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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3GAT3 beta-1,3-glucuronyltransferase 3 JBrowse link 18 54,020,547 54,025,264 RGD:13508589
G EXT2 exostosin glycosyltransferase 2 JBrowse link 18 44,987,310 45,122,339 RGD:13508589
G EXTL3 exostosin like glycosyltransferase 3 JBrowse link 25 28,788,803 28,833,964 RGD:13508589
G GLCE glucuronic acid epimerase JBrowse link 30 33,093,318 33,208,754 RGD:13508589
G UGDH UDP-glucose 6-dehydrogenase JBrowse link 3 72,935,532 72,964,151 RGD:13508589
G XYLT1 xylosyltransferase 1 JBrowse link 6 26,742,853 27,041,666 RGD:13508589
G XYLT2 xylosyltransferase 2 JBrowse link 9 26,316,812 26,329,333 RGD:13508589
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 6 61,124,393 61,298,912 RGD:13508589
G HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 JBrowse link 12 70,137,232 70,387,797 RGD:13508589
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 19 22,343,193 22,372,464 RGD:13508589
G HS6ST2 heparan sulfate 6-O-sulfotransferase 2 JBrowse link X 103,529,705 103,816,049 RGD:13508589
G HS6ST3 heparan sulfate 6-O-sulfotransferase 3 JBrowse link 22 47,257,641 47,265,143 RGD:13508589
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EXT1 exostosin glycosyltransferase 1 JBrowse link 13 17,172,497 17,457,084 RGD:13508589
G EXT2 exostosin glycosyltransferase 2 JBrowse link 18 44,987,310 45,122,339 RGD:13508589
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 6 61,124,393 61,298,912 RGD:13508589
G NDST1 N-deacetylase and N-sulfotransferase 1 JBrowse link 4 58,580,231 58,639,750 RGD:13508589
G NDST2 N-deacetylase and N-sulfotransferase 2 JBrowse link 4 24,235,051 24,243,411 RGD:13508589
G NDST3 N-deacetylase and N-sulfotransferase 3 JBrowse link 32 37,309,829 37,487,977 RGD:13508589
G NDST4 N-deacetylase and N-sulfotransferase 4 JBrowse link 32 34,347,865 34,606,763 RGD:13508589
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CTNNB1 catenin beta 1 JBrowse link 23 10,559,722 10,572,933 RGD:13508589
G TCF7L2 transcription factor 7 like 2 JBrowse link 28 23,966,079 24,162,775 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14457
    metabolic process 9082
      primary metabolic process 8118
        protein metabolic process 4411
          glycoprotein metabolic process 281
            proteoglycan metabolic process 53
              proteoglycan biosynthetic process 38
                heparan sulfate proteoglycan biosynthetic process 19
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 2
                  regulation of heparan sulfate proteoglycan biosynthetic process + 2
Path 2
Term Annotations click to browse term
  biological_process 14457
    metabolic process 9082
      organic substance metabolic process 8574
        macromolecule metabolic process 7351
          cellular macromolecule metabolic process 6224
            cellular macromolecule biosynthetic process 3478
              glycoprotein biosynthetic process 233
                proteoglycan biosynthetic process 38
                  heparan sulfate proteoglycan biosynthetic process 19
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 2
                    regulation of heparan sulfate proteoglycan biosynthetic process + 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.