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ONTOLOGY REPORT - ANNOTATIONS


Term:vascular associated smooth muscle contraction
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Accession:GO:0014829 term browser browse the term
Definition:A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion.
Synonyms:exact_synonym: vascular smooth muscle contraction


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vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle IEA
ISO
GO_REF:0000107
MGI:3665248 (MGI:3665239|PMID:11053242)
Ensembl
RGD
PMID:11053242 GO_REF:0000107, MGI:3665239 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actg2 actin gamma 2, smooth muscle IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Comp cartilage oligomeric matrix protein IEA
ISO
GO_REF:0000107
MGI:2180787 (MGI:5824640|PMID:27498005)
Ensembl
RGD
PMID:27498005 GO_REF:0000107, MGI:5824640 NCBI chr16:20,798,437...20,807,070
Ensembl chr16:20,798,437...20,807,070
JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 IMP RGD PMID:18348285 RGD:2314690 NCBI chr 2:244,258,550...244,370,983
Ensembl chr 2:244,258,550...244,370,983
JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO (MGI:1927695|PMID:10967099) RGD PMID:10967099 MGI:1927695 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
artery smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IDA RGD PMID:21076237 RGD:5129195 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Bbs2 Bardet-Biedl syndrome 2 ISO MGI:3521669 (MGI:4867605|PMID:20852044) RGD PMID:20852044 MGI:4867605 NCBI chr19:11,385,921...11,421,523
Ensembl chr19:11,386,024...11,421,498
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G IMP RGD PMID:18759855 RGD:2308879 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Cd38 CD38 molecule IMP RGD PMID:21431168 RGD:13506923 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Edn1 endothelin 1 ISO
IDA
(PMID:8982507) RGD PMID:8982507, PMID:7586220 RGD:8662314 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 ISO
IEA
(PMID:8982507)
GO_REF:0000107
RGD
Ensembl
PMID:8982507 GO_REF:0000107 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Edn3 endothelin 3 NOT ISO (PMID:8982507) RGD PMID:8982507 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Ednra endothelin receptor type A ISO
IEA
(PMID:8982507)
GO_REF:0000107
RGD
Ensembl
PMID:8982507 GO_REF:0000107 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Grip2 glutamate receptor interacting protein 2 ISO MGI:3035933 (MGI:5609934|PMID:23117660) RGD PMID:23117660 MGI:5609934 NCBI chr 4:123,585,184...123,636,040
Ensembl chr 4:123,586,231...123,636,040
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IMP RGD PMID:14752059 RGD:7257678 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Mkks McKusick-Kaufman syndrome ISO MGI:3526444 (MGI:4867605|PMID:20852044) RGD PMID:20852044 MGI:4867605 NCBI chr 3:129,866,542...129,885,213
Ensembl chr 3:129,866,545...129,884,810
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta IEA
ISO
GO_REF:0000107
MGI:2179831 (MGI:4356406|PMID:19553501)
Ensembl
RGD
PMID:19553501 GO_REF:0000107, MGI:4356406 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:19088082 RGD:10042965 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
negative regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap42 Rho GTPase activating protein 42 ISO MGI:3871380 (MGI:5638847|PMID:24335996) RGD PMID:24335996 MGI:5638847 NCBI chr 8:7,210,999...7,446,215
Ensembl chr 8:7,213,822...7,426,611
JBrowse link
G Dock4 dedicator of cytokinesis 4 ISO (PMID:22158624) RGD PMID:22158624 NCBI chr 6:60,374,839...60,782,648
Ensembl chr 6:60,566,196...60,782,556
JBrowse link
G Dock5 dedicator of cytokinesis 5 ISO (PMID:22158624) RGD PMID:22158624 NCBI chr15:44,449,108...44,627,774
Ensembl chr15:44,453,308...44,627,765
JBrowse link
positive regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 IMP RGD PMID:8428203 RGD:2303387 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Rhoa ras homolog family member A ISO (MGI:5638847|PMID:24335996) RGD PMID:24335996 MGI:5638847 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2b adrenoceptor alpha 2B IMP RGD PMID:18054907 RGD:2313547 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 ISS
ISO
GO_REF:0000024
(MGI:6282934|PMID:24805951)
UniProt
RGD
PMID:24805951 GO_REF:0000024, MGI:6282934 NCBI chr 7:41,114,606...41,223,138
Ensembl chr 7:41,114,697...41,220,579
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IMP inhibition decreases both calcium-stimulated and unstimulated myogenic tone in middle cerebral arteries (p<0.001) RGD PMID:10198244 RGD:2293329 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G P2rx1 purinergic receptor P2X 1 ISO MGI:2181608 (MGI:3694186|PMID:16920810) RGD PMID:16920810 MGI:3694186 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 ISO (MGI:5921050|PMID:26715683) RGD PMID:26715683 MGI:5921050 NCBI chr 5:100,924,621...100,983,412
Ensembl chr 5:100,924,622...100,977,902
JBrowse link
regulation of vein smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr7 5-hydroxytryptamine receptor 7 IMP RGD PMID:31125290 RGD:14696717 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
vein smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 ISO
IBA
(PMID:9422810)
PMID:21873635
RGD PMID:9422810, PMID:21873635 RGD:13792537 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:8982507), (PMID:9422810)
Ensembl
RGD
PMID:8982507, PMID:9422810, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Edn3 endothelin 3 ISO
IBA
(PMID:8982507)
PMID:21873635
RGD PMID:8982507, PMID:21873635 RGD:13792537 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Ednrb endothelin receptor type B ISO (PMID:8982507) RGD PMID:8982507 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    multicellular organismal process 9047
      system process 3456
        muscle system process 461
          muscle contraction 336
            smooth muscle contraction 123
              vascular associated smooth muscle contraction 30
                artery smooth muscle contraction + 13
                negative regulation of vascular associated smooth muscle contraction + 3
                positive regulation of vascular associated smooth muscle contraction + 2
                regulation of vascular associated smooth muscle contraction + 11
                vein smooth muscle contraction + 5
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological quality 4280
        regulation of anatomical structure size 621
          regulation of tube size 189
            regulation of tube diameter 188
              blood vessel diameter maintenance 188
                negative regulation of blood vessel diameter 117
                  vasoconstriction 109
                    vascular associated smooth muscle contraction 30
                      artery smooth muscle contraction + 13
                      negative regulation of vascular associated smooth muscle contraction + 3
                      positive regulation of vascular associated smooth muscle contraction + 2
                      regulation of vascular associated smooth muscle contraction + 11
                      vein smooth muscle contraction + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.