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ONTOLOGY REPORT - ANNOTATIONS


Term:somatic diversification of immunoglobulins
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Accession:GO:0016445 term browser browse the term
Definition:The somatic process that results in the generation of sequence diversity of immunoglobulins.
Synonyms:exact_synonym: somatic diversification of antibodies


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somatic diversification of immunoglobulins term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CTNNBL1 catenin beta like 1 JBrowse link 17 40,809,932 40,948,844 RGD:14298760
immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G POLB DNA polymerase beta JBrowse link 17 11,356,130 11,388,122 RGD:14298760
immunoglobulin V(D)J recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP1 forkhead box P1 JBrowse link 13 52,346,844 52,974,358 RGD:14298760
G LIG4 DNA ligase 4 JBrowse link 11 75,537,027 75,547,711 RGD:14298760
G PRKDC protein kinase, DNA-activated, catalytic subunit JBrowse link 4 79,687,375 79,850,146 RGD:14298760
G TCF3 transcription factor 3 JBrowse link 2 76,859,079 76,906,275 RGD:14298760
isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 12 42,874,705 42,920,438 RGD:14298760
G CD40LG CD40 ligand JBrowse link X 111,778,666 111,788,901 RGD:14298760
G EXOSC3 exosome component 3 JBrowse link 1 238,536,341 238,541,756 RGD:14298760
G EXOSC6 exosome component 6 JBrowse link 6 13,295,591 13,296,942 RGD:14298760
G LIG4 DNA ligase 4 JBrowse link 11 75,537,027 75,547,711 RGD:14298760
G MLH1 mutL homolog 1 JBrowse link 13 21,791,276 21,877,789 RGD:14298760
G MSH2 mutS homolog 2 JBrowse link 3 93,082,958 93,163,556 RGD:14298760
G MSH6 mutS homolog 6 JBrowse link 3 92,792,590 92,814,154 RGD:14298760
G NBN nibrin JBrowse link 4 46,787,664 46,854,331 RGD:14298760
G SWAP70 switching B cell complex subunit SWAP70 JBrowse link 2 49,721,120 49,805,262 RGD:14298760
G UNG uracil DNA glycosylase JBrowse link 14 41,746,498 41,757,841 RGD:14298760
isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCR6 C-C motif chemokine receptor 6 JBrowse link 1 2,016,600 2,034,172 RGD:14298760
isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 15 101,360,355 101,373,498 RGD:14298760
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARP3 poly(ADP-ribose) polymerase family member 3 JBrowse link 13 34,075,807 34,084,384 RGD:14298760
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 13 125,377,247 125,401,328 RGD:14298760
G FOXP3 forkhead box P3 JBrowse link X 43,303,777 43,328,164 RGD:14298760
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 2 143,688,946 143,734,523 RGD:14298760
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EXOSC3 exosome component 3 JBrowse link 1 238,536,341 238,541,756 RGD:14298760
G EXOSC6 exosome component 6 JBrowse link 6 13,295,591 13,296,942 RGD:14298760
G HMCES 5-hydroxymethylcytosine binding, ES cell specific JBrowse link 13 71,732,311 71,752,296 RGD:14298760
G KMT5B lysine methyltransferase 5B JBrowse link 2 4,710,510 4,768,237 RGD:14298760
G KMT5C lysine methyltransferase 5C JBrowse link 6 59,517,058 59,524,551 RGD:14298760
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 6 71,773,680 71,779,192 RGD:14298760
G RIF1 replication timing regulatory factor 1 JBrowse link 15 769,518 832,036 RGD:14298760
G SHLD1 shieldin complex subunit 1 JBrowse link 17 14,610,723 14,706,082 RGD:14298760
G SHLD2 shieldin complex subunit 2 JBrowse link 14 88,005,599 88,121,155 RGD:14298760
G TFRC transferrin receptor JBrowse link 13 133,976,765 133,997,554 RGD:14298760
G TP53BP1 tumor protein p53 binding protein 1 JBrowse link 1 127,958,500 128,032,370 RGD:14298760
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MLH1 mutL homolog 1 JBrowse link 13 21,791,276 21,877,789 RGD:14298760
G MSH2 mutS homolog 2 JBrowse link 3 93,082,958 93,163,556 RGD:14298760
G NSD2 nuclear receptor binding SET domain protein 2 JBrowse link 8 938,832 1,018,032 RGD:14298760
G TGFB1 transforming growth factor beta 1 JBrowse link 6 49,332,169 49,348,642 RGD:14298760
G TNFSF13 TNF superfamily member 13 JBrowse link 12 52,853,646 52,857,033 RGD:14298760
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G STAT6 signal transducer and activator of transcription 6 JBrowse link 5 22,406,356 22,422,412 RGD:14298760
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 12 42,874,705 42,920,438 RGD:14298760
G CD28 CD28 molecule JBrowse link 15 107,128,103 107,155,431 RGD:14298760
G CD40 CD40 molecule JBrowse link 17 48,286,116 48,298,188 RGD:14298760
G IL2 interleukin 2 JBrowse link 8 101,640,938 101,645,683 RGD:14298760
G MLH1 mutL homolog 1 JBrowse link 13 21,791,276 21,877,789 RGD:14298760
G MSH2 mutS homolog 2 JBrowse link 3 93,082,958 93,163,556 RGD:14298760
G PAXIP1 PAX interacting protein 1 JBrowse link 18 3,066,853 3,111,239 RGD:14298760
G PTPRC protein tyrosine phosphatase receptor type C JBrowse link 10 21,482,984 21,601,627 RGD:14298760
G TBX21 T-box transcription factor 21 JBrowse link 12 23,996,415 24,009,353 RGD:14298760
regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APLF aprataxin and PNKP like factor JBrowse link 3 73,752,115 73,831,158 RGD:14298760
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor JBrowse link 12 44,916,716 44,940,732 RGD:14298760
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 43,303,777 43,328,164 RGD:14298760
G IL27RA interleukin 27 receptor subunit alpha JBrowse link 2 65,127,278 65,149,665 RGD:14298760
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 2 143,688,946 143,734,523 RGD:14298760
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MCM3AP minichromosome maintenance complex component 3 associated protein RGD:14298760
G MLH1 mutL homolog 1 JBrowse link 13 21,791,276 21,877,789 RGD:14298760
G MSH2 mutS homolog 2 JBrowse link 3 93,082,958 93,163,556 RGD:14298760
G MSH6 mutS homolog 6 JBrowse link 3 92,792,590 92,814,154 RGD:14298760
G PMS2 PMS1 homolog 2, mismatch repair system component JBrowse link 3 5,118,002 5,145,634 RGD:14298760
G POLB DNA polymerase beta JBrowse link 17 11,356,130 11,388,122 RGD:14298760
G POLM DNA polymerase mu JBrowse link 18 51,077,845 51,091,354 RGD:14298760
G POLQ DNA polymerase theta JBrowse link 13 138,962,634 139,108,499 RGD:14298760
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 JBrowse link 17 40,117,348 40,171,935 RGD:14298760
G UNG uracil DNA glycosylase JBrowse link 14 41,746,498 41,757,841 RGD:14298760
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MSH3 mutS homolog 3 JBrowse link 2 89,255,647 89,456,102 RGD:14298760
G MSH6 mutS homolog 6 JBrowse link 3 92,792,590 92,814,154 RGD:14298760
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MSH2 mutS homolog 2 JBrowse link 3 93,082,958 93,163,556 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14973
    immune system process 1581
      somatic diversification of immune receptors 58
        somatic diversification of immunoglobulins 50
          alternate splicing of immunoglobulin genes 0
          gene conversion of immunoglobulin genes + 0
          somatic diversification of immunoglobulin genes by N region addition 0
          somatic diversification of immunoglobulins involved in immune response + 39
          somatic hypermutation of immunoglobulin genes + 10
          somatic recombination of immunoglobulin gene segments + 44
Path 2
Term Annotations click to browse term
  biological_process 14973
    developmental process 4208
      anatomical structure development 3899
        multicellular organism development 3457
          system development 3156
            immune system development 681
              somatic diversification of immune receptors 58
                somatic diversification of immunoglobulins 50
                  alternate splicing of immunoglobulin genes 0
                  gene conversion of immunoglobulin genes + 0
                  somatic diversification of immunoglobulin genes by N region addition 0
                  somatic diversification of immunoglobulins involved in immune response + 39
                  somatic hypermutation of immunoglobulin genes + 10
                  somatic recombination of immunoglobulin gene segments + 44
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.