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Term:regulation of phosphatidylinositol 3-kinase signaling
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Accession:GO:0014066 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
Synonyms:exact_synonym: regulation of PI3K cascade;   regulation of phosphoinositide 3-kinase cascade
 related_synonym: regulation of PI 3-kinase cascade;   regulation of phosphatidylinositol 3-kinase cascade

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regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link NW_004955555 426,894 446,235 RGD:9068941
G Crnn cornulin JBrowse link NW_004955589 47,743 75,383 RGD:9068941
G Dipk2a divergent protein kinase domain 2A JBrowse link NW_004955508 1,954,600 1,975,842 RGD:9068941
G Egfr epidermal growth factor receptor JBrowse link NW_004955456 321,222 456,431 RGD:9068941
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) JBrowse link NW_004955523 1,407,812 1,441,829 RGD:9068941
G Fbxl2 F-box and leucine rich repeat protein 2 JBrowse link NW_004955421 512,197 617,524 RGD:9068941
G Lime1 Lck interacting transmembrane adaptor 1 JBrowse link NW_004955528 490,319 492,943 RGD:9068941
G Ppp1r16b protein phosphatase 1 regulatory subunit 16B JBrowse link NW_004955445 17,864,103 17,961,295 RGD:9068941
G Ptpn13 protein tyrosine phosphatase non-receptor type 13 JBrowse link NW_004955474 2,988,109 3,140,520 RGD:9068941
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link NW_004955416 5,494,030 5,561,608 RGD:9068941
negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cryba1 crystallin beta A1 JBrowse link NW_004955481 3,952,976 3,986,548 RGD:9068941
G Dab2ip DAB2 interacting protein JBrowse link NW_004955419 6,229,437 6,416,619 RGD:9068941
G Inpp5e inositol polyphosphate-5-phosphatase E JBrowse link NW_004955513 4,304,483 4,313,087 RGD:9068941
G Klf4 Kruppel like factor 4 JBrowse link NW_004955419 19,280,311 19,284,097 RGD:9068941
G Ncor1 nuclear receptor corepressor 1 JBrowse link NW_004955467 1,408,292 1,568,539 RGD:9068941
G Nlrc3 NLR family CARD domain containing 3 JBrowse link NW_004955442 13,795,322 13,834,362 RGD:9068941
G Nop53 NOP53 ribosome biogenesis factor JBrowse link NW_004955574 1,505,997 1,514,680 RGD:9068941
G Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF JBrowse link NW_004955581 148,571 265,062 RGD:9068941
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 JBrowse link NW_004955455 5,474,569 5,488,420 RGD:9068941
G Serpine2 serpin family E member 2 JBrowse link NW_004955453 10,049,822 10,076,155 RGD:9068941
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link NW_004955553 1,639,267 1,656,850 RGD:9068941
G Slc9a3r2 SLC9A3 regulator 2 JBrowse link NW_004955442 15,224,214 15,235,372 RGD:9068941
G Stambp STAM binding protein JBrowse link NW_004955424 11,831,910 11,879,577 RGD:9068941
G Tsc2 TSC complex subunit 2 JBrowse link NW_004955442 15,178,356 15,216,978 RGD:9068941
G Twist1 twist family bHLH transcription factor 1 JBrowse link NW_004955410 22,003,981 22,005,483 RGD:9068941
positive regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 JBrowse link NW_004955458 5,436,544 5,448,201 RGD:9068941
G Agt angiotensinogen JBrowse link NW_004955492 7,863,662 7,874,863 RGD:9068941
G Angpt1 angiopoietin 1 JBrowse link NW_004955417 30,199,508 30,386,695 RGD:9068941
G Cat catalase JBrowse link NW_004955422 11,783,973 11,826,970 RGD:9068941
G Cbl Cbl proto-oncogene JBrowse link NW_004955412 20,307,011 20,388,539 RGD:9068941
G Ccl5 C-C motif chemokine ligand 5 JBrowse link NW_004955481 10,293,758 10,301,118 RGD:9068941
G Cd28 CD28 molecule JBrowse link NW_004955457 11,159,769 11,253,099 RGD:9068941
G Cntf ciliary neurotrophic factor JBrowse link NW_004955511 3,527,552 3,531,275 RGD:9068941
G Csf3 colony stimulating factor 3 JBrowse link NW_004955451 14,688,181 14,690,126 RGD:9068941
G Dcn decorin JBrowse link NW_004955405 28,335,493 28,371,912 RGD:9068941
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link NW_004955451 14,442,816 14,456,009 RGD:9068941
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link NW_004955457 3,177,905 4,236,152 RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link NW_004955422 1,356,675 1,367,788 RGD:9068941
G F2r coagulation factor II thrombin receptor JBrowse link NW_004955425 24,144,905 24,164,498 RGD:9068941
G F2rl1 F2R like trypsin receptor 1 JBrowse link NW_004955425 24,050,901 24,054,039 RGD:9068941
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link NW_004955452 6,840,274 6,863,460 RGD:9068941
G Flt1 fms related receptor tyrosine kinase 1 JBrowse link NW_004955497 7,653,309 7,831,737 RGD:9068941
G Fshr follicle stimulating hormone receptor JBrowse link NW_004955441 15,422,190 15,585,446 RGD:9068941
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link NW_004955411 36,403,156 36,597,660 RGD:9068941
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link NW_004955460 8,790,798 8,794,902 RGD:9068941
G Hax1 HCLS1 associated protein X-1 JBrowse link NW_004955545 816,789 819,667 RGD:9068941
G Hcls1 hematopoietic cell-specific Lyn substrate 1 JBrowse link NW_004955427 20,999,934 21,020,401 RGD:9068941
G Hgf hepatocyte growth factor JBrowse link NW_004955410 4,114,280 4,181,953 RGD:9068941
G Igf1 insulin like growth factor 1 JBrowse link NW_004955405 37,505,830 37,582,152 RGD:9068941
G Igf1r insulin like growth factor 1 receptor JBrowse link NW_004955416 26,101,090 26,382,660 RGD:9068941
G Il18 interleukin 18 JBrowse link NW_004955412 13,807,361 13,826,007 RGD:9068941
G Ins insulin JBrowse link NW_004955422 13,909,408 13,910,419 RGD:9068941
G Jak2 Janus kinase 2 JBrowse link NW_004955434 9,227,897 9,341,208 RGD:9068941
G Kdr kinase insert domain receptor JBrowse link NW_004955447 15,810,816 15,851,702 RGD:9068941
G Lep leptin JBrowse link NW_004955479 9,266,604 9,276,568 RGD:9068941
G Maz MYC associated zinc finger protein JBrowse link NW_004955493 7,149,600 7,152,449 RGD:9068941
G Mydgf myeloid derived growth factor JBrowse link NW_004955495 4,320,532 4,330,921 RGD:9068941
G Myoc myocilin JBrowse link NW_004955406 12,182,115 12,194,683 RGD:9068941
G Ncf1 neutrophil cytosolic factor 1 JBrowse link NW_004955456 13,353,780 13,363,956 RGD:9068941
G Nedd4 NEDD4 E3 ubiquitin protein ligase JBrowse link NW_004955409 183,645 281,252 RGD:9068941
G Nkx3-1 NK3 homeobox 1 JBrowse link NW_004955403 46,807,846 46,809,924 RGD:9068941
G Nrg1 neuregulin 1 JBrowse link NW_004955463 8,009,436 9,037,116 RGD:9068941
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link NW_004955432 2,284,283 2,629,631 RGD:9068941
G Osm oncostatin M JBrowse link NW_004955455 4,510,711 4,515,282 RGD:9068941
G Pdgfa platelet derived growth factor subunit A JBrowse link NW_004955460 8,328,400 8,346,755 RGD:9068941
G Pdgfb platelet derived growth factor subunit B JBrowse link NW_004955413 25,150,702 25,166,987 RGD:9068941
G Pdgfrb platelet derived growth factor receptor beta JBrowse link NW_004955415 4,365,848 4,403,317 RGD:9068941
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 JBrowse link NW_004955507 2,805,782 2,918,664 RGD:9068941
G Pld2 phospholipase D2 JBrowse link NW_004955467 10,239,177 10,250,516 RGD:9068941
G Plxnb1 plexin B1 JBrowse link NW_004955532 471,652 499,525 RGD:9068941
G Prr5 proline rich 5 JBrowse link NW_004955413 29,360,125 29,379,196 RGD:9068941
G Prr5l proline rich 5 like JBrowse link NW_004955422 9,972,588 10,069,411 RGD:9068941
G Ptk2 protein tyrosine kinase 2 JBrowse link NW_004955461 14,337,914 14,622,779 RGD:9068941
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 JBrowse link NW_004955413 4,525,954 4,547,177 RGD:9068941
G Rara retinoic acid receptor alpha JBrowse link NW_004955451 14,876,663 14,917,134 RGD:9068941
G Reln reelin JBrowse link NW_004955410 8,424,439 8,863,966 RGD:9068941
G Rgl2 ral guanine nucleotide dissociation stimulator like 2 JBrowse link NW_004955437 1,851,005 1,857,567 RGD:9068941
G Selp selectin P JBrowse link NW_004955462 7,658,371 7,692,870 RGD:9068941
G Sema4d semaphorin 4D JBrowse link NW_004955515 2,573,816 2,676,387 RGD:9068941
G Serpina12 serpin family A member 12 JBrowse link NW_004955438 17,826,596 17,849,341 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004955425 20,280,725 20,307,663 RGD:9068941
G Sox9 SRY-box transcription factor 9 JBrowse link NW_004955478 941,684 945,563 RGD:9068941
G Tek TEK receptor tyrosine kinase JBrowse link NW_004955472 7,633,790 7,748,130 RGD:9068941
G Tgfb2 transforming growth factor beta 2 JBrowse link NW_004955406 174,949 249,248 RGD:9068941
G Tnf tumor necrosis factor JBrowse link NW_004955437 117,267 119,899 RGD:9068941
G Ube3a ubiquitin protein ligase E3A JBrowse link NW_004955533 3,733,148 3,828,353 RGD:9068941
G Unc5b unc-5 netrin receptor B JBrowse link NW_004955437 20,120,996 20,199,877 RGD:9068941
G Wnt16 Wnt family member 16 JBrowse link NW_004955479 3,065,312 3,077,260 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11825
    signaling 4135
      signal transduction 3655
        intracellular signal transduction 1964
          regulation of intracellular signal transduction 1435
            regulation of phosphatidylinositol 3-kinase signaling 88
              negative regulation of phosphatidylinositol 3-kinase signaling 15
              positive regulation of phosphatidylinositol 3-kinase signaling 63
Path 2
Term Annotations click to browse term
  biological_process 11825
    biological regulation 8661
      regulation of biological process 8226
        regulation of cellular process 7809
          signal transduction 3655
            intracellular signal transduction 1964
              inositol lipid-mediated signaling 136
                phosphatidylinositol-mediated signaling 134
                  phosphatidylinositol 3-kinase signaling 113
                    regulation of phosphatidylinositol 3-kinase signaling 88
                      negative regulation of phosphatidylinositol 3-kinase signaling 15
                      positive regulation of phosphatidylinositol 3-kinase signaling 63
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.