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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylinositol 3-kinase signaling
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Accession:GO:0014065 term browser browse the term
Definition:A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
Synonyms:exact_synonym: PI 3-kinase cascade;   PI3K cascade;   PI3K signal transduction;   PI3K signaling;   phosphatidylinositol 3-kinase signal transduction;   phosphoinositide 3-kinase cascade
 related_synonym: phosphatidylinositol 3-kinase cascade


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phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO (PMID:26514923) RGD PMID:26514923 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G C1qbp complement C1q binding protein ISO
ISS
(PMID:16177118)
GO_REF:0000024
RGD
UniProt
PMID:16177118 GO_REF:0000024 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Cd160 CD160 molecule ISO (PMID:17307798) RGD PMID:17307798 NCBI chr 2:198,933,681...198,965,380
Ensembl chr 2:198,935,133...198,942,732
JBrowse link
G Csf2 colony stimulating factor 2 ISO (PMID:24520418) RGD PMID:24520418 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Edn1 endothelin 1 ISO (PMID:17078114) RGD PMID:17078114 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO (PMID:7556068) RGD PMID:7556068 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO
IEA
(PMID:7556068)
GO_REF:0000107
RGD
Ensembl
PMID:7556068 GO_REF:0000107 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Gata3 GATA binding protein 3 ISO
ISS
(MGI:MGI:5285154|PMID:20696860)
GO_REF:0000024
RGD
UniProt
PMID:20696860 GO_REF:0000024, MGI:MGI:5285154 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO (PMID:16517693) RGD PMID:16517693 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:16517693)
Ensembl
UniProt
RGD
PMID:16517693 GO_REF:0000024, GO_REF:0000107 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Igf1 insulin-like growth factor 1 ISO
IEA
(PMID:24508636)
GO_REF:0000107
RGD
Ensembl
PMID:24508636 GO_REF:0000107 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Irs1 insulin receptor substrate 1 ISO
IEA
(PMID:7782332)
GO_REF:0000107
RGD
Ensembl
PMID:7782332 GO_REF:0000107 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Kbtbd2 kelch repeat and BTB domain containing 2 ISO MGI:MGI:5806485 (MGI:MGI:5806303|PMID:27708159) RGD PMID:27708159 MGI:MGI:5806303 NCBI chr 4:87,088,759...87,111,576
Ensembl chr 4:87,088,759...87,111,025
JBrowse link
G LOC100910021 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:106,862,181...106,871,375
Ensembl chr 8:106,863,494...106,870,994
JBrowse link
G LOC100910838 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:21,764,829...21,774,163
Ensembl chr12:22,026,075...22,037,347
Ensembl chr12:22,026,075...22,037,347
JBrowse link
G LOC685590 similar to Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:23,243,126...23,254,011
Ensembl chr  X:23,243,470...23,246,719
JBrowse link
G Ltk leukocyte receptor tyrosine kinase ISO (PMID:9223670) RGD PMID:9223670 NCBI chr 3:111,553,679...111,560,556
Ensembl chr 3:111,553,680...111,560,556
JBrowse link
G Myo16 myosin XVI ISO
IBA
(MGI:MGI:5304984|PMID:21946561)
PMID:21873635
RGD PMID:21946561, PMID:21873635 MGI:MGI:5304984, RGD:13792537 NCBI chr16:84,575,149...85,177,834
Ensembl chr16:84,575,150...84,939,323
JBrowse link
G Nf1 neurofibromin 1 ISO
ISS
IEA
MGI:MGI:1857444 (MGI:MGI:3032882|PMID:14724565)
GO_REF:0000024
GO_REF:0000107
RGD
HGNC
Ensembl
PMID:14724565 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3032882 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nyap1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 ISO (MGI:MGI:5304984|PMID:21946561) RGD PMID:21946561 MGI:MGI:5304984 NCBI chr12:22,025,186...22,037,428
Ensembl chr12:22,026,075...22,037,347
JBrowse link
G Nyap2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 ISO (MGI:MGI:5304984|PMID:21946561) RGD PMID:21946561 MGI:MGI:5304984 NCBI chr 9:86,873,942...87,151,060
Ensembl chr 9:86,874,685...87,120,573
JBrowse link
G Pear1 platelet endothelial aggregation receptor 1 ISO MGI:MGI:4363617 (MGI:MGI:5817200|PMID:27614188) RGD PMID:27614188 MGI:MGI:5817200 NCBI chr 2:187,114,219...187,134,209
Ensembl chr 2:187,114,217...187,133,993
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:49,848,939...49,909,404
Ensembl chr13:49,850,189...49,911,202
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:173,732,196...174,102,502
Ensembl chr 4:173,732,248...174,102,496
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO
IEA
IBA
(PMID:25339672)
GO_REF:0000002
PMID:21873635
RGD
InterPro
PMID:25339672, PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO
IBA
(PMID:25339672)
PMID:21873635
RGD PMID:25339672, PMID:21873635 RGD:13792537 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO
IBA
(PMID:12507995)
PMID:21873635
RGD PMID:12507995, PMID:21873635 RGD:13792537 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA
ISO
GO_REF:0000107
(PMID:21321938), (PMID:7782332)
Ensembl
RGD
PMID:7782332, PMID:21321938 GO_REF:0000107 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO
ISS
(PMID:23604317)
GO_REF:0000024
RGD
UniProt
PMID:23604317 GO_REF:0000024 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 ISO (PMID:12507995) RGD PMID:12507995 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Plekha1 pleckstrin homology domain containing A1 ISO (PMID:12101241) RGD PMID:12101241 NCBI chr 1:201,429,716...201,481,411
Ensembl chr 1:201,429,771...201,480,877
JBrowse link
G Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 ISO MGI:MGI:3856561 (MGI:MGI:5550173|PMID:24367090) RGD PMID:24367090 MGI:MGI:5550173 NCBI chr 5:7,622,668...7,941,715
Ensembl chr 5:7,627,771...7,941,822
JBrowse link
G Pten phosphatase and tensin homolog IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Sirt2 sirtuin 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23908241)
Ensembl
UniProt
RGD
PMID:23908241 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
JBrowse link
G Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:74,552,859...74,662,194
Ensembl chr16:74,558,529...74,662,194
JBrowse link
G Tsc2 TSC complex subunit 2 ISO (MGI:MGI:3050929|PMID:15249583) RGD PMID:15249583 MGI:MGI:3050929 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Xbp1 X-box binding protein 1 ISO (PMID:23529610) RGD PMID:23529610 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 ISO
ISS
(PMID:15538381)
GO_REF:0000024
RGD
UniProt
PMID:15538381 GO_REF:0000024 NCBI chr 6:103,308,032...103,313,074
Ensembl chr 6:103,308,045...103,313,074
JBrowse link
negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btn2a2 butyrophilin, subfamily 2, member A2 ISO MGI:MGI:88327 (MGI:MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:MGI:5520006 NCBI chr17:43,867,243...43,878,734
Ensembl chr17:43,868,191...43,879,839
JBrowse link
G Cryba1 crystallin, beta A1 IMP RGD PMID:21993393 RGD:10059647 NCBI chr10:65,160,777...65,167,504
Ensembl chr10:65,161,152...65,167,494
JBrowse link
G Dab2ip DAB2 interacting protein IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:19903888)
Ensembl
UniProt
RGD
PMID:19903888 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:14,889,263...15,060,286
Ensembl chr 3:14,889,510...15,060,286
JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E IDA RGD PMID:21436142 RGD:12911213 NCBI chr 3:3,843,307...3,856,154
Ensembl chr 3:3,843,307...3,855,981
JBrowse link
G Klf4 Kruppel like factor 4 IMP PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO (MGI:MGI:3723397|PMID:17606624) RGD PMID:17606624 MGI:MGI:3723397 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 ISO (MGI:MGI:5883388|PMID:27951586) RGD PMID:27951586 MGI:MGI:5883388 NCBI chr10:11,809,531...11,844,184
Ensembl chr10:11,810,926...11,842,482
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO (PMID:16971513) RGD PMID:16971513 NCBI chr 1:77,836,522...77,843,991
Ensembl chr 1:77,836,196...77,844,189
JBrowse link
G Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF ISO (MGI:MGI:6101642|PMID:28826662) RGD PMID:28826662 MGI:MGI:6101642 NCBI chr10:45,353,185...45,483,570
Ensembl chr10:45,338,009...45,481,008
JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:3806716|PMID:18632611)
(PMID:17475214)
Ensembl
RGD
PMID:17475214, PMID:18632611 GO_REF:0000107, MGI:MGI:3806716 NCBI chr14:83,559,397...83,572,481
Ensembl chr14:83,560,541...83,572,473
JBrowse link
G Serpine2 serpin family E member 2 ISO
IEA
MGI:MGI:88380 (MGI:MGI:3810206|PMID:18398001)
GO_REF:0000107
RGD
Ensembl
PMID:18398001 GO_REF:0000107, MGI:MGI:3810206 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 ISO
ISS
MGI:MGI:97528 (MGI:MGI:3617099|PMID:16456542)
GO_REF:0000024
RGD
UniProt
PMID:16456542 GO_REF:0000024, MGI:MGI:3617099 NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145
JBrowse link
G Slc9a3r2 SLC9A3 regulator 2 ISO MGI:MGI:97528 (MGI:MGI:3617099|PMID:16456542) RGD PMID:16456542 MGI:MGI:3617099 NCBI chr10:14,003,330...14,015,066
Ensembl chr10:14,003,320...14,013,870
JBrowse link
G Stambp Stam binding protein ISO (PMID:23542699) RGD PMID:23542699 NCBI chr 4:115,249,343...115,277,340
Ensembl chr 4:115,249,351...115,275,068
JBrowse link
G Tsc2 TSC complex subunit 2 ISO MGI:MGI:1857938 (MGI:MGI:3586939|PMID:16027169) RGD PMID:16027169 MGI:MGI:3586939 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO (PMID:17003487) RGD PMID:17003487 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
positive regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor ISO (MGI:MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:MGI:2664591 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 IMP PMID:14528310
PMID:18469807
UniProt PMID:14528310, PMID:18469807 RGD:1299350, RGD:8553892 NCBI chr 7:70,360,199...70,377,422
Ensembl chr 7:70,364,813...70,377,422
JBrowse link
G Agt angiotensinogen ISO (PMID:15652490) RGD PMID:15652490 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Angpt1 angiopoietin 1 ISO
IEA
(MGI:MGI:3848848|PMID:19409199)
GO_REF:0000107
RGD
Ensembl
PMID:19409199 GO_REF:0000107, MGI:MGI:3848848 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Cat catalase ISO (MGI:MGI:3037350|PMID:15020231) RGD PMID:15020231 MGI:MGI:3037350 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbl Cbl proto-oncogene ISO (PMID:17003487) RGD PMID:17003487 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO
IEA
IDA
(PMID:7544376)
GO_REF:0000107
PMID:10477596
RGD
Ensembl
PMID:7544376, PMID:10477596 GO_REF:0000107, RGD:8553666 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd28 Cd28 molecule ISO
IEA
(MGI:MGI:5520006|PMID:23589618)
GO_REF:0000107
RGD
Ensembl
PMID:23589618 GO_REF:0000107, MGI:MGI:5520006 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cntf ciliary neurotrophic factor IDA RGD PMID:15574731 RGD:1626128 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Csf3 colony stimulating factor 3 ISO (PMID:23001182) RGD PMID:23001182 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Dcn decorin ISO (PMID:23798385) RGD PMID:23798385 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IMP RGD PMID:16168116 RGD:1582137 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO
IEA
MGI:MGI:96083 (MGI:MGI:3796800|PMID:18458158)
GO_REF:0000107
RGD
Ensembl
PMID:18458158 GO_REF:0000107, MGI:MGI:3796800 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G F2 coagulation factor II ISO
IEA
MGI:MGI:101780|MGI:MGI:101802 (MGI:MGI:3810206|PMID:18398001)
GO_REF:0000107
RGD
Ensembl
PMID:18398001 GO_REF:0000107, MGI:MGI:3810206 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F2r coagulation factor II (thrombin) receptor ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
MGI:MGI:88380 (MGI:MGI:3810206|PMID:18398001), (MGI:MGI:5285163|PMID:20215560)
UniProt
Ensembl
RGD
PMID:18398001, PMID:20215560 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3810206, MGI:MGI:5285163 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO
ISS
(MGI:MGI:5285163|PMID:20215560)
GO_REF:0000024
RGD
UniProt
PMID:20215560 GO_REF:0000024, MGI:MGI:5285163 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase ISO (PMID:10739672) RGD PMID:10739672 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 IEA
ISO
GO_REF:0000107
(PMID:14633857)
Ensembl
RGD
PMID:14633857 GO_REF:0000107 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fpr2 formyl peptide receptor 2 IMP PMID:30511586 ARUK-UCL PMID:30511586 RGD:14695080 NCBI chr 1:59,800,558...59,809,507
Ensembl chr 1:59,800,984...59,802,401
JBrowse link
G Fshr follicle stimulating hormone receptor ISO
ISS
(PMID:24058690)
GO_REF:0000024
RGD
UniProt
PMID:24058690 GO_REF:0000024 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase IMP PMID:18469807 UniProt PMID:18469807 RGD:8553892 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gh1 growth hormone 1 ISO (PMID:7782332) RGD PMID:7782332 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IDA
ISO
IEA
(PMID:15705806)
GO_REF:0000107
RGD
Ensembl
PMID:15705806, PMID:19717735 GO_REF:0000107, RGD:4892081 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Hax1 HCLS1 associated protein X-1 ISO
IEA
(PMID:23001182)
GO_REF:0000107
RGD
Ensembl
PMID:23001182 GO_REF:0000107 NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322
JBrowse link
G Hcls1 hematopoietic cell specific Lyn substrate 1 ISO (PMID:23001182) RGD PMID:23001182 NCBI chr11:66,736,966...66,759,402
Ensembl chr11:66,736,966...66,759,402
JBrowse link
G Hcst hematopoietic cell signal transducer ISO
IBA
(PMID:10426994)
PMID:21873635
RGD PMID:10426994, PMID:21873635 RGD:13792537 NCBI chr 1:88,879,425...88,881,653
Ensembl chr 1:88,879,428...88,881,460
JBrowse link
G Hgf hepatocyte growth factor ISO (PMID:20655899) RGD PMID:20655899 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Igf1 insulin-like growth factor 1 ISO
IEA
IDA
(PMID:7688386)
GO_REF:0000107
(MGI:MGI:5005047|PMID:21413931)
PMID:17023532
RGD
Ensembl
PMID:7688386, PMID:21413931, PMID:17023532 GO_REF:0000107, MGI:MGI:5005047, RGD:1600072 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:25186839, PMID:21873635 RGD:10046020, RGD:13792537 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il18 interleukin 18 IEA
ISO
GO_REF:0000107
(PMID:21321938)
Ensembl
RGD
PMID:21321938 GO_REF:0000107 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Ins2 insulin 2 ISO (PMID:7688386) RGD PMID:7688386 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Jak2 Janus kinase 2 ISO (MGI:MGI:3828423|PMID:7782332) RGD PMID:7782332 MGI:MGI:3828423 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Kdr kinase insert domain receptor IMP
IEA
ISO
GO_REF:0000107
(PMID:9804796)
Ensembl
RGD
PMID:9804796, PMID:18221855 GO_REF:0000107, RGD:2292019 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Lep leptin IDA
IBA
ISO
PMID:11677594
PMID:21873635
(MGI:MGI:4821191|PMID:20620997)
(PMID:24340098)
RGD PMID:20620997, PMID:24340098, PMID:11677594, PMID:21873635 MGI:MGI:4821191, RGD:10448951, RGD:13792537 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G LOC103694380 tumor necrosis factor-like IMP PMID:12729461 ARUK-UCL PMID:12729461 RGD:13673777 NCBI chr20:4,855,792...4,858,447
Ensembl chr20:4,855,829...4,858,447
JBrowse link
G Maz MYC associated zinc finger protein ISO (PMID:25487955) RGD PMID:25487955 NCBI chr 1:198,456,699...198,460,126
Ensembl chr 1:198,456,699...198,460,126
JBrowse link
G Mydgf myeloid-derived growth factor ISO (MGI:MGI:5609664|PMID:25581518) RGD PMID:25581518 MGI:MGI:5609664 NCBI chr 9:10,885,521...10,892,744
Ensembl chr 9:10,885,560...10,892,405
JBrowse link
G Myoc myocilin IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:21656515)
Ensembl
UniProt
RGD
PMID:21656515 GO_REF:0000024, GO_REF:0000107 NCBI chr13:80,517,531...80,527,928
Ensembl chr13:80,517,536...80,527,928
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO (PMID:26514923) RGD PMID:26514923 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase ISO (PMID:17218260) RGD PMID:17218260 NCBI chr 8:79,323,408...79,408,842
Ensembl chr 8:79,323,408...79,408,833
JBrowse link
G Nkx3-1 NK3 homeobox 1 ISO
ISS
(PMID:20395202)
GO_REF:0000024
RGD
UniProt
PMID:20395202 GO_REF:0000024 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nrg1 neuregulin 1 ISO MGI:MGI:104771 (MGI:MGI:3796800|PMID:18458158) RGD PMID:18458158 MGI:MGI:3796800 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IMP
IBA
PMID:10985347
PMID:21873635
UniProt
GO_Central
PMID:10985347, PMID:21873635 RGD:8553408, RGD:13792537 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Osm oncostatin M ISO RNAcentral:URS0000574A2C_9606 (PMID:28972028) RGD PMID:28972028 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Pdgfa platelet derived growth factor subunit A IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:11788434)
Ensembl
UniProt
RGD
PMID:11788434, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO
IBA
ISS
IEA
MGI:MGI:1349482|MGI:MGI:1890662 (MGI:MGI:3617099|PMID:16456542)
PMID:21873635
(PMID:10734101), (PMID:11788434), (PMID:17942966)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:10734101, PMID:11788434, PMID:16456542, PMID:17942966, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3617099, RGD:13792537 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfc platelet derived growth factor C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:179,952,227...180,126,897
Ensembl chr 2:179,952,227...180,128,283
JBrowse link
G Pdgfd platelet derived growth factor D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:4,441,010...4,666,754
Ensembl chr 8:4,440,876...4,669,014
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO
ISS
(MGI:MGI:5009390|PMID:17942966)
GO_REF:0000024
RGD
UniProt
PMID:17942966 GO_REF:0000024, MGI:MGI:5009390 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 ISO (MGI:MGI:5305503|PMID:22187460), (MGI:MGI:5305504|PMID:22187458) RGD PMID:22187458, PMID:22187460 MGI:MGI:5305503, MGI:MGI:5305504 NCBI chr 1:260,527,344...260,679,132
Ensembl chr 1:260,527,781...260,638,915
JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:15705590 RGD:2299907 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Plxnb1 plexin B1 ISO (MGI:MGI:4413657|PMID:19788569) RGD PMID:19788569 MGI:MGI:4413657 NCBI chr 8:117,832,826...117,858,515
Ensembl chr 8:117,836,701...117,856,689
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta ISO (MGI:MGI:3621068|PMID:16581799) RGD PMID:16581799 MGI:MGI:3621068 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Prr5 proline rich 5 ISO
IEA
MGI:MGI:1919696 (MGI:MGI:5005047|PMID:21413931)
GO_REF:0000107
RGD
Ensembl
PMID:21413931 GO_REF:0000107, MGI:MGI:5005047 NCBI chr 7:125,569,791...125,609,340
Ensembl chr 7:125,576,327...125,613,114
JBrowse link
G Prr5l proline rich 5 like ISO
IEA
MGI:MGI:1924714 (MGI:MGI:5005047|PMID:21413931)
GO_REF:0000107
RGD
Ensembl
PMID:21413931 GO_REF:0000107, MGI:MGI:5005047 NCBI chr 3:91,290,207...91,461,208
Ensembl chr 3:91,291,875...91,370,167
JBrowse link
G Ptk2 protein tyrosine kinase 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:15166238)
Ensembl
UniProt
RGD
PMID:15166238 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO
IEA
(PMID:19838216)
GO_REF:0000107
RGD
Ensembl
PMID:19838216 GO_REF:0000107 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Rara retinoic acid receptor, alpha IMP PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Reln reelin ISO
IEA
(MGI:MGI:5286805|PMID:21664258)
GO_REF:0000107
RGD
Ensembl
PMID:21664258 GO_REF:0000107, MGI:MGI:5286805 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Rgl2 ral guanine nucleotide dissociation stimulator-like 2 ISO (MGI:MGI:5547674|PMID:24069211) RGD PMID:24069211 MGI:MGI:5547674 NCBI chr20:5,458,509...5,466,853
Ensembl chr20:5,458,509...5,466,265
JBrowse link
G Ror1 receptor tyrosine kinase-like orphan receptor 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:118,892,874...119,239,528
Ensembl chr 5:119,097,715...119,241,733
JBrowse link
G Ror2 receptor tyrosine kinase-like orphan receptor 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:11,953,552...12,134,386
Ensembl chr17:11,953,552...12,134,386
JBrowse link
G Selp selectin P IEA
ISO
GO_REF:0000107
(PMID:17632516)
Ensembl
RGD
PMID:17632516 GO_REF:0000107 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Sema4d semaphorin 4D ISO (PMID:16055703) RGD PMID:16055703 NCBI chr17:13,516,276...13,538,513
Ensembl chr17:13,488,376...13,553,974
JBrowse link
G Serpina12 serpin family A member 12 ISO
IEA
MGI:MGI:5568548 (MGI:MGI:5563627|PMID:22837305)
GO_REF:0000107
RGD
Ensembl
PMID:22837305 GO_REF:0000107, MGI:MGI:5563627 NCBI chr 6:127,696,501...127,711,238
Ensembl chr 6:127,696,252...127,711,212
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:4821191|PMID:20620997) RGD PMID:20620997 MGI:MGI:4821191 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sox9 SRY-box transcription factor 9 ISO
ISS
(MGI:MGI:4950303|PMID:21367821)
GO_REF:0000024
RGD
UniProt
PMID:21367821 GO_REF:0000024, MGI:MGI:4950303 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Tek TEK receptor tyrosine kinase ISO
IBA
(PMID:12816861), (PMID:18425120), (PMID:19223473)
PMID:21873635
RGD PMID:12816861, PMID:18425120, PMID:19223473, PMID:21873635 RGD:13792537 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO
ISS
(PMID:18223299)
GO_REF:0000024
RGD
UniProt
PMID:18223299 GO_REF:0000024 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnf tumor necrosis factor IMP PMID:12729461 ARUK-UCL PMID:12729461 RGD:13673777 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ube3a ubiquitin protein ligase E3A ISO MGI:MGI:2181811 (MGI:MGI:3616918|PMID:16254014) RGD PMID:16254014 MGI:MGI:3616918 NCBI chr 1:116,586,901...116,678,161
Ensembl chr 1:116,587,815...116,679,973
JBrowse link
G Unc5b unc-5 netrin receptor B IEA
ISO
GO_REF:0000107
(PMID:18469807)
Ensembl
RGD
PMID:18469807 GO_REF:0000107 NCBI chr20:30,339,680...30,406,593
Ensembl chr20:30,339,673...30,406,295
JBrowse link
G Wnt16 Wnt family member 16 ISO (PMID:19951988) RGD PMID:19951988 NCBI chr 4:49,369,246...49,388,156
Ensembl chr 4:49,369,296...49,379,703
JBrowse link
regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 IDA PMID:11694516 UniProt PMID:11694516 RGD:11041061 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cep55 centrosomal protein 55 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:256,745,251...256,760,794
Ensembl chr 1:256,745,288...256,760,796
JBrowse link
G Crnn cornulin ISO
IBA
(PMID:30009832)
PMID:21873635
RGD PMID:30009832, PMID:21873635 RGD:13792537 NCBI chr 2:193,427,097...193,432,070
Ensembl chr 2:193,429,176...193,431,487
JBrowse link
G Dipk2a divergent protein kinase domain 2A ISO
IBA
(PMID:23784961)
PMID:21873635
RGD PMID:23784961, PMID:21873635 RGD:13792537 NCBI chr 8:102,140,713...102,159,828
Ensembl chr 8:102,088,505...102,159,828
JBrowse link
G Egfr epidermal growth factor receptor ISO (PMID:26514923) RGD PMID:26514923 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 ISO
ISS
(MGI:MGI:4881347|PMID:21074248)
GO_REF:0000024
RGD
UniProt
PMID:21074248 GO_REF:0000024, MGI:MGI:4881347 NCBI chr 6:108,087,677...108,123,811
Ensembl chr 6:108,087,418...108,120,579
JBrowse link
G Fbxl2 F-box and leucine-rich repeat protein 2 ISO (PMID:23604317) RGD PMID:23604317 NCBI chr 8:122,240,393...122,290,439
Ensembl chr 8:122,243,016...122,311,431
JBrowse link
G Lime1 Lck interacting transmembrane adaptor 1 ISO
IBA
(MGI:MGI:3769059|PMID:16249387)
PMID:21873635
RGD PMID:16249387, PMID:21873635 MGI:MGI:3769059, RGD:13792537 NCBI chr 3:176,881,881...176,888,230
Ensembl chr 3:176,882,027...176,884,350
JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B ISO (PMID:25007873) RGD PMID:25007873 NCBI chr 3:155,160,474...155,267,002
Ensembl chr 3:155,160,481...155,262,941
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 ISO (PMID:23604317) RGD PMID:23604317 NCBI chr14:7,688,551...7,863,664
Ensembl chr14:7,688,551...7,863,664
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 ISO MGI:MGI:2386261 (MGI:MGI:3758152|PMID:17190838) RGD PMID:17190838 MGI:MGI:3758152 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    signaling 7588
      signal transduction 7015
        intracellular signal transduction 2615
          inositol lipid-mediated signaling 180
            phosphatidylinositol-mediated signaling 177
              phosphatidylinositol 3-kinase signaling 140
                negative regulation of phosphatidylinositol 3-kinase signaling 16
                positive regulation of phosphatidylinositol 3-kinase signaling 76
                regulation of phosphatidylinositol 3-kinase signaling + 103
Path 2
Term Annotations click to browse term
  biological_process 20017
    biological regulation 13767
      regulation of biological process 13081
        regulation of cellular process 12570
          signal transduction 7015
            intracellular signal transduction 2615
              inositol lipid-mediated signaling 180
                phosphatidylinositol-mediated signaling 177
                  phosphatidylinositol 3-kinase signaling 140
                    negative regulation of phosphatidylinositol 3-kinase signaling 16
                    positive regulation of phosphatidylinositol 3-kinase signaling 76
                    regulation of phosphatidylinositol 3-kinase signaling + 103
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.