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ONTOLOGY REPORT - ANNOTATIONS


Term:macroautophagy
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Accession:GO:0016236 term browser browse the term
Definition:The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
Comment:Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities.
Synonyms:broad_synonym: autophagy
 alt_id: GO:0034262


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macroautophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07048308.1 RGD:13792537
G AABR07072668.1 RGD:13792537
G Acbd5 acyl-CoA binding domain containing 5 JBrowse link 17 89,882,465 89,923,982 RGD:1624291
G Atg10 autophagy related 10 JBrowse link 2 19,853,546 20,152,918 RGD:13792537
G Atg13 autophagy related 13 JBrowse link 3 80,580,549 80,614,554 RGD:13792537
G Atg14 autophagy related 14 JBrowse link 15 24,343,418 24,374,776 RGD:1624291
G Atg3 autophagy related 3 JBrowse link 11 60,585,192 60,613,706 RGD:1624291
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:1624291
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:1624291
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1600115
RGD:1624291
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
G Ei24 EI24, autophagy associated transmembrane protein JBrowse link 8 39,254,883 39,271,238 RGD:13792537
G Gabarap GABA type A receptor-associated protein JBrowse link 10 56,601,288 56,604,223 RGD:13792537
G Gabarapl1 GABA type A receptor associated protein like 1 JBrowse link 4 163,293,724 163,302,866 RGD:13792537
G Gabarapl2 GABA type A receptor associated protein like 2 JBrowse link 19 44,164,935 44,175,771 RGD:13792537
G Hdac10 histone deacetylase 10 JBrowse link 7 130,102,335 130,109,036 RGD:1600115
RGD:1624291
G LOC100359937 GABA(A) receptor-associated protein-like 2-like JBrowse link 8 95,943,674 95,944,604 RGD:13792537
G LOC294154 similar to chromosome 6 open reading frame 106 isoform a JBrowse link 20 7,331,321 7,397,588 RGD:13792537
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:1624291
RGD:13792537
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:1624291
RGD:13792537
G Nbr1 NBR1, autophagy cargo receptor JBrowse link 10 89,455,202 89,483,791 RGD:1600115
RGD:13792537
RGD:1624291
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha JBrowse link 1 185,210,922 185,326,314 RGD:1624291
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta JBrowse link 13 49,848,939 49,909,404 RGD:1624291
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 JBrowse link 18 22,964,121 23,047,896 RGD:1600115
RGD:1624291
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 JBrowse link 8 114,300,248 114,350,686 RGD:13792537
G Plaa phospholipase A2, activating protein JBrowse link 5 113,548,913 113,578,928 RGD:1624291
RGD:1600115
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:1624291
RGD:1600115
G Tbc1d5 TBC1 domain family, member 5 JBrowse link 9 1,144,641 1,747,732 RGD:1624291
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:1624291
G Tmem74 transmembrane protein 74 JBrowse link 7 82,684,666 82,689,753 RGD:1624291
G Tp53inp2 tumor protein p53 inducible nuclear protein 2 JBrowse link 3 150,910,398 150,918,525 RGD:1624291
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1624291
G Ubxn6 UBX domain protein 6 JBrowse link 9 10,995,516 11,000,643 RGD:1624291
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:1624291
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1624291
RGD:13792537
RGD:1600115
G Yod1 YOD1 deubiquitinase JBrowse link 13 47,441,296 47,443,013 RGD:1624291
RGD:1600115
G Zfyve1 zinc finger FYVE-type containing 1 JBrowse link 6 107,031,411 107,080,590 RGD:1624291
aggrephagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acbd5 acyl-CoA binding domain containing 5 JBrowse link 17 89,882,465 89,923,982 RGD:1624291
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:1624291
RGD:1600115
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:1624291
RGD:13792537
RGD:1600115
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1600115
RGD:1624291
G Wdfy3 WD repeat and FYVE domain containing 3 JBrowse link 14 9,169,409 9,384,835 RGD:1624291
G Wdr81 WD repeat domain 81 JBrowse link 10 62,273,817 62,287,213 RGD:1624291
RGD:1600115
autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07048308.1 RGD:13792537
G AABR07072668.1 RGD:13792537
G Ambra1 autophagy and beclin 1 regulator 1 JBrowse link 3 80,634,470 80,830,068 RGD:1624291
G Atg101 autophagy related 101 JBrowse link 7 142,929,381 142,938,559 RGD:1624291
RGD:13792537
G Atg12 autophagy related 12 JBrowse link 18 40,721,799 40,732,143 RGD:1624291
RGD:13792537
G Atg13 autophagy related 13 JBrowse link 3 80,580,549 80,614,554 RGD:1624291
RGD:13792537
G Atg14 autophagy related 14 JBrowse link 15 24,343,418 24,374,776 RGD:1624291
RGD:13792537
G Atg16l1 autophagy related 16-like 1 JBrowse link 9 94,879,876 94,915,231 RGD:13792537
G Atg16l2 autophagy related 16-like 2 JBrowse link 1 166,401,271 166,415,078 RGD:13792537
G Atg2a autophagy related 2A JBrowse link 1 221,612,584 221,632,291 RGD:1624291
RGD:13792537
G Atg2b autophagy related 2B JBrowse link 6 129,449,451 129,519,599 RGD:13792537
G Atg3 autophagy related 3 JBrowse link 11 60,585,192 60,613,706 RGD:1600115
RGD:13792537
RGD:1624291
G Atg4b autophagy related 4B, cysteine peptidase JBrowse link 9 100,888,457 100,920,123 RGD:1624291
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:1643189
RGD:13792537
RGD:1624291
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:1624291
RGD:13792537
G Atg9a autophagy related 9A JBrowse link 9 82,382,800 82,393,429 RGD:1624291
RGD:13792537
G Atg9b autophagy related 9B JBrowse link 4 7,314,369 7,322,095 RGD:1624291
RGD:13792537
G Bag3 BAG cochaperone 3 JBrowse link 1 199,941,258 199,965,191 RGD:12793031
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1643189
RGD:13792537
RGD:1600115
RGD:1624291
G Becn2 beclin 2 JBrowse link 13 93,971,720 93,974,467 RGD:13792537
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:1624291
G Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 JBrowse link 2 211,243,398 211,323,283 RGD:1624291
RGD:1600115
G Emc6 ER membrane protein complex subunit 6 JBrowse link 10 59,741,772 59,743,338 RGD:1624291
RGD:13792537
G Epm2a EPM2A glucan phosphatase, laforin JBrowse link 1 5,448,958 5,571,512 RGD:1624291
G Gabarap GABA type A receptor-associated protein JBrowse link 10 56,601,288 56,604,223 RGD:13792537
G Gabarapl1 GABA type A receptor associated protein like 1 JBrowse link 4 163,293,724 163,302,866 RGD:13792537
G Gabarapl2 GABA type A receptor associated protein like 2 JBrowse link 19 44,164,935 44,175,771 RGD:13792537
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G LOC100359937 GABA(A) receptor-associated protein-like 2-like JBrowse link 8 95,943,674 95,944,604 RGD:13792537
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:8554284
RGD:13792537
RGD:1624291
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:13792537
G Nsfl1c NSFL1 cofactor JBrowse link 3 146,980,923 147,005,478 RGD:13792537
G Pacs2 phosphofurin acidic cluster sorting protein 2 JBrowse link 6 137,824,136 137,889,144 RGD:1624291
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 JBrowse link 18 22,964,121 23,047,896 RGD:2303129
RGD:13792537
RGD:1624291
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291
G Rab1a RAB1A, member RAS oncogene family JBrowse link 14 104,475,082 104,500,176 RGD:1624291
RGD:13792537
RGD:1600115
G Rab1b RAB1B, member RAS oncogene family JBrowse link 1 220,483,529 220,491,469 RGD:13792537
G Rab23 RAB23, member RAS oncogene family JBrowse link 9 38,469,784 38,496,185 RGD:1624291
RGD:13792537
G Rab33b RAB33B, member RAS oncogene family JBrowse link 2 140,541,619 140,552,220 RGD:1624291
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:1624291
G Rb1cc1 RB1-inducible coiled-coil 1 JBrowse link 5 13,033,918 13,097,369 RGD:1624291
RGD:13792537
G Rufy4 RUN and FYVE domain containing 4 JBrowse link 9 81,401,080 81,422,016 RGD:1624291
RGD:13792537
G Sting1 stimulator of interferon response cGAMP interactor 1 JBrowse link 18 28,529,537 28,535,828 RGD:1600115
RGD:13792537
RGD:1624291
G Stx12 syntaxin 12 JBrowse link 5 151,044,050 151,072,893 RGD:1624291
RGD:1600115
G Synpo2 synaptopodin 2 JBrowse link 2 227,255,243 227,411,924 RGD:12793031
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:1624291
G Tmem41b transmembrane protein 41B JBrowse link 1 174,605,833 174,620,192 RGD:1624291
RGD:1600115
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 JBrowse link 5 24,402,895 24,419,651 RGD:13792537
G Tp53inp2 tumor protein p53 inducible nuclear protein 2 JBrowse link 3 150,910,398 150,918,525 RGD:1624291
RGD:13792537
RGD:1600115
G Trappc8 trafficking protein particle complex 8 JBrowse link 18 15,298,673 15,375,034 RGD:13792537
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1624291
RGD:13792537
RGD:1600115
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:13792537
G Ubxn2a UBX domain protein 2A JBrowse link 6 28,969,471 28,997,987 RGD:13792537
G Ubxn2b UBX domain protein 2B JBrowse link 5 19,285,368 19,314,199 RGD:13792537
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:1624291
RGD:13792537
G Ulk2 unc-51 like autophagy activating kinase 2 JBrowse link 10 48,050,079 48,129,377 RGD:13792537
G Vmp1 vacuole membrane protein 1 JBrowse link 10 73,901,988 74,001,900 RGD:1600115
RGD:1624291
G Wdr45 WD repeat domain 45 JBrowse link X 15,621,249 15,627,159 RGD:1600115
RGD:13792537
RGD:1624291
G Wdr45b WD repeat domain 45B JBrowse link 10 110,523,843 110,555,769 RGD:1624291
RGD:13792537
G Wipi1 WD repeat domain, phosphoinositide interacting 1 JBrowse link 10 97,859,730 97,896,949 RGD:1624291
RGD:13792537
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 12 13,969,704 13,998,134 RGD:1600115
RGD:13792537
RGD:1624291
autophagosome maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07048308.1 RGD:13792537
G AABR07072668.1 RGD:13792537
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
G Epg5 ectopic P-granules autophagy protein 5 homolog JBrowse link 18 74,299,965 74,397,115 RGD:1624291
RGD:13792537
G Gabarap GABA type A receptor-associated protein JBrowse link 10 56,601,288 56,604,223 RGD:13792537
G Gabarapl1 GABA type A receptor associated protein like 1 JBrowse link 4 163,293,724 163,302,866 RGD:13792537
G Gabarapl2 GABA type A receptor associated protein like 2 JBrowse link 19 44,164,935 44,175,771 RGD:13792537
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:1624291
RGD:13792537
RGD:1600115
G Lix1 limb and CNS expressed 1 JBrowse link 1 59,156,021 59,212,878 RGD:13792537
G Lix1l limb and CNS expressed 1 like JBrowse link 2 198,726,110 198,751,987 RGD:13792537
G LOC100359937 GABA(A) receptor-associated protein-like 2-like JBrowse link 8 95,943,674 95,944,604 RGD:13792537
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:1624291
RGD:13792537
G Map1lc3b microtubule-associated protein 1 light chain 3 beta JBrowse link 19 53,635,449 53,643,970 RGD:1624291
RGD:13792537
G Mcoln1 mucolipin 1 JBrowse link 12 2,054,629 2,068,682 RGD:1624291
G Mfsd8 major facilitator superfamily domain containing 8 JBrowse link 2 127,706,618 127,784,129 RGD:1624291
G Rubcnl rubicon like autophagy enhancer JBrowse link 15 57,065,512 57,109,197 RGD:1624291
RGD:13792537
G Snap29 synaptosome associated protein 29 JBrowse link 11 87,827,633 87,858,107 RGD:1624291
RGD:1600115
G Snapin SNAP-associated protein JBrowse link 2 189,878,159 189,880,743 RGD:1624291
G Snx14 sorting nexin 14 JBrowse link 8 96,018,943 96,088,405 RGD:1624291
G Stx17 syntaxin 17 JBrowse link 5 63,866,346 63,926,276 RGD:1600115
RGD:1624291
G Tecpr1 tectonin beta-propeller repeat containing 1 JBrowse link 12 12,374,132 12,403,382 RGD:1624291
RGD:1600115
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1624291
RGD:1600115
G Uvrag UV radiation resistance associated JBrowse link 1 163,844,804 164,101,568 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:1624291
G Vamp8 vesicle-associated membrane protein 8 JBrowse link 4 100,250,301 100,252,756 RGD:1624291
RGD:1600115
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1624291
RGD:13792537
RGD:1600115
G Vipas39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog JBrowse link 6 111,271,283 111,296,013 RGD:1624291
G Vps16 VPS16 core subunit of CORVET and HOPS complexes JBrowse link 3 122,947,887 122,969,543 RGD:1624291
G Vps33a VPS33A core subunit of CORVET and HOPS complexes JBrowse link 12 38,459,816 38,482,903 RGD:1624291
G Vps33b VPS33B, late endosome and lysosome associated JBrowse link 1 142,060,955 142,083,955 RGD:1624291
G Vti1b vesicle transport through interaction with t-SNAREs 1B JBrowse link 6 102,340,261 102,353,612 RGD:1624291
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 12 13,969,704 13,998,134 RGD:1624291
autophagosome membrane docking term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg14 autophagy related 14 JBrowse link 15 24,343,418 24,374,776 RGD:1624291
G Snap29 synaptosome associated protein 29 JBrowse link 11 87,827,633 87,858,107 RGD:1600115
RGD:1624291
G Stx17 syntaxin 17 JBrowse link 5 63,866,346 63,926,276 RGD:1624291
G Vamp8 vesicle-associated membrane protein 8 JBrowse link 4 100,250,301 100,252,756 RGD:1600115
RGD:1624291
autophagosome organization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp13a2 ATPase cation transporting 13A2 JBrowse link 5 159,512,208 159,531,631 RGD:1624291
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha JBrowse link 1 185,210,922 185,326,314 RGD:1624291
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta JBrowse link 13 49,848,939 49,909,404 RGD:1624291
autophagosome-endosome fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rubcnl rubicon like autophagy enhancer JBrowse link 15 57,065,512 57,109,197 RGD:1624291
RGD:13792537
autophagosome-lysosome fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp13a2 ATPase cation transporting 13A2 JBrowse link 5 159,512,208 159,531,631 RGD:1624291
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
G Rubcnl rubicon like autophagy enhancer JBrowse link 15 57,065,512 57,109,197 RGD:1624291
RGD:13792537
engulfment of target by autophagosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
glycophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rb1cc1 RB1-inducible coiled-coil 1 JBrowse link 5 13,033,918 13,097,369 RGD:13792537
G Stbd1 starch binding domain 1 JBrowse link 14 16,976,355 16,979,760 RGD:1624291
RGD:1600115
lipophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:1624291
RGD:1600115
mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ambra1 autophagy and beclin 1 regulator 1 JBrowse link 3 80,634,470 80,830,068 RGD:1624291
G Atg13 autophagy related 13 JBrowse link 3 80,580,549 80,614,554 RGD:1624291
RGD:13792537
G Atg14 autophagy related 14 JBrowse link 15 24,343,418 24,374,776 RGD:1624291
RGD:13792537
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:1624291
RGD:13792537
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:1624291
negative regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1624291
G Chmp4b charged multivesicular body protein 4B JBrowse link 3 150,188,275 150,227,453 RGD:1624291
G Ehmt2 euchromatic histone lysine methyltransferase 2 JBrowse link 20 4,576,033 4,592,980 RGD:1624291
G Fez1 fasciculation and elongation protein zeta 1 JBrowse link 8 39,305,128 39,350,270 RGD:1624291
RGD:1600115
G Fez2 fasciculation and elongation protein zeta 2 JBrowse link 6 963,903 1,003,955 RGD:1624291
RGD:1600115
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:13792537
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:1624291
RGD:13792537
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link 1 194,767,484 194,769,519 RGD:1600115
RGD:1624291
G Phf23 PHD finger protein 23 JBrowse link 10 56,605,078 56,609,236 RGD:1624291
RGD:13792537
RGD:1600115
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Scfd1 sec1 family domain containing 1 JBrowse link 6 72,124,408 72,202,703 RGD:1624291
G Sec22b SEC22 homolog B, vesicle trafficking protein JBrowse link 2 200,076,079 200,096,861 RGD:1624291
G Smcr8 SMCR8-C9orf72 complex subunit JBrowse link 10 47,019,326 47,026,465 RGD:1624291
G Tmem39a transmembrane protein 39a JBrowse link 11 64,723,181 64,752,514 RGD:1624291
RGD:1600115
negative regulation of autophagosome maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
G Phf23 PHD finger protein 23 JBrowse link 10 56,605,078 56,609,236 RGD:1624291
RGD:13792537
RGD:1600115
G Rubcn rubicon autophagy regulator JBrowse link 11 71,150,506 71,199,254 RGD:1624291
RGD:13792537
G Tmem39a transmembrane protein 39a JBrowse link 11 64,723,181 64,752,514 RGD:1600115
RGD:1624291
G Ubqln4 ubiquilin 4 JBrowse link 2 187,915,701 187,931,035 RGD:1624291
negative regulation of macroautophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1624291
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
G Lzts1 leucine zipper tumor suppressor 1 JBrowse link 16 22,250,452 22,306,667 RGD:1624291
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
RGD:13792537
G Npc1 NPC intracellular cholesterol transporter 1 JBrowse link 18 3,616,878 3,662,656 RGD:1624291
G Nrbp2 nuclear receptor binding protein 2 JBrowse link 7 117,145,106 117,151,694 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Poldip2 DNA polymerase delta interacting protein 2 JBrowse link 10 65,781,994 65,790,833 RGD:1624291
G Qsox1 quiescin sulfhydryl oxidase 1 JBrowse link 13 73,423,396 73,460,890 RGD:1624291
G Smcr8 SMCR8-C9orf72 complex subunit JBrowse link 10 47,019,326 47,026,465 RGD:1624291
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:10448950
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:11568679
G Usp36 ubiquitin specific peptidase 36 JBrowse link 10 107,292,828 107,324,355 RGD:1624291
negative regulation of macroautophagy by TORC1 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
negative regulation of mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
G Rnf41 ring finger protein 41 JBrowse link 7 2,827,242 2,854,230 RGD:1624291
G Tigar TP53 induced glycolysis regulatory phosphatase JBrowse link 4 159,635,145 159,654,108 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Usp30 ubiquitin specific peptidase 30 JBrowse link 12 48,262,663 48,316,580 RGD:13208875
negative regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:1624291
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vps13c vacuolar protein sorting 13 homolog C JBrowse link 8 73,682,814 73,843,290 RGD:1624291
RGD:1600115
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1600115
RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
positive regulation of aggrephagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bag3 BAG cochaperone 3 JBrowse link 1 199,941,258 199,965,191 RGD:1624291
G Hspb8 heat shock protein family B (small) member 8 JBrowse link 12 45,905,371 45,920,014 RGD:1624291
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1600115
RGD:1624291
positive regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561937
G Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 JBrowse link 2 211,243,398 211,323,283 RGD:1624291
RGD:1600115
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 JBrowse link 3 11,970,401 12,009,463 RGD:1624291
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha JBrowse link 17 85,533,056 85,748,843 RGD:1624291
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta JBrowse link 10 85,655,223 85,684,138 RGD:1624291
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma JBrowse link 7 70,483,948 70,498,995 RGD:1624291
RGD:1600115
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 JBrowse link 13 44,578,208 44,649,876 RGD:1624291
RGD:1600115
G Rab3gap2 RAB3 GTPase activating non-catalytic protein subunit 2 JBrowse link 13 103,157,806 103,229,010 RGD:1624291
RGD:1600115
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:1600115
RGD:1624291
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 JBrowse link 2 250,709,812 250,744,216 RGD:1600115
RGD:1624291
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:13208863
positive regulation of autophagosome maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Calcoco2 calcium binding and coiled-coil domain 2 JBrowse link 10 83,935,087 83,963,750 RGD:1624291
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
G Fyco1 FYVE and coiled-coil domain autophagy adaptor 1 JBrowse link 8 132,844,042 132,910,905 RGD:1624291
RGD:13792537
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Smcr8 SMCR8-C9orf72 complex subunit JBrowse link 10 47,019,326 47,026,465 RGD:1624291
positive regulation of lipophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1600115
RGD:1624291
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:1624291
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:1624291
positive regulation of macroautophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:1624291
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:1624291
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:1624291
G Epm2a EPM2A glucan phosphatase, laforin JBrowse link 1 5,448,958 5,571,512 RGD:1624291
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:1624291
G Gpsm1 G-protein signaling modulator 1 JBrowse link 3 3,767,394 3,794,360 RGD:1624291
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1624291
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1600115
RGD:13792537
RGD:1624291
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1624291
RGD:1600115
G Larp1 La ribonucleoprotein 1, translational regulator JBrowse link 10 43,435,738 43,501,186 RGD:1624291
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 JBrowse link 8 50,256,969 50,310,043 RGD:1624291
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase JBrowse link X 15,462,621 15,467,890 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Rab12 RAB12, member RAS oncogene family JBrowse link 9 114,683,985 114,709,613 RGD:1624291
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:1600115
RGD:1624291
G Rufy4 RUN and FYVE domain containing 4 JBrowse link 9 81,401,080 81,422,016 RGD:1624291
RGD:13792537
G Scoc short coiled-coil protein JBrowse link 19 24,584,435 24,614,167 RGD:1624291
RGD:1600115
G Sesn1 sestrin 1 JBrowse link 20 46,667,116 46,758,306 RGD:13792537
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
RGD:13792537
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:13792537
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Sting1 stimulator of interferon response cGAMP interactor 1 JBrowse link 18 28,529,537 28,535,828 RGD:1600115
RGD:13792537
RGD:1624291
G Supt5h SPT5 homolog, DSIF elongation factor subunit JBrowse link 1 85,437,780 85,466,854 RGD:1624291
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Trim13 tripartite motif-containing 13 JBrowse link 15 41,897,191 41,936,545 RGD:1624291
RGD:13792537
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:10448950
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1624291
RGD:1600115
G Wac WW domain containing adaptor with coiled-coil JBrowse link 17 60,887,606 60,946,630 RGD:1624291
positive regulation of mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:13432560
G Vps13d vacuolar protein sorting 13 homolog D JBrowse link 5 162,891,451 163,119,239 RGD:1624291
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc37 cell division cycle 37, HSP90 cochaperone JBrowse link 8 22,160,922 22,173,797 RGD:1624291
RGD:1600115
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link X 21,474,627 21,603,348 RGD:1600115
RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Tomm7 translocase of outer mitochondrial membrane 7 JBrowse link 4 7,835,949 7,842,790 RGD:1624291
positive regulation of xenophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 JBrowse link 3 11,970,401 12,009,463 RGD:1624291
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:1624291
G Nod1 nucleotide-binding oligomerization domain containing 1 JBrowse link 4 85,123,965 85,175,206 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1624291
RGD:1600115
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
protein lipidation involved in autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg16l1 autophagy related 16-like 1 JBrowse link 9 94,879,876 94,915,231 RGD:1624291
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:1624291
RGD:1600115
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 12 13,969,704 13,998,134 RGD:1624291
protein localization to phagophore assembly site term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg13 autophagy related 13 JBrowse link 3 80,580,549 80,614,554 RGD:13792537
G Atg16l1 autophagy related 16-like 1 JBrowse link 9 94,879,876 94,915,231 RGD:1624291
G Atg9a autophagy related 9A JBrowse link 9 82,382,800 82,393,429 RGD:13792537
G Atg9b autophagy related 9B JBrowse link 4 7,314,369 7,322,095 RGD:13792537
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:1624291
G Pacs2 phosphofurin acidic cluster sorting protein 2 JBrowse link 6 137,824,136 137,889,144 RGD:1624291
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 JBrowse link 18 22,964,121 23,047,896 RGD:1624291
G Stx17 syntaxin 17 JBrowse link 5 63,866,346 63,926,276 RGD:1624291
G Trappc8 trafficking protein particle complex 8 JBrowse link 18 15,298,673 15,375,034 RGD:13792537
G Wdr45 WD repeat domain 45 JBrowse link X 15,621,249 15,627,159 RGD:13792537
G Wdr45b WD repeat domain 45B JBrowse link 10 110,523,843 110,555,769 RGD:13792537
G Wipi1 WD repeat domain, phosphoinositide interacting 1 JBrowse link 10 97,859,730 97,896,949 RGD:13792537
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 12 13,969,704 13,998,134 RGD:1624291
RGD:1600115
RGD:13792537
regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07006774.1 RGD:13792537
G AABR07006775.1 RGD:13792537
G Ift20 intraflagellar transport 20 JBrowse link 10 65,805,808 65,811,353 RGD:1624291
G Ift88 intraflagellar transport 88 JBrowse link 15 37,690,417 37,786,855 RGD:1624291
G LOC100363782 RAB1B, member RAS oncogene family-like RGD:1600115
G LOC102555167 ras-related protein Rab-1B-like JBrowse link 1 220,480,828 220,491,456 RGD:1600115
G LOC685933 hypothetical protein LOC685933 JBrowse link 1 257,828,474 257,885,689 RGD:13792537
G Mtmr3 myotubularin related protein 3 JBrowse link 14 84,701,559 84,820,487 RGD:1624291
RGD:1600115
G Nprl2 NPR2-like, GATOR1 complex subunit JBrowse link 8 116,297,950 116,301,123 RGD:13792537
G Nprl3 NPR3-like, GATOR1 complex subunit JBrowse link 10 15,620,824 15,661,332 RGD:13792537
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing JBrowse link 9 71,911,744 72,005,816 RGD:1624291
G Rab1b RAB1B, member RAS oncogene family JBrowse link 1 220,483,529 220,491,469 RGD:1600115
RGD:1624291
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:1600115
RGD:1624291
G Rnf5 ring finger protein 5 JBrowse link 20 4,366,244 4,368,690 RGD:1624291
G Tbc1d12 TBC1 domain family, member 12 JBrowse link 1 257,517,128 257,599,659 RGD:13792537
G Tbc1d14 TBC1 domain family, member 14 JBrowse link 14 79,172,272 79,438,765 RGD:1624291
RGD:13792537
RGD:1600115
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
regulation of autophagosome maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:13792537
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
G Tbc1d25 TBC1 domain family, member 25 JBrowse link X 15,064,733 15,088,579 RGD:1624291
RGD:13792537
regulation of autophagosome size term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp13a2 ATPase cation transporting 13A2 JBrowse link 5 159,512,208 159,531,631 RGD:1624291
RGD:13442482
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
regulation of macroautophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp13a2 ATPase cation transporting 13A2 JBrowse link 5 159,512,208 159,531,631 RGD:1624291
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 JBrowse link 10 88,914,264 88,967,736 RGD:1624291
RGD:1600115
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:1600115
RGD:1624291
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:13792537
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
RGD:13792537
reticulophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC103689968 protein FAM134B JBrowse link 2 78,103,358 78,257,109 RGD:1600115
RGD:13792537
G LOC103690028 zinc finger protein 622 JBrowse link 2 78,261,699 78,276,942 RGD:1600115
G Rb1cc1 RB1-inducible coiled-coil 1 JBrowse link 5 13,033,918 13,097,369 RGD:13792537
RGD:1624291
G Retreg1 reticulophagy regulator 1 JBrowse link 2 78,391,921 78,401,569 RGD:1624291
RGD:1600115
RGD:13792537
G Sting1 stimulator of interferon response cGAMP interactor 1 JBrowse link 18 28,529,537 28,535,828 RGD:1600115
RGD:13792537
RGD:1624291
G Tex264 testis expressed 264 JBrowse link 8 115,360,706 115,388,299 RGD:1624291
selective autophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:1600115
RGD:1624291
substrate localization to autophagosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
xenophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg16l1 autophagy related 16-like 1 JBrowse link 9 94,879,876 94,915,231 RGD:1624291
G Calcoco2 calcium binding and coiled-coil domain 2 JBrowse link 10 83,935,087 83,963,750 RGD:1624291
G Lgals8 galectin 8 JBrowse link 17 66,487,451 66,515,316 RGD:1600115
RGD:1624291
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 12 13,969,704 13,998,134 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19575
    cellular process 18359
      process utilizing autophagic mechanism 440
        autophagy 440
          macroautophagy 211
            amphisome-lysosome fusion 0
            autophagosome maturation + 44
            autophagosome organization + 105
            autophagosome-endosome fusion 1
            autophagosome-lysosome fusion 3
            negative regulation of macroautophagy + 32
            positive regulation of macroautophagy + 68
            regulation of macroautophagy + 115
            selective autophagy + 54
Path 2
Term Annotations click to browse term
  biological_process 19575
    metabolic process 11899
      catabolic process 2481
        cellular catabolic process 2120
          autophagy 440
            macroautophagy 211
              amphisome-lysosome fusion 0
              autophagosome maturation + 44
              autophagosome organization + 105
              autophagosome-endosome fusion 1
              autophagosome-lysosome fusion 3
              negative regulation of macroautophagy + 32
              positive regulation of macroautophagy + 68
              regulation of macroautophagy + 115
              selective autophagy + 54
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.