Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
go back to main search page
Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


show annotations for term's descendants       view all columns           Sort by:
 
heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3GALT6 beta-1,3-galactosyltransferase 6 JBrowse link 1 1,232,237 1,235,041 RGD:2290271
G B3GAT3 beta-1,3-glucuronyltransferase 3 JBrowse link 11 62,615,296 62,621,986 RGD:2290271
G DSE dermatan sulfate epimerase JBrowse link 6 116,254,171 116,444,861 RGD:2290271
G EXT1 exostosin glycosyltransferase 1 JBrowse link 8 117,794,490 118,111,826 RGD:2290271
G EXT2 exostosin glycosyltransferase 2 JBrowse link 11 44,095,659 44,251,981 RGD:2290271
G EXTL2 exostosin like glycosyltransferase 2 JBrowse link 1 100,872,372 100,895,411 RGD:2290271
G EXTL3 exostosin like glycosyltransferase 3 JBrowse link 8 28,607,736 28,755,599 RGD:2290271
G GLCE glucuronic acid epimerase JBrowse link 15 69,160,555 69,272,209 RGD:2290271
G HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 JBrowse link 17 14,301,081 14,349,406 RGD:2290271
G NDST3 N-deacetylase and N-sulfotransferase 3 JBrowse link 4 118,033,322 118,258,945 RGD:2290271
G UGDH UDP-glucose 6-dehydrogenase JBrowse link 4 39,498,755 39,527,439 RGD:2290271
G VANGL2 VANGL planar cell polarity protein 2 JBrowse link 1 160,400,564 160,428,674 RGD:2290271
G XYLT1 xylosyltransferase 1 JBrowse link 16 17,101,769 17,470,960 RGD:2290271
G XYLT2 xylosyltransferase 2 JBrowse link 17 50,346,126 50,361,185 RGD:2290271
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 1 86,914,635 87,109,982 RGD:2290271
G HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 JBrowse link 17 14,301,081 14,349,406 RGD:2290271
G HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 JBrowse link 6 114,055,586 114,342,395 RGD:2290271
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 2 128,265,480 128,318,868 RGD:2290271
G HS6ST2 heparan sulfate 6-O-sulfotransferase 2 JBrowse link X 132,626,012 132,961,370 RGD:2290271
G HS6ST3 heparan sulfate 6-O-sulfotransferase 3 JBrowse link 13 96,090,634 96,839,562 RGD:2290271
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 JBrowse link 8 19,404,161 19,758,029 RGD:2290271
G EXT1 exostosin glycosyltransferase 1 JBrowse link 8 117,794,490 118,111,826 RGD:2290271
G EXT2 exostosin glycosyltransferase 2 JBrowse link 11 44,095,659 44,251,981 RGD:2290271
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 1 86,914,635 87,109,982 RGD:2290271
G NDST1 N-deacetylase and N-sulfotransferase 1 JBrowse link 5 150,497,779 150,558,211 RGD:2290271
G NDST2 N-deacetylase and N-sulfotransferase 2 JBrowse link 10 73,801,916 73,811,820 RGD:2290271
G NDST3 N-deacetylase and N-sulfotransferase 3 JBrowse link 4 118,033,322 118,258,945 RGD:2290271
G NDST4 N-deacetylase and N-sulfotransferase 4 JBrowse link 4 114,824,122 115,114,133 RGD:2290271
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CTNNB1 catenin beta 1 JBrowse link 3 41,199,422 41,240,445 RGD:2290271
G PXYLP1 2-phosphoxylose phosphatase 1 JBrowse link 3 141,231,825 141,294,924 RGD:2290271
G TCF7L2 transcription factor 7 like 2 JBrowse link 10 112,950,247 113,167,678 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18104
    metabolic process 11847
      primary metabolic process 10695
        protein metabolic process 5970
          glycoprotein metabolic process 418
            proteoglycan metabolic process 90
              proteoglycan biosynthetic process 64
                heparan sulfate proteoglycan biosynthetic process 26
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 6
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 8
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 18104
    metabolic process 11847
      organic substance metabolic process 11269
        macromolecule metabolic process 9763
          cellular macromolecule metabolic process 8494
            cellular macromolecule biosynthetic process 4988
              glycoprotein biosynthetic process 345
                proteoglycan biosynthetic process 64
                  heparan sulfate proteoglycan biosynthetic process 26
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 6
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 8
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.