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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of epithelial to mesenchymal transition
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Accession:GO:0010717 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


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regulation of epithelial to mesenchymal transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clasp1 cytoplasmic linker associated protein 1 JBrowse link 13 34,365,038 34,584,651 RGD:1624291
RGD:1600115
G Clasp2 cytoplasmic linker associated protein 2 JBrowse link 8 122,003,719 122,185,495 RGD:1624291
G Dag1 dystroglycan 1 JBrowse link 8 116,980,501 116,993,182 RGD:1624291
RGD:1600115
G Ell3 elongation factor for RNA polymerase II 3 JBrowse link 3 113,400,395 113,405,869 RGD:1624291
RGD:1600115
G Epha3 Eph receptor A3 JBrowse link 11 421,253 783,037 RGD:1624291
RGD:1600115
G Grem1 gremlin 1, DAN family BMP antagonist JBrowse link 3 105,203,309 105,214,989 RGD:1624291
RGD:1600115
G LOC103690035 TGF-beta receptor type-1-like JBrowse link 5 64,565,358 64,585,219 RGD:1600115
G Mcrip1 MAPK regulated co-repressor interacting protein 1 JBrowse link 10 109,720,144 109,727,595 RGD:1624291
RGD:1600115
G Phldb1 pleckstrin homology-like domain, family B, member 1 JBrowse link 8 48,997,189 49,045,176 RGD:1600115
RGD:1624291
G Phldb2 pleckstrin homology-like domain, family B, member 2 JBrowse link 11 60,042,879 60,051,229 RGD:1624291
RGD:1600115
G Pofut2 protein O-fucosyltransferase 2 JBrowse link 20 12,117,811 12,128,747 RGD:1624291
RGD:1600115
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1624291
RGD:1600115
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1600115
G Tiam1 TIAM Rac1 associated GEF 1 JBrowse link 11 29,931,083 30,061,173 RGD:1624291
RGD:1600115
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:1624291
RGD:1600115
negative regulation of epithelial to mesenchymal transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipor1 adiponectin receptor 1 JBrowse link 13 51,240,470 51,260,233 RGD:1624291
RGD:1600115
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Dact3 dishevelled-binding antagonist of beta-catenin 3 JBrowse link 1 78,800,754 78,812,483 RGD:1624291
RGD:1600115
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:1624291
RGD:1600115
G Foxa1 forkhead box A1 JBrowse link 6 78,516,579 78,549,669 RGD:1624291
RGD:1600115
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:1624291
RGD:1600115
G Hpn hepsin JBrowse link 1 89,534,112 89,549,575 RGD:1600115
RGD:13792537
RGD:1624291
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 JBrowse link 18 63,717,423 64,045,224 RGD:1624291
RGD:1600115
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link 5 164,943,183 164,956,255 RGD:1624291
RGD:1600115
G Nkx2-1 NK2 homeobox 1 JBrowse link 6 77,418,096 77,423,383 RGD:1600115
RGD:1624291
G Ovol2 ovo-like zinc finger 2 JBrowse link 3 138,433,990 138,464,511 RGD:1600115
RGD:1624291
G Pbld1 phenazine biosynthesis-like protein domain containing 1 JBrowse link 20 27,103,300 27,118,650 RGD:1624291
RGD:1600115
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:1624291
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
RGD:1600115
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 JBrowse link 1 226,543,671 226,572,414 RGD:1624291
RGD:1600115
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1600115
RGD:1624291
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
RGD:1600115
G Strap serine/threonine kinase receptor associated protein JBrowse link 4 171,730,629 171,744,877 RGD:1624291
G Tgfbr3 transforming growth factor beta receptor 3 JBrowse link 14 3,506,416 3,680,508 RGD:1624291
G Trim62 tripartite motif-containing 62 JBrowse link 5 147,068,725 147,099,024 RGD:1624291
RGD:1600115
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:11568680
G Usf3 upstream transcription factor family member 3 JBrowse link 11 61,427,140 61,499,668 RGD:1624291
RGD:1600115
G Vasn vasorin JBrowse link 10 11,121,041 11,131,548 RGD:1624291
RGD:1600115
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
negative regulation of neural crest formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fuz fuzzy planar cell polarity protein JBrowse link 1 100,891,832 100,896,811 RGD:1624291
RGD:1600115
positive regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:13601997
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:13601997
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
RGD:1600115
positive regulation of epithelial to mesenchymal transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:7243870
G Alx1 ALX homeobox 1 JBrowse link 7 44,751,865 44,771,458 RGD:1624291
RGD:1600115
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:1624291
RGD:1600115
G Bambi BMP and activin membrane-bound inhibitor JBrowse link 17 56,905,419 56,909,675 RGD:1624291
RGD:1600115
G Bcl9l BCL9 like JBrowse link 8 48,805,684 48,835,794 RGD:1624291
RGD:1600115
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:1600115
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1600115
RGD:1624291
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
RGD:1600115
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:1624291
RGD:1600115
G Crb2 crumbs cell polarity complex component 2 JBrowse link 3 22,037,812 22,061,247 RGD:1600115
RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1600115
RGD:1624291
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:1624291
RGD:1600115
G Foxc1 forkhead box C1 JBrowse link 17 33,947,501 33,951,484 RGD:1624291
RGD:1600115
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) JBrowse link 17 21,634,546 21,677,477 RGD:1624291
RGD:1600115
G Glipr2 GLI pathogenesis-related 2 JBrowse link 5 59,415,415 59,446,732 RGD:1624291
RGD:1600115
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:9590229
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
G Isl1 ISL LIM homeobox 1 JBrowse link 2 48,488,911 48,501,217 RGD:13210526
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:1600115
RGD:1624291
G Loxl2 lysyl oxidase-like 2 JBrowse link 15 51,276,022 51,365,238 RGD:1600115
RGD:1624291
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:1600115
RGD:1624291
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
RGD:1600115
G Myocd myocardin JBrowse link 10 51,682,053 51,781,458 RGD:13210526
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G Olfm1 olfactomedin 1 JBrowse link 3 6,761,031 6,798,739 RGD:1600115
G Pdpn podoplanin JBrowse link 5 161,947,137 161,981,441 RGD:1600115
RGD:1624291
G Rgcc regulator of cell cycle JBrowse link 15 61,551,861 61,564,695 RGD:1624291
RGD:1600115
G Sdcbp syndecan binding protein JBrowse link 5 19,471,664 19,498,499 RGD:1624291
RGD:1600115
G Serpinb3 serpin family B member 3 JBrowse link 13 27,186,701 27,193,211 RGD:1624291
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:1624291
RGD:1600115
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1624291
RGD:1600115
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1624291
RGD:1600115
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 JBrowse link 1 199,664,039 199,670,970 RGD:1624291
RGD:1600115
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1600115
RGD:1624291
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1624291
RGD:1600115
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
G Wwtr1 WW domain containing transcription regulator 1 JBrowse link 2 147,577,149 147,693,033 RGD:1624291
RGD:1600115
G Zfp703 zinc finger protein 703 JBrowse link 16 69,237,857 69,242,028 RGD:1624291
RGD:1600115
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
RGD:1600115
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1624291
RGD:1600115
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1624291
regulation of neural crest cell fate specification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    regulation of biological process 12516
      regulation of developmental process 2794
        regulation of multicellular organismal development 2220
          regulation of epithelial to mesenchymal transition 88
            negative regulation of epithelial to mesenchymal transition + 27
            positive regulation of epithelial to mesenchymal transition + 48
            regulation of cardiac epithelial to mesenchymal transition + 11
            regulation of neural crest formation + 2
Path 2
Term Annotations click to browse term
  biological_process 19245
    developmental process 6597
      anatomical structure development 6063
        multicellular organism development 5534
          system development 5081
            animal organ development 3881
              mesenchyme development 279
                mesenchymal cell differentiation 219
                  epithelial to mesenchymal transition 142
                    regulation of epithelial to mesenchymal transition 88
                      negative regulation of epithelial to mesenchymal transition + 27
                      positive regulation of epithelial to mesenchymal transition + 48
                      regulation of cardiac epithelial to mesenchymal transition + 11
                      regulation of neural crest formation + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.