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ONTOLOGY REPORT - ANNOTATIONS


Term:primary neural tube formation
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Accession:GO:0014020 term browser browse the term
Definition:The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.
Synonyms:exact_synonym: primary neural tube morphogenesis;   primary neurulation


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anterior neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
G Folr1 folate receptor alpha JBrowse link 1 166,934,457 166,945,864 RGD:1624291
G Grhl2 grainyhead-like transcription factor 2 JBrowse link 7 76,058,623 76,197,360 RGD:1624291
G Specc1l sperm antigen with calponin homology and coiled-coil domains 1-like JBrowse link 20 14,287,470 14,393,879 RGD:1624291
anterior neuropore closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gatad2a GATA zinc finger domain containing 2A JBrowse link 16 21,177,793 21,267,768 RGD:1624291
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:1624291
establishment of planar polarity involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cthrc1 collagen triple helix repeat containing 1 JBrowse link 7 77,966,722 77,977,004 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
initiation of neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kdm2b lysine demethylase 2B JBrowse link 12 39,021,924 39,161,954 RGD:1624291
negative regulation of planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
neural fold bending term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Luzp1 leucine zipper protein 1 JBrowse link 5 154,831,697 154,907,646 RGD:1624291
RGD:13792537
RGD:1600115
neural fold elevation formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
neural fold formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cecr2 CECR2, histone acetyl-lysine reader JBrowse link 4 153,217,521 153,327,153 RGD:1624291
G Cfl1 cofilin 1 JBrowse link 1 220,869,805 220,873,337 RGD:1624291
G Gatad2a GATA zinc finger domain containing 2A JBrowse link 16 21,177,793 21,267,768 RGD:1624291
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
G Ovol2 ovo-like zinc finger 2 JBrowse link 3 138,433,990 138,464,511 RGD:1624291
neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:1624291
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:1624291
G Alx1 ALX homeobox 1 JBrowse link 7 44,751,865 44,771,458 RGD:1624291
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:1624291
G Arhgap35 Rho GTPase activating protein 35 JBrowse link 1 78,456,409 78,573,374 RGD:1624291
RGD:1600115
G Arid1a AT-rich interaction domain 1A JBrowse link 5 151,904,687 151,977,973 RGD:1624291
G Bbs4 Bardet-Biedl syndrome 4 JBrowse link 8 64,115,005 64,154,432 RGD:1624291
G Bcl10 BCL10, immune signaling adaptor JBrowse link 2 251,805,392 251,814,957 RGD:1624291
RGD:734638
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Brd2 bromodomain containing 2 JBrowse link 20 3,910,555 3,921,074 RGD:1600115
G Cc2d2a coiled-coil and C2 domain containing 2A JBrowse link 14 71,895,128 71,979,452 RGD:1624291
G Cecr2 CECR2, histone acetyl-lysine reader JBrowse link 4 153,217,521 153,327,153 RGD:1624291
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 JBrowse link 1 12,823,363 12,825,806 RGD:1624291
G Cluap1 clusterin associated protein 1 JBrowse link 10 11,847,058 11,878,792 RGD:1624291
G Cobl cordon-bleu WH2 repeat protein JBrowse link 14 92,341,949 92,497,169 RGD:1624291
RGD:1600115
G Deaf1 DEAF1 transcription factor JBrowse link 1 214,283,787 214,317,466 RGD:1600115
RGD:1624291
G Dlc1 DLC1 Rho GTPase activating protein JBrowse link 16 58,776,489 59,247,752 RGD:1624291
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:1624291
G Enah ENAH, actin regulator JBrowse link 13 100,297,421 100,415,335 RGD:1624291
G Fuz fuzzy planar cell polarity protein JBrowse link 1 100,891,832 100,896,811 RGD:1624291
RGD:1600115
G Fzd3 frizzled class receptor 3 JBrowse link 15 48,601,259 48,670,257 RGD:1624291
G Fzd6 frizzled class receptor 6 JBrowse link 7 77,898,329 77,931,034 RGD:1624291
G Glmn glomulin, FKBP associated protein JBrowse link 14 3,204,390 3,247,703 RGD:1624291
G Grhl2 grainyhead-like transcription factor 2 JBrowse link 7 76,058,623 76,197,360 RGD:1624291
G Grhl3 grainyhead-like transcription factor 3 JBrowse link 5 153,893,039 153,925,045 RGD:1624291
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 JBrowse link 6 72,509,658 72,596,285 RGD:1624291
G Ift122 intraflagellar transport 122 JBrowse link 4 147,756,574 147,826,983 RGD:1624291
G Ift172 intraflagellar transport 172 JBrowse link 6 26,390,686 26,485,459 RGD:1624291
G Ift57 intraflagellar transport 57 JBrowse link 11 53,664,638 53,731,779 RGD:1624291
G Kat2a lysine acetyltransferase 2A JBrowse link 10 88,611,586 88,619,558 RGD:1624291
G Kdm2a lysine demethylase 2A JBrowse link 1 219,566,130 219,642,294 RGD:1624291
G Kdm6a lysine demethylase 6A JBrowse link X 4,805,493 4,945,788 RGD:1624291
G Kif20b kinesin family member 20B JBrowse link 1 253,220,038 253,275,523 RGD:1624291
G Lhx2 LIM homeobox 2 JBrowse link 3 22,628,674 22,658,447 RGD:1624291
RGD:1600115
G Lias lipoic acid synthetase JBrowse link 14 44,507,217 44,524,287 RGD:1624291
G Lmo4 LIM domain only 4 JBrowse link 2 250,218,635 250,235,435 RGD:1624291
G LOC100909544 bromodomain-containing protein 2-like JBrowse link 20 3,910,555 3,918,348 RGD:1624291
G LOC108348112 bromodomain-containing protein 2 JBrowse link 20 5,262,742 5,269,337 RGD:1600115
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:1600115
RGD:1624291
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
RGD:13792537
G Med12 mediator complex subunit 12 JBrowse link X 71,174,653 71,197,812 RGD:1624291
G Mks1 MKS transition zone complex subunit 1 JBrowse link 10 75,149,814 75,160,481 RGD:1600115
RGD:1624291
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 6 99,282,850 99,350,367 RGD:1624291
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like JBrowse link 1 40,529,092 40,719,232 RGD:1624291
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:1624291
G Nckap1 NCK-associated protein 1 JBrowse link 3 67,725,180 67,804,680 RGD:1624291
G Nog noggin JBrowse link 10 76,811,759 76,813,386 RGD:1624291
RGD:1600115
G Opa1 OPA1, mitochondrial dynamin like GTPase JBrowse link 11 74,717,600 74,793,902 RGD:1624291
G Pax2 paired box 2 JBrowse link 1 264,493,579 264,585,073 RGD:1624291
RGD:1600115
G Pax3 paired box 3 JBrowse link 9 84,004,004 84,101,226 RGD:1624291
G Pfn1 profilin 1 JBrowse link 10 57,273,003 57,275,708 RGD:1624291
G Phactr4 phosphatase and actin regulator 4 JBrowse link 5 150,533,895 150,609,423 RGD:1624291
G Plxnb2 plexin B2 JBrowse link 7 130,135,484 130,161,568 RGD:1624291
G Prickle1 prickle planar cell polarity protein 1 JBrowse link 7 134,702,964 134,799,437 RGD:1600115
RGD:1624291
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:1624291
RGD:1600115
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:1624291
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:1624291
G Ptk7 protein tyrosine kinase 7 JBrowse link 9 16,662,588 16,729,888 RGD:1624291
G Rab23 RAB23, member RAS oncogene family JBrowse link 9 38,469,784 38,496,185 RGD:1624291
G Rala RAS like proto-oncogene A JBrowse link 17 49,676,073 49,729,133 RGD:1624291
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:1624291
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:1624291
G Rgma repulsive guidance molecule BMP co-receptor a JBrowse link 1 134,699,053 134,742,512 RGD:1624291
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:1624291
G Rps7 ribosomal protein S7 JBrowse link 6 47,899,525 47,904,389 RGD:1624291
G Sall1 spalt-like transcription factor 1 JBrowse link 19 23,387,737 23,405,025 RGD:1624291
G Sall4 spalt-like transcription factor 4 JBrowse link 3 165,520,155 165,538,176 RGD:1624291
G Scrib scribble planar cell polarity protein JBrowse link 7 117,105,810 117,128,802 RGD:1624291
G Sdc4 syndecan 4 JBrowse link 3 160,872,503 160,891,190 RGD:1624291
G Sec24b SEC24 homolog B, COPII coat complex component JBrowse link 2 230,286,886 230,356,887 RGD:1624291
G Sema4c semaphorin 4C JBrowse link 9 43,129,413 43,140,442 RGD:1624291
G Setd2 SET domain containing 2, histone lysine methyltransferase JBrowse link 8 118,802,478 118,888,224 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
G Shroom3 shroom family member 3 JBrowse link 14 16,622,767 16,903,265 RGD:1624291
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:1624291
G Spint1 serine peptidase inhibitor, Kunitz type 1 JBrowse link 3 111,049,132 111,061,991 RGD:1624291
G Spint2 serine peptidase inhibitor, Kunitz type, 2 JBrowse link 1 87,199,373 87,221,826 RGD:1624291
G St14 suppression of tumorigenicity 14 JBrowse link 8 32,240,113 32,280,813 RGD:1624291
G Stil STIL, centriolar assembly protein JBrowse link 5 133,819,302 133,851,362 RGD:1624291
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:1624291
G Tbxt T-box transcription factor T JBrowse link 1 52,887,067 52,900,691 RGD:1624291
G Tead2 TEA domain transcription factor 2 JBrowse link 1 101,213,782 101,230,483 RGD:1624291
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Tgif1 TGFB-induced factor homeobox 1 JBrowse link 9 119,181,079 119,190,698 RGD:1624291
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:1624291
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
G Trim71 tripartite motif containing 71 JBrowse link 8 122,553,015 122,604,787 RGD:1624291
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:1624291
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1624291
G Tulp3 TUB like protein 3 JBrowse link 4 161,636,084 161,677,807 RGD:1624291
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Vasp vasodilator-stimulated phosphoprotein JBrowse link 1 80,170,608 80,185,882 RGD:1624291
RGD:13792537
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
G Zeb2 zinc finger E-box binding homeobox 2 JBrowse link 3 29,857,289 29,985,932 RGD:1624291
G Zic2 Zic family member 2 JBrowse link 15 108,908,366 108,913,812 RGD:1624291
G Zic5 Zic family member 5 JBrowse link 15 108,891,992 108,907,601 RGD:1624291
planar cell polarity pathway involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1624291
RGD:13792537
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:1624291
RGD:13792537
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:1624291
RGD:13792537
G Fzd1 frizzled class receptor 1 JBrowse link 4 26,470,864 26,475,262 RGD:1624291
RGD:1600115
G Fzd2 frizzled class receptor 2 JBrowse link 10 90,550,147 90,552,057 RGD:1624291
RGD:1600115
G Grhl3 grainyhead-like transcription factor 3 JBrowse link 5 153,893,039 153,925,045 RGD:1624291
G Ptk7 protein tyrosine kinase 7 JBrowse link 9 16,662,588 16,729,888 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1624291
RGD:1600115
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
regulation of establishment of planar polarity involved in neural tube closure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sec24b SEC24 homolog B, COPII coat complex component JBrowse link 2 230,286,886 230,356,887 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    developmental process 6697
      anatomical structure morphogenesis 2853
        embryonic morphogenesis 686
          morphogenesis of embryonic epithelium 184
            embryonic epithelial tube formation 157
              primary neural tube formation 120
                neural fold formation + 9
                neural rod cavitation 0
                neural rod formation + 0
                neural tube closure + 113
Path 2
Term Annotations click to browse term
  biological_process 19578
    developmental process 6697
      anatomical structure development 6155
        tissue development 2076
          epithelium development 1222
            morphogenesis of an epithelium 577
              epithelial tube morphogenesis 394
                epithelial tube formation 164
                  embryonic epithelial tube formation 157
                    neural tube formation 135
                      primary neural tube formation 120
                        neural fold formation + 9
                        neural rod cavitation 0
                        neural rod formation + 0
                        neural tube closure + 113
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.