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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of protein processing
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Accession:GO:0010955 term browser browse the term
Definition:Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.
Synonyms:exact_synonym: negative regulation of protein maturation by peptide bond cleavage


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negative regulation of protein processing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp4 acid phosphatase 4 ISO (PMID:15219672) RGD PMID:15219672 NCBI chr 1:100,226,311...100,234,536
Ensembl chr 1:100,227,157...100,234,040
JBrowse link
G Cdh1 cadherin 1 ISO (MGI:MGI:3763814|PMID:17344476) RGD PMID:17344476 MGI:MGI:3763814 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 ISO
ISS
(PMID:22445366)
GO_REF:0000024
RGD
UniProt
PMID:22445366 GO_REF:0000024 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
JBrowse link
G Fmr1 FMRP translational regulator 1 IMP Casp3 RGD PMID:22817682 RGD:11566024 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Gas1 growth arrest-specific 1 ISO (PMID:21357679) RGD PMID:21357679 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Glg1 golgi glycoprotein 1 ISO
IEA
MGI:MGI:4829764|MGI:MGI:97513 (MGI:MGI:4829577|PMID:20530870)
GO_REF:0000107
RGD
Ensembl
PMID:20530870 GO_REF:0000107, MGI:MGI:4829577 NCBI chr19:42,983,879...43,088,074
Ensembl chr19:42,983,869...43,090,841
JBrowse link
G Il1r2 interleukin 1 receptor type 2 ISO
IEA
(MGI:MGI:5468848|PMID:23395675)
GO_REF:0000107
RGD
Ensembl
PMID:23395675 GO_REF:0000107, MGI:MGI:5468848 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like ISO (PMID:19188362) RGD PMID:19188362 NCBI chr 1:169,720,247...169,721,788
Ensembl chr 1:169,720,253...169,721,758
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO (PMID:21370995) RGD PMID:21370995 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Mdm2 MDM2 proto-oncogene IMP caspase-3 RGD PMID:19638633 RGD:2317364 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A IMP Casp3 RGD PMID:21925170 RGD:9999170 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Snx12 sorting nexin 12 ISO (PMID:22709416) RGD PMID:22709416 NCBI chr  X:70,989,822...71,127,330
Ensembl chr  X:70,989,822...71,127,278
JBrowse link
G Tmem59 transmembrane protein 59 ISO (PMID:20427278) RGD PMID:20427278 NCBI chr 5:126,783,061...126,804,177
Ensembl chr 5:126,783,061...126,804,175
JBrowse link
G Tmem98 transmembrane protein 98 ISS
ISO
GO_REF:0000024
(MGI:MGI:6258499|PMID:30249802)
UniProt
RGD
PMID:30249802 GO_REF:0000024, MGI:MGI:6258499 NCBI chr10:68,173,380...68,184,289
Ensembl chr10:68,173,369...68,184,320
JBrowse link
inhibition of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cast calpastatin ISO
IBA
(PMID:2407243)
PMID:21873635
RGD PMID:2407243, PMID:21873635 RGD:13792537 NCBI chr 2:1,452,111...1,561,669
Ensembl chr 2:1,452,116...1,561,464
JBrowse link
G Cst7 cystatin F ISO
IBA
MGI:MGI:5910746 (MGI:MGI:5904382|PMID:28251676)
PMID:21873635
RGD PMID:28251676, PMID:21873635 MGI:MGI:5904382, RGD:13792537 NCBI chr 3:146,363,913...146,373,365
Ensembl chr 3:146,365,092...146,373,365
JBrowse link
G Nlrp1b NLR family, pyrin domain containing 1B ISO (PMID:11821383) RGD PMID:11821383 NCBI chr10:57,755,957...57,847,867 JBrowse link
G Nol3 nucleolar protein 3 IMP
IDA
PMID:16639714
PMID:17292893
UniProt PMID:16639714, PMID:17292893 RGD:10047164, RGD:10047212 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
inhibition of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l12 BCL2 like 12 ISO (PMID:22262180) RGD PMID:22262180 NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:176,438,335...176,443,864
Ensembl chr 3:176,439,199...176,443,195
JBrowse link
G Fcmr Fc fragment of IgM receptor ISO (MGI:MGI:3576402|PMID:15632112) RGD PMID:15632112 MGI:MGI:3576402 NCBI chr13:47,602,701...47,617,065
Ensembl chr13:47,602,692...47,617,064
JBrowse link
G Nol3 nucleolar protein 3 ISO
IEA
(PMID:15509781)
GO_REF:0000107
RGD
Ensembl
PMID:15509781 GO_REF:0000107 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO
IBA
IEA
(MGI:MGI:2681362|PMID:14623868)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:14623868, PMID:21873635 GO_REF:0000107, MGI:MGI:2681362, RGD:13792537 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
negative regulation of plasminogen activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpb2 carboxypeptidase B2 IMP RGD PMID:23369837 RGD:7243115 NCBI chr15:57,290,849...57,339,762
Ensembl chr15:57,290,849...57,339,760
JBrowse link
G Ctsz cathepsin Z ISO (PMID:19433310) RGD PMID:19433310 NCBI chr 3:172,527,107...172,537,877
Ensembl chr 3:172,527,107...172,537,877
JBrowse link
G Serpine1 serpin family E member 1 ISO
IEA
(MGI:MGI:4418017|PMID:19855083)
(PMID:18835034), (PMID:19855083), (PMID:8508955)
GO_REF:0000107
RGD
Ensembl
PMID:8508955, PMID:18835034, PMID:19855083 GO_REF:0000107, MGI:MGI:4418017 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Serpine2 serpin family E member 2 ISO
IEA
(PMID:19855083)
GO_REF:0000107
(MGI:MGI:4418017|PMID:19855083)
RGD
Ensembl
PMID:19855083 GO_REF:0000107, MGI:MGI:4418017 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Serpinf2 serpin family F member 2 ISO (PMID:134998) RGD PMID:134998 NCBI chr10:62,264,247...62,272,353
Ensembl chr10:62,264,788...62,273,119
JBrowse link
G Thbs1 thrombospondin 1 ISO (PMID:6438154) RGD PMID:6438154 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
negative regulation of protein processing involved in protein targeting to mitochondrion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt4 sirtuin 4 IMP RGD PMID:24029877 RGD:9586053 NCBI chr12:46,862,358...46,876,593
Ensembl chr12:46,868,416...46,876,592
JBrowse link
zymogen inhibition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Furin furin (paired basic amino acid cleaving enzyme) ISO (PMID:11799113), (PMID:9130696) RGD PMID:9130696, PMID:11799113 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      primary metabolic process 10920
        protein metabolic process 6228
          proteolysis 1894
            protein processing 240
              negative regulation of protein processing 32
                negative regulation of peptide hormone processing 0
                negative regulation of plasminogen activation 6
                negative regulation of protein processing in phagocytic vesicle 0
                negative regulation of protein processing involved in protein targeting to mitochondrion 1
                negative regulation of sterol regulatory element binding protein cleavage 0
                zymogen inhibition + 11
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      organic substance metabolic process 11651
        macromolecule metabolic process 10086
          protein metabolic process 6228
            cellular protein metabolic process 5570
              regulation of cellular protein metabolic process 2805
                negative regulation of cellular protein metabolic process 1135
                  negative regulation of proteolysis 403
                    negative regulation of protein processing 32
                      negative regulation of peptide hormone processing 0
                      negative regulation of plasminogen activation 6
                      negative regulation of protein processing in phagocytic vesicle 0
                      negative regulation of protein processing involved in protein targeting to mitochondrion 1
                      negative regulation of sterol regulatory element binding protein cleavage 0
                      zymogen inhibition + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.