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Term:regulation of phosphatidylinositol 3-kinase signaling
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Accession:GO:0014066 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
Synonyms:exact_synonym: regulation of PI3K cascade;   regulation of phosphoinositide 3-kinase cascade
 related_synonym: regulation of PI 3-kinase cascade;   regulation of phosphatidylinositol 3-kinase cascade

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regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link NW_004936706 37,480 53,306 RGD:9068941
G Dipk2a divergent protein kinase domain 2A JBrowse link NW_004936519 10,966,822 10,988,311 RGD:9068941
G Egfr epidermal growth factor receptor JBrowse link NW_004936678 365,005 560,546 RGD:9068941
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) JBrowse link NW_004936488 3,241,004 3,280,360 RGD:9068941
G Fbxl2 F-box and leucine rich repeat protein 2 JBrowse link NW_004936473 23,567,251 23,659,708 RGD:9068941
G Lime1 Lck interacting transmembrane adaptor 1 JBrowse link NW_004936514 10,980,136 10,983,323 RGD:9068941
G Ppp1r16b protein phosphatase 1 regulatory subunit 16B JBrowse link NW_004936561 2,552,168 2,654,085 RGD:9068941
G Ptpn13 protein tyrosine phosphatase non-receptor type 13 JBrowse link NW_004936920 313,762 510,334 RGD:9068941
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link NW_004936471 2,152,231 2,222,260 RGD:9068941
negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cryba1 crystallin beta A1 JBrowse link NW_004936538 5,392,159 5,400,583 RGD:9068941
G Dab2ip DAB2 interacting protein JBrowse link NW_004936487 10,056,809 10,243,021 RGD:9068941
G Inpp5e inositol polyphosphate-5-phosphatase E JBrowse link NW_004936669 1,377,005 1,385,287 RGD:9068941
G Klf4 Kruppel like factor 4 JBrowse link NW_004936559 5,105,456 5,109,970 RGD:9068941
G LOC101962737 obscurin JBrowse link NW_004936864 619 33,574 RGD:9068941
G Ncor1 nuclear receptor corepressor 1 JBrowse link NW_004936821 382,756 538,254 RGD:9068941
G Nlrc3 NLR family CARD domain containing 3 JBrowse link NW_004936694 757,121 773,924 RGD:9068941
G Nop53 NOP53 ribosome biogenesis factor JBrowse link NW_004936664 1,334,487 1,343,867 RGD:9068941
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 JBrowse link NW_004936755 444,264 456,071 RGD:9068941
G Serpine2 serpin family E member 2 JBrowse link NW_004936569 5,642,328 5,668,278 RGD:9068941
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link NW_004936594 119,808 136,620 RGD:9068941
G Slc9a3r2 SLC9A3 regulator 2 JBrowse link NW_004936694 2,000,977 2,006,102 RGD:9068941
G Stambp STAM binding protein JBrowse link NW_004936556 143,483 174,383 RGD:9068941
G Tsc2 TSC complex subunit 2 JBrowse link NW_004936694 1,958,152 1,993,373 RGD:9068941
G Twist1 twist family bHLH transcription factor 1 JBrowse link NW_004936546 5,331,220 5,332,669 RGD:9068941
positive regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 JBrowse link NW_004936646 1,865,154 1,881,614 RGD:9068941
G Agt angiotensinogen JBrowse link NW_004936484 19,713,299 19,721,144 RGD:9068941
G Angpt1 angiopoietin 1 JBrowse link NW_004936470 37,105,469 37,328,183 RGD:9068941
G Cat catalase JBrowse link NW_004936533 3,601,270 3,637,128 RGD:9068941
G Cbl Cbl proto-oncogene JBrowse link NW_004936542 4,136,389 4,235,746 RGD:9068941
G Ccl5 C-C motif chemokine ligand 5 JBrowse link NW_004936490 253,279 259,947 RGD:9068941
G Cd28 CD28 molecule JBrowse link NW_004936631 335,411 363,407 RGD:9068941
G Cntf ciliary neurotrophic factor JBrowse link NW_004936581 3,710,171 3,715,753 RGD:9068941
G Csf3 colony stimulating factor 3 JBrowse link NW_004936490 15,142,526 15,146,375 RGD:9068941
G Dcn decorin JBrowse link NW_004936507 7,887,259 7,923,055 RGD:9068941
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link NW_004936490 14,887,062 14,910,038 RGD:9068941
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link NW_004936586 4,065,767 5,100,690 RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link NW_004936562 2,371,725 2,388,617 RGD:9068941
G F2r coagulation factor II thrombin receptor JBrowse link NW_004936549 226,508 247,024 RGD:9068941
G F2rl1 F2R like trypsin receptor 1 JBrowse link NW_004936549 142,281 153,575 RGD:9068941
G Fgr FGR proto-oncogene, Src family tyrosine kinase JBrowse link NW_004936474 11,897,998 11,919,153 RGD:9068941
G Flt1 fms related receptor tyrosine kinase 1 JBrowse link NW_004936472 23,442,946 23,617,523 RGD:9068941
G Fshr follicle stimulating hormone receptor JBrowse link NW_004936508 3,601,205 3,754,234 RGD:9068941
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link NW_004936679 388,500 588,518 RGD:9068941
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link NW_004936754 1,288,891 1,293,555 RGD:9068941
G Hax1 HCLS1 associated protein X-1 JBrowse link NW_004936580 3,961,433 3,964,322 RGD:9068941
G Hcls1 hematopoietic cell-specific Lyn substrate 1 JBrowse link NW_004936536 8,065,489 8,084,777 RGD:9068941
G Hcst hematopoietic cell signal transducer JBrowse link NW_004936570 460,890 462,354 RGD:9068941
G Hgf hepatocyte growth factor JBrowse link NW_004936734 354,798 428,356 RGD:9068941
G Igf1 insulin like growth factor 1 JBrowse link NW_004936492 11,709,623 11,784,028 RGD:9068941
G Igf1r insulin like growth factor 1 receptor JBrowse link NW_004936483 4,563,995 4,860,231 RGD:9068941
G Il18 interleukin 18 JBrowse link NW_004936612 2,306,963 2,325,086 RGD:9068941
G Ins insulin JBrowse link NW_004936816 1,002,137 1,003,357 RGD:9068941
G Jak2 Janus kinase 2 JBrowse link NW_004936503 111,722 243,627 RGD:9068941
G Kdr kinase insert domain receptor JBrowse link NW_004936482 17,537,697 17,581,320 RGD:9068941
G Lep leptin JBrowse link NW_004936479 15,394,966 15,411,334 RGD:9068941
G LOC101969021 somatotropin JBrowse link NW_004936541 4,524,397 4,528,234 RGD:9068941
G LOC101973578 adenosine receptor A3 JBrowse link NW_004936690 152,777 168,411 RGD:9068941
G LOC101975744 semaphorin-4D JBrowse link NW_004936780 317,926 350,113 RGD:9068941
G Maz MYC associated zinc finger protein JBrowse link NW_004936501 12,664,861 12,668,819 RGD:9068941
G Mydgf myeloid derived growth factor JBrowse link NW_004936588 2,706,329 2,716,545 RGD:9068941
G Myoc myocilin JBrowse link NW_004936481 15,544,733 15,556,813 RGD:9068941
G Ncf1 neutrophil cytosolic factor 1 JBrowse link NW_004936543 3,617,369 3,630,990 RGD:9068941
G Nedd4 NEDD4 E3 ubiquitin protein ligase JBrowse link NW_004936471 17,254,777 17,374,725 RGD:9068941
G Nkx3-1 NK3 homeobox 1 JBrowse link NW_004936555 7,087,677 7,091,334 RGD:9068941
G Nrg1 neuregulin 1 JBrowse link NW_004936766 1,104,841 1,306,368 RGD:9068941
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link NW_004936680 267,850 621,467 RGD:9068941
G Osm oncostatin M JBrowse link NW_004936904 390,089 394,195 RGD:9068941
G Pdgfa platelet derived growth factor subunit A JBrowse link NW_004936754 808,894 828,554 RGD:9068941
G Pdgfb platelet derived growth factor subunit B JBrowse link NW_004936492 2,353,840 2,368,573 RGD:9068941
G Pdgfrb platelet derived growth factor receptor beta JBrowse link NW_004936504 4,762,251 4,799,789 RGD:9068941
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 JBrowse link NW_004936636 2,822,100 2,935,252 RGD:9068941
G Pld2 phospholipase D2 JBrowse link NW_004936677 2,870,664 2,883,545 RGD:9068941
G Plxnb1 plexin B1 JBrowse link NW_004936529 197,834 226,064 RGD:9068941
G Prr5 proline rich 5 JBrowse link NW_004936718 2,094,802 2,170,916 RGD:9068941
G Prr5l proline rich 5 like JBrowse link NW_004936533 1,895,594 1,975,442 RGD:9068941
G Ptk2 protein tyrosine kinase 2 JBrowse link NW_004936470 10,379,855 10,578,531 RGD:9068941
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 JBrowse link NW_004936709 864,206 884,630 RGD:9068941
G Rara retinoic acid receptor alpha JBrowse link NW_004936490 15,376,217 15,420,638 RGD:9068941
G Reln reelin JBrowse link NW_004936479 19,628,488 20,088,278 RGD:9068941
G Rgl2 ral guanine nucleotide dissociation stimulator like 2 JBrowse link NW_004936476 25,566,714 25,574,667 RGD:9068941
G Selp selectin P JBrowse link NW_004936481 17,076,660 17,112,501 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004936521 10,296,097 10,316,673 RGD:9068941
G Sox9 SRY-box transcription factor 9 JBrowse link NW_004936655 1,849,044 1,852,648 RGD:9068941
G Tek TEK receptor tyrosine kinase JBrowse link NW_004936611 2,420,176 2,531,726 RGD:9068941
G Tgfb2 transforming growth factor beta 2 JBrowse link NW_004936628 310,720 394,002 RGD:9068941
G Tnf tumor necrosis factor JBrowse link NW_004936727 1,936,066 1,937,766 RGD:9068941
G Ube3a ubiquitin protein ligase E3A JBrowse link NW_004936471 41,187,665 41,290,345 RGD:9068941
G Unc5b unc-5 netrin receptor B JBrowse link NW_004936521 7,472,788 7,547,408 RGD:9068941
G Wnt16 Wnt family member 16 JBrowse link NW_004936605 3,855,640 3,867,166 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11930
    signaling 4162
      signal transduction 3676
        intracellular signal transduction 1972
          regulation of intracellular signal transduction 1437
            regulation of phosphatidylinositol 3-kinase signaling 89
              negative regulation of phosphatidylinositol 3-kinase signaling 15
              positive regulation of phosphatidylinositol 3-kinase signaling 65
Path 2
Term Annotations click to browse term
  biological_process 11930
    biological regulation 8731
      regulation of biological process 8293
        regulation of cellular process 7873
          signal transduction 3676
            intracellular signal transduction 1972
              inositol lipid-mediated signaling 137
                phosphatidylinositol-mediated signaling 135
                  phosphatidylinositol 3-kinase signaling 115
                    regulation of phosphatidylinositol 3-kinase signaling 89
                      negative regulation of phosphatidylinositol 3-kinase signaling 15
                      positive regulation of phosphatidylinositol 3-kinase signaling 65
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.