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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of calcidiol 1-monooxygenase activity
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Accession:GO:0010956 term browser browse the term
Definition:Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.


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negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 ISO (PMID:16549446) RGD PMID:16549446 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor ISO (PMID:15947108) RGD PMID:15947108 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO
IEA
(PMID:15243130)
GO_REF:0000107
RGD
Ensembl
PMID:15243130 GO_REF:0000107 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      negative regulation of metabolic process 3315
        negative regulation of oxidoreductase activity 35
          negative regulation of monooxygenase activity 14
            negative regulation of calcidiol 1-monooxygenase activity 3
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of metabolic process 7007
          regulation of primary metabolic process 6028
            regulation of lipid metabolic process 397
              regulation of steroid metabolic process 117
                negative regulation of steroid metabolic process 26
                  negative regulation of steroid biosynthetic process 25
                    negative regulation of vitamin D biosynthetic process 5
                      negative regulation of calcidiol 1-monooxygenase activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.