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ONTOLOGY REPORT - ANNOTATIONS


Term:core-binding factor complex
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Accession:GO:0016513 term browser browse the term
Definition:A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.
Synonyms:exact_synonym: CBF complex
 narrow_synonym: AML1 complex;   PEPB2 complex


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core-binding factor complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G D CBFB core-binding factor subunit beta JBrowse link 5 82,253,496 82,313,765 RGD:13508589
G R Cbfb core-binding factor subunit beta JBrowse link 19 37,127,508 37,171,075 RGD:13792537
G M Cbfb core binding factor beta JBrowse link 8 105,170,674 105,217,989 RGD:2290270
G H CBFB core-binding factor subunit beta JBrowse link 16 67,029,149 67,101,058 RGD:2290271
G R Runx1 RUNX family transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:13524617
G M Runx1 runt related transcription factor 1 JBrowse link 16 92,601,466 92,826,074 RGD:2290270
G H RUNX1 RUNX family transcription factor 1 JBrowse link 21 34,787,801 35,049,334 RGD:2290271
G M Runx3 runt related transcription factor 3 JBrowse link 4 135,120,645 135,177,990 RGD:2290270
G H RUNX3 RUNX family transcription factor 3 JBrowse link 1 24,899,511 24,965,158 RGD:2290271

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  cellular_component 132215
    protein-containing complex 39029
      transcription regulator complex 3257
        RNA polymerase II transcription regulator complex 1206
          core-binding factor complex 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.