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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase signaling
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Accession:GO:0014065 term browser browse the term
Definition:A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
Synonyms:exact_synonym: PI 3-kinase cascade;   PI3K cascade;   PI3K signal transduction;   PI3K signaling;   phosphatidylinositol 3-kinase signal transduction;   phosphoinositide 3-kinase cascade
 related_synonym: phosphatidylinositol 3-kinase cascade


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phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO (PMID:26514923) CAFA PMID:26514923 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G C1QBP complement C1q binding protein ISO (PMID:16177118) UniProtKB PMID:16177118 NCBI chr17:5,481,114...5,487,482
Ensembl chr17:5,473,239...5,479,735
JBrowse link
G CD160 CD160 molecule ISO (PMID:17307798) UniProt PMID:17307798 NCBI chr 1:122,025,605...122,031,980 JBrowse link
G CSF2 colony stimulating factor 2 ISO (PMID:24520418) AgBase PMID:24520418 NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146
JBrowse link
G EDN1 endothelin 1 ISO (PMID:17078114) BHF-UCL PMID:17078114 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO (PMID:7556068) BHF-UCL PMID:7556068 NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 ISO (PMID:7556068) BHF-UCL PMID:7556068 NCBI chr12:32,811,533...32,834,958
Ensembl chr12:33,063,434...33,084,994
JBrowse link
G GATA3 GATA binding protein 3 ISO (MGI:MGI:5285154|PMID:20696860) UniProtKB PMID:20696860 MGI:MGI:5285154 NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A ISO (PMID:16517693) UniProtKB PMID:16517693 NCBI chr13:27,976,415...28,042,941
Ensembl chr13:46,694,273...46,759,826
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B ISO (PMID:16517693) UniProtKB PMID:16517693 NCBI chr2B:118,362,719...118,381,253
Ensembl chr2B:237,153,709...237,170,591
JBrowse link
G IGF1 insulin like growth factor 1 ISO (PMID:24508636) AgBase PMID:24508636 NCBI chr12:99,986,887...100,066,773 JBrowse link
G IRS1 insulin receptor substrate 1 ISO (PMID:7782332) BHF-UCL PMID:7782332 NCBI chr2B:113,973,191...114,041,127
Ensembl chr2B:232,849,239...232,852,967
JBrowse link
G KBTBD2 kelch repeat and BTB domain containing 2 ISO (MGI:MGI:5806303|PMID:27708159) MGI PMID:27708159 MGI:MGI:5806303 NCBI chr 7:33,463,369...33,490,367
Ensembl chr 7:33,863,972...33,892,200
JBrowse link
G LTK leukocyte receptor tyrosine kinase ISO (PMID:9223670) UniProtKB PMID:9223670 NCBI chr15:20,444,471...20,455,586
Ensembl chr15:38,685,255...38,695,381
JBrowse link
G MYO16 myosin XVI ISO (MGI:MGI:5304984|PMID:21946561) UniProtKB PMID:21946561 MGI:MGI:5304984 NCBI chr13:89,754,451...90,338,658
Ensembl chr13:108,922,993...109,473,752
JBrowse link
G NF1 neurofibromin 1 ISO (MGI:MGI:3032882|PMID:14724565) MGI PMID:14724565 MGI:MGI:3032882 NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295
JBrowse link
G NYAP1 neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 ISO (MGI:MGI:5304984|PMID:21946561) UniProtKB PMID:21946561 MGI:MGI:5304984 NCBI chr 7:92,512,796...92,523,743
Ensembl chr 7:105,914,389...105,925,434
JBrowse link
G NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 ISO (MGI:MGI:5304984|PMID:21946561) UniProtKB PMID:21946561 MGI:MGI:5304984 NCBI chr2B:112,639,043...112,970,053
Ensembl chr2B:231,456,729...231,755,037
JBrowse link
G PEAR1 platelet endothelial aggregation receptor 1 ISO (MGI:MGI:5817200|PMID:27614188) MGI PMID:27614188 MGI:MGI:5817200 NCBI chr 1:132,236,550...132,259,273
Ensembl chr 1:136,069,341...136,080,165
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO (PMID:25339672) CAFA PMID:25339672 NCBI chr 3:135,685,120...135,867,096
Ensembl chr 3:143,288,563...143,431,314
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO (PMID:25339672) CAFA PMID:25339672 NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO (PMID:12507995) UniProtKB PMID:12507995 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO (PMID:21321938)
(PMID:7782332)
BHF-UCL PMID:7782332, PMID:21321938 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960
JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 ISO (PMID:23604317) UniProtKB PMID:23604317 NCBI chr19:17,632,265...17,649,664 JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 ISO (PMID:12507995) UniProt PMID:12507995 NCBI chr17:42,686,483...42,773,668
Ensembl chr17:47,475,201...47,507,282
JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 ISO (PMID:12101241) UniProtKB PMID:12101241 NCBI chr10:118,942,896...119,001,185
Ensembl chr10:122,354,765...122,412,588
JBrowse link
G PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 ISO (MGI:MGI:5550173|PMID:24367090) MGI PMID:24367090 MGI:MGI:5550173 NCBI chr 8:64,489,817...64,769,602
Ensembl chr 8:66,215,974...66,430,138
JBrowse link
G SIRT2 sirtuin 2 ISO (PMID:23908241) UniProtKB PMID:23908241 NCBI chr19:35,984,453...36,005,582
Ensembl chr19:44,533,965...44,554,799
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:3050929|PMID:15249583) MGI PMID:15249583 MGI:MGI:3050929 NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569
JBrowse link
G XBP1 X-box binding protein 1 ISO (PMID:23529610) UniProtKB PMID:23529610 NCBI chr22:9,863,479...9,869,491 JBrowse link
G ZFP36L1 ZFP36 ring finger protein like 1 ISO (PMID:15538381) UniProtKB PMID:15538381 NCBI chr14:49,372,058...49,379,116
Ensembl chr14:68,247,347...68,255,805
JBrowse link
negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTN2A2 butyrophilin subfamily 2 member A2 ISO (MGI:MGI:5520006|PMID:23589618) MGI PMID:23589618 MGI:MGI:5520006 NCBI chr 6:26,215,215...26,227,261
Ensembl chr 6:26,873,828...26,885,592
JBrowse link
G CRYBA1 crystallin beta A1 ISO RGD PMID:21993393 RGD:10059647 NCBI chr17:27,522,647...27,530,767
Ensembl chr17:28,032,809...28,040,525
JBrowse link
G DAB2IP DAB2 interacting protein ISO (PMID:19903888) UniProtKB PMID:19903888 NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336
JBrowse link
G INPP5E inositol polyphosphate-5-phosphatase E ISO RGD PMID:21436142 RGD:12911213 NCBI chr 9:107,502,838...107,516,325
Ensembl chr 9:136,483,144...136,492,731
JBrowse link
G KLF4 Kruppel like factor 4 ISO PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr 9:78,634,545...78,639,447
Ensembl chr 9:106,820,954...106,825,797
JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO (MGI:MGI:3723397|PMID:17606624) MGI PMID:17606624 MGI:MGI:3723397 NCBI chr17:34,934,452...35,121,195 JBrowse link
G NLRC3 NLR family CARD domain containing 3 ISO (MGI:MGI:5883388|PMID:27951586) UniProtKB PMID:27951586 MGI:MGI:5883388 NCBI chr16:2,463,940...2,487,961
Ensembl chr16:3,637,612...3,674,088
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor ISO (PMID:16971513) UniProtKB PMID:16971513 NCBI chr19:44,739,739...44,751,303 JBrowse link
G OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF ISO (MGI:MGI:6101642|PMID:28826662) UniProt PMID:28826662 MGI:MGI:6101642 NCBI chr 1:203,605,558...203,781,491
Ensembl chr 1:208,825,607...208,992,246
JBrowse link
G PIK3IP1 phosphoinositide-3-kinase interacting protein 1 ISO (PMID:17475214)
(MGI:MGI:3806716|PMID:18632611)
UniProtKB PMID:17475214, PMID:18632611 MGI:MGI:3806716 NCBI chr22:12,305,518...12,316,434
Ensembl chr22:30,141,326...30,152,397
JBrowse link
G SERPINE2 serpin family E member 2 ISO (MGI:MGI:3810206|PMID:18398001) MGI PMID:18398001 MGI:MGI:3810206 NCBI chr2B:111,221,317...111,285,491
Ensembl chr2B:229,797,655...229,861,040
JBrowse link
G SLC9A3R1 SLC9A3 regulator 1 ISO (MGI:MGI:3617099|PMID:16456542) UniProtKB
MGI
PMID:16456542 MGI:MGI:3617099 NCBI chr17:68,694,468...68,715,157
Ensembl chr17:74,250,406...74,271,234
JBrowse link
G SLC9A3R2 SLC9A3 regulator 2 ISO (MGI:MGI:3617099|PMID:16456542) MGI PMID:16456542 MGI:MGI:3617099 NCBI chr16:664,310...676,640
Ensembl chr16:2,115,583...2,127,069
JBrowse link
G STAMBP STAM binding protein ISO (PMID:23542699) UniProtKB PMID:23542699 NCBI chr2A:73,900,128...73,936,571
Ensembl chr2A:75,410,434...75,451,086
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:3586939|PMID:16027169) MGI PMID:16027169 MGI:MGI:3586939 NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 ISO (PMID:17003487) BHF-UCL PMID:17003487 NCBI chr 7:19,761,041...19,765,665 JBrowse link
positive regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 ISO PMID:14528310
PMID:18469807
UniProt PMID:14528310, PMID:18469807 RGD:1299350, RGD:8553892 NCBI chr12:31,187,821...31,201,594 JBrowse link
G AGT angiotensinogen ISO (PMID:15652490) BHF-UCL PMID:15652490 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044
JBrowse link
G ANGPT1 angiopoietin 1 ISO (MGI:MGI:3848848|PMID:19409199) MGI PMID:19409199 MGI:MGI:3848848 NCBI chr 8:103,893,234...104,137,661
Ensembl chr 8:106,042,041...106,286,783
JBrowse link
G ARHGAP8 Rho GTPase activating protein 8 ISO (MGI:MGI:5005047|PMID:21413931) MGI PMID:21413931 MGI:MGI:5005047 NCBI chr22:25,650,927...25,755,578 JBrowse link
G CAT catalase ISO (MGI:MGI:3037350|PMID:15020231) MGI PMID:15020231 MGI:MGI:3037350 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160
JBrowse link
G CBL Cbl proto-oncogene ISO (PMID:17003487) BHF-UCL PMID:17003487 NCBI chr11:114,044,996...114,149,204
Ensembl chr11:117,973,187...118,074,671
JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO PMID:10477596
(PMID:7544376)
BHF-UCL PMID:7544376, PMID:10477596 RGD:8553666 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172
JBrowse link
G CD28 CD28 molecule ISO (MGI:MGI:5520006|PMID:23589618) MGI PMID:23589618 MGI:MGI:5520006 NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213
JBrowse link
G CNTF ciliary neurotrophic factor ISO RGD PMID:15574731 RGD:1626128 NCBI chr11:53,876,081...53,882,870
Ensembl chr11:57,336,792...57,341,121
JBrowse link
G CSF3 colony stimulating factor 3 ISO (PMID:23001182) BHF-UCL PMID:23001182 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729
JBrowse link
G DCN decorin ISO (PMID:23798385) MGI PMID:23798385 NCBI chr12:88,678,791...88,715,677
Ensembl chr12:91,994,129...92,031,413
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:16168116 RGD:1582137 NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO (MGI:MGI:3796800|PMID:18458158) MGI PMID:18458158 MGI:MGI:3796800 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006
JBrowse link
G F2 coagulation factor II, thrombin ISO (MGI:MGI:3810206|PMID:18398001) MGI PMID:18398001 MGI:MGI:3810206 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
JBrowse link
G F2R coagulation factor II thrombin receptor ISO (MGI:MGI:5285163|PMID:20215560)
(MGI:MGI:3810206|PMID:18398001)
UniProtKB
MGI
PMID:18398001, PMID:20215560 MGI:MGI:3810206, MGI:MGI:5285163 NCBI chr 5:38,565,957...38,585,725
Ensembl chr 5:39,110,170...39,129,688
JBrowse link
G F2RL1 F2R like trypsin receptor 1 ISO (MGI:MGI:5285163|PMID:20215560) UniProtKB PMID:20215560 MGI:MGI:5285163 NCBI chr 5:38,462,521...38,478,882
Ensembl chr 5:39,006,331...39,024,265
JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase ISO (PMID:10739672) UniProtKB PMID:10739672 NCBI chr 1:26,872,781...26,895,751
Ensembl chr 1:27,918,758...27,941,678
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 ISO (PMID:14633857) UniProtKB PMID:14633857 NCBI chr13:9,584,850...9,779,542 JBrowse link
G FPR2 formyl peptide receptor 2 ISO PMID:30511586 ARUK-UCL PMID:30511586 RGD:14695080 NCBI chr19:48,663,622...48,715,535 JBrowse link
G FSHR follicle stimulating hormone receptor ISO (PMID:24058690) UniProtKB PMID:24058690 NCBI chr2A:49,088,450...49,287,688
Ensembl chr2A:50,008,328...50,207,258
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase ISO PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr 6:109,469,750...109,684,086
Ensembl chr 6:113,545,944...113,604,451
JBrowse link
G HAX1 HCLS1 associated protein X-1 ISO (PMID:23001182) BHF-UCL PMID:23001182 NCBI chr 1:129,627,564...129,630,920
Ensembl chr 1:133,241,077...133,244,431
JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 ISO (PMID:23001182) BHF-UCL PMID:23001182 NCBI chr 3:118,733,505...118,763,177
Ensembl chr 3:125,642,973...125,669,095
JBrowse link
G HCST hematopoietic cell signal transducer ISO (PMID:10426994) UniProtKB PMID:10426994 NCBI chr19:32,817,826...32,821,149
Ensembl chr19:41,568,739...41,570,544
JBrowse link
G HGF hepatocyte growth factor ISO (PMID:20655899) BHF-UCL PMID:20655899 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811
JBrowse link
G IGF1 insulin like growth factor 1 ISO PMID:17023532
(MGI:MGI:5005047|PMID:21413931)
(PMID:7688386)
BHF-UCL
MGI
PMID:7688386, PMID:17023532, PMID:21413931 MGI:MGI:5005047, RGD:1600072 NCBI chr12:99,986,887...100,066,773 JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO RGD PMID:25186839 RGD:10046020 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974
JBrowse link
G IL18 interleukin 18 ISO (PMID:21321938) BHF-UCL PMID:21321938 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371
JBrowse link
G INS insulin ISO (PMID:7688386) BHF-UCL PMID:7688386 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666
JBrowse link
G JAK2 Janus kinase 2 ISO (MGI:MGI:3828423|PMID:7782332) BHF-UCL PMID:7782332 MGI:MGI:3828423 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626
JBrowse link
G KDR kinase insert domain receptor ISO (PMID:9804796) RGD
UniProtKB
PMID:9804796, PMID:18221855 RGD:2292019 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109
JBrowse link
G LEP leptin ISO (MGI:MGI:4821191|PMID:20620997)
(PMID:24340098)
PMID:11677594
UniProtKB
UniProt
PMID:11677594, PMID:20620997, PMID:24340098 MGI:MGI:4821191, RGD:10448951 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519
JBrowse link
G LOC100967334 G-protein coupled estrogen receptor 1 ISO (PMID:15705806) RGD
UniProtKB
PMID:15705806, PMID:19717735 RGD:4892081 NCBI chr 7:1,245,873...1,251,915 JBrowse link
G LOC100971425 somatotropin ISO (PMID:7782332) BHF-UCL PMID:7782332 NCBI chr17:58,010,848...58,013,421 JBrowse link
G MAZ MYC associated zinc finger protein ISO (PMID:25487955) ARUK-UCL PMID:25487955 Ensembl chr16:30,049,806...30,070,469 JBrowse link
G MYDGF myeloid derived growth factor ISO (MGI:MGI:5609664|PMID:25581518) UniProtKB PMID:25581518 MGI:MGI:5609664 NCBI chr19:3,674,001...3,689,123
Ensembl chr19:4,627,108...4,639,608
JBrowse link
G MYOC myocilin ISO (PMID:21656515) UniProtKB PMID:21656515 NCBI chr 1:147,128,541...147,146,227
Ensembl chr 1:150,841,630...150,858,628
JBrowse link
G NCF1 neutrophil cytosolic factor 1 ISO (PMID:26514923) CAFA PMID:26514923 Ensembl chr 7:81,917,167...81,932,589 JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase ISO (PMID:17218260) BHF-UCL PMID:17218260 NCBI chr15:34,798,880...34,963,823
Ensembl chr15:53,118,411...53,283,076
JBrowse link
G NKX3-1 NK3 homeobox 1 ISO (PMID:20395202) UniProtKB PMID:20395202 NCBI chr 8:22,926,145...22,930,396
Ensembl chr 8:19,863,275...19,864,942
JBrowse link
G NRG1 neuregulin 1 ISO (MGI:MGI:3796800|PMID:18458158) MGI PMID:18458158 MGI:MGI:3796800 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO PMID:10985347 UniProt PMID:10985347 RGD:8553408 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678
JBrowse link
G OSM oncostatin M ISO (PMID:28972028) BHF-UCL PMID:28972028 NCBI chr22:11,298,965...11,303,009
Ensembl chr22:29,101,085...29,105,081
JBrowse link
G PDGFA platelet derived growth factor subunit A ISO (PMID:11788434) UniProtKB PMID:11788434 NCBI chr 7:648,722...672,023 JBrowse link
G PDGFB platelet derived growth factor subunit B ISO (PMID:10734101), (PMID:11788434), (PMID:17942966)
(MGI:MGI:3617099|PMID:16456542)
UniProtKB
MGI
PMID:10734101, PMID:11788434, PMID:16456542, PMID:17942966 MGI:MGI:3617099 NCBI chr22:20,127,223...20,148,407
Ensembl chr22:37,944,018...37,964,883
JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO (MGI:MGI:5009390|PMID:17942966) UniProtKB PMID:17942966 MGI:MGI:5009390 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530
JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 ISO (MGI:MGI:5305503|PMID:22187460), (MGI:MGI:5305504|PMID:22187458) UniProtKB PMID:22187458, PMID:22187460 MGI:MGI:5305503, MGI:MGI:5305504 NCBI chr10:93,210,174...93,339,545
Ensembl chr10:96,714,159...96,841,131
JBrowse link
G PLD2 phospholipase D2 ISO RGD PMID:15705590 RGD:2299907 NCBI chr17:4,853,919...4,870,254
Ensembl chr17:4,843,217...4,858,425
JBrowse link
G PLXNB1 plexin B1 ISO (MGI:MGI:4413657|PMID:19788569) UniProtKB PMID:19788569 MGI:MGI:4413657 NCBI chr 3:48,325,892...48,352,128
Ensembl chr 3:49,408,666...49,434,913
JBrowse link
G PRR5L proline rich 5 like ISO (MGI:MGI:5005047|PMID:21413931) MGI PMID:21413931 MGI:MGI:5005047 NCBI chr11:36,269,291...36,438,954
Ensembl chr11:36,223,385...36,311,659
JBrowse link
G PTK2 protein tyrosine kinase 2 ISO (PMID:15166238) UniProtKB PMID:15166238 NCBI chr 8:137,330,777...137,677,306
Ensembl chr 8:140,412,773...140,684,898
JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO (PMID:19838216) BHF-UCL PMID:19838216 NCBI chr12:7,075,879...7,093,041
Ensembl chr12:6,991,099...7,008,830
JBrowse link
G RARA retinoic acid receptor alpha ISO PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr17:16,932,485...16,980,958 JBrowse link
G RELN reelin ISO (MGI:MGI:5286805|PMID:21664258) BHF-UCL PMID:21664258 MGI:MGI:5286805 NCBI chr 7:95,464,285...95,984,813
Ensembl chr 7:108,208,344...108,728,037
JBrowse link
G RGL2 ral guanine nucleotide dissociation stimulator like 2 ISO (MGI:MGI:5547674|PMID:24069211) MGI PMID:24069211 MGI:MGI:5547674 NCBI chr 6:32,863,954...32,871,684
Ensembl chr 6:33,978,024...33,985,749
JBrowse link
G SELP selectin P ISO (PMID:17632516) UniProtKB PMID:17632516 NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701
JBrowse link
G SEMA4D semaphorin 4D ISO (PMID:16055703) UniProtKB PMID:16055703 NCBI chr 9:60,451,420...60,588,519
Ensembl chr 9:88,497,528...88,560,811
JBrowse link
G SERPINA12 serpin family A member 12 ISO (MGI:MGI:5563627|PMID:22837305) MGI PMID:22837305 MGI:MGI:5563627 NCBI chr14:75,110,414...75,141,569
Ensembl chr14:94,442,931...94,473,779
JBrowse link
G SIRT1 sirtuin 1 ISO (MGI:MGI:4821191|PMID:20620997) UniProtKB PMID:20620997 MGI:MGI:4821191 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G SOX9 SRY-box transcription factor 9 ISO (MGI:MGI:4950303|PMID:21367821) UniProtKB PMID:21367821 MGI:MGI:4950303 NCBI chr17:66,028,737...66,034,122 JBrowse link
G TEK TEK receptor tyrosine kinase ISO (PMID:12816861), (PMID:18425120), (PMID:19223473) UniProtKB PMID:12816861, PMID:18425120, PMID:19223473 NCBI chr 9:26,955,339...27,077,809
Ensembl chr 9:27,561,421...27,683,572
JBrowse link
G TGFB2 transforming growth factor beta 2 ISO (PMID:18223299) BHF-UCL PMID:18223299 NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041
JBrowse link
G TNF tumor necrosis factor ISO PMID:12729461 ARUK-UCL PMID:12729461 RGD:13673777 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G UBE3A ubiquitin protein ligase E3A ISO (MGI:MGI:3616918|PMID:16254014) MGI PMID:16254014 MGI:MGI:3616918 NCBI chr15:4,494,029...4,595,415
Ensembl chr15:22,747,075...22,825,459
JBrowse link
G UNC5B unc-5 netrin receptor B ISO (PMID:18469807) UniProtKB PMID:18469807 NCBI chr10:67,682,415...67,772,760
Ensembl chr10:70,207,998...70,298,038
JBrowse link
G WNT16 Wnt family member 16 ISO (PMID:19951988) BHF-UCL PMID:19951988 NCBI chr 7:113,338,322...113,354,002
Ensembl chr 7:126,025,337...126,041,057
JBrowse link
regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 ISO PMID:11694516 UniProt PMID:11694516 RGD:11041061 NCBI chr19:39,395,550...39,417,063 JBrowse link
G CRNN cornulin ISO (PMID:30009832) UniProt PMID:30009832 NCBI chr 1:127,743,094...127,748,737 JBrowse link
G DIPK2A divergent protein kinase domain 2A ISO (PMID:23784961) UniProtKB PMID:23784961 NCBI chr 3:140,999,699...141,019,908
Ensembl chr 3:148,590,378...148,607,520
JBrowse link
G EGFR epidermal growth factor receptor ISO (PMID:26514923) CAFA PMID:26514923 NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615
JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISO (MGI:MGI:4881347|PMID:21074248) UniProtKB PMID:21074248 MGI:MGI:4881347 NCBI chr14:54,522,428...54,578,501
Ensembl chr14:73,376,684...73,410,468
JBrowse link
G FBXL2 F-box and leucine rich repeat protein 2 ISO (PMID:23604317) UniProtKB PMID:23604317 NCBI chr 3:33,199,436...33,308,831
Ensembl chr 3:33,501,525...33,610,039
JBrowse link
G LIME1 Lck interacting transmembrane adaptor 1 ISO (MGI:MGI:3769059|PMID:16249387) MGI PMID:16249387 MGI:MGI:3769059
G PPP1R16B protein phosphatase 1 regulatory subunit 16B ISO (PMID:25007873) GO_Central PMID:25007873 NCBI chr20:35,130,114...35,248,031
Ensembl chr20:36,237,535...36,354,329
JBrowse link
G PTPN13 protein tyrosine phosphatase non-receptor type 13 ISO (PMID:23604317) UniProtKB PMID:23604317 NCBI chr 4:78,893,598...79,118,745
Ensembl chr 4:89,623,271...89,847,616
JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 ISO (MGI:MGI:3758152|PMID:17190838) MGI PMID:17190838 MGI:MGI:3758152 NCBI chr15:17,417,684...17,494,333
Ensembl chr15:35,675,348...35,750,315
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12524
    signaling 4286
      signal transduction 3809
        intracellular signal transduction 2043
          inositol lipid-mediated signaling 143
            phosphatidylinositol-mediated signaling 141
              phosphatidylinositol 3-kinase signaling 120
                negative regulation of phosphatidylinositol 3-kinase signaling 16
                positive regulation of phosphatidylinositol 3-kinase signaling 66
                regulation of phosphatidylinositol 3-kinase signaling + 92
Path 2
Term Annotations click to browse term
  biological_process 12524
    biological regulation 9129
      regulation of biological process 8652
        regulation of cellular process 8181
          signal transduction 3809
            intracellular signal transduction 2043
              inositol lipid-mediated signaling 143
                phosphatidylinositol-mediated signaling 141
                  phosphatidylinositol 3-kinase signaling 120
                    negative regulation of phosphatidylinositol 3-kinase signaling 16
                    positive regulation of phosphatidylinositol 3-kinase signaling 66
                    regulation of phosphatidylinositol 3-kinase signaling + 92
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.