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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of macroautophagy
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Accession:GO:0016241 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of macroautophagy.
Synonyms:exact_synonym: regulation of starvation-induced autophagy


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regulation of macroautophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp13a2 ATPase cation transporting 13A2 JBrowse link 5 159,512,208 159,531,631 RGD:1624291
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 JBrowse link 10 88,914,264 88,967,736 RGD:1624291
RGD:1600115
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:1600115
RGD:1624291
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:13792537
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
RGD:13792537
negative regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1624291
G Chmp4b charged multivesicular body protein 4B JBrowse link 3 150,188,275 150,227,453 RGD:1624291
G Ehmt2 euchromatic histone lysine methyltransferase 2 JBrowse link 20 4,576,033 4,592,980 RGD:1624291
G Fez1 fasciculation and elongation protein zeta 1 JBrowse link 8 39,305,128 39,350,270 RGD:1624291
RGD:1600115
G Fez2 fasciculation and elongation protein zeta 2 JBrowse link 6 963,903 1,003,955 RGD:1624291
RGD:1600115
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
RGD:13792537
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:1624291
RGD:13792537
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link 1 194,767,484 194,769,519 RGD:1600115
RGD:1624291
G Phf23 PHD finger protein 23 JBrowse link 10 56,605,078 56,609,236 RGD:1624291
RGD:13792537
RGD:1600115
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Scfd1 sec1 family domain containing 1 JBrowse link 6 72,124,408 72,202,703 RGD:1624291
G Sec22b SEC22 homolog B, vesicle trafficking protein JBrowse link 2 200,076,079 200,096,861 RGD:1624291
G Smcr8 SMCR8-C9orf72 complex subunit JBrowse link 10 47,019,326 47,026,465 RGD:1624291
G Tmem39a transmembrane protein 39a JBrowse link 11 64,723,181 64,752,514 RGD:1624291
RGD:1600115
negative regulation of autophagosome maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
G Phf23 PHD finger protein 23 JBrowse link 10 56,605,078 56,609,236 RGD:1624291
RGD:13792537
RGD:1600115
G Rubcn rubicon autophagy regulator JBrowse link 11 71,150,506 71,199,254 RGD:1624291
RGD:13792537
G Tmem39a transmembrane protein 39a JBrowse link 11 64,723,181 64,752,514 RGD:1600115
RGD:1624291
G Ubqln4 ubiquilin 4 JBrowse link 2 187,915,701 187,931,035 RGD:1624291
negative regulation of macroautophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1624291
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
G Lzts1 leucine zipper tumor suppressor 1 JBrowse link 16 22,250,452 22,306,667 RGD:1624291
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
RGD:13792537
G Npc1 NPC intracellular cholesterol transporter 1 JBrowse link 18 3,616,878 3,662,656 RGD:1624291
G Nrbp2 nuclear receptor binding protein 2 JBrowse link 7 117,145,106 117,151,694 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Poldip2 DNA polymerase delta interacting protein 2 JBrowse link 10 65,781,994 65,790,833 RGD:1624291
G Qsox1 quiescin sulfhydryl oxidase 1 JBrowse link 13 73,423,396 73,460,890 RGD:1624291
G Smcr8 SMCR8-C9orf72 complex subunit JBrowse link 10 47,019,326 47,026,465 RGD:1624291
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:10448950
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:11568679
G Usp36 ubiquitin specific peptidase 36 JBrowse link 10 107,292,828 107,324,355 RGD:1624291
negative regulation of macroautophagy by TORC1 signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
negative regulation of mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
G Rnf41 ring finger protein 41 JBrowse link 7 2,827,242 2,854,230 RGD:1624291
G Tigar TP53 induced glycolysis regulatory phosphatase JBrowse link 4 159,635,145 159,654,108 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Usp30 ubiquitin specific peptidase 30 JBrowse link 12 48,262,663 48,316,580 RGD:13208875
negative regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:1624291
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vps13c vacuolar protein sorting 13 homolog C JBrowse link 8 73,682,814 73,843,290 RGD:1624291
RGD:1600115
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1600115
RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 12 11,433,815 11,526,465 RGD:1624291
positive regulation of aggrephagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bag3 BAG cochaperone 3 JBrowse link 1 199,941,258 199,965,191 RGD:1624291
G Hspb8 heat shock protein family B (small) member 8 JBrowse link 12 45,905,371 45,920,014 RGD:1624291
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1600115
RGD:1624291
positive regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561937
G Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 JBrowse link 2 211,243,398 211,323,283 RGD:1624291
RGD:1600115
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 JBrowse link 3 11,970,401 12,009,463 RGD:1624291
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha JBrowse link 17 85,533,056 85,748,843 RGD:1624291
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta JBrowse link 10 85,655,223 85,684,138 RGD:1624291
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma JBrowse link 7 70,483,948 70,498,995 RGD:1624291
RGD:1600115
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 JBrowse link 13 44,578,208 44,649,876 RGD:1624291
RGD:1600115
G Rab3gap2 RAB3 GTPase activating non-catalytic protein subunit 2 JBrowse link 13 103,157,806 103,229,010 RGD:1624291
RGD:1600115
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:1600115
RGD:1624291
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 JBrowse link 2 250,709,812 250,744,216 RGD:1600115
RGD:1624291
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:13208863
positive regulation of autophagosome maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Calcoco2 calcium binding and coiled-coil domain 2 JBrowse link 10 83,935,087 83,963,750 RGD:1624291
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:1624291
G Fyco1 FYVE and coiled-coil domain autophagy adaptor 1 JBrowse link 8 132,844,042 132,910,905 RGD:1624291
RGD:13792537
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:1624291
G Smcr8 SMCR8-C9orf72 complex subunit JBrowse link 10 47,019,326 47,026,465 RGD:1624291
positive regulation of lipophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1600115
RGD:1624291
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:1624291
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:1624291
positive regulation of macroautophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:1624291
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:1624291
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:1624291
G Epm2a EPM2A glucan phosphatase, laforin JBrowse link 1 5,448,958 5,571,512 RGD:1624291
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:1624291
G Gpsm1 G-protein signaling modulator 1 JBrowse link 3 3,767,394 3,794,360 RGD:1624291
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:1624291
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1600115
RGD:13792537
RGD:1624291
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1624291
RGD:1600115
G Larp1 La ribonucleoprotein 1, translational regulator JBrowse link 10 43,435,738 43,501,186 RGD:1624291
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 JBrowse link 8 50,256,969 50,310,043 RGD:1624291
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase JBrowse link X 15,462,621 15,467,890 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Rab12 RAB12, member RAS oncogene family JBrowse link 9 114,683,985 114,709,613 RGD:1624291
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:1600115
RGD:1624291
G Rufy4 RUN and FYVE domain containing 4 JBrowse link 9 81,401,080 81,422,016 RGD:1624291
RGD:13792537
G Scoc short coiled-coil protein JBrowse link 19 24,584,435 24,614,167 RGD:1624291
RGD:1600115
G Sesn1 sestrin 1 JBrowse link 20 46,667,116 46,758,306 RGD:13792537
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:1624291
RGD:13792537
G Sesn3 sestrin 3 JBrowse link 8 12,823,060 12,878,749 RGD:13792537
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Sting1 stimulator of interferon response cGAMP interactor 1 JBrowse link 18 28,529,537 28,535,828 RGD:1600115
RGD:13792537
RGD:1624291
G Supt5h SPT5 homolog, DSIF elongation factor subunit JBrowse link 1 85,437,780 85,466,854 RGD:1624291
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Trim13 tripartite motif-containing 13 JBrowse link 15 41,897,191 41,936,545 RGD:1624291
RGD:13792537
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:10448950
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1624291
RGD:1600115
G Wac WW domain containing adaptor with coiled-coil JBrowse link 17 60,887,606 60,946,630 RGD:1624291
positive regulation of mitophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:13432560
G Vps13d vacuolar protein sorting 13 homolog D JBrowse link 5 162,891,451 163,119,239 RGD:1624291
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc37 cell division cycle 37, HSP90 cochaperone JBrowse link 8 22,160,922 22,173,797 RGD:1624291
RGD:1600115
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link X 21,474,627 21,603,348 RGD:1600115
RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Tomm7 translocase of outer mitochondrial membrane 7 JBrowse link 4 7,835,949 7,842,790 RGD:1624291
positive regulation of xenophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 JBrowse link 3 11,970,401 12,009,463 RGD:1624291
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:1624291
G Nod1 nucleotide-binding oligomerization domain containing 1 JBrowse link 4 85,123,965 85,175,206 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1624291
RGD:1600115
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
regulation of autophagosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07006774.1 RGD:13792537
G AABR07006775.1 RGD:13792537
G Ift20 intraflagellar transport 20 JBrowse link 10 65,805,808 65,811,353 RGD:1624291
G Ift88 intraflagellar transport 88 JBrowse link 15 37,690,417 37,786,855 RGD:1624291
G LOC100363782 RAB1B, member RAS oncogene family-like RGD:1600115
G LOC102555167 ras-related protein Rab-1B-like JBrowse link 1 220,480,828 220,491,456 RGD:1600115
G LOC685933 hypothetical protein LOC685933 JBrowse link 1 257,828,474 257,885,689 RGD:13792537
G Mtmr3 myotubularin related protein 3 JBrowse link 14 84,701,559 84,820,487 RGD:1624291
RGD:1600115
G Nprl2 NPR2-like, GATOR1 complex subunit JBrowse link 8 116,297,950 116,301,123 RGD:13792537
G Nprl3 NPR3-like, GATOR1 complex subunit JBrowse link 10 15,620,824 15,661,332 RGD:13792537
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing JBrowse link 9 71,911,744 72,005,816 RGD:1624291
G Rab1b RAB1B, member RAS oncogene family JBrowse link 1 220,483,529 220,491,469 RGD:1600115
RGD:1624291
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:1600115
RGD:1624291
G Rnf5 ring finger protein 5 JBrowse link 20 4,366,244 4,368,690 RGD:1624291
G Tbc1d12 TBC1 domain family, member 12 JBrowse link 1 257,517,128 257,599,659 RGD:13792537
G Tbc1d14 TBC1 domain family, member 14 JBrowse link 14 79,172,272 79,438,765 RGD:1624291
RGD:13792537
RGD:1600115
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
regulation of autophagosome maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clec16a C-type lectin domain containing 16A JBrowse link 10 5,002,196 5,196,914 RGD:13792537
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
G Tbc1d25 TBC1 domain family, member 25 JBrowse link X 15,064,733 15,088,579 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    cellular process 18362
      process utilizing autophagic mechanism 440
        autophagy 440
          macroautophagy 211
            regulation of macroautophagy 115
              negative regulation of macroautophagy + 32
              positive regulation of macroautophagy + 68
              regulation of aggrephagy + 3
              regulation of autophagosome assembly + 41
              regulation of autophagosome maturation + 12
              regulation of lipophagy + 5
              regulation of mitophagy + 17
              regulation of xenophagy + 8
Path 2
Term Annotations click to browse term
  biological_process 19578
    biological regulation 13539
      regulation of biological process 12843
        regulation of cellular process 12334
          regulation of cellular metabolic process 6083
            regulation of cellular catabolic process 758
              regulation of autophagy 289
                regulation of macroautophagy 115
                  negative regulation of macroautophagy + 32
                  positive regulation of macroautophagy + 68
                  regulation of aggrephagy + 3
                  regulation of autophagosome assembly + 41
                  regulation of autophagosome maturation + 12
                  regulation of lipophagy + 5
                  regulation of mitophagy + 17
                  regulation of xenophagy + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.