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ONTOLOGY REPORT - ANNOTATIONS


Term:myotube differentiation
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Accession:GO:0014902 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


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myotube differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Avpr1a arginine vasopressin receptor 1A JBrowse link 7 67,341,366 67,345,290 RGD:2300341
G Barx2 BARX homeobox 2 JBrowse link 8 32,950,878 33,018,245 RGD:1624291
RGD:1600115
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:1624291
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 JBrowse link 17 81,173,238 81,196,012 RGD:1624291
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:1624291
RGD:1600115
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:1624291
G Myef2 myelin expression factor 2 JBrowse link 3 117,353,490 117,389,582 RGD:1624291
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:1624291
RGD:9686131
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:1624291
G Pld3 phospholipase D family, member 3 JBrowse link 1 84,339,269 84,361,686 RGD:1600115
RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:1624291
RGD:1600115
G Sort1 sortilin 1 JBrowse link 2 211,078,092 211,156,312 RGD:1624291
RGD:1600115
G Stim1 stromal interaction molecule 1 JBrowse link 1 167,373,894 167,533,412 RGD:1624291
RGD:1600115
G Trdn triadin JBrowse link 1 25,403,390 25,787,664 RGD:634424
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrb3 adhesion G protein-coupled receptor B3 JBrowse link 9 31,280,623 32,022,535 RGD:1624291
RGD:1600115
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:1624291
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:1624291
RGD:1600115
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1298731
G Cast calpastatin JBrowse link 2 1,452,111 1,561,669 RGD:1298731
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
RGD:1600115
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:1624291
RGD:1600115
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B JBrowse link 1 85,112,819 85,120,840 RGD:1624291
RGD:1600115
G Fer1l5 fer-1-like family member 5 JBrowse link 9 42,943,362 42,998,126 RGD:1600115
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
RGD:1600115
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:1624291
G Mymk myomaker, myoblast fusion factor JBrowse link 3 5,608,243 5,617,689 RGD:1624291
G Mymx myomixer, myoblast fusion factor JBrowse link 9 17,781,397 17,783,074 RGD:1624291
RGD:13792537
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
RGD:1600115
G Myof myoferlin JBrowse link 1 256,585,410 256,734,727 RGD:1600115
G Neo1 neogenin 1 JBrowse link 8 63,649,871 63,756,394 RGD:1624291
G Nphs1 NPHS1 adhesion molecule, nephrin JBrowse link 1 88,922,346 88,950,560 RGD:1600115
RGD:1624291
G Pitx2 paired-like homeodomain 2 JBrowse link 2 233,602,732 233,621,059 RGD:1624291
G Plekho1 pleckstrin homology domain containing O1 JBrowse link 2 198,112,104 198,120,202 RGD:1624291
RGD:1600115
G Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 JBrowse link 3 45,683,773 45,917,687 RGD:1624291
RGD:1600115
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
RGD:1600115
myoblast fusion involved in skeletal muscle regeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:1600115
RGD:1624291
G Cd9 CD9 molecule JBrowse link 4 157,977,163 158,010,091 RGD:1600115
RGD:1624291
G Mymk myomaker, myoblast fusion factor JBrowse link 3 5,608,243 5,617,689 RGD:1624291
G Mymx myomixer, myoblast fusion factor JBrowse link 9 17,781,397 17,783,074 RGD:1624291
G Ptgfrn prostaglandin F2 receptor inhibitor JBrowse link 2 203,423,143 203,494,391 RGD:1600115
RGD:1624291
myotube cell development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:1624291
RGD:1600115
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
RGD:1600115
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:1624291
RGD:1600115
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:1624291
G Smyd3 SET and MYND domain containing 3 JBrowse link 13 97,330,120 97,807,813 RGD:1624291
myotube differentiation involved in skeletal muscle regeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl9 BCL9, transcription coactivator JBrowse link 2 199,334,644 199,420,083 RGD:1624291
RGD:1600115
G Klf5 Kruppel-like factor 5 JBrowse link 15 83,703,796 83,722,921 RGD:1624291
RGD:1600115
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
RGD:1600115
negative regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:1624291
RGD:1600115
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:1624291
G Il36g interleukin 36, gamma JBrowse link 3 1,285,658 1,291,836 RGD:1624291
negative regulation of myotube differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ankrd2 ankyrin repeat domain 2 JBrowse link 1 261,281,859 261,291,307 RGD:1624291
RGD:1600115
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:1580249
G Bhlha15 basic helix-loop-helix family, member a15 JBrowse link 12 12,403,385 12,409,103 RGD:1624291
RGD:1600115
G Bhlhe41 basic helix-loop-helix family, member e41 JBrowse link 4 180,230,742 180,235,138 RGD:1624291
RGD:1600115
G Ccn3 cellular communication network factor 3 JBrowse link 7 94,375,134 94,382,154 RGD:1624291
RGD:1600115
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:9587764
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:1624291
G Hdac3 histone deacetylase 3 JBrowse link 18 31,073,057 31,094,347 RGD:1624291
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:1624291
RGD:1600115
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:1624291
RGD:1600115
G Myocd myocardin JBrowse link 10 51,682,053 51,781,458 RGD:1624291
RGD:1600115
G Nkx2-5 NK2 homeobox 5 JBrowse link 10 16,635,989 16,638,758 RGD:1624291
RGD:1600115
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
RGD:1600115
G Plpp7 phospholipid phosphatase 7 (inactive) JBrowse link 3 11,114,551 11,130,427 RGD:1624291
RGD:1600115
G Tmem119 transmembrane protein 119 JBrowse link 12 48,598,498 48,605,704 RGD:1600115
RGD:1624291
G Trim72 tripartite motif containing 72 JBrowse link 1 199,450,042 199,457,902 RGD:1624291
RGD:1600115
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
neuromuscular junction development, skeletal muscle fiber term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pmp22 peripheral myelin protein 22 JBrowse link 10 49,538,588 49,568,583 RGD:1624291
positive regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 7 115,766,484 115,828,514 RGD:1624291
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:13792659
G Cd53 Cd53 molecule JBrowse link 2 209,489,279 209,537,098 RGD:1624291
RGD:1600115
G Cxcl12 C-X-C motif chemokine ligand 12 JBrowse link 4 149,261,044 149,273,891 RGD:1624291
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:1624291
RGD:1600115
G Ehd1 EH-domain containing 1 JBrowse link 1 221,644,867 221,667,242 RGD:1624291
RGD:1600115
G Ehd2 EH-domain containing 2 JBrowse link 1 77,847,599 77,865,870 RGD:1624291
RGD:1600115
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
RGD:1600115
G Flt3lg fms-related tyrosine kinase 3 ligand JBrowse link 1 101,126,006 101,131,413 RGD:1624291
RGD:1600115
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:1624291
RGD:1600115
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:1624291
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1600115
RGD:1624291
G Myf5 myogenic factor 5 JBrowse link 7 49,729,533 49,732,974 RGD:13792537
G Myf6 myogenic factor 6 JBrowse link 7 49,739,643 49,741,490 RGD:13792537
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
RGD:13792537
RGD:1600115
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:13792537
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:1624291
RGD:1600115
G Ripor2 RHO family interacting cell polarization regulator 2 JBrowse link 17 42,324,594 42,549,907 RGD:1624291
RGD:1600115
G Scgb3a1 secretoglobin, family 3A, member 1 JBrowse link 10 35,133,561 35,134,868 RGD:1624291
RGD:13792537
G Tnfsf14 TNF superfamily member 14 JBrowse link 9 9,761,363 9,765,461 RGD:1624291
RGD:1600115
positive regulation of myotube differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1624291
RGD:1600115
G Csrp3 cysteine and glycine rich protein 3 JBrowse link 1 104,147,205 104,166,389 RGD:10047266
G Maml1 mastermind-like transcriptional coactivator 1 JBrowse link 10 35,765,196 35,801,375 RGD:1624291
RGD:1600115
G Mamstr MEF2 activating motif and SAP domain containing transcriptional regulator JBrowse link 1 101,621,733 101,628,379 RGD:1624291
RGD:1600115
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1624291
RGD:1600115
G Mmp14 matrix metallopeptidase 14 JBrowse link 15 33,074,441 33,083,666 RGD:1624291
RGD:1600115
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
RGD:1600115
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:1624291
RGD:1600115
G Neu2 neuraminidase 2 JBrowse link 9 94,702,095 94,724,903 RGD:2316563
G Rbm24 RNA binding motif protein 24 JBrowse link 17 18,671,037 18,682,876 RGD:1624291
G Smyd1 SET and MYND domain containing 1 JBrowse link 4 99,071,122 99,125,143 RGD:1624291
RGD:1600115
G Thra thyroid hormone receptor alpha JBrowse link 10 86,657,285 86,684,935 RGD:1624291
positive regulation of skeletal muscle fiber development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actn3 actinin alpha 3 JBrowse link 1 220,120,532 220,136,460 RGD:1624291
RGD:1600115
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:1600115
G Lmod3 leiomodin 3 JBrowse link 4 129,604,378 129,619,136 RGD:1624291
RGD:1600115
G Myf5 myogenic factor 5 JBrowse link 7 49,729,533 49,732,974 RGD:13792537
G Myf6 myogenic factor 6 JBrowse link 7 49,739,643 49,741,490 RGD:13792537
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:13792537
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:1624291
RGD:13792537
RGD:1600115
G Shox2 short stature homeobox 2 JBrowse link 2 164,118,175 164,126,783 RGD:1624291
positive regulation of skeletal muscle fiber differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rbm24 RNA binding motif protein 24 JBrowse link 17 18,671,037 18,682,876 RGD:1624291
RGD:1600115
positive regulation of tongue muscle cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 JBrowse link 4 116,261,796 116,278,615 RGD:1624291
RGD:1600115
G Tbx1 T-box transcription factor 1 JBrowse link 11 86,552,022 86,561,647 RGD:1624291
RGD:1600115
regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:1624291
RGD:1600115
regulation of myotube differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmpk DM1 protein kinase JBrowse link 1 79,988,096 79,999,358 RGD:1624291
RGD:1600115
G Fbxo22 F-box protein 22 JBrowse link 8 59,770,032 59,786,061 RGD:1624291
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:1624291
G Rbm24 RNA binding motif protein 24 JBrowse link 17 18,671,037 18,682,876 RGD:1624291
G Rbm38 RNA binding motif protein 38 JBrowse link 3 171,037,891 171,050,500 RGD:1624291
RGD:1600115
G Sik1 salt-inducible kinase 1 JBrowse link 20 10,670,747 10,680,279 RGD:1624291
RGD:1600115
regulation of skeletal muscle fiber development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fbxo22 F-box protein 22 JBrowse link 8 59,770,032 59,786,061 RGD:1624291
RGD:1600115
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:1624291
RGD:1600115
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:1624291
G Hdac9 histone deacetylase 9 JBrowse link 6 53,487,367 54,358,694 RGD:1624291
G Naca nascent polypeptide associated complex subunit alpha JBrowse link 7 2,458,283 2,470,674 RGD:1624291
regulation of skeletal muscle fiber differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nln neurolysin JBrowse link 2 34,086,970 34,185,835 RGD:1624291
RGD:1600115
skeletal muscle fiber development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta1 actin, alpha 1, skeletal muscle JBrowse link 19 56,674,072 56,677,084 RGD:1624291
RGD:1600115
G Actn1 actinin, alpha 1 JBrowse link 6 103,376,557 103,470,497 RGD:1600115
G Bin3 bridging integrator 3 JBrowse link 15 51,799,339 51,818,697 RGD:1624291
RGD:1600115
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:1624291
G Cav2 caveolin 2 JBrowse link 4 44,573,264 44,580,640 RGD:1624291
RGD:1600115
G Dner delta/notch-like EGF repeat containing JBrowse link 9 91,965,866 92,291,172 RGD:1624291
RGD:1600115
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:1624291
RGD:1600115
G Homer1 homer scaffold protein 1 JBrowse link 2 22,909,550 23,012,303 RGD:1624291
RGD:1600115
G Kel Kell metallo-endopeptidase (Kell blood group) JBrowse link 4 70,979,504 70,996,920 RGD:1624291
RGD:1600115
G Klhl40 kelch-like family member 40 JBrowse link 8 130,416,265 130,421,871 RGD:1624291
RGD:13792537
G Klhl41 kelch-like family member 41 JBrowse link 3 55,910,177 55,923,303 RGD:1600115
G Lmod3 leiomodin 3 JBrowse link 4 129,604,378 129,619,136 RGD:1624291
RGD:1600115
G Myod1 myogenic differentiation 1 JBrowse link 1 102,396,538 102,399,248 RGD:1624291
RGD:1600115
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:1624291
G Myorg myogenesis regulating glycosidase JBrowse link 5 57,873,404 57,882,008 RGD:1624291
RGD:13792537
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:1624291
G P2rx2 purinergic receptor P2X 2 JBrowse link 12 52,397,666 52,401,005 RGD:1624291
RGD:1600115
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:1624291
RGD:1600115
G Rcan1 regulator of calcineurin 1 JBrowse link 11 32,539,689 32,620,274 RGD:1624291
G Ripor2 RHO family interacting cell polarization regulator 2 JBrowse link 17 42,324,594 42,549,907 RGD:1600115
G Ryr1 ryanodine receptor 1 JBrowse link 1 87,959,596 88,066,252 RGD:1600115
RGD:1624291
G Selenon selenoprotein N JBrowse link 5 152,748,497 152,765,489 RGD:1624291
RGD:13792537
G Six1 SIX homeobox 1 JBrowse link 6 95,929,060 95,934,296 RGD:13792537
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:1624291
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:1624291
RGD:1600115
G Stac3 SH3 and cysteine rich domain 3 JBrowse link 7 70,807,427 70,815,271 RGD:1624291
RGD:1600115
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:1624291
RGD:1600115
G Xk X-linked Kx blood group JBrowse link X 14,497,376 14,534,479 RGD:1624291
RGD:1600115
skeletal muscle fiber differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Klhl40 kelch-like family member 40 JBrowse link 8 130,416,265 130,421,871 RGD:1624291
G Six4 SIX homeobox 4 JBrowse link 6 95,984,868 95,999,709 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    cellular process 17226
      cellular developmental process 4428
        cell differentiation 4205
          muscle cell differentiation 408
            striated muscle cell differentiation 330
              myotube differentiation 128
                myoblast fusion + 47
                myotube cell development + 43
                myotube differentiation involved in skeletal muscle regeneration + 8
                negative regulation of myotube differentiation + 20
                positive regulation of myotube differentiation + 37
                regulation of myotube differentiation + 64
                skeletal muscle fiber differentiation + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.