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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase signaling
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Accession:GO:0014065 term browser browse the term
Definition:A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
Synonyms:exact_synonym: PI 3-kinase cascade;   PI3K cascade;   PI3K signal transduction;   PI3K signaling;   phosphatidylinositol 3-kinase signal transduction;   phosphoinositide 3-kinase cascade
 related_synonym: phosphatidylinositol 3-kinase cascade


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phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 IMP (PMID:26514923) CAFA PMID:26514923 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G C1QBP complement C1q binding protein IMP (PMID:16177118) UniProtKB PMID:16177118 NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830
JBrowse link
G CD160 CD160 molecule IDA (PMID:17307798) UniProt PMID:17307798 NCBI chr 1:145,719,312...145,739,288
Ensembl chr 1:145,719,471...145,739,288
JBrowse link
G CSF2 colony stimulating factor 2 ISO (PMID:24520418) AgBase PMID:24520418 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G EDN1 endothelin 1 IDA (PMID:17078114) BHF-UCL PMID:17078114 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 IDA (PMID:7556068) BHF-UCL PMID:7556068 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 IDA (PMID:7556068) BHF-UCL PMID:7556068 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505
JBrowse link
G GATA3 GATA binding protein 3 ISS UniProtKB GO_REF:0000024 NCBI chr10:8,045,420...8,075,198
Ensembl chr10:8,045,378...8,075,198
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A IDA (PMID:16517693) UniProtKB PMID:16517693 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,550...46,897,076
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B IDA (PMID:16517693) UniProtKB PMID:16517693 NCBI chr 2:231,108,230...231,126,172
Ensembl chr 2:231,108,230...231,125,042
JBrowse link
G IGF1 insulin like growth factor 1 IMP (PMID:24508636) AgBase PMID:24508636 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF1R insulin like growth factor 1 receptor IC (PMID:7541045) BHF-UCL PMID:7541045 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IRS1 insulin receptor substrate 1 IDA (PMID:7782332) BHF-UCL PMID:7782332 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,317...226,799,759
JBrowse link
G KBTBD2 kelch repeat and BTB domain containing 2 ISO (MGI:MGI:5806303|PMID:27708159) MGI PMID:27708159 MGI:MGI:5806303 NCBI chr 7:32,868,172...32,892,144
Ensembl chr 7:32,868,172...32,894,131
JBrowse link
G LTK leukocyte receptor tyrosine kinase IMP (PMID:9223670) UniProtKB PMID:9223670 NCBI chr15:41,503,637...41,513,887
Ensembl chr15:41,503,637...41,513,887
JBrowse link
G MYO16 myosin XVI IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr13:108,495,729...109,208,005
Ensembl chr13:108,596,152...109,208,005
JBrowse link
G NF1 neurofibromin 1 ISS HGNC GO_REF:0000024 NCBI chr17:31,094,927...31,377,677
Ensembl chr17:31,094,927...31,382,116
JBrowse link
G NYAP1 neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 IEA
ISS
InterPro
UniProtKB
GO_REF:0000002, GO_REF:0000024 NCBI chr 7:100,483,927...100,494,802
Ensembl chr 7:100,483,927...100,494,802
JBrowse link
G NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 ISS UniProtKB GO_REF:0000024 NCBI chr 2:225,399,710...225,703,654
Ensembl chr 2:225,399,710...225,654,018
JBrowse link
G PEAR1 platelet endothelial aggregation receptor 1 ISO (MGI:MGI:5817200|PMID:27614188) MGI PMID:27614188 MGI:MGI:5817200 NCBI chr 1:156,893,697...156,916,429
Ensembl chr 1:156,893,698...156,916,434
JBrowse link
G PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:17,086,575...17,207,986
Ensembl chr11:17,077,730...17,207,983
JBrowse link
G PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:204,422,633...204,494,815
Ensembl chr 1:204,422,628...204,494,724
JBrowse link
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:18,242,946...18,716,861
Ensembl chr12:18,242,961...18,648,416
Ensembl chr12:18,242,961...18,648,416
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IMP
IBA
IEA
TAS
(PMID:25339672)
(PMID:21873635)
(PMID:21321382)
CAFA
GO_Central
InterPro
UniProtKB
PMID:21321382, PMID:21873635, PMID:25339672 GO_REF:0000002 NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IMP
IBA
IEA
TAS
(PMID:25339672)
(PMID:21873635)
(PMID:17290298)
CAFA
GO_Central
InterPro
UniProtKB
PMID:17290298, PMID:21873635, PMID:25339672 GO_REF:0000002 NCBI chr 1:9,629,889...9,729,114
Ensembl chr 1:9,651,731...9,729,114
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma TAS
IBA
IDA
(PMID:17290298)
(PMID:21873635)
(PMID:12507995)
UniProtKB
GO_Central
PMID:12507995, PMID:17290298, PMID:21873635 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 IDA
IMP
(PMID:7782332)
(PMID:21321938)
BHF-UCL PMID:7782332, PMID:21321938 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 IDA (PMID:23604317) UniProtKB PMID:23604317 NCBI chr19:18,153,163...18,170,532
Ensembl chr19:18,153,163...18,170,532
JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 ISS UniProtKB GO_REF:0000024 NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712
JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 IDA (PMID:12101241) UniProtKB PMID:12101241 NCBI chr10:122,374,675...122,442,600
Ensembl chr10:122,374,696...122,442,602
JBrowse link
G PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 IEA Ensembl GO_REF:0000107 NCBI chr 8:67,951,918...68,237,032
Ensembl chr 8:67,952,046...68,237,032
JBrowse link
G PTEN phosphatase and tensin homolog IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G SIRT2 sirtuin 2 IMP (PMID:23908241) UniProtKB PMID:23908241 NCBI chr19:38,878,555...38,899,733
Ensembl chr19:38,878,555...38,899,862
JBrowse link
G TPTE transmembrane phosphatase with tensin homology IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr21:10,521,583...10,605,716
Ensembl chr21:10,521,553...10,606,140
JBrowse link
G TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:19,422,877...19,561,574
Ensembl chr13:19,422,877...19,536,762
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:3050929|PMID:15249583) MGI PMID:15249583 MGI:MGI:3050929 NCBI chr16:2,047,804...2,089,491
Ensembl chr16:2,047,967...2,089,491
JBrowse link
G TYRO3 TYRO3 protein tyrosine kinase NAS (PMID:10627473) UniProtKB PMID:10627473 NCBI chr15:41,559,212...41,583,589
Ensembl chr15:41,557,675...41,583,589
JBrowse link
G XBP1 X-box binding protein 1 IDA (PMID:23529610) UniProtKB PMID:23529610 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
G ZFP36L1 ZFP36 ring finger protein like 1 IDA (PMID:15538381) UniProtKB PMID:15538381 NCBI chr14:68,787,655...68,796,243
Ensembl chr14:68,787,660...68,796,253
JBrowse link
negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTN2A2 butyrophilin subfamily 2 member A2 IEA Ensembl GO_REF:0000107 NCBI chr 6:26,382,893...26,394,874
Ensembl chr 6:26,383,096...26,394,874
JBrowse link
G CRYBA1 crystallin beta A1 IEA Ensembl GO_REF:0000107 NCBI chr17:29,246,859...29,254,494
Ensembl chr17:29,246,859...29,254,494
Ensembl chr17:29,246,859...29,254,494
JBrowse link
G DAB2IP DAB2 interacting protein IDA (PMID:19903888) UniProtKB PMID:19903888 NCBI chr 9:121,566,883...121,785,530
Ensembl chr 9:121,567,057...121,785,530
JBrowse link
G INPP5E inositol polyphosphate-5-phosphatase E IEA Ensembl GO_REF:0000107 NCBI chr 9:136,428,619...136,439,861
Ensembl chr 9:136,428,619...136,439,845
JBrowse link
G KLF4 Kruppel like factor 4 IEA Ensembl GO_REF:0000107 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482
JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO (MGI:MGI:3723397|PMID:17606624) MGI PMID:17606624 MGI:MGI:3723397 NCBI chr17:16,029,157...16,216,475
Ensembl chr17:16,029,157...16,218,185
JBrowse link
G NLRC3 NLR family CARD domain containing 3 ISS UniProtKB GO_REF:0000024 NCBI chr16:3,539,033...3,577,782
Ensembl chr16:3,539,033...3,577,403
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor IMP (PMID:16971513) UniProtKB PMID:16971513 NCBI chr19:47,745,546...47,757,058
Ensembl chr19:47,745,546...47,757,058
JBrowse link
G OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF ISO (MGI:MGI:6101642|PMID:28826662) UniProt PMID:28826662 MGI:MGI:6101642 NCBI chr 1:228,208,044...228,378,876
Ensembl chr 1:228,208,063...228,378,876
JBrowse link
G PIK3IP1 phosphoinositide-3-kinase interacting protein 1 IDA (PMID:17475214) UniProtKB PMID:17475214 NCBI chr22:31,281,593...31,292,534
Ensembl chr22:31,281,594...31,292,534
JBrowse link
G PTEN phosphatase and tensin homolog TAS
NAS
(PMID:18082964)
(PMID:16762633)
BHF-UCL PMID:16762633, PMID:18082964 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G SERPINE2 serpin family E member 2 IEA Ensembl GO_REF:0000107 NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318
JBrowse link
G SLC9A3R1 SLC9A3 regulator 1 ISS UniProtKB GO_REF:0000024 NCBI chr17:74,748,628...74,769,353
Ensembl chr17:74,748,628...74,769,353
JBrowse link
G SLC9A3R2 SLC9A3 regulator 2 ISO (MGI:MGI:3617099|PMID:16456542) MGI PMID:16456542 MGI:MGI:3617099 NCBI chr16:2,026,902...2,039,026
Ensembl chr16:2,025,356...2,039,026
JBrowse link
G STAMBP STAM binding protein IMP (PMID:23542699) UniProtKB PMID:23542699 NCBI chr 2:73,828,911...73,873,656
Ensembl chr 2:73,828,916...73,873,659
JBrowse link
G TSC2 TSC complex subunit 2 ISS UniProtKB GO_REF:0000024 NCBI chr16:2,047,804...2,089,491
Ensembl chr16:2,047,967...2,089,491
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 IMP (PMID:17003487) BHF-UCL PMID:17003487 NCBI chr 7:19,113,047...19,117,636
Ensembl chr 7:19,020,991...19,117,636
JBrowse link
positive regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA3 adenosine A3 receptor ISO (MGI:MGI:2664591|PMID:12817016) MGI PMID:12817016 MGI:MGI:2664591 NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
JBrowse link
G AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 IEA Ensembl GO_REF:0000107 NCBI chr12:57,723,761...57,742,201
Ensembl chr12:57,723,761...57,742,157
JBrowse link
G AGT angiotensinogen IDA (PMID:15652490) BHF-UCL PMID:15652490 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G ANGPT1 angiopoietin 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055
JBrowse link
G BECN1 beclin 1 NAS (PMID:25215947) ParkinsonsUK-UCL PMID:25215947 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G CAT catalase IEA Ensembl GO_REF:0000107 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CBL Cbl proto-oncogene IMP (PMID:17003487) BHF-UCL PMID:17003487 NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926
Ensembl chr11:119,206,298...119,313,926
JBrowse link
G CCL5 C-C motif chemokine ligand 5 IDA (PMID:7544376) BHF-UCL PMID:7544376 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CD28 CD28 molecule IEA Ensembl GO_REF:0000107 NCBI chr 2:203,706,509...203,739,756
Ensembl chr 2:203,706,475...203,738,912
JBrowse link
G CNTF ciliary neurotrophic factor ISO RGD PMID:15574731 RGD:1626128 NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733
JBrowse link
G CSF3 colony stimulating factor 3 IDA (PMID:23001182) BHF-UCL PMID:23001182 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813
JBrowse link
G DCN decorin IDA (PMID:23798385) MGI PMID:23798385 NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217
Ensembl chr12:91,140,484...91,183,217
JBrowse link
G EPO erythropoietin TAS Reactome Reactome:R-HSA-9027276 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G EPOR erythropoietin receptor TAS Reactome Reactome:R-HSA-9027276 NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:16168116 RGD:1582137 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 TAS (PMID:17701904) BHF-UCL PMID:17701904 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 IEA Ensembl GO_REF:0000107 NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841
JBrowse link
G F2 coagulation factor II, thrombin IEA Ensembl GO_REF:0000107 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G F2R coagulation factor II thrombin receptor ISS UniProtKB GO_REF:0000024 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770
JBrowse link
G F2RL1 F2R like trypsin receptor 1 ISS UniProtKB GO_REF:0000024 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315
JBrowse link
G FGFR1 fibroblast growth factor receptor 1 TAS (PMID:15863030) UniProtKB PMID:15863030 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834
JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase IMP (PMID:10739672) UniProtKB PMID:10739672 NCBI chr 1:27,612,064...27,635,561
Ensembl chr 1:27,612,064...27,635,185
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 IMP (PMID:14633857) UniProtKB PMID:14633857 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G FLT3 fms related receptor tyrosine kinase 3 TAS (PMID:12951584) UniProtKB PMID:12951584 NCBI chr13:28,003,274...28,100,587
Ensembl chr13:28,003,274...28,100,592
JBrowse link
G FPR2 formyl peptide receptor 2 ISO PMID:30511586 ARUK-UCL PMID:30511586 RGD:14695080 NCBI chr19:51,752,026...51,770,531
Ensembl chr19:51,752,026...51,770,531
JBrowse link
G FSHR follicle stimulating hormone receptor IMP (PMID:24058690) UniProtKB PMID:24058690 NCBI chr 2:48,953,161...49,154,527
Ensembl chr 2:48,962,157...49,154,527
Ensembl chr 2:48,962,157...49,154,527
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452
JBrowse link
G GAB1 GRB2 associated binding protein 1 TAS Reactome Reactome:R-HSA-9027276 NCBI chr 4:143,336,876...143,474,565
Ensembl chr 4:143,336,762...143,474,568
JBrowse link
G GH1 growth hormone 1 IDA (PMID:7782332) BHF-UCL PMID:7782332 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 IDA (PMID:15705806) UniProtKB PMID:15705806 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815
JBrowse link
G HAX1 HCLS1 associated protein X-1 IMP (PMID:23001182) BHF-UCL PMID:23001182 NCBI chr 1:154,272,629...154,275,875
Ensembl chr 1:154,272,589...154,275,875
Ensembl chr 1:154,272,589...154,275,875
JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 IMP (PMID:23001182) BHF-UCL PMID:23001182 NCBI chr 3:121,631,399...121,660,903
Ensembl chr 3:121,631,399...121,660,927
JBrowse link
G HCST hematopoietic cell signal transducer IDA
IBA
(PMID:10426994)
(PMID:21873635)
UniProtKB
GO_Central
PMID:10426994, PMID:21873635 NCBI chr19:35,902,365...35,904,377
Ensembl chr19:35,902,529...35,904,377
JBrowse link
G HGF hepatocyte growth factor IDA (PMID:20655899) BHF-UCL PMID:20655899 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G IGF1 insulin like growth factor 1 IDA (PMID:7688386) BHF-UCL PMID:7688386 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF1R insulin like growth factor 1 receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IL18 interleukin 18 IDA (PMID:21321938) BHF-UCL PMID:21321938 NCBI chr11:112,143,251...112,164,104
Ensembl chr11:112,143,253...112,164,096
JBrowse link
G INS insulin IDA (PMID:7688386) BHF-UCL PMID:7688386 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G INSR insulin receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G IRS2 insulin receptor substrate 2 TAS Reactome Reactome:R-HSA-9027276 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583
JBrowse link
G JAK2 Janus kinase 2 ISS
TAS
BHF-UCL
Reactome
GO_REF:0000024, Reactome:R-HSA-9027276 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,128,183
Ensembl chr 9:4,984,390...5,128,183
JBrowse link
G KDR kinase insert domain receptor IDA (PMID:9804796) UniProtKB PMID:9804796 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase TAS (PMID:16129412) UniProtKB PMID:16129412 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,918...54,740,715
JBrowse link
G LEP leptin IDA
IBA
ISS
(PMID:24340098)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:24340098 GO_REF:0000024 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase TAS Reactome Reactome:R-HSA-9027276 NCBI chr 8:55,876,041...56,014,169
Ensembl chr 8:55,879,835...56,014,169
JBrowse link
G MAZ MYC associated zinc finger protein IDA (PMID:25487955) ARUK-UCL PMID:25487955 NCBI chr16:29,806,081...29,811,171
Ensembl chr16:29,806,106...29,811,164
JBrowse link
G MYDGF myeloid derived growth factor ISS UniProtKB GO_REF:0000024 NCBI chr19:4,657,545...4,670,391
Ensembl chr19:4,641,374...4,670,362
Ensembl chr19:4,641,374...4,670,362
JBrowse link
G MYOC myocilin IDA (PMID:21656515) UniProtKB PMID:21656515 NCBI chr 1:171,635,417...171,652,688
Ensembl chr 1:171,635,417...171,652,688
JBrowse link
G NCF1 neutrophil cytosolic factor 1 IMP (PMID:26514923) CAFA PMID:26514923 NCBI chr 7:74,773,962...74,789,376
Ensembl chr 7:74,773,962...74,789,376
JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase IMP (PMID:17218260) BHF-UCL PMID:17218260 NCBI chr15:55,826,917...55,993,612
Ensembl chr15:55,826,922...55,993,746
JBrowse link
G NKX3-1 NK3 homeobox 1 IDA (PMID:20395202) UniProtKB PMID:20395202 NCBI chr 8:23,678,693...23,682,938
Ensembl chr 8:23,678,697...23,682,938
JBrowse link
G NRG1 neuregulin 1 ISO (MGI:MGI:3796800|PMID:18458158) MGI PMID:18458158 MGI:MGI:3796800 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666
JBrowse link
G NTF3 neurotrophin 3 TAS Reactome Reactome:R-HSA-9603381 NCBI chr12:5,432,108...5,495,299
Ensembl chr12:5,432,108...5,521,536
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,640...156,881,850
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 9:84,668,458...85,027,070
Ensembl chr 9:84,668,551...85,027,070
JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 TAS
IBA
(PMID:21873635) Reactome
GO_Central
PMID:21873635 Reactome:R-HSA-9603381 NCBI chr15:87,859,749...88,256,796
Ensembl chr15:87,859,751...88,256,768
JBrowse link
G OSM oncostatin M IGI (PMID:28972028) BHF-UCL PMID:28972028 NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851
JBrowse link
G PDGFA platelet derived growth factor subunit A IDA
IBA
(PMID:11788434)
(PMID:21873635)
UniProtKB
GO_Central
PMID:11788434, PMID:21873635 NCBI chr 7:497,245...520,668
Ensembl chr 7:497,258...520,296
JBrowse link
G PDGFB platelet derived growth factor subunit B IDA
IBA
(PMID:10734101), (PMID:11788434), (PMID:17942966)
(PMID:21873635)
UniProtKB
GO_Central
PMID:10734101, PMID:11788434, PMID:17942966, PMID:21873635 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G PDGFC platelet derived growth factor C IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:156,760,454...156,971,799
Ensembl chr 4:156,760,454...156,971,799
JBrowse link
G PDGFD platelet derived growth factor D IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:103,907,189...104,164,147
Ensembl chr11:103,907,189...104,164,379
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha TAS (PMID:10734113) UniProtKB PMID:10734113 NCBI chr 4:54,229,127...54,298,245
Ensembl chr 4:54,229,280...54,298,245
JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISS UniProtKB GO_REF:0000024 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 ISS UniProtKB GO_REF:0000024 NCBI chr10:96,593,312...96,720,514
Ensembl chr10:96,593,315...96,720,514
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha TAS Reactome Reactome:R-HSA-9027276 NCBI chr 3:179,148,114...179,240,093
Ensembl chr 3:179,148,114...179,240,093
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta TAS Reactome Reactome:R-HSA-9027276 NCBI chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928
Ensembl chr 3:138,652,698...138,834,928
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta TAS Reactome Reactome:R-HSA-9027276 NCBI chr 1:9,629,889...9,729,114
Ensembl chr 1:9,651,731...9,729,114
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma TAS Reactome Reactome:R-HSA-9027276 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 TAS Reactome Reactome:R-HSA-9027276 NCBI chr 5:68,215,737...68,301,821
Ensembl chr 5:68,215,756...68,301,821
JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 TAS Reactome Reactome:R-HSA-9027276 NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712
JBrowse link
G PLD2 phospholipase D2 ISO RGD PMID:15705590 RGD:2299907 NCBI chr17:4,807,152...4,823,432
Ensembl chr17:4,807,152...4,823,434
JBrowse link
G PLXNB1 plexin B1 ISS UniProtKB GO_REF:0000024 NCBI chr 3:48,403,854...48,430,324
Ensembl chr 3:48,403,854...48,430,086
JBrowse link
G PPARD peroxisome proliferator activated receptor delta IEA Ensembl GO_REF:0000107 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PRR5 proline rich 5 IEA Ensembl GO_REF:0000107 NCBI chr22:44,668,751...44,737,681
Ensembl chr22:44,668,547...44,737,681
JBrowse link
G PRR5L proline rich 5 like IEA Ensembl GO_REF:0000107 NCBI chr11:36,296,288...36,465,204
Ensembl chr11:36,296,288...36,465,204
JBrowse link
G PTK2 protein tyrosine kinase 2 IMP (PMID:15166238) UniProtKB PMID:15166238 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 IMP (PMID:19838216) BHF-UCL PMID:19838216 NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316
JBrowse link
G RARA retinoic acid receptor alpha ISO PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G RELN reelin IEA Ensembl GO_REF:0000107 NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,784...103,989,658
JBrowse link
G RGL2 ral guanine nucleotide dissociation stimulator like 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:33,291,654...33,299,365
Ensembl chr 6:33,291,654...33,298,942
JBrowse link
G ROR1 receptor tyrosine kinase like orphan receptor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:63,774,017...64,181,498
Ensembl chr 1:63,774,017...64,181,498
JBrowse link
G ROR2 receptor tyrosine kinase like orphan receptor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:91,722,598...91,950,228
Ensembl chr 9:91,563,091...91,950,228
JBrowse link
G SELP selectin P IDA (PMID:17632516) UniProtKB PMID:17632516 NCBI chr 1:169,588,849...169,630,125
Ensembl chr 1:169,588,849...169,630,193
JBrowse link
G SEMA4D semaphorin 4D IMP (PMID:16055703) UniProtKB PMID:16055703 NCBI chr 9:89,360,787...89,498,113
Ensembl chr 9:89,360,787...89,498,130
JBrowse link
G SERPINA12 serpin family A member 12 IEA Ensembl GO_REF:0000107 NCBI chr14:94,481,651...94,517,844
Ensembl chr14:94,487,274...94,517,844
JBrowse link
G SIRT1 sirtuin 1 ISS UniProtKB GO_REF:0000024 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SOX9 SRY-box transcription factor 9 ISS UniProtKB GO_REF:0000024 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase TAS Reactome Reactome:R-HSA-9603381 NCBI chr20:37,344,690...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G TEK TEK receptor tyrosine kinase IMP
IBA
(PMID:12816861), (PMID:18425120), (PMID:19223473)
(PMID:21873635)
UniProtKB
GO_Central
PMID:12816861, PMID:18425120, PMID:19223473, PMID:21873635 NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174
JBrowse link
G TGFB2 transforming growth factor beta 2 IDA (PMID:18223299) BHF-UCL PMID:18223299 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TNF tumor necrosis factor ISS ARUK-UCL GO_REF:0000024 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G UBE3A ubiquitin protein ligase E3A IEA Ensembl GO_REF:0000107 NCBI chr15:25,333,728...25,439,381
Ensembl chr15:25,333,728...25,439,051
JBrowse link
G UNC5B unc-5 netrin receptor B IMP (PMID:18469807) UniProtKB PMID:18469807 NCBI chr10:71,212,535...71,302,879
Ensembl chr10:71,212,570...71,302,864
JBrowse link
G WNT16 Wnt family member 16 IMP (PMID:19951988) BHF-UCL PMID:19951988 NCBI chr 7:121,325,367...121,341,104
Ensembl chr 7:121,325,367...121,341,104
JBrowse link
regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AL121845.2 novel transcript, LIME1-SLC2A4RG readthrough IBA (PMID:21873635) GO_Central PMID:21873635 Ensembl chr20:63,738,270...63,740,398 JBrowse link
G AL121845.3 novel protein, ZGPAT-LIME1 readthrough IBA (PMID:21873635) GO_Central PMID:21873635 Ensembl chr20:63,708,864...63,739,103 JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 ISS UniProtKB GO_REF:0000024 NCBI chr19:42,507,306...42,528,482
Ensembl chr19:42,507,304...42,561,234
JBrowse link
G CEP55 centrosomal protein 55 IEA InterPro GO_REF:0000002 NCBI chr10:93,496,612...93,529,094
Ensembl chr10:93,496,612...93,529,092
JBrowse link
G CRNN cornulin IMP
IBA
(PMID:30009832)
(PMID:21873635)
UniProt
GO_Central
PMID:21873635, PMID:30009832 NCBI chr 1:152,409,243...152,414,263
Ensembl chr 1:152,409,243...152,414,263
JBrowse link
G DIPK2A divergent protein kinase domain 2A IDA
IBA
(PMID:23784961)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:23784961 NCBI chr 3:143,971,798...143,992,368
Ensembl chr 3:143,971,798...144,048,719
Ensembl chr 3:143,971,798...144,048,719
JBrowse link
G EGFR epidermal growth factor receptor IMP (PMID:26514923) CAFA PMID:26514923 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISS UniProtKB GO_REF:0000024 NCBI chr14:73,955,329...74,019,326
Ensembl chr14:73,958,010...74,019,399
JBrowse link
G FBXL2 F-box and leucine rich repeat protein 2 IDA (PMID:23604317) UniProtKB PMID:23604317 NCBI chr 3:33,277,025...33,422,698
Ensembl chr 3:33,277,025...33,403,662
JBrowse link
G IER3 immediate early response 3 TAS Reactome Reactome:R-HSA-6811558 NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548
JBrowse link
G LIME1 Lck interacting transmembrane adaptor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:63,735,701...63,739,103
Ensembl chr20:63,736,283...63,739,103
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 TAS Reactome Reactome:R-HSA-6811558 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 TAS Reactome Reactome:R-HSA-6811558 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha TAS Reactome Reactome:R-HSA-6811558 NCBI chr10:22,534,854...22,714,578
Ensembl chr10:22,534,854...22,714,578
JBrowse link
G PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta TAS Reactome Reactome:R-HSA-6811558 NCBI chr17:38,765,691...38,799,576
Ensembl chr17:38,765,689...38,800,126
JBrowse link
G PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma TAS Reactome Reactome:R-HSA-6811558 NCBI chr12:57,591,188...57,603,418
Ensembl chr12:57,591,174...57,603,418
JBrowse link
G PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha TAS Reactome Reactome:R-HSA-6811558 NCBI chr 1:151,197,954...151,249,536
Ensembl chr 1:151,197,949...151,249,536
JBrowse link
G PIP5K1B phosphatidylinositol-4-phosphate 5-kinase type 1 beta TAS Reactome Reactome:R-HSA-6811558 NCBI chr 9:68,705,240...69,009,176
Ensembl chr 9:68,705,240...69,009,176
JBrowse link
G PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma TAS Reactome Reactome:R-HSA-6811558 NCBI chr19:3,630,181...3,700,486
Ensembl chr19:3,630,183...3,700,479
Ensembl chr19:3,630,183...3,700,479
JBrowse link
G PPP1R16B protein phosphatase 1 regulatory subunit 16B IMP (PMID:25007873) GO_Central PMID:25007873 NCBI chr20:38,805,694...38,923,024
Ensembl chr20:38,805,697...38,923,024
JBrowse link
G PPP2R5B protein phosphatase 2 regulatory subunit B'beta TAS Reactome Reactome:R-HSA-6811558 NCBI chr11:64,917,553...64,934,478
Ensembl chr11:64,917,553...64,934,475
JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma TAS Reactome Reactome:R-HSA-6811558 NCBI chr14:101,760,573...101,927,992
Ensembl chr14:101,761,798...101,927,989
JBrowse link
G PTPN13 protein tyrosine phosphatase non-receptor type 13 IDA (PMID:23604317) UniProtKB PMID:23604317 NCBI chr 4:86,594,307...86,815,172
Ensembl chr 4:86,594,315...86,815,171
JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 IEA Ensembl GO_REF:0000107 NCBI chr15:38,488,097...38,564,814
Ensembl chr15:38,488,103...38,565,575
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18626
    signaling 7195
      signal transduction 6557
        intracellular signal transduction 2977
          inositol lipid-mediated signaling 204
            phosphatidylinositol-mediated signaling 201
              phosphatidylinositol 3-kinase signaling 163
                negative regulation of phosphatidylinositol 3-kinase signaling 17
                positive regulation of phosphatidylinositol 3-kinase signaling 94
                regulation of phosphatidylinositol 3-kinase signaling + 135
Path 2
Term Annotations click to browse term
  biological_process 18626
    biological regulation 13272
      regulation of biological process 12621
        regulation of cellular process 12017
          signal transduction 6557
            intracellular signal transduction 2977
              inositol lipid-mediated signaling 204
                phosphatidylinositol-mediated signaling 201
                  phosphatidylinositol 3-kinase signaling 163
                    negative regulation of phosphatidylinositol 3-kinase signaling 17
                    positive regulation of phosphatidylinositol 3-kinase signaling 94
                    regulation of phosphatidylinositol 3-kinase signaling + 135
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.