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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of macrophage derived foam cell differentiation
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Accession:GO:0010743 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


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negative regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 ISO
IEA
(MGI:MGI:4454250|PMID:20382126)
GO_REF:0000107
RGD
Ensembl
PMID:20382126 GO_REF:0000107, MGI:MGI:4454250 NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO
ISS
(PMID:11222466)
GO_REF:0000024
RGD
UniProt
PMID:11222466 GO_REF:0000024 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Crp C-reactive protein ISO (PMID:18322245) RGD PMID:18322245 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Itgav integrin subunit alpha V ISO (PMID:15215180) RGD PMID:15215180 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb3 integrin subunit beta 3 ISO (PMID:15215180) RGD PMID:15215180 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Nfkbia NFKB inhibitor alpha ISO (PMID:16938301) RGD PMID:16938301 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO (PMID:19114110) RGD PMID:19114110 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO (PMID:19114110) RGD PMID:19114110 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
positive regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15b arachidonate 15-lipoxygenase, type B IEA
ISO
GO_REF:0000107
(PMID:22912809)
Ensembl
RGD
PMID:22912809 GO_REF:0000107 NCBI chr10:55,773,748...55,783,489
Ensembl chr10:55,774,006...55,783,489
JBrowse link
G Apob apolipoprotein B ISO (PMID:17244792), (PMID:18322245), (PMID:19114110) RGD PMID:17244792, PMID:18322245, PMID:19114110 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Cd36 CD36 molecule ISO (PMID:10772654)
(MGI:MGI:2447499|PMID:12376530), (MGI:MGI:3836139|PMID:10772654)
RGD PMID:10772654, PMID:12376530 MGI:MGI:2447499, MGI:MGI:3836139 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Csf1 colony stimulating factor 1 ISO
IEA
(PMID:17244792)
GO_REF:0000107
RGD
Ensembl
PMID:17244792 GO_REF:0000107 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf2 colony stimulating factor 2 ISO (PMID:19032770) RGD PMID:19032770 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Il18 interleukin 18 ISO
IEA
(MGI:MGI:3608083|PMID:12829194)
GO_REF:0000107
RGD
Ensembl
PMID:12829194 GO_REF:0000107, MGI:MGI:3608083 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Lpl lipoprotein lipase ISO UniProtKB:P35951 (MGI:MGI:1888585|PMID:10858435) RGD PMID:10858435 MGI:MGI:1888585 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO
IEA
(PMID:18262097)
GO_REF:0000107
RGD
Ensembl
PMID:18262097 GO_REF:0000107 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Msr1 macrophage scavenger receptor 1 ISO UniProtKB:Q08857 (MGI:MGI:2447499|PMID:12376530) RGD PMID:12376530 MGI:MGI:2447499 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Pf4 platelet factor 4 ISO (PMID:17244792) RGD PMID:17244792 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Pla2g3 phospholipase A2, group III ISO (PMID:18801741) RGD PMID:18801741 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Pla2g5 phospholipase A2, group V ISS
ISO
GO_REF:0000024
(MGI:MGI:6393145|PMID:14962950)
UniProt
RGD
PMID:14962950 GO_REF:0000024, MGI:MGI:6393145 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Prkch protein kinase C, eta ISO
ISS
(MGI:MGI:5306557|PMID:20558593)
GO_REF:0000024
RGD
UniProt
PMID:20558593 GO_REF:0000024, MGI:MGI:5306557 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      regulation of developmental process 2644
        regulation of cell differentiation 1683
          regulation of macrophage derived foam cell differentiation 21
            negative regulation of macrophage derived foam cell differentiation 8
            positive regulation of macrophage derived foam cell differentiation 13
Path 2
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      cellular developmental process 4459
        cell differentiation 4363
          foam cell differentiation 25
            macrophage derived foam cell differentiation 25
              regulation of macrophage derived foam cell differentiation 21
                negative regulation of macrophage derived foam cell differentiation 8
                positive regulation of macrophage derived foam cell differentiation 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.