulation_of_gene_expression


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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    regulation of biological process 12959
      regulation of metabolic process 6886
        regulation of macromolecule metabolic process 6375
          regulation of gene expression 4685
            circadian regulation of gene expression 71
            modulation by virus of host gene expression + 1
            negative regulation of gene expression + 2076
            positive regulation of gene expression + 2499
            posttranscriptional regulation of gene expression + 541
            pre-B cell allelic exclusion 3
            regulation of RNA splicing + 173
            regulation of cytokine production + 759
            regulation of dosage compensation by inactivation of X chromosome + 5
            regulation of gene expression, epigenetic + 154
            regulation of gene silencing + 74
            regulation of histone gene expression + 0
            regulation of mRNA catabolic process + 129
            regulation of mRNA export from nucleus + 8
            regulation of mRNA processing + 164
            regulation of mitochondrial gene expression + 32
            regulation of protein maturation + 76
            regulation of rRNA processing + 14
            regulation of rhodopsin gene expression + 4
            regulation of snoRNA processing + 0
            regulation of tRNA processing + 0
            regulation of transcription, DNA-templated + 3182
            signal transduction involved in regulation of gene expression 24
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of metabolic process 6886
          regulation of macromolecule metabolic process 6375
            regulation of gene expression 4685
              circadian regulation of gene expression 71
              modulation by virus of host gene expression + 1
              negative regulation of gene expression + 2076
              positive regulation of gene expression + 2499
              posttranscriptional regulation of gene expression + 541
              pre-B cell allelic exclusion 3
              regulation of RNA splicing + 173
              regulation of cytokine production + 759
              regulation of dosage compensation by inactivation of X chromosome + 5
              regulation of gene expression, epigenetic + 154
              regulation of gene silencing + 74
              regulation of histone gene expression + 0
              regulation of mRNA catabolic process + 129
              regulation of mRNA export from nucleus + 8
              regulation of mRNA processing + 164
              regulation of mitochondrial gene expression + 32
              regulation of protein maturation + 76
              regulation of rRNA processing + 14
              regulation of rhodopsin gene expression + 4
              regulation of snoRNA processing + 0
              regulation of tRNA processing + 0
              regulation of transcription, DNA-templated + 3182
              signal transduction involved in regulation of gene expression 24
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.