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ONTOLOGY REPORT - ANNOTATIONS


Term:proton-transporting two-sector ATPase complex
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Accession:GO:0016469 term browser browse the term
Definition:A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
Synonyms:exact_synonym: hydrogen-transporting two-sector ATPase complex
 related_synonym: vacuolar hydrogen-transporting ATPase


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mitochondrial proton-transporting ATP synthase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:8553598
RGD:13703047
RGD:1624291
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:8553598
RGD:13792537
RGD:1624291
RGD:1600115
G Atp5f1c ATP synthase F1 subunit gamma JBrowse link 17 72,209,321 72,231,562 RGD:8553598
RGD:1624291
G Atp5f1d ATP synthase F1 subunit delta JBrowse link 7 12,426,807 12,432,120 RGD:8553598
RGD:1624291
RGD:1600115
G Atp5f1e ATP synthase F1 subunit epsilon JBrowse link 3 172,563,105 172,566,007 RGD:8553598
RGD:1624291
G Atp5mc1 ATP synthase membrane subunit c locus 1 JBrowse link 10 83,895,941 83,898,640 RGD:8553598
G Atp5md ATP synthase membrane subunit DAPIT JBrowse link 1 266,859,961 266,866,753 RGD:8554153
RGD:13792537
RGD:8553598
G Atp5me ATP synthase membrane subunit e JBrowse link 14 2,325,308 2,326,436 RGD:8553598
RGD:13792537
RGD:1624291
G Atp5mf ATP synthase membrane subunit f JBrowse link 12 11,191,799 11,198,369 RGD:8553598
RGD:1624291
G Atp5mg ATP synthase membrane subunit g JBrowse link 8 49,220,441 49,227,273 RGD:8553598
RGD:1624291
G Atp5pb ATP synthase peripheral stalk-membrane subunit b JBrowse link 2 208,566,385 208,577,147 RGD:8553598
RGD:1624291
G Atp5pd ATP synthase peripheral stalk subunit d JBrowse link 10 103,967,340 103,972,552 RGD:632024
RGD:1624291
RGD:8553598
G Atp5pf ATP synthase peripheral stalk subunit F6 JBrowse link 11 24,286,806 24,294,419 RGD:8553598
RGD:13792537
RGD:1624291
G Atp5po ATP synthase peripheral stalk subunit OSCP JBrowse link 11 32,081,606 32,087,918 RGD:8553598
RGD:1624291
G LOC100911417 ATP synthase subunit b, mitochondrial-like JBrowse link 2 208,408,890 208,420,159 RGD:8553598
G LOC103693430 up-regulated during skeletal muscle growth protein 5 JBrowse link 10 89,187,162 89,187,504 RGD:8554153
RGD:13792537
RGD:8553598
G LOC691427 similar to 6.8 kDa mitochondrial proteolipid RGD:8553598
RGD:13792537
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 JBrowse link MT 7,919 8,599 RGD:1624291
RGD:13792537
RGD:1600115
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 JBrowse link MT 7,758 7,961 RGD:8553598
RGD:13792537
RGD:1624291
G Ppif peptidylprolyl isomerase F JBrowse link 16 1,979,191 1,985,912 RGD:1600115
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC105515.1 RGD:1600115
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:2292427
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:2292427
G Atp5f1c ATP synthase F1 subunit gamma JBrowse link 17 72,209,321 72,231,562 RGD:2292427
RGD:13792537
G Atp5f1d ATP synthase F1 subunit delta JBrowse link 7 12,426,807 12,432,120 RGD:2292427
RGD:13792537
G Atp5f1e ATP synthase F1 subunit epsilon JBrowse link 3 172,563,105 172,566,007 RGD:2292427
RGD:1624291
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp5mc1 ATP synthase membrane subunit c locus 1 JBrowse link 10 83,895,941 83,898,640 RGD:2292427
RGD:13792537
G Atp5mc2 ATP synthase membrane subunit c locus 2 JBrowse link 7 144,264,207 144,272,578 RGD:13792537
G Atp5mc3 ATP synthase membrane subunit c locus 3 JBrowse link 3 60,811,218 60,813,903 RGD:13792537
G Atp5me ATP synthase membrane subunit e JBrowse link 14 2,325,308 2,326,436 RGD:2292427
G Atp5mf ATP synthase membrane subunit f JBrowse link 12 11,191,799 11,198,369 RGD:2292427
G Atp5mg ATP synthase membrane subunit g JBrowse link 8 49,220,441 49,227,273 RGD:2292427
RGD:13792537
G Atp5pb ATP synthase peripheral stalk-membrane subunit b JBrowse link 2 208,566,385 208,577,147 RGD:2292427
RGD:13792537
G Atp5pd ATP synthase peripheral stalk subunit d JBrowse link 10 103,967,340 103,972,552 RGD:2292427
G Atp5pf ATP synthase peripheral stalk subunit F6 JBrowse link 11 24,286,806 24,294,419 RGD:2292427
G Atp5po ATP synthase peripheral stalk subunit OSCP JBrowse link 11 32,081,606 32,087,918 RGD:2292427
G LOC100911417 ATP synthase subunit b, mitochondrial-like JBrowse link 2 208,408,890 208,420,159 RGD:13792537
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 JBrowse link MT 7,758 7,961 RGD:1600115
mitochondrial proton-transporting ATP synthase, stator stalk term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp5pd ATP synthase peripheral stalk subunit d JBrowse link 10 103,967,340 103,972,552 RGD:13792537
G LOC500350 LRRGT00139 JBrowse link 4 170,347,410 170,382,370 RGD:13792537
plasma membrane proton-transporting V-type ATPase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6ap1 ATPase H+ transporting accessory protein 1 JBrowse link X 156,407,973 156,415,053 RGD:13792537
G Atp6ap1l ATPase H+ transporting accessory protein 1 like JBrowse link 2 19,781,375 19,809,355 RGD:13792537
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 JBrowse link 19 37,481,782 37,525,762 RGD:13792537
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 JBrowse link 5 33,843,591 33,892,446 RGD:13792537
proton-transporting ATP synthase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:1624291
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:1624291
G Atp5f1d ATP synthase F1 subunit delta JBrowse link 7 12,426,807 12,432,120 RGD:724594
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 JBrowse link MT 7,919 8,599 RGD:13792537
proton-transporting ATP synthase complex, catalytic core F(1) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:2292212
RGD:1600115
RGD:13792537
RGD:2292224
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:2292212
RGD:1600115
RGD:13792537
RGD:2292224
G Atp5f1c ATP synthase F1 subunit gamma JBrowse link 17 72,209,321 72,231,562 RGD:2292224
RGD:1600115
G Atp5f1d ATP synthase F1 subunit delta JBrowse link 7 12,426,807 12,432,120 RGD:724594
RGD:1600115
RGD:2292224
G Atp5f1e ATP synthase F1 subunit epsilon JBrowse link 3 172,563,105 172,566,007 RGD:2292224
G Taf3 TATA-box binding protein associated factor 3 JBrowse link 17 72,240,785 72,393,448 RGD:1600115
proton-transporting ATP synthase complex, coupling factor F(o) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07064224.1 RGD:1600115
G Atp5mc1 ATP synthase membrane subunit c locus 1 JBrowse link 10 83,895,941 83,898,640 RGD:13792537
G Atp5mc2 ATP synthase membrane subunit c locus 2 JBrowse link 7 144,264,207 144,272,578 RGD:1600115
RGD:13792537
G Atp5mc3 ATP synthase membrane subunit c locus 3 JBrowse link 3 60,811,218 60,813,903 RGD:1600115
RGD:13792537
G Dmac2l distal membrane arm assembly complex 2 like JBrowse link 6 92,057,782 92,076,022 RGD:1600115
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 JBrowse link MT 7,919 8,599 RGD:1600115
proton-transporting two-sector ATPase complex, catalytic domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 JBrowse link 4 153,351,434 153,373,558 RGD:1600115
G Atp6v1e2 ATPase H+ transporting V1 subunit E2 JBrowse link 6 10,510,370 10,517,059 RGD:1600115
proton-transporting V-type ATPase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6v1d ATPase H+ transporting V1 subunit D JBrowse link 6 102,032,271 102,047,754 RGD:1624291
RGD:13792537
proton-transporting V-type ATPase, V0 domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07030494.1 RGD:1600115
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 JBrowse link 12 37,368,321 37,398,233 RGD:1600115
G Atp6v0b ATPase, H+ transporting, lysosomal V0 subunit B RGD:1600115
G Atp6v0c ATPase H+ transporting V0 subunit C JBrowse link 10 13,537,031 13,543,407 RGD:1600115
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 JBrowse link 19 37,481,782 37,525,762 RGD:1600115
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 JBrowse link 5 33,843,591 33,892,446 RGD:1600115
G Atp6v0e1 ATPase H+ transporting V0 subunit e1 JBrowse link 10 16,769,857 16,792,930 RGD:1600115
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 JBrowse link 4 78,168,117 78,171,265 RGD:1600115
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:1600115
G Tctn2 tectonic family member 2 JBrowse link 12 37,400,896 37,427,256 RGD:1600115
proton-transporting V-type ATPase, V1 domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6ap1 ATPase H+ transporting accessory protein 1 JBrowse link X 156,407,973 156,415,053 RGD:1600115
G Atp6ap1l ATPase H+ transporting accessory protein 1 like JBrowse link 2 19,781,375 19,809,355 RGD:1600115
G Atp6v1a ATPase H+ transporting V1 subunit A JBrowse link 11 61,531,386 61,584,634 RGD:1600115
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 JBrowse link 4 115,417,100 115,435,754 RGD:1600115
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 JBrowse link 16 22,326,537 22,350,143 RGD:1600115
G Atp6v1c2 ATPase H+ transporting V1 subunit C2 JBrowse link 6 42,585,452 42,632,289 RGD:1600115
G Atp6v1f ATPase H+ transporting V1 subunit F JBrowse link 4 56,744,563 56,747,657 RGD:1600115
G Rnase4 ribonuclease A family member 4 JBrowse link 15 28,018,040 28,035,395 RGD:1600115
vacuolar proton-transporting V-type ATPase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07029470.2 RGD:13792537
G Atp6ap2 ATPase H+ transporting accessory protein 2 JBrowse link X 11,137,889 11,164,854 RGD:1624291
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 JBrowse link 10 88,914,264 88,967,736 RGD:13792537
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 JBrowse link 4 65,736,585 65,821,916 RGD:1624291
RGD:13792537
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 JBrowse link 19 37,481,782 37,525,762 RGD:1624291
RGD:13792537
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 JBrowse link 5 33,843,591 33,892,446 RGD:1624291
RGD:13792537
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 JBrowse link 4 115,417,100 115,435,754 RGD:1624291
RGD:1600115
G Atp6v1f ATPase H+ transporting V1 subunit F JBrowse link 4 56,744,563 56,747,657 RGD:1624291
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 JBrowse link 5 79,367,663 79,373,843 RGD:1624291
RGD:13792537
G Atp6v1g2 ATPase H+ transporting V1 subunit G2 JBrowse link 20 4,821,265 4,824,829 RGD:632223
RGD:13792537
RGD:1624291
G Atp6v1g3 ATPase H+ transporting V1 subunit G3 JBrowse link 13 55,265,794 55,288,651 RGD:13792537
G Ccdc115 coiled-coil domain containing 115 JBrowse link 9 37,774,876 37,778,839 RGD:1624291
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:13792537
G Tmem199 transmembrane protein 199 JBrowse link 10 65,775,721 65,780,293 RGD:1624291
RGD:1600115
vacuolar proton-transporting V-type ATPase, V0 domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 JBrowse link 10 88,914,264 88,967,736 RGD:1600115
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 JBrowse link 12 37,368,321 37,398,233 RGD:1600115
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 JBrowse link 4 65,736,585 65,821,916 RGD:1600115
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:1600115
vacuolar proton-transporting V-type ATPase, V1 domain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 JBrowse link 7 77,678,853 77,716,658 RGD:13792537
G Atp6v1c2 ATPase H+ transporting V1 subunit C2 JBrowse link 6 42,585,452 42,632,289 RGD:13792537
G Atp6v1h ATPase H+ transporting V1 subunit H JBrowse link 5 14,262,352 14,367,898 RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19843
    protein-containing complex 5779
      membrane protein complex 1210
        proton-transporting two-sector ATPase complex 59
          archaeal proton-transporting A-type ATPase complex 0
          proton-transporting ATP synthase complex + 27
          proton-transporting V-type ATPase complex + 30
          proton-transporting two-sector ATPase complex, catalytic domain + 19
          proton-transporting two-sector ATPase complex, proton-transporting domain + 28
Path 2
Term Annotations click to browse term
  cellular_component 19843
    cellular anatomical entity 19457
      membrane 9936
        membrane protein complex 1210
          proton-transporting two-sector ATPase complex 59
            archaeal proton-transporting A-type ATPase complex 0
            proton-transporting ATP synthase complex + 27
            proton-transporting V-type ATPase complex + 30
            proton-transporting two-sector ATPase complex, catalytic domain + 19
            proton-transporting two-sector ATPase complex, proton-transporting domain + 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.