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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3gat3 beta-1,3-glucuronyltransferase 3 JBrowse link 1 225,120,061 225,126,579 RGD:1624291
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Ext2 exostosin glycosyltransferase 2 JBrowse link 3 82,602,784 82,734,557 RGD:1624291
G Extl3 exostosin-like glycosyltransferase 3 JBrowse link 15 48,420,419 48,465,171 RGD:1624291
G Glce glucuronic acid epimerase JBrowse link 8 67,006,588 67,073,723 RGD:1624291
RGD:13792537
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 9 42,620,006 42,659,184 RGD:1624291
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:1580511
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link 18 55,951,497 56,014,107 RGD:12907548
G Ndst2 N-deacetylase and N-sulfotransferase 2 JBrowse link 15 3,995,797 4,006,491 RGD:1624291
G Ndst3 N-deacetylase and N-sulfotransferase 3 JBrowse link 2 227,736,491 227,903,657 RGD:1624291
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link 14 44,479,614 44,502,845 RGD:1600115
RGD:1624291
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Xylt1 xylosyltransferase 1 JBrowse link 1 186,939,698 187,264,758 RGD:1600115
RGD:13792537
RGD:1624291
G Xylt2 xylosyltransferase 2 JBrowse link 10 82,386,003 82,399,485 RGD:1600115
RGD:13792537
RGD:1624291
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 2 250,467,428 250,600,517 RGD:13792537
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 JBrowse link 20 40,236,437 40,545,502 RGD:1624291
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 9 42,620,006 42,659,184 RGD:1624291
RGD:13792537
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 JBrowse link X 138,675,326 138,972,774 RGD:1624291
RGD:13792537
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 JBrowse link 15 104,448,479 105,254,540 RGD:1624291
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:1624291
G Ext2 exostosin glycosyltransferase 2 JBrowse link 3 82,602,784 82,734,557 RGD:1624291
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 2 250,467,428 250,600,517 RGD:1624291
RGD:13792537
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link 18 55,951,497 56,014,107 RGD:13792537
G Ndst2 N-deacetylase and N-sulfotransferase 2 JBrowse link 15 3,995,797 4,006,491 RGD:13792537
G Ndst3 N-deacetylase and N-sulfotransferase 3 JBrowse link 2 227,736,491 227,903,657 RGD:1624291
RGD:13792537
G Ndst4 N-deacetylase and N-sulfotransferase 4 JBrowse link 2 229,170,781 229,496,732 RGD:13792537
G NEWGENE_1304700 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 JBrowse link 15 3,750,058 3,760,616 RGD:13792537
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Pxylp1 2-phosphoxylose phosphatase 1 JBrowse link 8 104,724,728 104,790,639 RGD:1624291
RGD:1600115
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      primary metabolic process 10563
        protein metabolic process 6070
          glycoprotein metabolic process 357
            proteoglycan metabolic process 74
              proteoglycan biosynthetic process 49
                heparan sulfate proteoglycan biosynthetic process 23
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 8
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      organic substance metabolic process 11297
        macromolecule metabolic process 9765
          cellular macromolecule metabolic process 8223
            cellular macromolecule biosynthetic process 4805
              glycoprotein biosynthetic process 292
                proteoglycan biosynthetic process 49
                  heparan sulfate proteoglycan biosynthetic process 23
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 8
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.