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ONTOLOGY REPORT - ANNOTATIONS


Term:heparan sulfate proteoglycan biosynthetic process
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Accession:GO:0015012 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Synonyms:exact_synonym: heparan sulfate proteoglycan anabolism;   heparan sulfate proteoglycan biosynthesis;   heparan sulfate proteoglycan formation;   heparan sulfate proteoglycan synthesis;   heparan sulphate proteoglycan biosynthesis;   heparan sulphate proteoglycan biosynthetic process
 related_synonym: heparin proteoglycan biosynthetic process
 xref: RESID:AA0210


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heparan sulfate proteoglycan biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link NW_004936740 228,377 242,318 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 327
    metabolic process 216
      primary metabolic process 202
        protein metabolic process 99
          glycoprotein metabolic process 8
            proteoglycan metabolic process 2
              proteoglycan biosynthetic process 2
                heparan sulfate proteoglycan biosynthetic process 1
                  heparan sulfate proteoglycan biosynthetic process, enzymatic modification 0
                  heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                  heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 0
                  positive regulation of heparan sulfate proteoglycan biosynthetic process + 0
                  regulation of heparan sulfate proteoglycan biosynthetic process + 0
Path 2
Term Annotations click to browse term
  biological_process 327
    metabolic process 216
      organic substance metabolic process 210
        macromolecule metabolic process 178
          cellular macromolecule metabolic process 163
            cellular macromolecule biosynthetic process 97
              glycoprotein biosynthetic process 6
                proteoglycan biosynthetic process 2
                  heparan sulfate proteoglycan biosynthetic process 1
                    heparan sulfate proteoglycan biosynthetic process, enzymatic modification 0
                    heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide 0
                    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process 0
                    positive regulation of heparan sulfate proteoglycan biosynthetic process + 0
                    regulation of heparan sulfate proteoglycan biosynthetic process + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.