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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G2/M transition of mitotic cell cycle
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Accession:GO:0010972 term browser browse the term
Definition:Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
Synonyms:exact_synonym: negative regulation of mitotic entry


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negative regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aven apoptosis and caspase activation inhibitor JBrowse link 3 103,980,612 104,117,193 RGD:13792537
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:2316109
G Fhl1 four and a half LIM domains 1 JBrowse link X 159,112,516 159,172,528 RGD:1624291
RGD:1600115
G Gpr132 G protein-coupled receptor 132 JBrowse link 6 137,652,213 137,671,658 RGD:1624291
RGD:13792537
G LOC100911456 migration and invasion-inhibitory protein-like JBrowse link 5 164,548,657 164,555,842 RGD:1600115
G Miip migration and invasion inhibitory protein JBrowse link 5 164,672,464 164,679,503 RGD:1600115
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 JBrowse link 15 47,211,682 47,270,343 RGD:1624291
G Rad21 RAD21 cohesin complex component JBrowse link 7 91,511,755 91,538,673 RGD:1624291
G Usp47 ubiquitin specific peptidase 47 JBrowse link 1 176,854,589 176,937,763 RGD:1624291
mitotic cytokinesis checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:1600115
G Chmp4c charged multivesicular body protein 4C JBrowse link 2 93,574,554 93,641,497 RGD:1600115
RGD:1624291
G Vps4a vacuolar protein sorting 4 homolog A JBrowse link 19 39,230,050 39,243,298 RGD:1624291
RGD:1600115
G Zfyve19 zinc finger FYVE-type containing 19 JBrowse link 3 111,013,856 111,021,841 RGD:1624291
RGD:13792537
mitotic DNA replication checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07049960.1 RGD:13792537
G Cdc6 cell division cycle 6 JBrowse link 10 86,819,477 86,833,301 RGD:13792537
G Clspn claspin JBrowse link 5 144,577,670 144,617,507 RGD:1624291
RGD:13792537
G Hus1 HUS1 checkpoint clamp component JBrowse link 14 89,194,086 89,208,825 RGD:13792537
G LOC103690165 checkpoint protein HUS1B JBrowse link 17 34,691,084 34,694,690 RGD:13792537
G Nae1 NEDD8 activating enzyme E1 subunit 1 JBrowse link 19 653,510 680,378 RGD:1600115
RGD:1624291
G Orc1 origin recognition complex, subunit 1 JBrowse link 5 128,186,651 128,212,901 RGD:13792537
G Rad17 RAD17 checkpoint clamp loader component JBrowse link 2 30,634,353 30,664,618 RGD:13792537
G Ticrr TOPBP1-interacting checkpoint and replication regulator JBrowse link 1 141,391,738 141,433,615 RGD:13792537
G Topbp1 DNA topoisomerase II binding protein 1 JBrowse link 8 111,790,655 111,835,224 RGD:13792537
G Zfp830 zinc finger protein 830 JBrowse link 10 70,118,250 70,119,714 RGD:1624291
RGD:13792537
RGD:1600115
mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07049960.1 RGD:13792537
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:1624291
G Brsk1 BR serine/threonine kinase 1 JBrowse link 1 72,701,281 72,727,061 RGD:1624291
G Brsk2 BR serine/threonine kinase 2 JBrowse link 1 214,918,757 214,940,883 RGD:8554801
G Ccng1 cyclin G1 JBrowse link 10 25,903,925 25,910,298 RGD:2316029
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:1624291
RGD:13792537
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1600115
RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Clspn claspin JBrowse link 5 144,577,670 144,617,507 RGD:1624291
RGD:13792537
G Donson DNA replication fork stabilization factor DONSON JBrowse link 11 31,834,608 31,847,751 RGD:1624291
G Foxn3 forkhead box N3 JBrowse link 6 123,183,720 123,577,719 RGD:1624291
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:1624291
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
RGD:1600115
G Ier3 immediate early response 3 JBrowse link 20 3,438,798 3,440,002 RGD:1624291
G LOC100302465 hypothetical LOC100302465 JBrowse link 1 206,324,763 206,417,143 RGD:1624291
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase JBrowse link 4 147,744,673 147,756,462 RGD:1624291
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1624291
RGD:13792537
RGD:1600115
G Mrnip MRN complex interacting protein JBrowse link 10 35,680,687 35,704,685 RGD:1624291
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1624291
RGD:13792537
RGD:1600115
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
G Syf2 SYF2 pre-mRNA-splicing factor JBrowse link 5 153,269,638 153,277,562 RGD:1624291
G Taok1 TAO kinase 1 JBrowse link 10 62,542,870 62,630,341 RGD:1600115
RGD:1624291
G Taok2 TAO kinase 2 JBrowse link 1 198,301,789 198,354,601 RGD:1600115
RGD:1624291
G Taok3 TAO kinase 3 JBrowse link 12 45,037,951 45,116,593 RGD:1600115
RGD:1624291
G Ticrr TOPBP1-interacting checkpoint and replication regulator JBrowse link 1 141,391,738 141,433,615 RGD:13792537
G Topbp1 DNA topoisomerase II binding protein 1 JBrowse link 8 111,790,655 111,835,224 RGD:13792537
G Trim39 tripartite motif-containing 39 JBrowse link 20 2,500,691 2,514,546 RGD:1600115
RGD:1624291
mitotic G2/M transition checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:1624291
RGD:1600115
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1624291
RGD:1600115
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rint1 RAD50 interactor 1 JBrowse link 4 7,851,602 7,885,446 RGD:1624291
RGD:13792537
signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18617
      cell cycle process 1203
        cell cycle phase transition 428
          mitotic cell cycle phase transition 387
            G2/M transition of mitotic cell cycle 127
              negative regulation of G2/M transition of mitotic cell cycle 50
                mitotic G2 cell size control checkpoint + 0
                mitotic G2/M transition checkpoint + 37
                mitotic cytokinesis checkpoint + 4
                signal transduction involved in mitotic G2 DNA damage checkpoint + 2
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          regulation of cell cycle 1031
            regulation of cell cycle process 618
              regulation of cell cycle phase transition 303
                regulation of mitotic cell cycle phase transition 270
                  regulation of G2/M transition of mitotic cell cycle 87
                    negative regulation of G2/M transition of mitotic cell cycle 50
                      mitotic G2 cell size control checkpoint + 0
                      mitotic G2/M transition checkpoint + 37
                      mitotic cytokinesis checkpoint + 4
                      signal transduction involved in mitotic G2 DNA damage checkpoint + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.