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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase signaling
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Accession:GO:0014065 term browser browse the term
Definition:A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
Synonyms:exact_synonym: PI 3-kinase cascade;   PI3K cascade;   PI3K signal transduction;   PI3K signaling;   phosphatidylinositol 3-kinase signal transduction;   phosphoinositide 3-kinase cascade
 related_synonym: phosphatidylinositol 3-kinase cascade


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phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193
JBrowse link
G C1QBP complement C1q binding protein IEA Ensembl GO_REF:0000107 NCBI chr 5:31,354,665...31,359,672
Ensembl chr 5:31,354,723...31,359,469
JBrowse link
G CD160 CD160 molecule ISO (PMID:17307798) UniProt PMID:17307798 NCBI chr17:58,548,137...58,564,077
Ensembl chr17:58,555,851...58,563,341
JBrowse link
G CSF2 colony stimulating factor 2 ISO (PMID:24520418) AgBase PMID:24520418 NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959
JBrowse link
G EDN1 endothelin 1 IEA Ensembl GO_REF:0000107 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr 9:22,760,373...22,785,367
Ensembl chr 9:22,759,256...22,785,294
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr10:406,856...424,746
Ensembl chr10:406,633...424,264
JBrowse link
G GATA3 GATA binding protein 3 ISS UniProtKB GO_REF:0000024 NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A IEA Ensembl GO_REF:0000107 NCBI chr22:4,453,715...4,510,934
Ensembl chr22:4,453,715...4,511,037
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B IEA Ensembl GO_REF:0000107 NCBI chr25:43,042,306...43,056,361
Ensembl chr25:43,042,173...43,056,612
JBrowse link
G IGF1 insulin like growth factor 1 IEA Ensembl GO_REF:0000107 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794
JBrowse link
G IRS1 insulin receptor substrate 1 ISO (PMID:7782332) BHF-UCL PMID:7782332 NCBI chr25:39,624,554...39,687,991 JBrowse link
G KBTBD2 kelch repeat and BTB domain containing 2 ISO (MGI:MGI:5806303|PMID:27708159) MGI PMID:27708159 MGI:MGI:5806303 NCBI chr14:44,941,116...45,001,887
Ensembl chr14:44,941,448...44,994,047
JBrowse link
G LOC606856 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr25:309,450...474,236 JBrowse link
G LTK leukocyte receptor tyrosine kinase ISO (PMID:9223670) UniProtKB PMID:9223670 NCBI chr30:8,541,328...8,550,108 JBrowse link
G MYO16 myosin XVI IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr22:57,313,714...57,794,415
Ensembl chr22:57,198,283...57,648,949
JBrowse link
G NF1 neurofibromin 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382
JBrowse link
G NYAP1 neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr 6:9,184,872...9,193,330
Ensembl chr 6:9,109,017...9,193,895
JBrowse link
G NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 IEA InterPro GO_REF:0000002 NCBI chr25:38,515,426...38,776,595
Ensembl chr25:38,516,357...38,771,407
JBrowse link
G PEAR1 platelet endothelial aggregation receptor 1 ISO (MGI:MGI:5817200|PMID:27614188) MGI PMID:27614188 MGI:MGI:5817200 NCBI chr 7:41,110,925...41,130,532
Ensembl chr 7:41,110,909...41,123,390
JBrowse link
G PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr21:39,693,211...39,868,603
Ensembl chr21:39,695,520...39,784,639
JBrowse link
G PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr38:974,248...1,016,226
Ensembl chr38:975,749...1,027,679
JBrowse link
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr27:28,446,629...28,818,198
Ensembl chr27:28,424,899...28,796,902
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr23:34,832,661...34,955,410
Ensembl chr23:34,836,540...34,993,939
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 5:62,884,596...62,936,882
Ensembl chr 5:62,909,009...62,935,971
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970
JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 ISO (PMID:23604317) UniProtKB PMID:23604317 NCBI chr20:44,826,037...44,838,449
Ensembl chr20:44,826,339...44,836,558
JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 ISO (PMID:12507995) UniProt PMID:12507995 NCBI chr 5:33,538,354...33,604,984
Ensembl chr 5:33,532,708...33,604,984
JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 IEA Ensembl GO_REF:0000107 NCBI chr28:32,025,791...32,081,824
Ensembl chr28:32,026,350...32,081,835
JBrowse link
G PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 IEA Ensembl GO_REF:0000107 NCBI chr29:17,458,098...17,738,069
Ensembl chr29:17,458,281...17,735,170
JBrowse link
G PTEN phosphatase and tensin homolog IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176
JBrowse link
G SIRT2 sirtuin 2 IEA Ensembl GO_REF:0000107 NCBI chr 1:114,224,922...114,235,041
Ensembl chr 1:114,224,900...114,234,583
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:3050929|PMID:15249583) MGI PMID:15249583 MGI:MGI:3050929 NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960
JBrowse link
G XBP1 X-box binding protein 1 ISO (PMID:23529610) UniProtKB PMID:23529610 NCBI chr26:22,162,675...22,168,149 JBrowse link
G ZFP36L1 ZFP36 ring finger protein like 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:42,663,287...42,668,665
Ensembl chr 8:42,664,223...42,668,514
JBrowse link
negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRYBA1 crystallin beta A1 ISO RGD PMID:21993393 RGD:10059647 NCBI chr 9:43,372,507...43,378,561
Ensembl chr 9:43,372,505...43,378,590
JBrowse link
G DAB2IP DAB2 interacting protein IEA Ensembl GO_REF:0000107 NCBI chr 9:60,725,887...60,918,242
Ensembl chr 9:60,726,809...60,918,139
JBrowse link
G INPP5E inositol polyphosphate-5-phosphatase E ISO RGD PMID:21436142 RGD:12911213 NCBI chr 9:49,061,014...49,071,474
Ensembl chr 9:49,061,968...49,070,191
JBrowse link
G KLF4 Kruppel like factor 4 ISO PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr11:62,881,840...62,886,676
Ensembl chr11:62,882,767...62,928,251
JBrowse link
G LOC100855640 butyrophilin subfamily 2 member A2 IEA Ensembl GO_REF:0000107 NCBI chr35:24,251,221...24,265,040
Ensembl chr35:24,251,799...24,262,496
JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO (MGI:MGI:3723397|PMID:17606624) MGI PMID:17606624 MGI:MGI:3723397 NCBI chr 5:39,687,530...39,837,003
Ensembl chr 5:39,687,543...39,836,464
JBrowse link
G NLRC3 NLR family CARD domain containing 3 ISO (MGI:MGI:5883388|PMID:27951586) UniProtKB PMID:27951586 MGI:MGI:5883388 NCBI chr 6:37,668,654...37,707,387
Ensembl chr 6:37,647,976...37,703,190
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor IEA Ensembl GO_REF:0000107 NCBI chr 1:108,307,039...108,315,732
Ensembl chr 1:108,307,042...108,316,495
JBrowse link
G OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF ISO (MGI:MGI:6101642|PMID:28826662) UniProt PMID:28826662 MGI:MGI:6101642 NCBI chr14:664,404...782,376 JBrowse link
G PIK3IP1 phosphoinositide-3-kinase interacting protein 1 IEA Ensembl GO_REF:0000107 NCBI chr26:24,243,195...24,255,335
Ensembl chr26:24,244,772...24,255,131
JBrowse link
G SERPINE2 serpin family E member 2 IEA Ensembl GO_REF:0000107 NCBI chr37:29,699,551...29,750,151
Ensembl chr37:29,700,024...29,724,228
JBrowse link
G SLC9A3R1 SLC9A3 regulator 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:5,661,792...5,679,783
Ensembl chr 9:5,662,464...5,679,570
JBrowse link
G SLC9A3R2 SLC9A3 regulator 2 ISO (MGI:MGI:3617099|PMID:16456542) MGI PMID:16456542 MGI:MGI:3617099 NCBI chr 6:38,905,070...38,915,028
Ensembl chr 6:38,905,635...38,942,774
JBrowse link
G STAMBP STAM binding protein IEA Ensembl GO_REF:0000107 NCBI chr17:49,194,810...49,221,017
Ensembl chr17:49,195,101...49,221,013
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:3586939|PMID:16027169) MGI PMID:16027169 MGI:MGI:3586939 NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960
JBrowse link
positive regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA3 adenosine A3 receptor ISO (MGI:MGI:2664591|PMID:12817016) MGI PMID:12817016 MGI:MGI:2664591 NCBI chr17:63,895,408...63,898,666
Ensembl chr17:63,895,408...63,898,666
JBrowse link
G AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 ISO PMID:14528310
PMID:18469807
UniProt PMID:14528310, PMID:18469807 RGD:1299350, RGD:8553892 NCBI chr10:1,791,273...1,807,710
Ensembl chr10:1,792,733...1,807,610
JBrowse link
G AGT angiotensinogen IEA Ensembl GO_REF:0000107 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G ANGPT1 angiopoietin 1 IEA Ensembl GO_REF:0000107 NCBI chr13:8,068,920...8,312,090
Ensembl chr13:8,048,205...8,311,618
JBrowse link
G CAT catalase IEA Ensembl GO_REF:0000107 NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447
JBrowse link
G CBL Cbl proto-oncogene IEA Ensembl GO_REF:0000107 NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956
JBrowse link
G CCL5 C-C motif chemokine ligand 5 IEA Ensembl GO_REF:0000107 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
JBrowse link
G CD28 CD28 molecule IEA Ensembl GO_REF:0000107 NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854
JBrowse link
G CNTF ciliary neurotrophic factor ISO RGD PMID:15574731 RGD:1626128 NCBI chr18:37,758,148...37,765,698 JBrowse link
G CSF3 colony stimulating factor 3 IEA Ensembl GO_REF:0000107 NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108
JBrowse link
G DCN decorin IEA Ensembl GO_REF:0000107 NCBI chr15:31,833,492...31,887,699
Ensembl chr15:31,833,746...31,877,417
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:16168116 RGD:1582137 NCBI chr 9:22,760,373...22,785,367
Ensembl chr 9:22,759,256...22,785,294
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 IEA Ensembl GO_REF:0000107 NCBI chr37:19,029,647...20,134,576
Ensembl chr37:19,037,217...20,134,426
JBrowse link
G F2 coagulation factor II, thrombin IEA Ensembl GO_REF:0000107 NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459
JBrowse link
G F2R coagulation factor II thrombin receptor ISS UniProt GO_REF:0000024 NCBI chr 3:29,870,159...29,889,837
Ensembl chr 3:29,872,155...29,889,687
JBrowse link
G F2RL1 F2R like trypsin receptor 1 ISS UniProtKB GO_REF:0000024 NCBI chr 3:29,801,119...29,810,006
Ensembl chr 3:29,800,211...29,810,180
JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr 2:72,678,858...72,692,417
Ensembl chr 2:72,680,675...72,690,251
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr25:11,231,958...11,410,379
Ensembl chr25:11,231,737...11,407,621
JBrowse link
G FPR2 formyl peptide receptor 2 ISO PMID:30511586 ARUK-UCL PMID:30511586 RGD:14695080 NCBI chr 1:105,343,096...105,353,563
Ensembl chr 1:105,344,463...105,372,070
JBrowse link
G FSHR follicle stimulating hormone receptor ISO (PMID:24058690) UniProtKB PMID:24058690 NCBI chr10:50,765,591...50,938,643
Ensembl chr10:50,770,995...50,938,474
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase ISO PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr12:68,105,060...68,316,630
Ensembl chr12:68,075,184...68,316,541
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:15,792,072...15,796,922
Ensembl chr 6:15,792,897...15,794,051
JBrowse link
G HAX1 HCLS1 associated protein X-1 IEA Ensembl GO_REF:0000107 NCBI chr 7:42,969,711...42,972,783
Ensembl chr 7:42,969,713...42,972,710
JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 IEA Ensembl GO_REF:0000107 NCBI chr33:24,901,023...24,925,710
Ensembl chr33:24,901,287...24,922,923
JBrowse link
G HCST hematopoietic cell signal transducer IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:116,760,605...116,763,355
Ensembl chr 1:116,760,714...116,762,024
JBrowse link
G HGF hepatocyte growth factor IEA Ensembl GO_REF:0000107 NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263
JBrowse link
G IGF1 insulin like growth factor 1 IEA Ensembl GO_REF:0000107 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794
JBrowse link
G IGF1R insulin like growth factor 1 receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387
JBrowse link
G IL18 interleukin 18 IEA Ensembl GO_REF:0000107 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
JBrowse link
G INS insulin ISO (PMID:7688386) BHF-UCL PMID:7688386 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G INSR insulin receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:52,017,261...52,136,061
Ensembl chr20:52,021,887...52,136,046
JBrowse link
G JAK2 Janus kinase 2 ISO (MGI:MGI:3828423|PMID:7782332) BHF-UCL PMID:7782332 MGI:MGI:3828423 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997
JBrowse link
G KDR kinase insert domain receptor IEA Ensembl GO_REF:0000107 NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042
JBrowse link
G LEP leptin ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395
JBrowse link
G MAZ MYC associated zinc finger protein ISO (PMID:25487955) ARUK-UCL PMID:25487955 NCBI chr 6:17,867,491...17,870,108
Ensembl chr 6:17,867,488...17,870,197
JBrowse link
G MYDGF myeloid derived growth factor IEA Ensembl GO_REF:0000107 NCBI chr20:55,084,060...55,096,544
Ensembl chr20:55,084,059...55,096,241
JBrowse link
G MYOC myocilin ISS UniProtKB GO_REF:0000024 NCBI chr 7:27,335,314...27,346,821
Ensembl chr 7:27,335,314...27,346,820
JBrowse link
G NCF1 neutrophil cytosolic factor 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458
JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase IEA Ensembl GO_REF:0000107 NCBI chr30:21,123,333...21,229,907
Ensembl chr30:21,126,043...21,229,870
JBrowse link
G NKX3-1 NK3 homeobox 1 ISS UniProt GO_REF:0000024 NCBI chr25:33,815,343...33,817,465
Ensembl chr25:33,815,095...33,817,474
JBrowse link
G NRG1 neuregulin 1 ISO (MGI:MGI:3796800|PMID:18458158) MGI PMID:18458158 MGI:MGI:3796800 NCBI chr16:31,697,958...32,771,888
Ensembl chr16:31,706,851...32,771,932
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:74,447,927...74,777,910
Ensembl chr 1:74,449,060...74,777,032
JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:51,131,470...51,491,112
Ensembl chr 3:51,138,751...51,513,024
JBrowse link
G OSM oncostatin M IEA Ensembl GO_REF:0000107 NCBI chr26:23,421,787...23,439,332
Ensembl chr26:23,421,787...23,426,036
JBrowse link
G PDGFA platelet derived growth factor subunit A IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:16,271,082...16,293,246
Ensembl chr 6:16,270,104...16,292,396
JBrowse link
G PDGFB platelet derived growth factor subunit B ISS
IEA
IBA
(PMID:21873635) UniProtKB
Ensembl
GO_Central
PMID:21873635 GO_REF:0000024, GO_REF:0000107 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746
JBrowse link
G PDGFC platelet derived growth factor C IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:54,143,637...54,239,962
Ensembl chr15:54,145,381...54,345,830
JBrowse link
G PDGFD platelet derived growth factor D IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:27,863,739...28,092,376
Ensembl chr 5:27,863,591...28,089,936
JBrowse link
G PDGFRB platelet derived growth factor receptor beta IEA Ensembl GO_REF:0000107 NCBI chr 4:58,925,922...58,963,639
Ensembl chr 4:58,926,351...58,962,283
JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 IEA Ensembl GO_REF:0000107 NCBI chr28:9,977,463...10,095,363
Ensembl chr28:9,978,900...10,095,284
JBrowse link
G PLD2 phospholipase D2 ISO RGD PMID:15705590 RGD:2299907 NCBI chr 5:31,755,881...31,767,131
Ensembl chr 5:31,756,433...31,767,066
JBrowse link
G PLXNB1 plexin B1 IEA Ensembl GO_REF:0000107 NCBI chr20:40,658,938...40,685,219
Ensembl chr20:40,661,772...40,684,265
JBrowse link
G PPARD peroxisome proliferator activated receptor delta IEA Ensembl GO_REF:0000107 NCBI chr12:4,492,867...4,579,340
Ensembl chr12:4,492,672...4,579,340
JBrowse link
G PRR5 proline rich 5 IEA Ensembl GO_REF:0000107 NCBI chr10:21,164,530...21,188,537
Ensembl chr10:21,164,530...21,210,148
JBrowse link
G PRR5L proline rich 5 like IEA Ensembl GO_REF:0000107 NCBI chr18:31,708,888...31,849,365
Ensembl chr18:31,706,546...31,849,491
JBrowse link
G PTK2 protein tyrosine kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr13:35,302,439...35,541,336
Ensembl chr13:35,303,380...35,541,294
JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 IEA Ensembl GO_REF:0000107 NCBI chr27:38,084,976...38,101,552
Ensembl chr27:38,084,980...38,101,937
JBrowse link
G RARA retinoic acid receptor alpha ISO PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr 9:22,254,803...22,298,614
Ensembl chr 9:22,254,806...22,289,459
JBrowse link
G RELN reelin IEA Ensembl GO_REF:0000107 NCBI chr18:16,275,822...16,773,875
Ensembl chr18:16,275,837...16,773,875
JBrowse link
G RGL2 ral guanine nucleotide dissociation stimulator like 2 IEA Ensembl GO_REF:0000107 NCBI chr12:2,731,366...2,739,141
Ensembl chr12:2,731,983...2,739,032
JBrowse link
G ROR1 receptor tyrosine kinase like orphan receptor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:46,010,097...46,477,882
Ensembl chr 5:46,013,195...46,190,880
JBrowse link
G ROR2 receptor tyrosine kinase like orphan receptor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:95,209,122...95,280,956
Ensembl chr 1:95,088,745...95,280,151
JBrowse link
G SELP selectin P IEA Ensembl GO_REF:0000107 NCBI chr 7:28,956,428...28,997,266
Ensembl chr 7:28,958,486...28,996,313
JBrowse link
G SEMA4D semaphorin 4D IEA Ensembl GO_REF:0000107 NCBI chr 1:96,825,963...96,878,956
Ensembl chr 1:96,814,674...96,878,968
JBrowse link
G SERPINA12 serpin family A member 12 IEA Ensembl GO_REF:0000107 NCBI chr 8:63,497,542...63,511,701
Ensembl chr 8:63,497,849...63,512,171
JBrowse link
G SIRT1 sirtuin 1 ISO (MGI:MGI:4821191|PMID:20620997) UniProtKB PMID:20620997 MGI:MGI:4821191 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
G SOX9 SRY-box transcription factor 9 ISS UniProtKB GO_REF:0000024 NCBI chr 9:8,275,049...8,278,172
Ensembl chr 9:8,275,049...8,278,172
JBrowse link
G TEK TEK receptor tyrosine kinase IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr11:45,278,375...45,377,300
Ensembl chr11:45,278,891...45,409,093
JBrowse link
G TGFB2 transforming growth factor beta 2 ISS AgBase GO_REF:0000024 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242
JBrowse link
G TNF tumor necrosis factor ISO PMID:12729461 ARUK-UCL PMID:12729461 RGD:13673777 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G UBE3A ubiquitin protein ligase E3A IEA Ensembl GO_REF:0000107 NCBI chr 3:35,347,034...35,442,329
Ensembl chr 3:35,347,064...35,440,256
JBrowse link
G UNC5B unc-5 netrin receptor B IEA Ensembl GO_REF:0000107 NCBI chr 4:22,003,131...22,084,107
Ensembl chr 4:22,003,131...22,081,744
JBrowse link
G WNT16 Wnt family member 16 IEA Ensembl GO_REF:0000107 NCBI chr14:59,388,034...59,404,812
Ensembl chr14:59,387,846...59,396,622
JBrowse link
regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 ISO PMID:11694516 UniProt PMID:11694516 RGD:11041061 NCBI chr 1:111,902,429...111,919,191
Ensembl chr 1:111,745,413...111,917,830
JBrowse link
G CEP55 centrosomal protein 55 IEA InterPro GO_REF:0000002 NCBI chr28:7,754,934...7,777,662
Ensembl chr28:7,754,964...7,778,481
JBrowse link
G CRNN cornulin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:61,380,706...61,386,294
Ensembl chr17:61,380,706...61,386,504
JBrowse link
G DIPK2A divergent protein kinase domain 2A IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr23:39,472,090...39,496,000 JBrowse link
G EGFR epidermal growth factor receptor IEA Ensembl GO_REF:0000107 NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631
JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISO (MGI:MGI:4881347|PMID:21074248) UniProtKB PMID:21074248 MGI:MGI:4881347 NCBI chr 8:47,193,463...47,245,865
Ensembl chr 8:47,196,439...47,229,964
JBrowse link
G FBXL2 F-box and leucine rich repeat protein 2 IEA Ensembl GO_REF:0000107 NCBI chr23:3,498,253...3,606,016
Ensembl chr23:3,498,979...3,607,093
JBrowse link
G LIME1 Lck interacting transmembrane adaptor 1 ISO (MGI:MGI:3769059|PMID:16249387) MGI PMID:16249387 MGI:MGI:3769059 NCBI chr24:47,269,922...47,272,288 JBrowse link
G PPP1R16B protein phosphatase 1 regulatory subunit 16B IEA Ensembl GO_REF:0000107 NCBI chr24:27,206,870...27,299,956
Ensembl chr24:27,205,880...27,295,801
JBrowse link
G PTPN13 protein tyrosine phosphatase non-receptor type 13 IEA Ensembl GO_REF:0000107 NCBI chr32:10,125,447...10,328,764
Ensembl chr32:10,125,441...10,328,757
JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 IEA Ensembl GO_REF:0000107 NCBI chr30:5,840,901...5,914,804
Ensembl chr30:5,841,738...5,914,810
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16162
    signaling 5992
      signal transduction 5449
        intracellular signal transduction 2483
          inositol lipid-mediated signaling 171
            phosphatidylinositol-mediated signaling 168
              phosphatidylinositol 3-kinase signaling 134
                negative regulation of phosphatidylinositol 3-kinase signaling 15
                positive regulation of phosphatidylinositol 3-kinase signaling 74
                regulation of phosphatidylinositol 3-kinase signaling + 100
Path 2
Term Annotations click to browse term
  biological_process 16162
    biological regulation 11532
      regulation of biological process 10947
        regulation of cellular process 10489
          signal transduction 5449
            intracellular signal transduction 2483
              inositol lipid-mediated signaling 171
                phosphatidylinositol-mediated signaling 168
                  phosphatidylinositol 3-kinase signaling 134
                    negative regulation of phosphatidylinositol 3-kinase signaling 15
                    positive regulation of phosphatidylinositol 3-kinase signaling 74
                    regulation of phosphatidylinositol 3-kinase signaling + 100
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.