Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic vesicle priming
go back to main search page
Accession:GO:0016082 term browser browse the term
Definition:A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
Comment:Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015)


show annotations for term's descendants           Sort by:
 
synaptic vesicle priming term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07053516.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 3:112,346,627...112,361,216 JBrowse link
G Cadps calcium dependent secretion activator IEA
ISO
GO_REF:0000107
MGI:MGI:2443963|UniProtKB:Q8BYR5 (MGI:MGI:3773298|PMID:18022372), (MGI:MGI:4879076|PMID:21040848), (MGI:MGI:5617001|PMID:25374362)
Ensembl
RGD
PMID:18022372, PMID:21040848, PMID:25374362 GO_REF:0000107, MGI:MGI:3773298, MGI:MGI:4879076, MGI:MGI:5617001 NCBI chr15:15,275,489...15,690,575
Ensembl chr15:15,275,541...15,667,778
JBrowse link
G Cadps2 calcium dependent secretion activator 2 ISO MGI:MGI:1350922|UniProtKB:Q80TJ1 (MGI:MGI:4879076|PMID:21040848), (MGI:MGI:5617001|PMID:25374362), (MGI:MGI:6189303|PMID:25437547) RGD PMID:21040848, PMID:25374362, PMID:25437547 MGI:MGI:4879076, MGI:MGI:5617001, MGI:MGI:6189303 NCBI chr 4:50,326,447...50,861,161
Ensembl chr 4:50,326,442...50,860,756
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 ISO (MGI:MGI:5882646|PMID:27253063) RGD PMID:27253063 MGI:MGI:5882646 NCBI chr 4:152,087,393...152,380,023
Ensembl chr 4:152,087,379...152,380,184
JBrowse link
G Erc2 ELKS/RAB6-interacting/CAST family member 2 ISO (MGI:MGI:4415657|PMID:19874790) RGD PMID:19874790 MGI:MGI:4415657 NCBI chr16:3,258,580...4,283,592
Ensembl chr16:3,293,599...3,679,222
JBrowse link
G Napa NSF attachment protein alpha ISO (MGI:MGI:4879076|PMID:21040848) RGD PMID:21040848 MGI:MGI:4879076 NCBI chr 1:77,994,227...78,012,846
Ensembl chr 1:77,994,203...78,012,845
JBrowse link
G Otof otoferlin ISO
IBA
(MGI:MGI:4461353|PMID:20562868)
PMID:21873635
RGD PMID:20562868, PMID:21873635 MGI:MGI:4461353, RGD:13792537 NCBI chr 6:27,328,343...27,424,864
Ensembl chr 6:27,328,406...27,424,864
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 ISO (MGI:MGI:4887275|PMID:21262469), (MGI:MGI:5432438|PMID:22753485) RGD PMID:21262469, PMID:22753485 MGI:MGI:4887275, MGI:MGI:5432438 NCBI chr 9:28,440,408...28,973,246
Ensembl chr 9:28,442,229...28,973,246
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 ISO (MGI:MGI:5432438|PMID:22753485) RGD PMID:22753485 MGI:MGI:5432438 NCBI chr 7:78,091,998...78,594,164
Ensembl chr 7:78,092,037...78,594,138
JBrowse link
G Snap23 synaptosome associated protein 23 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:112,333,972...112,362,960 JBrowse link
G Snap25 synaptosome associated protein 25 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Snap29 synaptosome associated protein 29 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:87,827,633...87,858,107
Ensembl chr11:87,827,651...87,858,107
JBrowse link
G Snap47 synaptosome associated protein 47 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:45,757,196...45,798,734
Ensembl chr10:45,757,197...45,798,715
JBrowse link
G Snca synuclein alpha ISO (PMID:30404828) RGD PMID:30404828 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Stxbp1 syntaxin binding protein 1 ISO (MGI:MGI:3695670|PMID:17110441) RGD PMID:17110441 MGI:MGI:3695670 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a ISO (MGI:MGI:3831988|PMID:19176798) RGD PMID:19176798 MGI:MGI:3831988 NCBI chr 2:198,321,100...198,336,889
Ensembl chr 2:198,321,142...198,336,913
JBrowse link
G Synj1 synaptojanin 1 ISO MGI:MGI:2179801 (MGI:MGI:2447947|PMID:12481038) RGD PMID:12481038 MGI:MGI:2447947 NCBI chr11:31,105,784...31,181,573
Ensembl chr11:31,104,787...31,180,642
JBrowse link
G Unc13a unc-13 homolog A IDA
IBA
ISO
IEA
PMID:21873635
UniProtKB:Q9Z1N9 (MGI:MGI:2158113|PMID:11832228), (MGI:MGI:5617001|PMID:25374362)
GO_REF:0000107
RGD
Ensembl
PMID:11832228, PMID:25374362, PMID:21499244, PMID:21873635 GO_REF:0000107, MGI:MGI:2158113, MGI:MGI:5617001, RGD:5686389, RGD:13792537 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287
JBrowse link
G Unc13b unc-13 homolog B IMP
IBA
ISO
ISS
PMID:22966208
PMID:21873635
MGI:MGI:2449706|UniProtKB:Q4KUS2 (MGI:MGI:2158113|PMID:11832228), (MGI:MGI:2181453|PMID:12070347), (MGI:MGI:5617001|PMID:25374362)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:11832228, PMID:12070347, PMID:25374362, PMID:22966208, PMID:21873635 GO_REF:0000024, MGI:MGI:2158113, MGI:MGI:2181453, MGI:MGI:5617001, RGD:11535109, RGD:13792537 NCBI chr 5:58,505,449...58,714,396
Ensembl chr 5:58,505,500...58,715,576
JBrowse link
G Unc13c unc-13 homolog C IMP
IBA
PMID:22966208
PMID:21873635
ParkinsonsUK-UCL
GO_Central
PMID:22966208, PMID:21873635 RGD:11535109, RGD:13792537 NCBI chr 8:80,202,736...80,656,363
Ensembl chr 8:80,203,609...80,631,926
JBrowse link
positive regulation of synaptic vesicle priming term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rims1 regulating synaptic membrane exocytosis 1 IGI PMID:21262469 ParkinsonsUK-UCL PMID:21262469 RGD:10047275 NCBI chr 9:28,440,408...28,973,246
Ensembl chr 9:28,442,229...28,973,246
JBrowse link
G Unc13b unc-13 homolog B IGI PMID:21262469 ParkinsonsUK-UCL PMID:21262469, PMID:21262469 RGD:10047275, RGD:10047275 NCBI chr 5:58,505,449...58,714,396
Ensembl chr 5:58,505,500...58,715,576
JBrowse link
regulation of synaptic vesicle priming term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Napa NSF attachment protein alpha ISO
IBA
MGI:MGI:104562 (MGI:MGI:4879076|PMID:21040848)
PMID:21873635
RGD PMID:21040848, PMID:21873635 MGI:MGI:4879076, RGD:13792537 NCBI chr 1:77,994,227...78,012,846
Ensembl chr 1:77,994,203...78,012,845
JBrowse link
G Napb NSF attachment protein beta ISO
IBA
IEA
MGI:MGI:104563 (MGI:MGI:4879076|PMID:21040848)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:21040848, PMID:21873635 GO_REF:0000107, MGI:MGI:4879076, RGD:13792537 NCBI chr 3:143,017,571...143,063,904
Ensembl chr 3:143,020,454...143,063,983
JBrowse link
G Rab3a RAB3A, member RAS oncogene family IDA PMID:21689256 UniProt PMID:21689256 RGD:14390056 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206
JBrowse link
G Stx1a syntaxin 1A ISO UniProtKB:O35526|UniProtKB:P61264 (MGI:MGI:5521403|PMID:24133272) RGD PMID:24133272 MGI:MGI:5521403 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Stx1b syntaxin 1B ISO
ISS
UniProtKB:O35526 (MGI:MGI:5521403|PMID:24133272)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:24133272 GO_REF:0000024, MGI:MGI:5521403 NCBI chr 1:199,251,842...199,270,465
Ensembl chr 1:199,251,844...199,270,627
JBrowse link
G Stxbp1 syntaxin binding protein 1 IMP
IDA
PMID:21689256 RGD
UniProt
PMID:19255244, PMID:21689256 RGD:2311128, RGD:14390056 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Stxbp5 syntaxin binding protein 5 ISO (MGI:MGI:3814264|PMID:18936251) RGD PMID:18936251 MGI:MGI:3814264 NCBI chr 1:3,858,917...4,011,684
Ensembl chr 1:3,858,909...4,011,511
JBrowse link
G Unc13a unc-13 homolog A IDA PMID:21689256 UniProt PMID:21689256 RGD:14390056 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      exocytic process 99
        synaptic vesicle priming 25
          negative regulation of synaptic vesicle priming 0
          positive regulation of synaptic vesicle priming 2
          regulation of synaptic vesicle priming + 10
Path 2
Term Annotations click to browse term
  biological_process 20028
    localization 6478
      establishment of localization 4887
        transport 4735
          export from cell 1007
            secretion by cell 956
              signal release 617
                signal release from synapse 209
                  neurotransmitter secretion 209
                    synaptic vesicle exocytosis 157
                      synaptic vesicle priming 25
                        negative regulation of synaptic vesicle priming 0
                        positive regulation of synaptic vesicle priming 2
                        regulation of synaptic vesicle priming + 10
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.