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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of gene expression
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Accession:GO:0010629 term browser browse the term
Definition:Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
Comment:This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.


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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    negative regulation of biological process 5686
      negative regulation of metabolic process 3307
        negative regulation of macromolecule metabolic process 3043
          negative regulation of gene expression 2160
            gene silencing + 256
            mRNA catabolic process + 231
            negative regulation of RNA splicing + 31
            negative regulation of cytokine production + 283
            negative regulation of gene expression, epigenetic + 94
            negative regulation of histone gene expression 0
            negative regulation of production of miRNAs involved in gene silencing by miRNA + 15
            negative regulation of production of siRNA involved in RNA interference 1
            negative regulation of protein maturation + 32
            negative regulation of rRNA processing 2
            negative regulation of rhodopsin gene expression 0
            negative regulation of snoRNA processing 0
            negative regulation of tRNA processing 0
            negative regulation of transcription, DNA-templated + 1346
            negative regulation of translation + 148
            pericentric heterochromatin assembly + 6
            suppression by virus of host gene expression + 0
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        macromolecule metabolic process 10098
          gene expression 6294
            regulation of gene expression 4784
              negative regulation of gene expression 2160
                gene silencing + 256
                mRNA catabolic process + 231
                negative regulation of RNA splicing + 31
                negative regulation of cytokine production + 283
                negative regulation of gene expression, epigenetic + 94
                negative regulation of histone gene expression 0
                negative regulation of production of miRNAs involved in gene silencing by miRNA + 15
                negative regulation of production of siRNA involved in RNA interference 1
                negative regulation of protein maturation + 32
                negative regulation of rRNA processing 2
                negative regulation of rhodopsin gene expression 0
                negative regulation of snoRNA processing 0
                negative regulation of tRNA processing 0
                negative regulation of transcription, DNA-templated + 1346
                negative regulation of translation + 148
                pericentric heterochromatin assembly + 6
                suppression by virus of host gene expression + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.