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ONTOLOGY REPORT - ANNOTATIONS


Term:RNA interference
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Accession:GO:0016246 term browser browse the term
Definition:The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
Comment:Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'.
Synonyms:exact_synonym: RNAi;   posttranscriptional gene silencing by siRNA
 xref: Wikipedia:RNA_interference
 never_in_taxon: NCBITaxon:4895 ! Schizosaccharomyces


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RNA interference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III ISO MGI:MGI:3589287 (MGI:MGI:3528782|PMID:15713842) RGD PMID:15713842 MGI:MGI:3528782 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Nrde2 NRDE-2, necessary for RNA interference, domain containing IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:124,136,949...124,177,426
Ensembl chr 6:124,142,395...124,177,404
JBrowse link
conversion of ds siRNA to ss siRNA involved in RNA interference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III ISO (PMID:19701182) RGD PMID:19701182 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
mRNA cleavage involved in gene silencing by siRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago1 argonaute RISC component 1 NOT ISO (PMID:15260970) RGD PMID:15260970 NCBI chr 5:144,444,390...144,479,430
Ensembl chr 5:144,448,792...144,479,306
JBrowse link
G Ago2 argonaute RISC catalytic component 2 IEA
ISO
GO_REF:0000107
(PMID:15260970), (PMID:22795694)
Ensembl
RGD
PMID:15260970, PMID:22795694 GO_REF:0000107 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Ago3 argonaute RISC catalytic component 3 NOT ISO (PMID:15260970) RGD PMID:15260970 NCBI chr 5:144,355,792...144,436,509
Ensembl chr 5:144,364,269...144,436,509
JBrowse link
G Ago4 argonaute RISC component 4 NOT ISO (PMID:15260970) RGD PMID:15260970 NCBI chr 5:144,501,875...144,557,165
Ensembl chr 5:144,504,938...144,556,889
JBrowse link
negative regulation of production of siRNA involved in RNA interference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tert telomerase reverse transcriptase ISO (PMID:19701182) RGD PMID:19701182 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
negative regulation of RNA interference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific ISO
IEA
(MGI:MGI:3573853|PMID:15556947)
GO_REF:0000107
RGD
Ensembl
PMID:15556947 GO_REF:0000107, MGI:MGI:3573853 NCBI chr 2:189,045,551...189,085,448
Ensembl chr 2:189,062,443...189,083,236
JBrowse link
positive regulation of RNA interference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xpo5 exportin 5 ISO (PMID:15613540) RGD PMID:15613540 NCBI chr 9:17,125,201...17,163,170
Ensembl chr 9:17,125,201...17,163,170
JBrowse link
production of siRNA involved in RNA interference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07012856.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 2:211,740,637...211,753,297 JBrowse link
G Dicer1 dicer 1 ribonuclease III ISO
IBA
(PMID:15973356), (PMID:17452327), (PMID:23661684)
PMID:21873635
(MGI:MGI:2679763|PMID:14528307), (MGI:MGI:5527004|PMID:24209619)
RGD PMID:14528307, PMID:15973356, PMID:17452327, PMID:23661684, PMID:24209619, PMID:21873635 MGI:MGI:2679763, MGI:MGI:5527004, RGD:13792537 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Drosha drosha ribonuclease III IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:62,887,267...63,000,307
Ensembl chr 2:62,887,267...62,999,572
JBrowse link
G Henmt1 HEN methyltransferase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:211,740,571...211,753,718 JBrowse link
G Mrpl44 mitochondrial ribosomal protein L44 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:85,542,763...85,547,814
Ensembl chr 9:85,542,702...85,548,144
JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:17452327)
Ensembl
UniProt
RGD
PMID:17452327 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:63,489,081...63,507,918
Ensembl chr 3:63,489,074...63,507,926
JBrowse link
G Tarbp2 TARBP2 subunit of RISC loading complex ISS
ISO
GO_REF:0000024
(PMID:15973356), (PMID:17452327)
UniProt
RGD
PMID:15973356, PMID:17452327 GO_REF:0000024 NCBI chr 7:144,121,688...144,126,860
Ensembl chr 7:144,121,744...144,126,857
JBrowse link
G Tert telomerase reverse transcriptase ISO (PMID:19701182) RGD PMID:19701182 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
regulation of production of siRNA involved in RNA interference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tarbp2 TARBP2 subunit of RISC loading complex IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:144,121,688...144,126,860
Ensembl chr 7:144,121,744...144,126,857
JBrowse link
siRNA loading onto RISC involved in RNA interference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 ISO
IEA
(PMID:19966796)
GO_REF:0000107
RGD
Ensembl
PMID:19966796 GO_REF:0000107 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Clp1 cleavage factor polyribonucleotide kinase subunit 1 ISO
ISS
(PMID:17495927)
GO_REF:0000024
RGD
UniProt
PMID:17495927 GO_REF:0000024 NCBI chr 3:72,125,269...72,137,122
Ensembl chr 3:72,125,273...72,128,973
JBrowse link
G Dicer1 dicer 1 ribonuclease III ISO (PMID:15973356) RGD PMID:15973356 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Tarbp2 TARBP2 subunit of RISC loading complex ISO (PMID:15973356) RGD PMID:15973356 NCBI chr 7:144,121,688...144,126,860
Ensembl chr 7:144,121,744...144,126,857
JBrowse link
targeting of mRNA for destruction involved in RNA interference term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clp1 cleavage factor polyribonucleotide kinase subunit 1 ISO
ISS
(PMID:17495927)
GO_REF:0000024
RGD
UniProt
PMID:17495927 GO_REF:0000024 NCBI chr 3:72,125,269...72,137,122
Ensembl chr 3:72,125,273...72,128,973
JBrowse link
G Dhx9 DExH-box helicase 9 ISO (PMID:17531811) RGD PMID:17531811 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dicer1 dicer 1 ribonuclease III ISO (PMID:15973356), (PMID:17452327) RGD PMID:15973356, PMID:17452327 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Tarbp2 TARBP2 subunit of RISC loading complex ISO
ISS
(PMID:15973356)
GO_REF:0000024
RGD
UniProt
PMID:15973356 GO_REF:0000024 NCBI chr 7:144,121,688...144,126,860
Ensembl chr 7:144,121,744...144,126,857
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      gene silencing 256
        gene silencing by RNA 153
          post-transcriptional gene silencing by RNA 131
            RNA interference 17
              RNA interference involved in olfactory learning 0
              mRNA cleavage involved in gene silencing by siRNA 4
              negative regulation of RNA interference + 2
              negative regulation of translation involved in RNA interference 0
              positive regulation of RNA interference 1
              production of lsiRNA involved in RNA interference 0
              production of siRNA involved in RNA interference + 8
              regulation of RNA interference + 3
              siRNA loading onto RISC involved in RNA interference 4
              targeting of mRNA for destruction involved in RNA interference 4
              transitive RNA interference + 0
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      organic substance metabolic process 11651
        macromolecule metabolic process 10086
          regulation of macromolecule metabolic process 6502
            regulation of gene expression 4813
              negative regulation of gene expression 2169
                gene silencing 256
                  posttranscriptional gene silencing 140
                    post-transcriptional gene silencing by RNA 131
                      RNA interference 17
                        RNA interference involved in olfactory learning 0
                        mRNA cleavage involved in gene silencing by siRNA 4
                        negative regulation of RNA interference + 2
                        negative regulation of translation involved in RNA interference 0
                        positive regulation of RNA interference 1
                        production of lsiRNA involved in RNA interference 0
                        production of siRNA involved in RNA interference + 8
                        regulation of RNA interference + 3
                        siRNA loading onto RISC involved in RNA interference 4
                        targeting of mRNA for destruction involved in RNA interference 4
                        transitive RNA interference + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.