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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase signaling
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Accession:GO:0014065 term browser browse the term
Definition:A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
Synonyms:exact_synonym: PI 3-kinase cascade;   PI3K cascade;   PI3K signal transduction;   PI3K signaling;   phosphatidylinositol 3-kinase signal transduction;   phosphoinositide 3-kinase cascade
 related_synonym: phosphatidylinositol 3-kinase cascade


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phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO (PMID:26514923) CAFA PMID:26514923
G C1QBP complement C1q binding protein IEA Ensembl GO_REF:0000107 NCBI chr12:51,548,361...51,553,076
Ensembl chr12:51,548,415...51,555,689
JBrowse link
G CD160 CD160 molecule ISO (PMID:17307798) UniProt PMID:17307798 NCBI chr 4:99,579,891...99,585,808 JBrowse link
G CSF2 colony stimulating factor 2 IMP (PMID:24520418) AgBase PMID:24520418 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G EDN1 endothelin 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 IEA Ensembl GO_REF:0000107 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,431,656...21,496,279
JBrowse link
G GATA3 GATA binding protein 3 IEA Ensembl GO_REF:0000107 NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,660...63,388,859
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A IEA Ensembl GO_REF:0000107 NCBI chr11:20,555,939...20,620,225
Ensembl chr11:20,555,961...20,619,629
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B IEA Ensembl GO_REF:0000107 NCBI chr15:131,844,578...131,860,417
Ensembl chr15:131,844,928...131,860,392
JBrowse link
G IGF1 insulin like growth factor 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IRS1 insulin receptor substrate 1 IEA Ensembl GO_REF:0000107 NCBI chr15:128,245,846...128,307,321
Ensembl chr15:128,245,846...128,308,335
JBrowse link
G KBTBD2 kelch repeat and BTB domain containing 2 ISO (MGI:MGI:5806303|PMID:27708159) MGI PMID:27708159 MGI:MGI:5806303 NCBI chr18:40,604,458...40,636,401
Ensembl chr18:40,604,558...40,637,085
JBrowse link
G LOC100625564 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:15,550,458...15,628,655 JBrowse link
G LTK leukocyte receptor tyrosine kinase ISO (PMID:9223670) UniProtKB PMID:9223670 NCBI chr 1:129,863,837...129,867,254 JBrowse link
G MYO16 myosin XVI ISO (MGI:MGI:5304984|PMID:21946561) UniProtKB PMID:21946561 MGI:MGI:5304984 NCBI chr11:75,739,783...76,271,958 JBrowse link
G NF1 neurofibromin 1 IEA Ensembl GO_REF:0000107 NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,171...43,754,176
JBrowse link
G NYAP1 neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 IEA Ensembl
InterPro
GO_REF:0000002, GO_REF:0000107 NCBI chr 3:8,408,698...8,418,499
Ensembl chr 3:8,408,729...8,417,098
JBrowse link
G NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 IEA InterPro GO_REF:0000002 NCBI chr15:127,032,643...127,295,098
Ensembl chr15:127,033,422...127,293,495
JBrowse link
G PEAR1 platelet endothelial aggregation receptor 1 ISO (MGI:MGI:5817200|PMID:27614188) MGI PMID:27614188 MGI:MGI:5817200 NCBI chr 4:93,178,854...93,205,186
Ensembl chr 4:93,177,143...93,205,156
JBrowse link
G PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:41,829,969...42,024,062
Ensembl chr 2:41,829,916...42,024,362
JBrowse link
G PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:65,073,728...65,154,861
Ensembl chr 9:65,073,738...65,154,538
JBrowse link
G PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:54,474,623...54,849,520
Ensembl chr 5:54,474,624...54,849,512
JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,277,232
JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr13:79,427,033...79,610,840
Ensembl chr13:79,425,812...79,610,840
JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 6:70,026,254...70,086,950
Ensembl chr 6:70,026,373...70,099,244
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 IEA Ensembl GO_REF:0000107 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 ISO (PMID:23604317) UniProtKB PMID:23604317 NCBI chr 2:59,637,363...59,652,075 JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 IDA (PMID:12507995) UniProt PMID:12507995 NCBI chr12:53,979,206...54,046,927
Ensembl chr12:53,979,215...54,055,377
JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 IEA Ensembl GO_REF:0000107 NCBI chr14:131,960,932...132,016,664
Ensembl chr14:131,946,792...132,016,660
JBrowse link
G PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 IEA Ensembl GO_REF:0000107 NCBI chr 4:66,712,412...66,996,258
Ensembl chr 4:66,715,234...67,116,135
JBrowse link
G PTEN phosphatase and tensin homolog IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:99,929,590...100,021,619 JBrowse link
G SIRT2 sirtuin 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:47,682,427...47,703,408
Ensembl chr 6:47,682,424...47,703,529
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:3050929|PMID:15249583) MGI PMID:15249583 MGI:MGI:3050929 NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,922...39,937,371
JBrowse link
G XBP1 X-box binding protein 1 ISO (PMID:23529610) UniProtKB PMID:23529610 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,017,036
JBrowse link
G ZFP36L1 ZFP36 ring finger protein like 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:92,490,069...92,495,864
Ensembl chr 7:92,490,011...92,495,574
JBrowse link
negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTN2A2 butyrophilin subfamily 2 member A2 IEA Ensembl GO_REF:0000107 NCBI chr 7:20,954,229...20,968,390
Ensembl chr 7:20,954,173...20,967,794
JBrowse link
G CRYBA1 crystallin beta A1 ISO RGD PMID:21993393 RGD:10059647 NCBI chr12:45,466,051...45,473,110
Ensembl chr12:45,368,561...45,473,100
JBrowse link
G DAB2IP DAB2 interacting protein IEA Ensembl GO_REF:0000107 NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,660...261,859,830
JBrowse link
G INPP5E inositol polyphosphate-5-phosphatase E ISO RGD PMID:21436142 RGD:12911213
G KLF4 Kruppel like factor 4 ISO PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr 1:248,604,817...248,609,574
Ensembl chr 1:248,604,820...248,609,574
JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO (MGI:MGI:3723397|PMID:17606624) MGI PMID:17606624 MGI:MGI:3723397 NCBI chr12:59,256,868...59,392,564 JBrowse link
G NLRC3 NLR family CARD domain containing 3 ISO (MGI:MGI:5883388|PMID:27951586) UniProtKB PMID:27951586 MGI:MGI:5883388 NCBI chr 3:38,673,590...38,719,188
Ensembl chr 3:38,673,622...38,717,451
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor IEA Ensembl GO_REF:0000107 NCBI chr 6:53,443,453...53,451,707
Ensembl chr 6:53,443,480...53,452,019
JBrowse link
G OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF ISO (MGI:MGI:6101642|PMID:28826662) UniProt PMID:28826662 MGI:MGI:6101642 NCBI chr 2:51,317,538...51,534,246
Ensembl chr 2:51,307,201...51,519,405
JBrowse link
G PIK3IP1 phosphoinositide-3-kinase interacting protein 1 IEA Ensembl GO_REF:0000107 NCBI chr14:48,040,848...48,051,660
Ensembl chr14:48,040,881...48,051,660
JBrowse link
G SERPINE2 serpin family E member 2 IEA Ensembl GO_REF:0000107 NCBI chr15:125,748,383...125,777,788
Ensembl chr15:125,747,294...125,816,215
JBrowse link
G SLC9A3R1 SLC9A3 regulator 1 IEA Ensembl GO_REF:0000107 NCBI chr12:6,466,138...6,483,539
Ensembl chr12:6,466,120...6,493,428
JBrowse link
G SLC9A3R2 SLC9A3 regulator 2 ISO (MGI:MGI:3617099|PMID:16456542) MGI PMID:16456542 MGI:MGI:3617099 NCBI chr 3:39,942,366...39,952,824
Ensembl chr 3:39,942,366...39,952,825
JBrowse link
G STAMBP STAM binding protein IEA Ensembl GO_REF:0000107 NCBI chr 3:69,156,012...69,188,256
Ensembl chr 3:69,133,978...69,188,182
JBrowse link
G TSC2 TSC complex subunit 2 ISO (MGI:MGI:3586939|PMID:16027169) MGI PMID:16027169 MGI:MGI:3586939 NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,922...39,937,371
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 ISO (PMID:17003487) BHF-UCL PMID:17003487 NCBI chr 9:88,286,911...88,290,131 JBrowse link
positive regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 ISO PMID:14528310
PMID:18469807
UniProt PMID:14528310, PMID:18469807 RGD:1299350, RGD:8553892 NCBI chr 5:23,015,777...23,035,943
Ensembl chr 5:23,015,777...23,033,519
JBrowse link
G AGT angiotensinogen IEA Ensembl GO_REF:0000107 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G ANGPT1 angiopoietin 1 IEA Ensembl GO_REF:0000107 NCBI chr 4:29,925,203...30,233,434
Ensembl chr 4:29,933,135...30,233,960
JBrowse link
G CAT catalase IEA Ensembl GO_REF:0000107 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CBL Cbl proto-oncogene IEA Ensembl GO_REF:0000107 NCBI chr 9:46,416,937...46,512,855
Ensembl chr 9:46,404,999...46,512,834
JBrowse link
G CCL5 C-C motif chemokine ligand 5 IEA Ensembl GO_REF:0000107 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
JBrowse link
G CD28 CD28 molecule IEA Ensembl GO_REF:0000107 NCBI chr15:107,128,103...107,155,431
Ensembl chr15:107,128,208...107,162,943
JBrowse link
G CNTF ciliary neurotrophic factor ISO RGD PMID:15574731 RGD:1626128 NCBI chr 2:12,492,777...12,495,401 JBrowse link
G CSF3 colony stimulating factor 3 IEA Ensembl GO_REF:0000107 NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,445...22,342,163
JBrowse link
G DCN decorin IEA Ensembl GO_REF:0000107 NCBI chr 5:91,678,601...91,713,925
Ensembl chr 5:91,678,608...91,714,235
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:16168116 RGD:1582137 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 IEA Ensembl GO_REF:0000107 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,973,037...114,696,375
JBrowse link
G F2 coagulation factor II, thrombin IEA Ensembl GO_REF:0000107 NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,451...15,819,138
JBrowse link
G F2R coagulation factor II thrombin receptor ISS UniProt GO_REF:0000024 NCBI chr 2:85,642,794...85,659,133
Ensembl chr 2:85,641,474...85,656,636
JBrowse link
G F2RL1 F2R like trypsin receptor 1 ISS UniProt GO_REF:0000024 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858
JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr 6:84,809,534...84,830,401
Ensembl chr 6:84,809,542...84,830,361
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,620,700...5,795,264
JBrowse link
G FSHR follicle stimulating hormone receptor ISS UniProt GO_REF:0000024 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase ISO PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr 1:77,584,675...77,810,605
Ensembl chr 1:77,585,439...77,810,581
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,982
JBrowse link
G HAX1 HCLS1 associated protein X-1 IEA Ensembl GO_REF:0000107 NCBI chr 4:95,467,629...95,470,972
Ensembl chr 4:95,467,629...95,470,288
JBrowse link
G HCLS1 hematopoietic cell-specific Lyn substrate 1 IEA Ensembl GO_REF:0000107 NCBI chr13:138,852,387...138,883,088
Ensembl chr13:138,855,142...138,906,351
JBrowse link
G HCST hematopoietic cell signal transducer IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 6:45,304,744...45,309,048 JBrowse link
G HGF hepatocyte growth factor IEA Ensembl GO_REF:0000107 NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,437,087...98,513,156
JBrowse link
G IGF1 insulin like growth factor 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,037
JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO RGD PMID:25186839 RGD:10046020 NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,925...137,690,666
JBrowse link
G IL18 interleukin 18 IEA Ensembl GO_REF:0000107 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G INS insulin IEA Ensembl GO_REF:0000107 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G INSR insulin receptor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:71,797,209...71,939,923
Ensembl chr 2:71,797,204...71,936,139
JBrowse link
G JAK2 Janus kinase 2 ISO (MGI:MGI:3828423|PMID:7782332) BHF-UCL PMID:7782332 MGI:MGI:3828423 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148
JBrowse link
G KDR kinase insert domain receptor IEA Ensembl GO_REF:0000107 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,116...41,856,339
JBrowse link
G LEP leptin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,447
JBrowse link
G LOC106504546 serpin A12 IEA Ensembl GO_REF:0000107 NCBI chr 7:115,720,892...115,734,810
Ensembl chr 7:115,720,677...115,734,816
JBrowse link
G MAZ MYC associated zinc finger protein IEA Ensembl GO_REF:0000107 NCBI chr 3:18,043,032...18,047,531
Ensembl chr 3:18,042,007...18,047,530
JBrowse link
G MYDGF myeloid derived growth factor IEA Ensembl GO_REF:0000107 NCBI chr 2:74,185,042...74,202,306
Ensembl chr 2:74,185,037...74,202,301
JBrowse link
G MYOC myocilin IEA Ensembl GO_REF:0000107 NCBI chr 9:114,087,370...114,098,765
Ensembl chr 9:114,087,374...114,098,743
JBrowse link
G NCF1 neutrophil cytosolic factor 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:11,820,367...11,834,394
Ensembl chr 3:11,820,285...11,839,426
JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase IEA Ensembl GO_REF:0000107 NCBI chr 1:115,941,945...116,069,884
Ensembl chr 1:115,941,937...116,070,317
JBrowse link
G NKX3-1 NK3 homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr14:7,783,296...7,787,036
Ensembl chr14:7,782,421...7,787,034
JBrowse link
G NRG1 neuregulin 1 ISO (MGI:MGI:3796800|PMID:18458158) MGI PMID:18458158 MGI:MGI:3796800 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,627,334...53,688,332
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,237,930
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:191,535,262...191,941,675
Ensembl chr 1:191,535,300...191,925,353
JBrowse link
G OSM oncostatin M IEA Ensembl GO_REF:0000107 NCBI chr14:47,242,767...47,246,836
Ensembl chr14:47,243,743...47,266,595
JBrowse link
G PDGFA platelet derived growth factor subunit A IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 3:296,399...322,967
Ensembl chr 3:303,311...323,036
JBrowse link
G PDGFB platelet derived growth factor subunit B IEA Ensembl GO_REF:0000107 Ensembl chr 5:8,986,461...9,007,446 JBrowse link
G PDGFC platelet derived growth factor C IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:45,579,065...45,808,789
Ensembl chr 8:45,578,001...45,808,748
JBrowse link
G PDGFD platelet derived growth factor D IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:34,388,636...34,621,227
Ensembl chr 9:34,388,636...34,621,244
JBrowse link
G PDGFRB platelet derived growth factor receptor beta IEA Ensembl GO_REF:0000107 NCBI chr 2:151,155,753...151,192,818
Ensembl chr 2:151,155,754...151,192,647
JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 IEA Ensembl GO_REF:0000107 NCBI chr14:108,038,396...108,303,942
Ensembl chr14:108,039,409...108,303,929
JBrowse link
G PLD2 phospholipase D2 ISO RGD PMID:15705590 RGD:2299907 NCBI chr12:52,073,913...52,087,804
Ensembl chr12:52,073,896...52,087,809
JBrowse link
G PLXNB1 plexin B1 IEA Ensembl GO_REF:0000107 NCBI chr13:31,113,910...31,140,133
Ensembl chr13:31,113,914...31,140,218
JBrowse link
G PPARD peroxisome proliferator activated receptor delta IEA Ensembl GO_REF:0000107 NCBI chr 7:31,222,533...31,295,221
Ensembl chr 7:31,222,589...31,295,212
JBrowse link
G PRR5 proline rich 5 IEA Ensembl GO_REF:0000107 NCBI chr 5:4,467,231...4,525,610
Ensembl chr 5:4,467,232...4,525,588
JBrowse link
G PRR5L proline rich 5 like IEA Ensembl GO_REF:0000107 NCBI chr 2:24,646,865...24,812,642
Ensembl chr 2:24,646,867...24,812,610
JBrowse link
G PTK2 protein tyrosine kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr 4:2,656,606...2,896,060
Ensembl chr 4:2,656,613...2,896,060
JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 IEA Ensembl GO_REF:0000107 NCBI chr 5:63,762,109...63,779,086
Ensembl chr 5:63,762,112...63,808,350
JBrowse link
G RARA retinoic acid receptor alpha ISO PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr12:22,047,449...22,085,759
Ensembl chr12:22,047,442...22,085,674
JBrowse link
G RELN reelin IEA Ensembl GO_REF:0000107 NCBI chr 9:103,460,855...103,963,728
Ensembl chr 9:103,460,857...103,963,965
JBrowse link
G RGL2 ral guanine nucleotide dissociation stimulator like 2 IEA Ensembl GO_REF:0000107 NCBI chr 7:29,655,530...29,662,375
Ensembl chr 7:29,645,129...29,663,189
JBrowse link
G ROR1 receptor tyrosine kinase like orphan receptor 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:148,314,575...148,834,659
Ensembl chr 6:148,315,283...148,761,721
JBrowse link
G ROR2 receptor tyrosine kinase like orphan receptor 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:2,803,840...3,035,384
Ensembl chr14:2,804,061...3,035,241
JBrowse link
G SELP selectin P IEA Ensembl GO_REF:0000107 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,406,203
JBrowse link
G SEMA4D semaphorin 4D IEA Ensembl GO_REF:0000107 NCBI chr14:957,074...1,078,522
Ensembl chr14:957,081...1,078,509
JBrowse link
G SIRT1 sirtuin 1 IEA Ensembl GO_REF:0000107 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,157...71,123,299
JBrowse link
G SOX9 SRY-box transcription factor 9 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr12:8,642,154...8,647,315
Ensembl chr12:8,642,158...8,647,315
JBrowse link
G TEK TEK receptor tyrosine kinase IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:195,938,177...196,052,294
Ensembl chr 1:195,937,394...196,051,957
JBrowse link
G TGFB2 transforming growth factor beta 2 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
G TNF tumor necrosis factor ISO PMID:12729461 ARUK-UCL PMID:12729461 RGD:13673777 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G UBE3A ubiquitin protein ligase E3A IEA Ensembl GO_REF:0000107 NCBI chr 1:141,887,179...142,001,595
Ensembl chr 1:141,887,168...141,997,241
JBrowse link
G UNC5B unc-5 netrin receptor B IEA Ensembl GO_REF:0000107 NCBI chr14:74,120,055...74,208,055
Ensembl chr14:74,120,050...74,205,273
JBrowse link
G WNT16 Wnt family member 16 IEA Ensembl GO_REF:0000107 NCBI chr18:25,621,802...25,633,730
Ensembl chr18:25,621,830...25,633,858
JBrowse link
regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 ISO PMID:11694516 UniProt PMID:11694516 RGD:11041061 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G CEP55 centrosomal protein 55 IEA InterPro GO_REF:0000002 NCBI chr14:104,957,256...104,980,690
Ensembl chr14:104,957,311...104,987,638
JBrowse link
G CRNN cornulin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:96,933,221...96,938,980
Ensembl chr 4:96,933,712...96,943,351
JBrowse link
G DIPK2A divergent protein kinase domain 2A IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:84,634,716...84,656,112
Ensembl chr13:84,634,030...84,657,371
JBrowse link
G EGFR epidermal growth factor receptor IEA Ensembl GO_REF:0000107 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,478,882
JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) ISO (MGI:MGI:4881347|PMID:21074248) UniProtKB PMID:21074248 MGI:MGI:4881347 NCBI chr 7:97,270,698...97,316,578
Ensembl chr 7:97,262,305...97,316,571
JBrowse link
G FBXL2 F-box and leucine rich repeat protein 2 IEA Ensembl GO_REF:0000107 NCBI chr13:19,128,145...19,206,458
Ensembl chr13:19,127,358...19,221,241
JBrowse link
G LIME1 Lck interacting transmembrane adaptor 1 ISO (MGI:MGI:3769059|PMID:16249387) MGI PMID:16249387 MGI:MGI:3769059 NCBI chr17:62,652,618...62,655,342 JBrowse link
G PPP1R16B protein phosphatase 1 regulatory subunit 16B IEA Ensembl GO_REF:0000107 NCBI chr17:41,753,697...41,866,671
Ensembl chr17:41,752,845...41,866,375
JBrowse link
G PTPN13 protein tyrosine phosphatase non-receptor type 13 IEA Ensembl GO_REF:0000107 NCBI chr 8:132,035,170...132,200,425
Ensembl chr 8:132,035,156...132,249,411
JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:132,702,495...132,786,536
Ensembl chr 1:132,702,541...132,786,532
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16524
    signaling 6450
      signal transduction 5920
        intracellular signal transduction 2481
          inositol lipid-mediated signaling 170
            phosphatidylinositol-mediated signaling 167
              phosphatidylinositol 3-kinase signaling 133
                negative regulation of phosphatidylinositol 3-kinase signaling 16
                positive regulation of phosphatidylinositol 3-kinase signaling 72
                regulation of phosphatidylinositol 3-kinase signaling + 99
Path 2
Term Annotations click to browse term
  biological_process 16524
    biological regulation 11994
      regulation of biological process 11420
        regulation of cellular process 10970
          signal transduction 5920
            intracellular signal transduction 2481
              inositol lipid-mediated signaling 170
                phosphatidylinositol-mediated signaling 167
                  phosphatidylinositol 3-kinase signaling 133
                    negative regulation of phosphatidylinositol 3-kinase signaling 16
                    positive regulation of phosphatidylinositol 3-kinase signaling 72
                    regulation of phosphatidylinositol 3-kinase signaling + 99
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.