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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of tumor necrosis factor-mediated signaling pathway
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Accession:GO:0010803 term browser browse the term
Definition:Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
Synonyms:exact_synonym: regulation of TNF signaling;   regulation of TNF-mediated signaling pathway;   regulation of tumor necrosis factor-mediated signalling pathway


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regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:5912943|PMID:28701375)
(PMID:26997266), (PMID:27458237), (PMID:27591049)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:26997266, PMID:27458237, PMID:27591049, PMID:28701375 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5912943 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 ISO
IEA
(PMID:15701637)
GO_REF:0000107
RGD
Ensembl
PMID:15701637 GO_REF:0000107 NCBI chr 2:206,224,015...206,274,910
Ensembl chr 2:206,224,015...206,274,079
JBrowse link
G Otulin OTU deubiquitinase with linear linkage specificity ISO
IBA
(PMID:26997266)
(MGI:MGI:5804663|PMID:27523608), (MGI:MGI:6192867|PMID:29950720)
PMID:21873635
RGD PMID:26997266, PMID:27523608, PMID:29950720, PMID:21873635 MGI:MGI:5804663, MGI:MGI:6192867, RGD:13792537 NCBI chr 2:80,267,724...80,293,204
Ensembl chr 2:80,269,587...80,293,181
JBrowse link
G Pycard PYD and CARD domain containing ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO
ISS
(PMID:21455173)
(MGI:MGI:4947438|PMID:21455180), (MGI:MGI:4947439|PMID:21455173)
GO_REF:0000024
RGD
UniProt
PMID:21455173, PMID:21455180 GO_REF:0000024, MGI:MGI:4947438, MGI:MGI:4947439 NCBI chr 7:117,413,151...117,417,455
Ensembl chr 7:117,413,152...117,417,363
JBrowse link
G Spata2 spermatogenesis associated 2 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(MGI:MGI:5912943|PMID:28701375)
(PMID:27307491), (PMID:27458237), (PMID:27545878), (PMID:27591049)
UniProt
RGD
PMID:27307491, PMID:27458237, PMID:27545878, PMID:27591049, PMID:28701375, PMID:21873635 GO_REF:0000024, MGI:MGI:5912943, RGD:13792537 NCBI chr 3:164,229,211...164,239,483
Ensembl chr 3:164,230,852...164,239,250
JBrowse link
G Sphk1 sphingosine kinase 1 ISO
IEA
IMP
ISS
(PMID:20577214)
GO_REF:0000107
PMID:28284343
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20577214, PMID:28284343 GO_REF:0000024, GO_REF:0000107, RGD:14397556 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Syk spleen associated tyrosine kinase ISO
IEA
(PMID:19151749)
GO_REF:0000107
RGD
Ensembl
PMID:19151749 GO_REF:0000107 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO
ISS
(PMID:10604883)
GO_REF:0000024
RGD
UniProt
PMID:10604883 GO_REF:0000024 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Apoa1 apolipoprotein A1 ISO (PMID:21571275) RGD PMID:21571275 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Ccdc3 coiled-coil domain containing 3 ISO (PMID:25193116) RGD PMID:25193116 NCBI chr17:76,991,722...77,093,515
Ensembl chr17:76,995,043...77,093,308
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Gas6 growth arrest specific 6 ISO
ISS
(PMID:19657094)
GO_REF:0000024
RGD
UniProt
PMID:19657094 GO_REF:0000024 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (MGI:MGI:6148454|PMID:22424771) RGD PMID:22424771 MGI:MGI:6148454 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Hist2h2be histone cluster 2 H2B family member E ISO (PMID:11859126) RGD PMID:11859126 NCBI chr 2:198,360,837...198,363,399
Ensembl chr 2:198,360,998...198,361,378
JBrowse link
G Nlrp1b NLR family, pyrin domain containing 1B ISO (PMID:11821383) RGD PMID:11821383 NCBI chr10:57,755,957...57,847,867 JBrowse link
G Nol3 nucleolar protein 3 IEA
ISO
GO_REF:0000107
(MGI:MGI:5617337|PMID:24440909)
Ensembl
RGD
PMID:24440909 GO_REF:0000107, MGI:MGI:5617337 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 IEA
ISO
GO_REF:0000107
(MGI:MGI:5707586|PMID:18972444)
Ensembl
RGD
PMID:18972444 GO_REF:0000107, MGI:MGI:5707586 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO (PMID:24113711)
MGI:MGI:5441750 (MGI:MGI:5546581|PMID:23950925)
RGD PMID:23950925, PMID:24113711 MGI:MGI:5546581 NCBI chr 1:220,191,209...220,204,032
Ensembl chr 1:220,190,067...220,204,032
JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 ISO (MGI:MGI:4453084|PMID:20054338) RGD PMID:20054338 MGI:MGI:4453084 NCBI chr 7:11,414,565...11,428,090
Ensembl chr 7:11,414,446...11,428,552
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO
ISS
(MGI:MGI:3530208|PMID:15696169)
GO_REF:0000024
RGD
UniProt
PMID:15696169 GO_REF:0000024, MGI:MGI:3530208 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ISO
ISS
(PMID:18450452)
GO_REF:0000024
RGD
UniProt
PMID:18450452 GO_REF:0000024 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G Traip TRAF-interacting protein ISO (PMID:19151749) RGD PMID:19151749 NCBI chr 8:116,730,170...116,750,528
Ensembl chr 8:116,730,641...116,750,709
JBrowse link
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA
(PMID:24813629)
GO_REF:0000107
RGD
Ensembl
PMID:24813629 GO_REF:0000107 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Casp1 caspase 1 ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp4 caspase 4 ISO (PMID:16920334) RGD PMID:16920334 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Cpne1 copine 1 ISO
IBA
(PMID:14674885)
PMID:21873635
RGD PMID:14674885, PMID:21873635 RGD:13792537 NCBI chr 3:151,617,733...151,625,448
NCBI chr 3:152,150,143...152,192,936
Ensembl chr 3:151,616,037...151,625,644
Ensembl chr 3:151,616,037...151,625,644
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO UniProtKB:Q9HC29 (PMID:24790089) RGD PMID:24790089 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO
ISS
(PMID:23453807)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:23453807 GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rbm12 RNA binding motif protein 12 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:151,616,038...151,658,427
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (MGI:MGI:6271183|PMID:30439713) RGD PMID:30439713 MGI:MGI:6271183 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO (MGI:MGI:5616328|PMID:11374864) RGD PMID:11374864 MGI:MGI:5616328 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Trim32 tripartite motif-containing 32 ISO (MGI:MGI:4453084|PMID:20054338) RGD PMID:20054338 MGI:MGI:4453084 NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K ISO (PMID:26707646) RGD PMID:26707646 NCBI chr14:44,289,247...44,348,691
Ensembl chr14:44,289,247...44,348,691
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    regulation of biological process 13075
      regulation of response to stimulus 3981
        regulation of signal transduction 2934
          regulation of cytokine-mediated signaling pathway 113
            regulation of tumor necrosis factor-mediated signaling pathway 35
              negative regulation of tumor necrosis factor-mediated signaling pathway 15
              positive regulation of tumor necrosis factor-mediated signaling pathway 12
Path 2
Term Annotations click to browse term
  biological_process 20028
    response to stimulus 10583
      response to chemical 6342
        response to organic substance 3865
          response to cytokine 1132
            cellular response to cytokine stimulus 998
              cytokine-mediated signaling pathway 406
                regulation of cytokine-mediated signaling pathway 113
                  regulation of tumor necrosis factor-mediated signaling pathway 35
                    negative regulation of tumor necrosis factor-mediated signaling pathway 15
                    positive regulation of tumor necrosis factor-mediated signaling pathway 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.