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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of epithelial to mesenchymal transition
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Accession:GO:0010718 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


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positive regulation of epithelial to mesenchymal transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IMP RGD PMID:21743278 RGD:7243870 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Alx1 ALX homeobox 1 ISO
ISS
(PMID:23288509)
GO_REF:0000024
RGD
UniProt
PMID:23288509 GO_REF:0000024 NCBI chr 7:44,751,865...44,771,458
Ensembl chr 7:44,751,873...44,771,458
JBrowse link
G Axin2 axin 2 ISO
IEA
(PMID:17072303)
GO_REF:0000107
RGD
Ensembl
PMID:17072303 GO_REF:0000107 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor ISO (PMID:19328798) RGD PMID:19328798 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bcl9l BCL9 like ISO (PMID:19328798) RGD PMID:19328798 NCBI chr 8:48,805,684...48,835,794
Ensembl chr 8:48,805,684...48,834,312
JBrowse link
G Bmp2 bone morphogenetic protein 2 ISO
IEA
(PMID:20890042)
GO_REF:0000107
MGI:MGI:3583785 (MGI:MGI:3611958|PMID:16314491)
RGD
Ensembl
PMID:16314491, PMID:20890042 GO_REF:0000107, MGI:MGI:3611958 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp4 bone morphogenetic protein 4 IEA
ISO
GO_REF:0000107
UniProtKB:P23359 (MGI:MGI:5502250|PMID:23863481)
Ensembl
RGD
PMID:23863481 GO_REF:0000107, MGI:MGI:5502250 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO UniProtKB:P21275 (MGI:MGI:5502250|PMID:23863481) RGD PMID:23863481 MGI:MGI:5502250 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Col1a1 collagen type I alpha 1 chain ISO (PMID:20018240) RGD PMID:20018240 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Crb2 crumbs cell polarity complex component 2 ISS
ISO
GO_REF:0000024
(MGI:MGI:5296388|PMID:22072575), (MGI:MGI:5823085|PMID:27870829)
UniProt
RGD
PMID:22072575, PMID:27870829 GO_REF:0000024, MGI:MGI:5296388, MGI:MGI:5823085 NCBI chr 3:22,037,812...22,061,247
Ensembl chr 3:22,038,357...22,058,871
JBrowse link
G Ctnnb1 catenin beta 1 ISO UniProtKB:Q9NX18 (PMID:23983127) RGD PMID:23983127 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dab2 DAB adaptor protein 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:5442513|PMID:15734730)
Ensembl
RGD
PMID:15734730 GO_REF:0000107, MGI:MGI:5442513 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO (PMID:20154697) RGD PMID:20154697 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Foxc1 forkhead box C1 ISO (PMID:22991501) RGD PMID:22991501 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) ISO (PMID:21750175)
(MGI:MGI:5545971|PMID:21750175)
RGD PMID:21750175 MGI:MGI:5545971 NCBI chr17:21,634,546...21,677,477
Ensembl chr17:21,634,551...21,739,408
JBrowse link
G Glipr2 GLI pathogenesis-related 2 ISO (PMID:23516513) RGD PMID:23516513 NCBI chr 5:59,415,415...59,446,732
Ensembl chr 5:59,416,076...59,446,647
JBrowse link
G Hdac2 histone deacetylase 2 IMP RGD PMID:19553350 RGD:9590229 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Il1b interleukin 1 beta IEA
ISO
GO_REF:0000107
(PMID:25204733)
Ensembl
RGD
PMID:25204733 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 ISO (PMID:25916550) RGD PMID:25916550 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Isl1 ISL LIM homeobox 1 IMP PMID:23270756 BHF-UCL PMID:23270756 RGD:13210526 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 IEA
ISO
GO_REF:0000107
(PMID:20018240)
Ensembl
RGD
PMID:20018240 GO_REF:0000107 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Loxl2 lysyl oxidase-like 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:24239292)
Ensembl
UniProt
RGD
PMID:24239292 GO_REF:0000024, GO_REF:0000107 NCBI chr15:51,276,022...51,365,238
Ensembl chr15:51,303,909...51,365,234
JBrowse link
G Mdk midkine ISS
ISO
GO_REF:0000024
(PMID:18469519)
UniProt
RGD
PMID:18469519 GO_REF:0000024 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO (PMID:27919618) RGD PMID:27919618 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myocd myocardin IMP PMID:23270756 BHF-UCL PMID:23270756 RGD:13210526 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986
JBrowse link
G Notch1 notch receptor 1 ISO (MGI:MGI:4837019|PMID:20890042) RGD PMID:20890042 MGI:MGI:4837019 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Olfm1 olfactomedin 1 ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Pdpn podoplanin ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:17046996), (PMID:21376833)
UniProt
RGD
PMID:17046996, PMID:21376833, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441
JBrowse link
G Rgcc regulator of cell cycle ISO (PMID:19158077), (PMID:21307346) RGD PMID:19158077, PMID:21307346 NCBI chr15:61,551,861...61,564,695
Ensembl chr15:61,551,861...61,564,695
JBrowse link
G Sdcbp syndecan binding protein ISO
ISS
(PMID:25893292)
GO_REF:0000024
RGD
UniProt
PMID:25893292 GO_REF:0000024 NCBI chr 5:19,471,664...19,498,499
Ensembl chr 5:19,471,664...19,498,485
JBrowse link
G Serpinb3 serpin family B member 3 ISO (PMID:20527027) RGD PMID:20527027 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592
JBrowse link
G Smad2 SMAD family member 2 ISO (MGI:MGI:2683382|PMID:14691138) RGD PMID:14691138 MGI:MGI:2683382 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 ISO (PMID:18505915), (PMID:21307346) RGD PMID:18505915, PMID:21307346 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 ISO
IEA
(MGI:MGI:2683382|PMID:14691138)
GO_REF:0000107
RGD
Ensembl
PMID:14691138 GO_REF:0000107, MGI:MGI:2683382 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Snai1 snail family transcriptional repressor 1 ISO (PMID:20018240), (PMID:23288509)
(MGI:MGI:4837019|PMID:20890042), (MGI:MGI:5548026|PMID:24239292)
RGD PMID:20018240, PMID:20890042, PMID:23288509, PMID:24239292 MGI:MGI:4837019, MGI:MGI:5548026 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO
ISS
(MGI:MGI:3821807|PMID:18794329)
(PMID:17999987), (PMID:18505915)
GO_REF:0000024
RGD
UniProt
PMID:17999987, PMID:18505915, PMID:18794329 GO_REF:0000024, MGI:MGI:3821807 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 ISO (PMID:18762808) RGD PMID:18762808 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISS
ISO
GO_REF:0000024
(PMID:17999987), (PMID:18505915)
UniProt
RGD
PMID:17999987, PMID:18505915 GO_REF:0000024 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO
ISS
(MGI:MGI:2683382|PMID:14691138)
(PMID:18505915), (PMID:18718461)
GO_REF:0000024
RGD
AgBase
PMID:14691138, PMID:18505915, PMID:18718461 GO_REF:0000024, MGI:MGI:2683382 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO UniProtKB:P10600 (MGI:MGI:3820811|PMID:18718461) RGD PMID:18718461 MGI:MGI:3820811 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO (PMID:26459119) RGD PMID:26459119 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO (PMID:18297062)
(MGI:MGI:4838344|PMID:20804746), (MGI:MGI:5284765|PMID:18297062), (MGI:MGI:5284780|PMID:17332324)
RGD PMID:17332324, PMID:18297062, PMID:20804746 MGI:MGI:4838344, MGI:MGI:5284765, MGI:MGI:5284780 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 ISO (PMID:18227151) RGD PMID:18227151 NCBI chr 2:147,577,149...147,693,033
Ensembl chr 2:147,577,089...147,693,082
JBrowse link
G Zfp703 zinc finger protein 703 ISO (MGI:MGI:4940410|PMID:21317240) RGD PMID:21317240 MGI:MGI:4940410 NCBI chr16:69,237,857...69,242,028
Ensembl chr16:69,237,857...69,242,028
JBrowse link
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 ISO
IEA
ISS
(PMID:17072303)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17072303 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO (PMID:17072303) RGD PMID:17072303 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514
JBrowse link
positive regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jag1 jagged canonical Notch ligand 1 IGI PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Notch1 notch receptor 1 IGI PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twist1 twist family bHLH transcription factor 1 ISO (MGI:MGI:4838344|PMID:20804746) RGD PMID:20804746 MGI:MGI:4838344 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 ISO
IEA
(MGI:MGI:3610266|PMID:16140292)
GO_REF:0000107
RGD
Ensembl
PMID:16140292 GO_REF:0000107, MGI:MGI:3610266 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G Eng endoglin ISO (MGI:MGI:4368063|PMID:19703439) RGD PMID:19703439 MGI:MGI:4368063 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO (MGI:MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:MGI:3830400 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO (MGI:MGI:3820811|PMID:18718461) RGD PMID:18718461 MGI:MGI:3820811 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO (MGI:MGI:3801267|PMID:17050629) RGD PMID:17050629 MGI:MGI:3801267 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    multicellular organismal process 9056
      positive regulation of multicellular organismal process 2062
        positive regulation of epithelial to mesenchymal transition 48
          canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition 2
          positive regulation of cardiac epithelial to mesenchymal transition + 8
          positive regulation of mesodermal to mesenchymal transition involved in gastrulation 0
          positive regulation of neural crest formation + 0
Path 2
Term Annotations click to browse term
  biological_process 20015
    developmental process 6813
      anatomical structure development 6257
        multicellular organism development 5736
          system development 5273
            animal organ development 4027
              mesenchyme development 290
                mesenchymal cell differentiation 230
                  epithelial to mesenchymal transition 151
                    regulation of epithelial to mesenchymal transition 95
                      positive regulation of epithelial to mesenchymal transition 48
                        canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition 2
                        positive regulation of cardiac epithelial to mesenchymal transition + 8
                        positive regulation of mesodermal to mesenchymal transition involved in gastrulation 0
                        positive regulation of neural crest formation + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.