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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3galt6 beta-1,3-galactosyltransferase 6 JBrowse link NW_004955486 9,553,765 9,555,675 RGD:9068941
G B3gat3 beta-1,3-glucuronyltransferase 3 JBrowse link NW_004955599 573,982 578,032 RGD:9068941
G Dse dermatan sulfate epimerase JBrowse link NW_004955526 348,673 393,328 RGD:9068941
G Ext1 exostosin glycosyltransferase 1 JBrowse link NW_004955417 23,798,044 24,067,759 RGD:9068941
G Ext2 exostosin glycosyltransferase 2 JBrowse link NW_004955422 3,303,948 3,438,381 RGD:9068941
G Extl2 exostosin like glycosyltransferase 2 JBrowse link NW_004955435 5,509,648 5,527,751 RGD:9068941
G Extl3 exostosin like glycosyltransferase 3 JBrowse link NW_004955403 51,076,323 51,102,435 RGD:9068941
G Glce glucuronic acid epimerase JBrowse link NW_004955450 7,149,721 7,226,835 RGD:9068941
G Ndst3 N-deacetylase and N-sulfotransferase 3 JBrowse link NW_004955428 21,671,432 21,853,492 RGD:9068941
G Ugdh UDP-glucose 6-dehydrogenase JBrowse link NW_004955443 7,868,893 7,882,136 RGD:9068941
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link NW_004955468 12,162,084 12,189,322 RGD:9068941
G Xylt1 xylosyltransferase 1 JBrowse link NW_004955442 1,787,338 2,042,523 RGD:9068941
G Xylt2 xylosyltransferase 2 JBrowse link NW_004955451 11,347,254 11,354,489 RGD:9068941
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link NW_004955423 7,090,246 7,253,608 RGD:9068941
G Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 JBrowse link NW_004955526 2,418,217 2,652,025 RGD:9068941
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link NW_004955459 2,273,100 2,310,993 RGD:9068941
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 JBrowse link NW_004955473 2,002,475 2,291,868 RGD:9068941
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 JBrowse link NW_004955404 13,461,906 14,129,089 RGD:9068941
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link NW_004955403 43,178,520 43,347,121 RGD:9068941
G Ext1 exostosin glycosyltransferase 1 JBrowse link NW_004955417 23,798,044 24,067,759 RGD:9068941
G Ext2 exostosin glycosyltransferase 2 JBrowse link NW_004955422 3,303,948 3,438,381 RGD:9068941
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link NW_004955423 7,090,246 7,253,608 RGD:9068941
G Ndst1 N-deacetylase and N-sulfotransferase 1 JBrowse link NW_004955415 4,017,142 4,078,927 RGD:9068941
G Ndst2 N-deacetylase and N-sulfotransferase 2 JBrowse link NW_004955437 18,090,198 18,099,328 RGD:9068941
G Ndst3 N-deacetylase and N-sulfotransferase 3 JBrowse link NW_004955428 21,671,432 21,853,492 RGD:9068941
G Ndst4 N-deacetylase and N-sulfotransferase 4 JBrowse link NW_004955428 24,376,587 24,636,555 RGD:9068941
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin beta 1 JBrowse link NW_004955420 29,030,716 29,047,447 RGD:9068941
G Pxylp1 2-phosphoxylose phosphatase 1 JBrowse link NW_004955508 4,390,647 4,449,782 RGD:9068941
G Tcf7l2 transcription factor 7 like 2 JBrowse link NW_004955431 18,020,309 18,207,926 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14616
    metabolic process 10124
      primary metabolic process 9148
        protein metabolic process 5281
          glycoprotein metabolic process 391
            proteoglycan metabolic process 88
              proteoglycan biosynthetic process 62
                heparan sulfate proteoglycan biosynthetic process 25
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 8
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 14616
    metabolic process 10124
      organic substance metabolic process 9625
        macromolecule metabolic process 8332
          cellular macromolecule metabolic process 7276
            cellular macromolecule biosynthetic process 4225
              glycoprotein biosynthetic process 320
                proteoglycan biosynthetic process 62
                  heparan sulfate proteoglycan biosynthetic process 25
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 8
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.