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ONTOLOGY REPORT - ANNOTATIONS


Term:response to isoquinoline alkaloid
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Accession:GO:0014072 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids.


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response to isoquinoline alkaloid term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IEP oxycodone RGD PMID:23439660 RGD:11041186 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
cellular response to isoquinoline alkaloid term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr1 early growth response 1 IEP berberine RGD PMID:16448624 RGD:5131909 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Mecp2 methyl CpG binding protein 2 IDA bicuculline RGD PMID:22262897 RGD:12790719 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
cellular response to morphine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy8 adenylate cyclase 8 ISS
ISO
IDA
IEA
GO_REF:0000024
(MGI:3808962|PMID:18222416)
PMID:16186630
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:18222416, PMID:16186630 GO_REF:0000024, GO_REF:0000107, MGI:3808962, RGD:13825193 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804
JBrowse link
G Aif1 allograft inflammatory factor 1 IEP morphine RGD PMID:19176808 RGD:2313012 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Atg7 autophagy related 7 IEP RGD PMID:23800874 RGD:11557986 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP RGD PMID:20578038 RGD:4889899 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 IEP RGD PMID:18178009 RGD:6483056 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Oprm1 opioid receptor, mu 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B ISS
ISO
GO_REF:0000024
(MGI:3834288|PMID:18439408)
UniProt
RGD
PMID:18439408 GO_REF:0000024, MGI:3834288 NCBI chr10:82,800,704...82,816,735
Ensembl chr10:82,800,704...82,816,731
JBrowse link
G RT1-Bb RT1 class II, locus Bb IEP RGD PMID:14742686 RGD:7488923 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
response to codeine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IEP RGD PMID:24914722 RGD:11041146 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
response to morphine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IEP RGD PMID:26554626 RGD:11041102 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 IEP RGD PMID:22845665 RGD:11099987 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ada adenosine deaminase IMP RGD PMID:19934879 RGD:5128863 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adcy5 adenylate cyclase 5 IEP RGD PMID:18801381 RGD:13464135 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adra1b adrenoceptor alpha 1B ISO MGI:2148638 (MGI:2178201|PMID:11923452) RGD PMID:11923452 MGI:2178201 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Cnr1 cannabinoid receptor 1 IMP RGD PMID:19804815, PMID:19463710 RGD:2314642, RGD:2314667 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 IEP RGD PMID:18657552 RGD:10059657 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 IEP RGD PMID:28108674 RGD:13463594 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP RGD PMID:20977699 RGD:4890043 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Drd1 dopamine receptor D1 IEP RGD PMID:23775491 RGD:7248563 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 ISO MGI:1857875|MGI:2387895|MGI:2388386|MGI:2656648 (MGI:2151226|PMID:11567069), (MGI:2178015|PMID:11264672), (MGI:3576272|PMID:12182883), (MGI:3653553|PMID:9252189), (MGI:3655899|PMID:11943831) RGD PMID:9252189, PMID:11264672, PMID:11567069, PMID:11943831, PMID:12182883 MGI:2151226, MGI:2178015, MGI:3576272, MGI:3653553, MGI:3655899 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 ISO MGI:1857159 (MGI:2450222|PMID:12574430) RGD PMID:12574430 MGI:2450222 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:16293342, PMID:16741068 RGD:1581828, RGD:4892606 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 IEP RGD PMID:20553911 RGD:9685461 NCBI chr 1:259,692,020...259,818,922
Ensembl chr 1:259,739,955...259,819,494
JBrowse link
G Fadd Fas associated via death domain IDA RGD PMID:21088039 RGD:11341805 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fga fibrinogen alpha chain IEP in conjunction with memory test RGD PMID:24855564 RGD:9685019 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit IEP RGD PMID:15772255 RGD:2293776 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Ghr growth hormone receptor IEP RGD PMID:11335057 RGD:2307381 NCBI chr 2:53,149,225...53,413,954
Ensembl chr 2:53,150,370...53,413,638
JBrowse link
G Gnao1 G protein subunit alpha o1 IEP RGD PMID:8458398 RGD:2302014 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 IEP RGD PMID:24528483 RGD:13506244 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Gpi glucose-6-phosphate isomerase IMP RGD PMID:6447740 RGD:11051960 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 IEA
ISO
GO_REF:0000107
MGI:1928270 (MGI:3797147|PMID:18423864)
Ensembl
RGD
PMID:18423864 GO_REF:0000107, MGI:3797147 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IEP RGD PMID:29081032 RGD:13506833 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IEP RGD PMID:29081032 RGD:13506833 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IEP RGD PMID:12384166 RGD:727454 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:15317861 RGD:1626676 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:20190558 RGD:11560529 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Mdm2 MDM2 proto-oncogene IEP RGD PMID:14625023 RGD:2317407 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mir338 microRNA 338 IEP RGD PMID:28108674 RGD:13463594 NCBI chr10:109,195,251...109,195,316 JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:24382350 RGD:10040983 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Npff neuropeptide FF-amide peptide precursor IEP RGD PMID:15207282 RGD:2316569 NCBI chr 7:144,127,084...144,127,873
Ensembl chr 7:144,127,085...144,127,873
JBrowse link
G Oprk1 opioid receptor, kappa 1 IEP RGD PMID:16753266 RGD:9831397 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 IEP RGD PMID:16194531, PMID:16753266 RGD:2316627, RGD:9831397 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 IEP RGD PMID:18771713 RGD:2308891 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 IEP RGD PMID:19758790 RGD:2326031 NCBI chr13:90,579,844...90,589,466
Ensembl chr13:90,579,846...90,589,466
JBrowse link
G Penk proenkephalin IEP RGD PMID:23300784 RGD:10003095 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pitx3 paired-like homeodomain 3 IEP RGD PMID:23215787 RGD:11535121 NCBI chr 1:265,886,766...265,899,947
Ensembl chr 1:265,887,230...265,899,958
JBrowse link
G Plcg1 phospholipase C, gamma 1 IEP RGD PMID:17524370 RGD:2299883 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B ISO MGI:3799291 (MGI:3797712|PMID:18496528) RGD PMID:18496528 MGI:3797712 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO (MGI:3588907|PMID:16102737) RGD PMID:16102737 MGI:3588907 NCBI chr15:43,673,958...43,733,182
Ensembl chr15:43,673,960...43,733,182
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit ISO (MGI:3588907|PMID:16102737) RGD PMID:16102737 MGI:3588907 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
JBrowse link
G Prkce protein kinase C, epsilon ISO MGI:2152043 (MGI:3798724|PMID:16899053) RGD PMID:16899053 MGI:3798724 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prkcg protein kinase C, gamma ISS
ISO
GO_REF:0000024
(MGI:3760696|PMID:11246146)
UniProt
RGD
PMID:11246146 GO_REF:0000024, MGI:3760696 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP RGD PMID:18400403 RGD:2298784 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgs4 regulator of G-protein signaling 4 IEP RGD PMID:22056472, PMID:12653973 RGD:13524518, RGD:13524581 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Srr serine racemase IEP RGD PMID:18603832 RGD:2302212 NCBI chr10:61,756,138...61,772,327
Ensembl chr10:61,756,138...61,772,293
JBrowse link
G Tac1 tachykinin, precursor 1 IEP RGD PMID:17950674 RGD:2304334 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tac3 tachykinin precursor 3 IEP RGD PMID:7536308 RGD:2305965 NCBI chr 7:71,023,976...71,030,582
Ensembl chr 7:71,023,976...71,030,582
JBrowse link
G Tacr1 tachykinin receptor 1 IEP RGD PMID:17950674 RGD:2304334 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tacr3 tachykinin receptor 3 IEP RGD PMID:7536308 RGD:2305965 NCBI chr 2:240,021,152...240,118,971
Ensembl chr 2:240,021,152...240,118,971
JBrowse link
G Tlr4 toll-like receptor 4 IEP RGD PMID:18599265 RGD:7777128 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      response to chemical 6337
        response to organic substance 3864
          response to organic cyclic compound 1451
            response to isoquinoline alkaloid 60
              cellular response to isoquinoline alkaloid + 10
              response to codeine + 1
              response to dextromethorphan + 0
              response to morphine + 58
Path 2
Term Annotations click to browse term
  biological_process 20020
    response to stimulus 10580
      response to chemical 6337
        response to organic substance 3864
          response to organonitrogen compound 1456
            response to alkaloid 184
              response to isoquinoline alkaloid 60
                cellular response to isoquinoline alkaloid + 10
                response to codeine + 1
                response to dextromethorphan + 0
                response to morphine + 58
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.