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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase signaling
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Accession:GO:0014065 term browser browse the term
Definition:A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
Synonyms:exact_synonym: PI 3-kinase cascade;   PI3K cascade;   PI3K signal transduction;   PI3K signaling;   phosphatidylinositol 3-kinase signal transduction;   phosphoinositide 3-kinase cascade
 related_synonym: phosphatidylinositol 3-kinase cascade


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phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G C1qbp complement component 1, q subcomponent binding protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:70,977,846...70,983,026
Ensembl chr11:70,977,836...70,983,026
JBrowse link
G Cd160 CD160 antigen ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:96,798,763...96,829,351
Ensembl chr 3:96,798,763...96,829,351
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) ISO (PMID:24520418) AgBase PMID:24520418 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Edn1 endothelin 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:128,567,523...128,589,635
Ensembl chr10:128,567,523...128,589,652
JBrowse link
G Gata3 GATA binding protein 3 IMP (MGI:MGI:5285154|PMID:20696860) UniProtKB PMID:20696860 MGI:MGI:5285154 NCBI chr 2:9,857,078...9,887,953
Ensembl chr 2:9,857,078...9,890,034
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr14:74,640,874...74,706,859
Ensembl chr14:74,640,840...74,709,494
JBrowse link
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:86,097,546...86,116,231
Ensembl chr 1:86,099,026...86,111,970
JBrowse link
G Igf1 insulin-like growth factor 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Irs1 insulin receptor substrate 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933
JBrowse link
G Kbtbd2 kelch repeat and BTB (POZ) domain containing 2 IMP (MGI:MGI:5806303|PMID:27708159) MGI PMID:27708159 MGI:MGI:5806303 NCBI chr 6:56,777,525...56,797,813
Ensembl chr 6:56,777,524...56,797,813
JBrowse link
G Ltk leukocyte tyrosine kinase ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:119,751,326...119,760,431
Ensembl chr 2:119,751,320...119,760,431
JBrowse link
G Myo16 myosin XVI IDA
IBA
(MGI:MGI:5304984|PMID:21946561)
(MGI:MGI:6201960|PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:21946561 MGI:MGI:5304984, MGI:MGI:6201960 NCBI chr 8:10,153,911...10,634,742
Ensembl chr 8:10,153,911...10,634,742
JBrowse link
G Nf1 neurofibromin 1 IMP (MGI:MGI:3032882|PMID:14724565) MGI PMID:14724565 MGI:MGI:3032882 NCBI chr11:79,339,590...79,581,609
Ensembl chr11:79,339,693...79,581,612
JBrowse link
G Nyap1 neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1 IDA (MGI:MGI:5304984|PMID:21946561) UniProtKB PMID:21946561 MGI:MGI:5304984 NCBI chr 5:137,730,882...137,741,168
Ensembl chr 5:137,729,899...137,741,607
JBrowse link
G Nyap2 neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2 IDA (MGI:MGI:5304984|PMID:21946561) UniProtKB PMID:21946561 MGI:MGI:5304984 NCBI chr 1:81,076,522...81,367,706
Ensembl chr 1:81,076,950...81,341,764
JBrowse link
G Pear1 platelet endothelial aggregation receptor 1 IMP (MGI:MGI:5817200|PMID:27614188) MGI PMID:27614188 MGI:MGI:5817200 NCBI chr 3:87,749,097...87,769,110
Ensembl chr 3:87,747,890...87,824,306
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:116,337,265...116,443,465
Ensembl chr 7:116,337,265...116,443,449
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 1:133,045,672...133,108,691
Ensembl chr 1:133,045,667...133,108,687
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 6:139,614,072...139,969,284
Ensembl chr 6:139,587,221...139,969,284
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:32,397,065...32,466,112
Ensembl chr 3:32,397,671...32,468,486
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 9:99,038,402...99,140,235
Ensembl chr 9:99,036,654...99,140,621
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 4:149,649,168...149,702,566
Ensembl chr 4:149,649,168...149,702,571
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr12:32,173,397...32,208,677
Ensembl chr12:32,173,473...32,208,659
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr13:101,680,761...101,768,217
Ensembl chr13:101,680,563...101,768,217
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 8:70,768,176...70,776,712
Ensembl chr 8:70,768,176...70,776,713
JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 ISO (PMID:12507995) UniProt PMID:12507995 NCBI chr11:68,432,125...68,497,849
Ensembl chr11:68,432,121...68,497,849
JBrowse link
G Plekha1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:130,860,551...130,913,494
Ensembl chr 7:130,865,756...130,913,312
JBrowse link
G Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 IMP (MGI:MGI:5550173|PMID:24367090) MGI PMID:24367090 MGI:MGI:5550173 NCBI chr 1:10,993,273...11,303,683
Ensembl chr 1:10,993,465...11,303,681
JBrowse link
G Pten phosphatase and tensin homolog IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Sirt2 sirtuin 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:28,766,752...28,788,665
Ensembl chr 7:28,766,735...28,788,661
JBrowse link
G Tpte transmembrane phosphatase with tensin homology IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 8:22,283,315...22,371,418
Ensembl chr 8:22,283,441...22,371,418
JBrowse link
G Tsc2 TSC complex subunit 2 IMP (MGI:MGI:3050929|PMID:15249583) MGI PMID:15249583 MGI:MGI:3050929 NCBI chr17:24,595,816...24,632,676
Ensembl chr17:24,595,816...24,632,630
JBrowse link
G Xbp1 X-box binding protein 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr12:80,107,760...80,113,013
Ensembl chr12:80,107,754...80,113,013
JBrowse link
negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btn2a2 butyrophilin, subfamily 2, member A2 IGI (MGI:MGI:5520006|PMID:23589618) MGI PMID:23589618 MGI:MGI:5520006 NCBI chr13:23,477,049...23,488,858
Ensembl chr13:23,477,676...23,488,857
JBrowse link
G Cryba1 crystallin, beta A1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr11:77,718,614...77,725,293
Ensembl chr11:77,718,615...77,725,283
JBrowse link
G Dab2ip disabled 2 interacting protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:35,558,446...35,730,994
Ensembl chr 2:35,558,266...35,730,994
JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 2:26,396,249...26,409,244
Ensembl chr 2:26,396,249...26,409,203
JBrowse link
G Klf4 Kruppel-like factor 4 (gut) ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 4:55,527,137...55,532,475
Ensembl chr 4:55,527,143...55,532,466
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IMP (MGI:MGI:3723397|PMID:17606624) MGI PMID:17606624 MGI:MGI:3723397 NCBI chr11:62,315,663...62,457,414
Ensembl chr11:62,316,426...62,458,541
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 IMP (MGI:MGI:5883388|PMID:27951586) UniProtKB PMID:27951586 MGI:MGI:5883388 NCBI chr16:3,943,807...3,979,017
Ensembl chr16:3,945,007...3,976,632
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:15,937,835...15,946,108
Ensembl chr 7:15,936,183...15,946,074
JBrowse link
G Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF IDA (MGI:MGI:6101642|PMID:28826662) UniProt PMID:28826662 MGI:MGI:6101642 NCBI chr11:58,994,256...59,136,375
Ensembl chr11:58,994,256...59,139,170
JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 IDA
ISO
(MGI:MGI:3806716|PMID:18632611) UniProtKB
MGI
PMID:18632611 GO_REF:0000096, MGI:MGI:3806716, MGI:MGI:4834177 NCBI chr11:3,319,241...3,342,971
Ensembl chr11:3,330,401...3,342,971
JBrowse link
G Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 IGI (MGI:MGI:3810206|PMID:18398001) MGI PMID:18398001 MGI:MGI:3810206 NCBI chr 1:79,794,317...79,858,665
Ensembl chr 1:79,794,197...79,861,180
JBrowse link
G Slc9a3r1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 IGI
IMP
(MGI:MGI:3617099|PMID:16456542) MGI
UniProtKB
PMID:16456542 MGI:MGI:3617099 NCBI chr11:115,163,341...115,181,178
Ensembl chr11:115,163,341...115,181,181
JBrowse link
G Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 IGI (MGI:MGI:3617099|PMID:16456542) MGI PMID:16456542 MGI:MGI:3617099 NCBI chr17:24,639,281...24,650,305
Ensembl chr17:24,639,286...24,650,327
JBrowse link
G Stambp STAM binding protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 6:83,543,206...83,575,826
Ensembl chr 6:83,543,211...83,572,729
JBrowse link
G Tsc2 TSC complex subunit 2 IMP (MGI:MGI:3586939|PMID:16027169) MGI PMID:16027169 MGI:MGI:3586939 NCBI chr17:24,595,816...24,632,676
Ensembl chr17:24,595,816...24,632,630
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr12:33,957,671...33,959,831
Ensembl chr12:33,957,671...33,959,829
JBrowse link
positive regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor IDA (MGI:MGI:2664591|PMID:12817016) MGI PMID:12817016 MGI:MGI:2664591 NCBI chr 3:105,904,421...105,908,928
Ensembl chr 3:105,870,858...105,908,926
JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr10:127,075,269...127,093,170
Ensembl chr10:127,075,284...127,093,169
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Angpt1 angiopoietin 1 IDA (MGI:MGI:3848848|PMID:19409199) MGI PMID:19409199 MGI:MGI:3848848 NCBI chr15:42,424,667...42,676,977
Ensembl chr15:42,424,723...42,676,977
JBrowse link
G Cat catalase IDA (MGI:MGI:3037350|PMID:15020231) MGI PMID:15020231 MGI:MGI:3037350 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cbl Casitas B-lineage lymphoma ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:44,142,976...44,234,259
Ensembl chr 9:44,142,976...44,234,049
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 ISO RGD
MGI
GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:4834177 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Cd28 CD28 antigen IDA (MGI:MGI:5520006|PMID:23589618) MGI PMID:23589618 MGI:MGI:5520006 NCBI chr 1:60,746,388...60,773,359
Ensembl chr 1:60,716,800...60,773,359
JBrowse link
G Cntf ciliary neurotrophic factor ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr19:12,763,528...12,765,632
Ensembl chr19:12,763,660...12,765,632
JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:98,700,183...98,703,631
Ensembl chr11:98,701,263...98,703,629
JBrowse link
G Dcn decorin ISO MGI GO_REF:0000008, MGI:MGI:2154458 NCBI chr10:97,479,500...97,518,163
Ensembl chr10:97,479,609...97,518,143
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IGI (MGI:MGI:3796800|PMID:18458158) MGI PMID:18458158 MGI:MGI:3796800 NCBI chr 1:68,031,884...69,108,576
Ensembl chr 1:68,032,186...69,108,059
JBrowse link
G F2 coagulation factor II IGI (MGI:MGI:3810206|PMID:18398001) MGI PMID:18398001 MGI:MGI:3810206 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G F2r coagulation factor II (thrombin) receptor IGI
IDA
(MGI:MGI:3810206|PMID:18398001)
(MGI:MGI:5285163|PMID:20215560)
MGI
UniProtKB
PMID:18398001, PMID:20215560 MGI:MGI:3810206, MGI:MGI:5285163 NCBI chr13:95,601,780...95,618,466
Ensembl chr13:95,601,803...95,618,487
JBrowse link
G F2rl1 coagulation factor II (thrombin) receptor-like 1 IDA (MGI:MGI:5285163|PMID:20215560) UniProtKB PMID:20215560 MGI:MGI:5285163 NCBI chr13:95,511,718...95,525,240
Ensembl chr13:95,511,732...95,525,227
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 4:132,974,095...133,001,893
Ensembl chr 4:132,974,095...133,001,910
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Fpr2 formyl peptide receptor 2 ISO MGI GO_REF:0000096, MGI:MGI:4417868 NCBI chr17:17,887,824...17,893,952
Ensembl chr17:17,887,824...17,893,952
JBrowse link
G Fshr follicle stimulating hormone receptor ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:88,984,952...89,200,675
Ensembl chr17:88,984,952...89,200,675
JBrowse link
G Fyn Fyn proto-oncogene ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr10:39,369,743...39,565,381
Ensembl chr10:39,368,855...39,565,381
JBrowse link
G Gh growth hormone ISO (PMID:7782332) BHF-UCL PMID:7782332 NCBI chr11:106,300,261...106,303,703
Ensembl chr11:106,300,271...106,301,865
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO RGD
MGI
GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:4834177 NCBI chr 5:139,423,150...139,427,800
Ensembl chr 5:139,423,151...139,427,800
JBrowse link
G Hax1 HCLS1 associated X-1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 3:89,995,446...89,998,716
Ensembl chr 3:89,995,446...89,998,780
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:36,934,983...36,963,214
Ensembl chr16:36,934,983...36,963,212
JBrowse link
G Hcst hematopoietic cell signal transducer ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 7:30,417,712...30,419,854
Ensembl chr 7:30,417,712...30,419,854
JBrowse link
G Hgf hepatocyte growth factor ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152
JBrowse link
G Igf1 insulin-like growth factor 1 IDA
ISO
(MGI:MGI:5005047|PMID:21413931) MGI
RGD
PMID:21413931 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:4834177, MGI:MGI:5005047 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igf1r insulin-like growth factor I receptor ISO
IBA
(MGI:MGI:6201960|PMID:21873635) RGD
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:6201960 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Il18 interleukin 18 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Ins2 insulin II ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Insr insulin receptor IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Jak2 Janus kinase 2 IMP (MGI:MGI:3828423|PMID:7782332) BHF-UCL PMID:7782332 MGI:MGI:3828423 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Kdr kinase insert domain protein receptor ISO MGI
RGD
GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:4834177 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Lep leptin IDA
IBA
ISO
(MGI:MGI:4821191|PMID:20620997)
(MGI:MGI:6201960|PMID:21873635)
UniProtKB
GO_Central
MGI
RGD
PMID:20620997, PMID:21873635 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:4821191, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Maz MYC-associated zinc finger protein (purine-binding transcription factor) ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 7:127,021,450...127,027,188
Ensembl chr 7:127,022,130...127,027,037
JBrowse link
G Mydgf myeloid derived growth factor IDA (MGI:MGI:5609664|PMID:25581518) UniProtKB PMID:25581518 MGI:MGI:5609664 NCBI chr17:56,176,541...56,183,920
Ensembl chr17:56,175,744...56,183,920
JBrowse link
G Myoc myocilin ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:162,639,150...162,649,694
Ensembl chr 1:162,639,155...162,649,693
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:134,220,053...134,229,628
Ensembl chr 5:134,220,053...134,229,625
JBrowse link
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4 ISO (PMID:17218260) BHF-UCL PMID:17218260 NCBI chr 9:72,662,331...72,749,851
Ensembl chr 9:72,662,346...72,749,852
JBrowse link
G Nkx3-1 NK3 homeobox 1 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr14:69,190,692...69,194,658
Ensembl chr14:69,190,638...69,194,662
JBrowse link
G Nrg1 neuregulin 1 IGI (MGI:MGI:3796800|PMID:18458158) MGI PMID:18458158 MGI:MGI:3796800 NCBI chr 8:31,807,452...32,891,609
Ensembl chr 8:31,814,551...32,884,797
JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:87,778,244...87,795,242
Ensembl chr 3:87,778,244...87,795,162
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 ISO
IBA
(MGI:MGI:6201960|PMID:21873635) RGD
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:6201960 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 7:78,179,986...78,581,034
Ensembl chr 7:78,175,959...78,738,012
JBrowse link
G Osm oncostatin M ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:4,236,785...4,241,026
Ensembl chr11:4,236,420...4,241,026
JBrowse link
G Pdgfa platelet derived growth factor, alpha ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 5:138,976,014...139,000,792
Ensembl chr 5:138,976,014...138,997,370
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide IGI
IBA
ISO
(MGI:MGI:3617099|PMID:16456542)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:16456542, PMID:21873635 GO_REF:0000096, MGI:MGI:3617099, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr15:79,995,865...80,024,614
Ensembl chr15:79,995,874...80,014,977
JBrowse link
G Pdgfc platelet-derived growth factor, C polypeptide IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 3:81,036,416...81,214,040
Ensembl chr 3:81,036,416...81,214,040
JBrowse link
G Pdgfd platelet-derived growth factor, D polypeptide IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 9:6,168,363...6,534,284
Ensembl chr 9:6,168,584...6,378,850
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide IDA (MGI:MGI:5009390|PMID:17942966) UniProtKB PMID:17942966 MGI:MGI:5009390 NCBI chr18:61,045,127...61,085,067
Ensembl chr18:61,045,150...61,085,061
JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 IMP (MGI:MGI:5305503|PMID:22187460), (MGI:MGI:5305504|PMID:22187458) UniProtKB PMID:22187458, PMID:22187460 MGI:MGI:5305503, MGI:MGI:5305504 NCBI chr19:41,272,541...41,385,102
Ensembl chr19:41,272,377...41,385,102
JBrowse link
G Pld2 phospholipase D2 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr11:70,539,492...70,558,110
Ensembl chr11:70,540,064...70,558,110
JBrowse link
G Plxnb1 plexin B1 IMP (MGI:MGI:4413657|PMID:19788569) UniProtKB PMID:19788569 MGI:MGI:4413657 NCBI chr 9:109,093,849...109,119,915
Ensembl chr 9:109,095,389...109,119,917
JBrowse link
G Ppard peroxisome proliferator activator receptor delta IDA (MGI:MGI:3621068|PMID:16581799) MGI PMID:16581799 MGI:MGI:3621068 NCBI chr17:28,232,754...28,301,469
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Prr5 proline rich 5 (renal) IGI
IMP
(MGI:MGI:5005047|PMID:21413931) MGI PMID:21413931 MGI:MGI:5005047 NCBI chr15:84,663,206...84,706,409
Ensembl chr15:84,669,620...84,703,673
JBrowse link
G Prr5l proline rich 5 like IGI (MGI:MGI:5005047|PMID:21413931) MGI PMID:21413931 MGI:MGI:5005047 NCBI chr 2:101,713,110...101,883,052
Ensembl chr 2:101,714,285...101,883,027
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr15:73,205,102...73,423,820
Ensembl chr15:73,205,102...73,423,280
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 6:124,720,707...124,738,709
Ensembl chr 6:124,720,707...124,738,714
JBrowse link
G Rara retinoic acid receptor, alpha ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr11:98,927,800...98,974,942
Ensembl chr11:98,927,818...98,974,942
JBrowse link
G Reln reelin IDA (MGI:MGI:5286805|PMID:21664258) BHF-UCL PMID:21664258 MGI:MGI:5286805 NCBI chr 5:21,884,454...22,344,705
Ensembl chr 5:21,884,454...22,344,702
JBrowse link
G Rgl2 ral guanine nucleotide dissociation stimulator-like 2 IDA (MGI:MGI:5547674|PMID:24069211) MGI PMID:24069211 MGI:MGI:5547674 NCBI chr17:33,929,514...33,937,687
Ensembl chr17:33,929,543...33,937,687
JBrowse link
G Ror1 receptor tyrosine kinase-like orphan receptor 1 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr 4:100,095,791...100,444,806
Ensembl chr 4:100,095,791...100,444,765
JBrowse link
G Ror2 receptor tyrosine kinase-like orphan receptor 2 IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr13:53,109,317...53,286,124
Ensembl chr13:53,109,312...53,286,124
JBrowse link
G Selp selectin, platelet ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:164,115,264...164,150,026
Ensembl chr 1:164,115,264...164,150,026
JBrowse link
G Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr13:51,685,529...51,793,678
Ensembl chr13:51,685,529...51,793,747
JBrowse link
G Serpina12 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 IMP (MGI:MGI:5563627|PMID:22837305) MGI PMID:22837305 MGI:MGI:5563627 NCBI chr12:104,028,769...104,044,443
Ensembl chr12:104,028,769...104,044,443
JBrowse link
G Sirt1 sirtuin 1 IMP (MGI:MGI:4821191|PMID:20620997) UniProtKB PMID:20620997 MGI:MGI:4821191 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 IMP (MGI:MGI:4950303|PMID:21367821) UniProtKB PMID:21367821 MGI:MGI:4950303 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760
JBrowse link
G Tek TEK receptor tyrosine kinase ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 4:94,739,086...94,874,976
Ensembl chr 4:94,739,289...94,874,976
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 1:186,622,787...186,709,697
Ensembl chr 1:186,622,792...186,705,989
JBrowse link
G Tnf tumor necrosis factor ISO MGI GO_REF:0000096, MGI:MGI:4417868 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Ube3a ubiquitin protein ligase E3A IMP (MGI:MGI:3616918|PMID:16254014) MGI PMID:16254014 MGI:MGI:3616918 NCBI chr 7:59,228,750...59,310,837
Ensembl chr 7:59,228,750...59,311,536
JBrowse link
G Unc5b unc-5 netrin receptor B ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr10:60,762,594...60,831,581
Ensembl chr10:60,762,593...60,831,581
JBrowse link
G Wnt16 wingless-type MMTV integration site family, member 16 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 6:22,288,178...22,298,522
Ensembl chr 6:22,288,227...22,298,522
JBrowse link
regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 ISO PMID:11694516 UniProt PMID:11694516 RGD:11041061 NCBI chr 7:25,461,702...25,477,647
Ensembl chr 7:25,461,707...25,477,603
JBrowse link
G Cep55 centrosomal protein 55 IEA UniProtKB GO_REF:0000002, MGI:MGI:2152098 NCBI chr19:38,054,970...38,074,425
Ensembl chr19:38,055,011...38,074,423
JBrowse link
G Crnn cornulin ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 3:93,144,789...93,149,818
Ensembl chr 3:93,144,787...93,149,819
JBrowse link
G Dipk2a divergent protein kinase domain 2A ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr 9:94,517,864...94,538,081
Ensembl chr 9:94,517,864...94,538,081
JBrowse link
G Egfr epidermal growth factor receptor ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 IMP (MGI:MGI:4881347|PMID:21074248) UniProtKB PMID:21074248 MGI:MGI:4881347 NCBI chr12:84,373,875...84,409,029
Ensembl chr12:84,373,857...84,409,029
JBrowse link
G Fbxl2 F-box and leucine-rich repeat protein 2 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 9:113,958,557...114,026,803
Ensembl chr 9:113,963,637...114,046,191
JBrowse link
G Lime1 Lck interacting transmembrane adaptor 1 IMP
IBA
(MGI:MGI:3769059|PMID:16249387)
(MGI:MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:16249387, PMID:21873635 MGI:MGI:3769059, MGI:MGI:6201960 NCBI chr 2:181,381,235...181,383,628
Ensembl chr 2:181,380,078...181,383,628
JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 2:158,666,733...158,766,334
Ensembl chr 2:158,665,398...158,766,334
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr 5:103,425,192...103,598,361
Ensembl chr 5:103,425,192...103,598,303
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 IMP (MGI:MGI:3758152|PMID:17190838) MGI PMID:17190838 MGI:MGI:3758152 NCBI chr 2:117,279,983...117,342,877
Ensembl chr 2:117,279,993...117,343,001
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23369
    signaling 6935
      signal transduction 6319
        intracellular signal transduction 2561
          inositol lipid-mediated signaling 174
            phosphatidylinositol-mediated signaling 171
              phosphatidylinositol 3-kinase signaling 136
                negative regulation of phosphatidylinositol 3-kinase signaling 16
                positive regulation of phosphatidylinositol 3-kinase signaling 75
                regulation of phosphatidylinositol 3-kinase signaling + 102
Path 2
Term Annotations click to browse term
  biological_process 23369
    biological regulation 13071
      regulation of biological process 12448
        regulation of cellular process 11895
          signal transduction 6319
            intracellular signal transduction 2561
              inositol lipid-mediated signaling 174
                phosphatidylinositol-mediated signaling 171
                  phosphatidylinositol 3-kinase signaling 136
                    negative regulation of phosphatidylinositol 3-kinase signaling 16
                    positive regulation of phosphatidylinositol 3-kinase signaling 75
                    regulation of phosphatidylinositol 3-kinase signaling + 102
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.