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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3gat3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) JBrowse link 19 8,920,374 8,927,236 RGD:2290270
G Ext1 exostosin glycosyltransferase 1 JBrowse link 15 53,068,261 53,346,183 RGD:2290270
G Ext2 exostosin glycosyltransferase 2 JBrowse link 2 93,695,631 93,822,568 RGD:2290270
G Extl3 exostosin-like glycosyltransferase 3 JBrowse link 14 65,052,059 65,149,899 RGD:2290270
G Glce glucuronyl C5-epimerase JBrowse link 9 62,057,244 62,122,609 RGD:2290270
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 1 36,068,400 36,106,446 RGD:2290270
G Lipc lipase, hepatic JBrowse link 9 70,798,128 70,952,221 RGD:2290270
G Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 JBrowse link 18 60,684,494 60,749,035 RGD:2290270
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 JBrowse link 14 20,723,730 20,734,570 RGD:2290270
G Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 JBrowse link 3 123,526,166 123,691,174 RGD:2290270
G Ugdh UDP-glucose dehydrogenase JBrowse link 5 65,413,207 65,435,842 RGD:2290270
G Vangl2 VANGL planar cell polarity 2 JBrowse link 1 172,000,960 172,027,318 RGD:2290270
G Xylt1 xylosyltransferase 1 JBrowse link 7 117,380,979 117,667,630 RGD:2290270
G Xylt2 xylosyltransferase II JBrowse link 11 94,663,845 94,677,518 RGD:2290270
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 3 144,429,701 144,570,216 RGD:2290270
G Hs3st5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 JBrowse link 10 36,506,590 36,834,397 RGD:2290270
G Hs6st1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 1 36,068,400 36,106,446 RGD:2290270
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 JBrowse link X 51,386,637 51,681,705 RGD:2290270
G Hs6st3 heparan sulfate 6-O-sulfotransferase 3 JBrowse link 14 119,137,516 119,869,815 RGD:2290270
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ext1 exostosin glycosyltransferase 1 JBrowse link 15 53,068,261 53,346,183 RGD:2290270
G Ext2 exostosin glycosyltransferase 2 JBrowse link 2 93,695,631 93,822,568 RGD:2290270
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 3 144,429,701 144,570,216 RGD:2290270
G Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 JBrowse link 18 60,684,494 60,749,035 RGD:2290270
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 JBrowse link 14 20,723,730 20,734,570 RGD:2290270
G Ndst3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 JBrowse link 3 123,526,166 123,691,174 RGD:2290270
G Ndst4 N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4 JBrowse link 3 125,404,029 125,728,351 RGD:2290270
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctnnb1 catenin (cadherin associated protein), beta 1 JBrowse link 9 120,933,400 120,960,507 RGD:2290270
G Pxylp1 2-phosphoxylose phosphatase 1 JBrowse link 9 96,823,336 96,892,688 RGD:2290270
G Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box JBrowse link 19 55,741,797 55,933,659 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23155
    metabolic process 10896
      primary metabolic process 9539
        protein metabolic process 5314
          glycoprotein metabolic process 333
            proteoglycan metabolic process 72
              proteoglycan biosynthetic process 48
                heparan sulfate proteoglycan biosynthetic process 22
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                  regulation of heparan sulfate proteoglycan biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 23155
    metabolic process 10896
      organic substance metabolic process 10351
        macromolecule metabolic process 8879
          cellular macromolecule metabolic process 7349
            cellular macromolecule biosynthetic process 4180
              glycoprotein biosynthetic process 273
                proteoglycan biosynthetic process 48
                  heparan sulfate proteoglycan biosynthetic process 22
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 3
                    regulation of heparan sulfate proteoglycan biosynthetic process + 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.