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Term:negative regulation of phosphatidylinositol 3-kinase signaling
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Accession:GO:0014067 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
Synonyms:exact_synonym: down regulation of phosphatidylinositol 3-kinase cascade;   downregulation of phosphatidylinositol 3-kinase cascade;   negative regulation of PI 3-kinase cascade;   negative regulation of PI3K cascade;   negative regulation of phosphoinositide 3-kinase cascade
 narrow_synonym: inhibition of phosphatidylinositol 3-kinase cascade
 related_synonym: negative regulation of phosphatidylinositol 3-kinase cascade

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negative regulation of phosphatidylinositol 3-kinase signaling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cryba1 crystallin beta A1 ISO RGD PMID:21993393 RGD:10059647 NCBI chrNW_004936538:5,392,159...5,400,583 JBrowse link
G Dab2ip DAB2 interacting protein ISO (PMID:19903888) UniProtKB PMID:19903888 NCBI chrNW_004936487:10,056,809...10,243,021 JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E ISO RGD PMID:21436142 RGD:12911213 NCBI chrNW_004936669:1,377,005...1,385,287 JBrowse link
G Klf4 Kruppel like factor 4 ISO PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chrNW_004936559:5,105,456...5,109,970 JBrowse link
G LOC101962737 obscurin ISO (MGI:MGI:6101642|PMID:28826662) UniProt PMID:28826662 MGI:MGI:6101642 NCBI chrNW_004936864:619...33,574 JBrowse link
G Ncor1 nuclear receptor corepressor 1 ISO (MGI:MGI:3723397|PMID:17606624) MGI PMID:17606624 MGI:MGI:3723397 NCBI chrNW_004936821:382,756...538,254 JBrowse link
G Nlrc3 NLR family CARD domain containing 3 ISO (MGI:MGI:5883388|PMID:27951586) UniProtKB PMID:27951586 MGI:MGI:5883388 NCBI chrNW_004936694:757,121...773,924 JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO (PMID:16971513) UniProtKB PMID:16971513 NCBI chrNW_004936664:1,334,487...1,343,867 JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 ISO (PMID:17475214)
UniProtKB PMID:17475214, PMID:18632611 MGI:MGI:3806716 NCBI chrNW_004936755:444,264...456,071 JBrowse link
G Serpine2 serpin family E member 2 ISO (MGI:MGI:3810206|PMID:18398001) MGI PMID:18398001 MGI:MGI:3810206 NCBI chrNW_004936569:5,642,328...5,668,278 JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 ISO (MGI:MGI:3617099|PMID:16456542) UniProtKB
PMID:16456542 MGI:MGI:3617099 NCBI chrNW_004936594:119,808...136,620 JBrowse link
G Slc9a3r2 SLC9A3 regulator 2 ISO (MGI:MGI:3617099|PMID:16456542) MGI PMID:16456542 MGI:MGI:3617099 NCBI chrNW_004936694:2,000,977...2,006,102 JBrowse link
G Stambp STAM binding protein ISO (PMID:23542699) UniProtKB PMID:23542699 NCBI chrNW_004936556:143,483...174,383 JBrowse link
G Tsc2 TSC complex subunit 2 ISO (MGI:MGI:3586939|PMID:16027169) MGI PMID:16027169 MGI:MGI:3586939 NCBI chrNW_004936694:1,958,152...1,993,373 JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO (PMID:17003487) BHF-UCL PMID:17003487 NCBI chrNW_004936546:5,331,220...5,332,669 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11962
    signaling 4166
      negative regulation of signaling 1282
        negative regulation of signal transduction 1132
          negative regulation of intracellular signal transduction 502
            negative regulation of phosphatidylinositol 3-kinase signaling 15
Path 2
Term Annotations click to browse term
  biological_process 11962
    biological regulation 8755
      regulation of biological process 8316
        regulation of cellular process 7896
          signal transduction 3695
            intracellular signal transduction 1982
              inositol lipid-mediated signaling 139
                phosphatidylinositol-mediated signaling 137
                  phosphatidylinositol 3-kinase signaling 117
                    regulation of phosphatidylinositol 3-kinase signaling 89
                      negative regulation of phosphatidylinositol 3-kinase signaling 15
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.