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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of cardiac muscle hypertrophy
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Accession:GO:0010613 term browser browse the term
Definition:Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.


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positive regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adk adenosine kinase IMP RGD PMID:21335462 RGD:6482642 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Adra1a adrenoceptor alpha 1A ISO (MGI:5888970|PMID:27994061) RGD PMID:27994061 MGI:5888970 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Agt angiotensinogen IDA PMID:8348686 BHF-UCL PMID:8348686 RGD:8553767 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Becn1 beclin 1 ISO MGI:2683833 (MGI:5888970|PMID:27994061) RGD PMID:27994061 MGI:5888970 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bmp10 bone morphogenetic protein 10 ISO
IEA
IMP
(PMID:17921333)
GO_REF:0000107
RGD
Ensembl
PMID:17921333, PMID:17921333 GO_REF:0000107, RGD:2302083 NCBI chr 4:119,224,906...119,230,534
Ensembl chr 4:119,225,040...119,230,728
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta ISO
ISS
(PMID:17179159)
GO_REF:0000024
RGD
UniProt
PMID:17179159 GO_REF:0000024 NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039
JBrowse link
G Cdk9 cyclin-dependent kinase 9 IMP RGD PMID:20081228 RGD:9698419 NCBI chr 3:11,742,269...11,747,117
Ensembl chr 3:11,742,266...11,747,113
JBrowse link
G Ece1 endothelin converting enzyme 1 IMP RGD PMID:20099522 RGD:7243873 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Edn1 endothelin 1 ISO (PMID:12847114) RGD PMID:12847114 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 ISO
IEA
UniProtKB:P63328|UniProtKB:Q02078 (PMID:24161931)
GO_REF:0000107
RGD
Ensembl
PMID:24161931 GO_REF:0000107 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link
G Igf1 insulin-like growth factor 1 ISO (PMID:19654000), (PMID:19933931) RGD PMID:19654000, PMID:19933931 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Mef2a myocyte enhancer factor 2a ISO
IEA
UniProtKB:P61296 (PMID:24161931)
GO_REF:0000107
RGD
Ensembl
PMID:24161931 GO_REF:0000107 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
JBrowse link
G Mef2c myocyte enhancer factor 2C IMP PMID:19654000 UniProt PMID:19654000 RGD:5131609 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mtpn myotrophin IMP
ISO
PMID:18693253
(PMID:10329199)
RGD PMID:10329199, PMID:18693253 RGD:8553542 NCBI chr 4:63,012,009...63,039,422
Ensembl chr 4:63,012,011...63,039,422
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 IMP PMID:25625556 UniProt PMID:25625556 RGD:10054073 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP PMID:25625556 UniProt PMID:25625556 RGD:10054073 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pde5a phosphodiesterase 5A IEA
ISO
GO_REF:0000107
(MGI:3836877|PMID:19127022)
Ensembl
RGD
PMID:19127022 GO_REF:0000107, MGI:3836877 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pde9a phosphodiesterase 9A ISS
ISO
GO_REF:0000024
(MGI:5634842|PMID:25799991)
UniProt
RGD
PMID:25799991 GO_REF:0000024, MGI:5634842 NCBI chr20:10,123,624...10,216,325
Ensembl chr20:10,123,651...10,216,548
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha ISO RNAcentral:URS0000021B51_10090|UniProtKB:P61296 (MGI:5562625|PMID:24161931), (MGI:5784969|PMID:24657879) RGD PMID:24161931, PMID:24657879 MGI:5562625, MGI:5784969 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Prkca protein kinase C, alpha IDA PMID:11864993 UniProt PMID:11864993 RGD:8554603 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptk2 protein tyrosine kinase 2 IEA
ISO
GO_REF:0000107
(MGI:5888970|PMID:27994061)
Ensembl
RGD
PMID:27994061 GO_REF:0000107, MGI:5888970 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 IEA
ISO
GO_REF:0000107
(PMID:28679962)
Ensembl
RGD
PMID:28679962 GO_REF:0000107 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IMP
ISO
PMID:28679962
(MGI:6158813|PMID:28679962)
RGD PMID:28679962, PMID:28679962 MGI:6158813, RGD:13601991 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Slc9a1 solute carrier family 9 member A1 ISO (PMID:21359875) RGD PMID:21359875 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Twf1 twinfilin actin-binding protein 1 ISO (MGI:5882879|PMID:20571053) RGD PMID:20571053 MGI:5882879 NCBI chr 7:135,838,647...135,850,542
Ensembl chr 7:135,838,648...135,850,542
JBrowse link
positive regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp3ca protein phosphatase 3 catalytic subunit alpha ISO (MGI:3848765|PMID:19287093) RGD PMID:19287093 MGI:3848765 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 ISO
IEA
(PMID:19287093)
GO_REF:0000107
RGD
Ensembl
PMID:19287093 GO_REF:0000107 NCBI chr 2:123,329,954...123,467,574
Ensembl chr 2:123,329,875...123,407,496
JBrowse link
positive regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:18194989 RGD:5129139 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Akap6 A-kinase anchoring protein 6 IMP
IDA
RGD PMID:21550986, PMID:16306226 RGD:6902940, RGD:2312613 NCBI chr 6:73,553,111...73,991,992
Ensembl chr 6:73,553,210...73,990,534
JBrowse link
G Ccn4 cellular communication network factor 4 IMP RGD PMID:21376054 RGD:5129173 NCBI chr 7:107,695,227...107,723,759
Ensembl chr 7:107,695,215...107,723,772
JBrowse link
G Ddx39b DExD-box helicase 39B IMP RGD PMID:20116367 RGD:10401141 NCBI chr20:4,806,103...4,818,600
Ensembl chr20:4,806,108...4,818,568
JBrowse link
G Edn1 endothelin 1 ISO RNAcentral:URS000006FDD4_9606|RNAcentral:URS000013D17D_9606 (PMID:24117217) RGD PMID:24117217 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ep300 E1A binding protein p300 IMP RGD PMID:12724418 RGD:2312280 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Fdps farnesyl diphosphate synthase IMP RGD PMID:19716825 RGD:2316294 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Hamp hepcidin antimicrobial peptide IMP RGD PMID:24424338 RGD:11041632 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Igf1 insulin-like growth factor 1 ISO
IEA
RNAcentral:URS000006FDD4_9606|RNAcentral:URS000013D17D_9606 (PMID:24117217)
GO_REF:0000107
RGD
Ensembl
PMID:24117217 GO_REF:0000107 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:21318349, PMID:21933187 RGD:10040977, RGD:10040978 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP RGD PMID:22989630 RGD:7174736 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 IMP RGD PMID:23261455 RGD:13514044 NCBI chr15:27,739,416...27,749,650
Ensembl chr15:27,739,251...27,749,648
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 IMP RGD PMID:23487407 RGD:8693424 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:25281201 RGD:13514043 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc25a4 solute carrier family 25 member 4 IDA RGD PMID:21325829 RGD:9681466 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Trip10 thyroid hormone receptor interactor 10 IMP RGD PMID:23915320 RGD:11535145 NCBI chr 9:9,689,214...9,702,353
Ensembl chr 9:9,689,475...9,702,306
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    positive regulation of biological process 6648
      positive regulation of multicellular organismal process 1647
        positive regulation of muscle hypertrophy 41
          positive regulation of cardiac muscle hypertrophy 40
            positive regulation of cardiac muscle hypertrophy in response to stress 2
            positive regulation of cell growth involved in cardiac muscle cell development 16
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of multicellular organismal process 2916
          regulation of system process 650
            regulation of muscle system process 267
              regulation of muscle adaptation 110
                regulation of cardiac muscle hypertrophy 73
                  positive regulation of cardiac muscle hypertrophy 40
                    positive regulation of cardiac muscle hypertrophy in response to stress 2
                    positive regulation of cell growth involved in cardiac muscle cell development 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.