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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of macroautophagy
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Accession:GO:0016239 term browser browse the term
Definition:Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
Synonyms:exact_synonym: positive regulation of starvation-induced autophagy;   up regulation of macroautophagy;   upregulation of macroautophagy
 narrow_synonym: activation of macroautophagy;   stimulation of macroautophagy


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positive regulation of macroautophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:1624291
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:1624291
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:1624291
G Epm2a EPM2A glucan phosphatase, laforin JBrowse link 1 5,448,958 5,571,512 RGD:1624291
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:1624291
G Gpsm1 G-protein signaling modulator 1 JBrowse link 3 3,767,394 3,794,360 RGD:1624291
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1624291
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1600115
RGD:1624291
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1624291
RGD:1600115
G Larp1 La ribonucleoprotein 1, translational regulator JBrowse link 10 43,435,738 43,501,186 RGD:1624291
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 JBrowse link 8 50,256,969 50,310,043 RGD:1624291
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase JBrowse link X 15,462,621 15,467,890 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Rab12 RAB12, member RAS oncogene family JBrowse link 9 114,683,985 114,709,613 RGD:1624291
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:1600115
RGD:1624291
G Rufy4 RUN and FYVE domain containing 4 JBrowse link 9 81,401,080 81,422,016 RGD:1624291
RGD:13792537
G Scoc short coiled-coil protein JBrowse link 19 24,584,435 24,614,167 RGD:1624291
RGD:1600115
G Sesn1 sestrin 1 JBrowse link 20 46,667,116 46,758,306 RGD:13792537
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
RGD:13792537
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:13792537
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Sting1 stimulator of interferon response cGAMP interactor 1 JBrowse link 18 28,529,537 28,535,828 RGD:1600115
RGD:13792537
RGD:1624291
G Supt5h SPT5 homolog, DSIF elongation factor subunit JBrowse link 1 85,437,780 85,466,854 RGD:1624291
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Trim13 tripartite motif-containing 13 JBrowse link 15 41,897,191 41,936,545 RGD:1624291
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:10448950
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1624291
RGD:1600115
G Wac WW domain containing adaptor with coiled-coil JBrowse link 17 60,887,606 60,946,630 RGD:1624291
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vps13c vacuolar protein sorting 13 homolog C JBrowse link 8 73,682,814 73,843,290 RGD:1624291
RGD:1600115
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1600115
RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
positive regulation of aggrephagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bag3 BAG cochaperone 3 JBrowse link 1 199,941,258 199,965,191 RGD:1624291
G Hspb8 heat shock protein family B (small) member 8 JBrowse link 12 45,905,371 45,920,014 RGD:1624291
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1600115
RGD:1624291
positive regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561937
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 JBrowse link 3 11,970,401 12,009,463 RGD:1624291
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha JBrowse link 17 85,533,056 85,748,843 RGD:1624291
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta JBrowse link 10 85,655,223 85,684,138 RGD:1624291
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma JBrowse link 7 70,483,948 70,498,995 RGD:1624291
RGD:1600115
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 JBrowse link 13 44,578,208 44,649,876 RGD:1624291
RGD:1600115
G Rab3gap2 RAB3 GTPase activating non-catalytic protein subunit 2 JBrowse link 13 103,157,806 103,229,010 RGD:1624291
RGD:1600115
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:1600115
RGD:1624291
G RGD1310209 similar to KIAA1324 protein JBrowse link 2 211,243,398 211,323,283 RGD:1624291
RGD:1600115
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 JBrowse link 2 250,709,812 250,744,216 RGD:1600115
RGD:1624291
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:13208863
positive regulation of autophagosome maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Calcoco2 calcium binding and coiled-coil domain 2 JBrowse link 10 83,935,087 83,963,750 RGD:1624291
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
G Fyco1 FYVE and coiled-coil domain autophagy adaptor 1 JBrowse link 8 132,844,042 132,910,905 RGD:1624291
RGD:13792537
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Smcr8 SMCR8-C9orf72 complex subunit JBrowse link 10 47,019,326 47,026,465 RGD:1624291
positive regulation of lipophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1600115
RGD:1624291
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:1624291
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:1624291
positive regulation of mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:13432560
G Vps13d vacuolar protein sorting 13 homolog D JBrowse link 5 162,891,451 163,119,239 RGD:1624291
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc37 cell division cycle 37 JBrowse link 8 22,160,922 22,173,797 RGD:1624291
RGD:1600115
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link X 21,474,627 21,603,348 RGD:1600115
RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Tomm7 translocase of outer mitochondrial membrane 7 JBrowse link 4 7,835,949 7,842,790 RGD:1624291
positive regulation of xenophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 JBrowse link 3 11,970,401 12,009,463 RGD:1624291
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:1624291
G Nod1 nucleotide-binding oligomerization domain containing 1 JBrowse link 4 85,123,965 85,175,206 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1624291
RGD:1600115
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    cellular process 18179
      process utilizing autophagic mechanism 435
        autophagy 435
          macroautophagy 211
            positive regulation of macroautophagy 68
              positive regulation of aggrephagy 3
              positive regulation of autophagosome assembly 11
              positive regulation of autophagosome maturation 6
              positive regulation of lipophagy 5
              positive regulation of mitophagy + 11
              positive regulation of xenophagy 8
Path 2
Term Annotations click to browse term
  biological_process 19439
    biological regulation 13446
      regulation of biological process 12748
        regulation of metabolic process 6582
          regulation of catabolic process 897
            regulation of cellular catabolic process 747
              regulation of autophagy 284
                positive regulation of autophagy 145
                  positive regulation of macroautophagy 68
                    positive regulation of aggrephagy 3
                    positive regulation of autophagosome assembly 11
                    positive regulation of autophagosome maturation 6
                    positive regulation of lipophagy 5
                    positive regulation of mitophagy + 11
                    positive regulation of xenophagy 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.