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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3GAT3 beta-1,3-glucuronyltransferase 3 JBrowse link 2 9,119,621 9,125,081 RGD:14298760
G EXT2 exostosin glycosyltransferase 2 JBrowse link 2 18,099,790 18,239,229 RGD:14298760
G EXTL3 exostosin like glycosyltransferase 3 JBrowse link 14 12,437,551 12,563,548 RGD:14298760
G GLCE glucuronic acid epimerase JBrowse link 1 167,007,930 167,122,196 RGD:14298760
G UGDH UDP-glucose 6-dehydrogenase JBrowse link 8 30,725,281 30,759,359 RGD:14298760
G VANGL2 VANGL planar cell polarity protein 2 JBrowse link 4 90,051,994 90,080,701 RGD:14298760
G XYLT1 xylosyltransferase 1 JBrowse link 3 27,158,438 27,492,629 RGD:14298760
G XYLT2 xylosyltransferase 2 JBrowse link 12 26,640,802 26,656,809 RGD:14298760
heparan sulfate proteoglycan biosynthetic process, enzymatic modification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 4 129,101,900 129,258,372 RGD:14298760
G HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 JBrowse link 1 79,956,485 80,140,140 RGD:14298760
G HS6ST1 heparan sulfate 6-O-sulfotransferase 1 JBrowse link 15 59,066,448 59,108,780 RGD:14298760
G HS6ST2 heparan sulfate 6-O-sulfotransferase 2 JBrowse link X 108,755,577 109,043,976 RGD:14298760
G HS6ST3 heparan sulfate 6-O-sulfotransferase 3 JBrowse link 11 65,516,180 66,193,410 RGD:14298760
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EXT1 exostosin glycosyltransferase 1 JBrowse link 4 20,645,002 20,935,769 RGD:14298760
G EXT2 exostosin glycosyltransferase 2 JBrowse link 2 18,099,790 18,239,229 RGD:14298760
G HS2ST1 heparan sulfate 2-O-sulfotransferase 1 JBrowse link 4 129,101,900 129,258,372 RGD:14298760
G NDST1 N-deacetylase and N-sulfotransferase 1 JBrowse link 2 151,433,925 151,525,909 RGD:14298760
G NDST2 N-deacetylase and N-sulfotransferase 2 JBrowse link 14 76,525,998 76,534,695 RGD:14298760
G NDST3 N-deacetylase and N-sulfotransferase 3 JBrowse link 8 105,221,344 105,370,067 RGD:14298760
G NDST4 N-deacetylase and N-sulfotransferase 4 JBrowse link 8 107,882,088 108,129,785 RGD:14298760
positive regulation of heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PXYLP1 2-phosphoxylose phosphatase 1 JBrowse link 13 81,951,336 82,049,385 RGD:14298760
G TCF7L2 transcription factor 7 like 2 JBrowse link 14 123,343,695 123,547,332 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15166
    metabolic process 9321
      primary metabolic process 8273
        protein metabolic process 4514
          glycoprotein metabolic process 295
            proteoglycan metabolic process 63
              proteoglycan biosynthetic process 43
                heparan sulfate proteoglycan biosynthetic process 20
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 2
                  regulation of heparan sulfate proteoglycan biosynthetic process + 2
Path 2
Term Annotations click to browse term
  biological_process 15166
    metabolic process 9321
      organic substance metabolic process 8758
        macromolecule metabolic process 7560
          cellular macromolecule metabolic process 6410
            cellular macromolecule biosynthetic process 3589
              glycoprotein biosynthetic process 242
                proteoglycan biosynthetic process 43
                  heparan sulfate proteoglycan biosynthetic process 20
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 5
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 7
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 2
                    regulation of heparan sulfate proteoglycan biosynthetic process + 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.