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ONTOLOGY REPORT - ANNOTATIONS


Term:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
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Accession:GO:0016702 term browser browse the term
Definition:Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
Synonyms:xref: EC:1.13.11;   reactome:R-HSA-2161775 "ALOX12 oxidises LTA4 to LXA4/B4";   reactome:R-HSA-2161907 "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4";   reactome:R-HSA-2161917 "ALOX5 oxidises 15S-HpETE to LXA4/B4";   reactome:R-HSA-5164399 "BCO2:Fe2+ cleaves betaC to APO10al and bION";   reactome:R-HSA-9018880 "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE";   reactome:R-HSA-9020274 "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA";   reactome:R-HSA-9026408 "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3";   reactome:R-HSA-9026918 "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA"


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oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:1600115
G Alox12b arachidonate 12-lipoxygenase, 12R type JBrowse link 10 55,744,646 55,756,524 RGD:1624291
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:1600115
G Aloxe3 arachidonate lipoxygenase 3 JBrowse link 10 55,711,996 55,735,915 RGD:1624291
RGD:1600115
G Bco2 beta-carotene oxygenase 2 JBrowse link 8 54,965,577 54,990,604 RGD:1624291
G Cdo1 cysteine dioxygenase type 1 JBrowse link 18 40,702,027 40,716,901 RGD:13792537
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 JBrowse link 20 28,920,616 28,972,576 RGD:1600115
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 JBrowse link 10 39,435,227 39,464,134 RGD:1600115
G P4ha3 prolyl 4-hydroxylase subunit alpha 3 JBrowse link 1 165,295,835 165,330,922 RGD:1600115
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:1642604
G Rpe65 retinoid isomerohydrolase RPE65 JBrowse link 2 266,141,581 266,169,197 RGD:1600115
G Tmlhe trimethyllysine hydroxylase, epsilon JBrowse link 20 237,461 285,125 RGD:1624291
3-hydroxyanthranilate 3,4-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Haao 3-hydroxyanthranilate 3,4-dioxygenase JBrowse link 6 7,045,145 7,059,227 RGD:2290301
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2290370
RGD:2290302
4-hydroxyphenylpyruvate dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hpd 4-hydroxyphenylpyruvate dioxygenase JBrowse link 12 38,828,606 38,839,956 RGD:632936
RGD:13792537
RGD:8554707
G Hpdl 4-hydroxyphenylpyruvate dioxygenase-like JBrowse link 5 135,675,826 135,677,432 RGD:1600115
acireductone dioxygenase [iron(II)-requiring] activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adi1 acireductone dioxygenase 1 JBrowse link 6 47,940,211 47,947,173 RGD:13792537
arachidonate 12(S)-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:1624291
RGD:1600115
G Alox12b arachidonate 12-lipoxygenase, 12R type JBrowse link 10 55,744,646 55,756,524 RGD:1600115
RGD:1624291
G Alox12e arachidonate 12-lipoxygenase, epidermal JBrowse link 10 56,927,676 56,935,141 RGD:1600115
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:70288
RGD:1624291
arachidonate 15-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:1624291
RGD:1600115
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:70287
RGD:1624291
G Alox15b arachidonate 15-lipoxygenase, type B JBrowse link 10 55,773,748 55,783,489 RGD:8554649
RGD:1624291
RGD:1600115
arachidonate 5-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:1600115
RGD:1624291
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 12 6,854,930 6,879,112 RGD:69749
arachidonate 8(R)-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12b arachidonate 12-lipoxygenase, 12R type JBrowse link 10 55,744,646 55,756,524 RGD:1600115
arachidonate 8(S)-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox15b arachidonate 15-lipoxygenase, type B JBrowse link 10 55,773,748 55,783,489 RGD:1600115
RGD:1624291
beta-carotene 15,15'-monooxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bco1 beta-carotene oxygenase 1 JBrowse link 19 49,637,059 49,673,577 RGD:634627
RGD:13792537
RGD:1624291
RGD:1600115
G Bco2 beta-carotene oxygenase 2 JBrowse link 8 54,965,577 54,990,604 RGD:13792537
carotenoid dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bco1 beta-carotene oxygenase 1 JBrowse link 19 49,637,059 49,673,577 RGD:13792537
G Bco2 beta-carotene oxygenase 2 JBrowse link 8 54,965,577 54,990,604 RGD:13792537
cysteine dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdo1 cysteine dioxygenase type 1 JBrowse link 18 40,702,027 40,716,901 RGD:68765
RGD:13792537
RGD:8554270
RGD:2301357
homogentisate 1,2-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hgd homogentisate 1, 2-dioxygenase JBrowse link 11 65,983,221 66,034,555 RGD:13792537
indoleamine 2,3-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ido1 indoleamine 2,3-dioxygenase 1 JBrowse link 16 72,216,326 72,228,098 RGD:2290190
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2290543
RGD:2290313
G Ido2 indoleamine 2,3-dioxygenase 2 JBrowse link 16 72,232,852 72,291,227 RGD:1600115
RGD:13792537
RGD:1624291
linoleate 13S-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:1624291
RGD:1600115
G Alox15b arachidonate 15-lipoxygenase, type B JBrowse link 10 55,773,748 55,783,489 RGD:1600115
RGD:1624291
linoleate 9S-lipoxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12b arachidonate 12-lipoxygenase, 12R type JBrowse link 10 55,744,646 55,756,524 RGD:1600115
RGD:1624291
quercetin 2,3-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pir pirin JBrowse link X 31,852,322 31,968,152 RGD:1624291
RGD:13792537
RGD:1600115
sulfur dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ethe1 ETHE1, persulfide dioxygenase JBrowse link 1 81,457,008 81,472,061 RGD:1624291
RGD:13792537
tryptophan 2,3-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ido1 indoleamine 2,3-dioxygenase 1 JBrowse link 16 72,216,326 72,228,098 RGD:1624291
RGD:13792537
RGD:1600115
G Ido2 indoleamine 2,3-dioxygenase 2 JBrowse link 16 72,232,852 72,291,227 RGD:13792537
G Tdo2 tryptophan 2,3-dioxygenase JBrowse link 2 180,897,059 180,914,919 RGD:2290190
RGD:13792537
RGD:1624291
RGD:2303721
RGD:2291804
RGD:2290313

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Term Annotations click to browse term
  molecular_function 19528
    catalytic activity 6039
      oxidoreductase activity 845
        dioxygenase activity 79
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 27
            1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity 0
            1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity 0
            1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity 0
            1-hydroxy-2-naphthoate 1,2-dioxygenase activity 0
            2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity 0
            2,2',3-trihydroxybiphenyl dioxygenase activity 0
            2,3-dihydroxy DDT 1,2-dioxygenase activity 0
            2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity 0
            2,3-dihydroxy-p-cumate dioxygenase activity 0
            2,3-dihydroxybenzoate 2,3-dioxygenase activity 0
            2,3-dihydroxybenzoate 3,4-dioxygenase activity 0
            2,3-dihydroxybiphenyl 1,2-dioxygenase activity 0
            2,3-dihydroxydiphenyl ether dioxygenase activity 0
            2,3-dihydroxyindole 2,3-dioxygenase activity 0
            2,4'-dihydroxyacetophenone dioxygenase activity 0
            2,5-dihydroxypyridine 5,6-dioxygenase activity 0
            2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity 0
            2-aminophenol 1,6-dioxygenase activity 0
            2-mercaptobenzothiazole dioxygenase activity 0
            3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity 0
            3,4-dihydroxyphenanthrene dioxygenase activity 0
            3,4-dihydroxyphenylacetate 2,3-dioxygenase activity 0
            3,5-dichlorocatechol 1,2-dioxygenase activity 0
            3-carboxyethylcatechol 2,3-dioxygenase activity 0
            3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity 0
            3-hydroxy-2-naphthoate 2,3-dioxygenase activity 0
            3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity 0
            3-hydroxyanthranilate 3,4-dioxygenase activity 1
            4,5-dihydroxybenzo(a)pyrene dioxygenase activity 0
            4,5-dihydroxypyrene dioxygenase activity 0
            4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity 0
            4-hydroxycatechol 1,2-dioxygenase activity 0
            4-hydroxymandelate synthase activity 0
            4-hydroxyphenylpyruvate dioxygenase activity 2
            5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity 0
            5,6-dimethylbenzimidazole synthase activity 0
            5-aminosalicylate dioxygenase activity 0
            7,8-dihydroxy benzo(a)pyrene dioxygenase activity 0
            7,8-dihydroxykynurenate 8,8a-dioxygenase activity 0
            9,10-dihydroxybenzo(a)pyrene dioxygenase activity 0
            9-cis-10'-apo-beta-carotenal cleavage oxygenase activity 0
            9-cis-beta-carotene 9',10'-cleavage oxygenase activity 0
            acetylacetone-cleaving enzyme activity 0
            acireductone dioxygenase (Ni2+-requiring) activity 0
            acireductone dioxygenase [iron(II)-requiring] activity 1
            all-trans-8'-apo-beta-carotenal 15,15'-oxygenase 0
            all-trans-beta-apo-10'-carotenal cleavage oxygenase activity 0
            arachidonate 12(R)-lipoxygenase activity 0
            arachidonate 12(S)-lipoxygenase activity 4
            arachidonate 15-lipoxygenase activity 3
            arachidonate 5-lipoxygenase activity 2
            arachidonate 8(R)-lipoxygenase activity 1
            arachidonate 8(S)-lipoxygenase activity 1
            benzo(a)pyrene 11,12-dioxygenase activity 0
            benzo(a)pyrene 4,5-dioxygenase activity 0
            benzo(a)pyrene 7,8-dioxygenase activity 0
            benzo(a)pyrene 9,10-dioxygenase activity 0
            beta,beta-carotene-9',10'-cleaving oxygenase activity 0
            beta-carotene 15,15'-monooxygenase activity 2
            beta-carotene oxygenase activity 0
            biphenyl-2,3-diol 1,2-dioxygenase activity 0
            caffeate 3,4-dioxygenase activity 0
            carbazole 1,9a-dioxygenase activity 0
            carotenoid dioxygenase activity + 2
            catechol dioxygenase activity + 0
            chloridazon-catechol dioxygenase activity 0
            chlorite O2-lyase activity 0
            chlorocatechol 1,2-dioxygenase activity 0
            cysteamine dioxygenase activity 0
            cysteine dioxygenase activity 1
            dihydroxydibenzothiophene dioxygenase activity 0
            dihydroxyfluorene dioxygenase activity + 0
            diphenyl ether 1,2-dioxygenase activity 0
            fatty acid alpha-oxygenase activity 0
            gallate dioxygenase activity 0
            gentisate 1,2-dioxygenase activity 0
            homogentisate 1,2-dioxygenase activity 1
            hydroquinone 1,2-dioxygenase activity 0
            hydroxyquinol 1,2-dioxygenase activity 0
            indole 2,3-dioxygenase activity 0
            indoleamine 2,3-dioxygenase activity 2
            lignostilbene alpha beta-dioxygenase activity 0
            linoleate 11-lipoxygenase activity 0
            linoleate 13S-lipoxygenase activity 2
            linoleate 8R-lipoxygenase 0
            linoleate 8R-lipoxygenase activity 0
            linoleate 9R-lipoxygenase activity 0
            linoleate 9S-lipoxygenase activity 1
            linolenate 9R-lipoxygenase activity 0
            lutein oxygenase activity 0
            p-cumate 2,3-dioxygenase activity 0
            peptide-tryptophan 2,3-dioxygenase activity 0
            phenanthrene dioxygenase activity 0
            phenanthrene-4-carboxylate dioxygenase activity 0
            protocatechuate 3,4-dioxygenase activity 0
            protocatechuate 3,4-dioxygenase type II activity 0
            protocatechuate 4,5-dioxygenase activity 0
            pyrene dioxygenase activity 0
            pyridine-3,4-diol dioxygenase activity 0
            pyrogallol 1,2-oxygenase activity 0
            quercetin 2,3-dioxygenase activity 1
            stizolobate synthase activity 0
            stizolobinate synthase activity 0
            styrene dioxygenase activity 0
            sulfur dioxygenase activity 1
            sulfur oxygenase/reductase activity 0
            tetrachlorobenzene dioxygenase activity 0
            tryptophan 2,3-dioxygenase activity 3
            violaxanthin oxygenase activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.