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ONTOLOGY REPORT - ANNOTATIONS


Term:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
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Accession:GO:0016702 term browser browse the term
Definition:Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
Synonyms:xref: EC:1.13.11;   reactome:R-HSA-2161775 "ALOX12 oxidises LTA4 to LXA4/B4";   reactome:R-HSA-2161907 "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4";   reactome:R-HSA-2161917 "ALOX5 oxidises 15S-HpETE to LXA4/B4";   reactome:R-HSA-5164399 "BCO2:Fe2+ cleaves betaC to APO10al and bION";   reactome:R-HSA-9018880 "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE";   reactome:R-HSA-9020274 "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA";   reactome:R-HSA-9026408 "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3";   reactome:R-HSA-9026918 "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA"


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oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADO 2-aminoethanethiol dioxygenase IEA InterPro GO_REF:0000002 NCBI chr14:66,277,224...66,281,964
Ensembl chr14:66,277,947...66,278,759
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type IEA InterPro GO_REF:0000002 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:53,292,530...53,302,850
Ensembl chr12:53,292,524...53,302,993
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase IEA InterPro GO_REF:0000002 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr12:53,259,867...53,281,127
Ensembl chr12:53,259,940...53,281,520
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,858,975...90,907,094
JBrowse link
G ALOXE3 arachidonate lipoxygenase 3 NOT ISO
IEA
(PMID:12881489) UniProtKB
InterPro
PMID:12881489 GO_REF:0000002 NCBI chr12:53,309,845...53,331,780
Ensembl chr12:53,309,845...53,331,324
JBrowse link
G BCO2 beta-carotene oxygenase 2 IEA InterPro GO_REF:0000002 NCBI chr 9:39,864,136...39,916,491
Ensembl chr 9:39,864,114...39,927,801
JBrowse link
G CDO1 cysteine dioxygenase type 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:119,927,768...119,940,690
Ensembl chr 2:119,892,691...119,940,665
JBrowse link
G P4HA1 prolyl 4-hydroxylase subunit alpha 1 IEA InterPro GO_REF:0000002 NCBI chr14:75,827,207...75,919,121
Ensembl chr14:75,825,140...75,918,917
JBrowse link
G P4HA2 prolyl 4-hydroxylase subunit alpha 2 IEA InterPro GO_REF:0000002 NCBI chr 2:134,502,210...134,595,444
Ensembl chr 2:134,502,210...134,595,430
JBrowse link
G P4HA3 prolyl 4-hydroxylase subunit alpha 3 IEA InterPro GO_REF:0000002 NCBI chr 9:8,627,365...8,681,804
Ensembl chr 9:8,627,412...8,667,774
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:8203528 RGD:1642604 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G RPE65 retinoid isomerohydrolase RPE65 IEA InterPro GO_REF:0000002 NCBI chr 6:144,206,078...144,229,471
Ensembl chr 6:144,206,077...144,293,709
JBrowse link
G TMLHE trimethyllysine hydroxylase, epsilon IEA Ensembl GO_REF:0000107 NCBI chr  X:125,601,920...125,673,716
Ensembl chr  X:125,598,105...125,673,680
JBrowse link
3-hydroxyanthranilate 3,4-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:97,580,756...97,595,033
Ensembl chr 3:97,580,851...97,595,021
JBrowse link
4-hydroxyphenylpyruvate dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPD 4-hydroxyphenylpyruvate dioxygenase ISS
IBA
IEA
(PMID:21873635) UniProt
GO_Central
InterPro
PMID:21873635 GO_REF:0000002, GO_REF:0000024 NCBI chr14:30,845,608...30,857,658
Ensembl chr14:30,845,613...30,857,667
JBrowse link
acireductone dioxygenase [iron(II)-requiring] activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:131,295,257...131,303,663
Ensembl chr 3:131,295,257...131,304,337
JBrowse link
arachidonate 12(S)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type IEA Ensembl GO_REF:0000107 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:53,292,530...53,302,850
Ensembl chr12:53,292,524...53,302,993
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase IEA Ensembl GO_REF:0000107 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,286,019...52,414,907
JBrowse link
arachidonate 15-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type IEA Ensembl GO_REF:0000107 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase IEA Ensembl GO_REF:0000107 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:53,259,867...53,281,127
Ensembl chr12:53,259,940...53,281,520
JBrowse link
arachidonate 5-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,858,975...90,907,094
JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein contributes_to ISO RGD PMID:2300173 RGD:69749 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
JBrowse link
arachidonate 8(R)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12B arachidonate 12-lipoxygenase, 12R type IEA Ensembl GO_REF:0000107 NCBI chr12:53,292,530...53,302,850
Ensembl chr12:53,292,524...53,302,993
JBrowse link
arachidonate 8(S)-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX15B arachidonate 15-lipoxygenase type B IEA Ensembl GO_REF:0000107 NCBI chr12:53,259,867...53,281,127
Ensembl chr12:53,259,940...53,281,520
JBrowse link
beta-carotene 15,15'-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCO1 beta-carotene oxygenase 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:7,008,330...7,054,089
Ensembl chr 6:7,012,613...7,105,271
JBrowse link
G BCO2 beta-carotene oxygenase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:39,864,136...39,916,491
Ensembl chr 9:39,864,114...39,927,801
JBrowse link
carotenoid dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCO2 beta-carotene oxygenase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:39,864,136...39,916,491
Ensembl chr 9:39,864,114...39,927,801
JBrowse link
cysteine dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDO1 cysteine dioxygenase type 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:119,927,768...119,940,690
Ensembl chr 2:119,892,691...119,940,665
JBrowse link
homogentisate 1,2-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HGD homogentisate 1,2-dioxygenase IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000003 NCBI chr13:139,660,315...139,710,402
Ensembl chr13:139,660,343...139,710,405
JBrowse link
indoleamine 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:9,245,283...9,260,140
Ensembl chr17:9,245,196...9,260,491
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr17:9,277,039...9,344,405
Ensembl chr17:9,277,069...9,343,749
JBrowse link
linoleate 13S-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type IEA Ensembl GO_REF:0000107 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase IEA Ensembl GO_REF:0000107 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,286,019...52,414,907
JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B IEA Ensembl GO_REF:0000107 NCBI chr12:53,259,867...53,281,127
Ensembl chr12:53,259,940...53,281,520
JBrowse link
linoleate 9S-lipoxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12B arachidonate 12-lipoxygenase, 12R type IEA Ensembl GO_REF:0000107 NCBI chr12:53,292,530...53,302,850
Ensembl chr12:53,292,524...53,302,993
JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B IEA Ensembl GO_REF:0000107 NCBI chr12:53,259,867...53,281,127
Ensembl chr12:53,259,940...53,281,520
JBrowse link
quercetin 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIR pirin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:11,934,157...12,034,629
Ensembl chr  X:11,934,161...12,033,746
JBrowse link
sulfur dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ETHE1 ETHE1 persulfide dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:50,375,836...50,395,769
Ensembl chr 6:50,375,841...50,396,237
JBrowse link
tryptophan 2,3-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:9,245,283...9,260,140
Ensembl chr17:9,245,196...9,260,491
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:9,277,039...9,344,405
Ensembl chr17:9,277,069...9,343,749
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase IBA
IEA
(PMID:21873635) GO_Central
UniProt
InterPro
PMID:21873635 GO_REF:0000002, GO_REF:0000003 NCBI chr 8:44,708,722...44,725,954
Ensembl chr 8:44,708,746...44,740,980
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 17444
    catalytic activity 5460
      oxidoreductase activity 724
        dioxygenase activity 83
          oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 26
            1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity 0
            1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity 0
            1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity 0
            1-hydroxy-2-naphthoate 1,2-dioxygenase activity 0
            2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity 0
            2,2',3-trihydroxybiphenyl dioxygenase activity 0
            2,3-dihydroxy DDT 1,2-dioxygenase activity 0
            2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity 0
            2,3-dihydroxy-p-cumate dioxygenase activity 0
            2,3-dihydroxybenzoate 2,3-dioxygenase activity 0
            2,3-dihydroxybenzoate 3,4-dioxygenase activity 0
            2,3-dihydroxybiphenyl 1,2-dioxygenase activity 0
            2,3-dihydroxydiphenyl ether dioxygenase activity 0
            2,3-dihydroxyindole 2,3-dioxygenase activity 0
            2,4'-dihydroxyacetophenone dioxygenase activity 0
            2,5-dihydroxypyridine 5,6-dioxygenase activity 0
            2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity 0
            2-aminophenol 1,6-dioxygenase activity 0
            2-mercaptobenzothiazole dioxygenase activity 0
            3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity 0
            3,4-dihydroxyphenanthrene dioxygenase activity 0
            3,4-dihydroxyphenylacetate 2,3-dioxygenase activity 0
            3,5-dichlorocatechol 1,2-dioxygenase activity 0
            3-carboxyethylcatechol 2,3-dioxygenase activity 0
            3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity 0
            3-hydroxy-2-naphthoate 2,3-dioxygenase activity 0
            3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity 0
            3-hydroxyanthranilate 3,4-dioxygenase activity 1
            4,5-dihydroxybenzo(a)pyrene dioxygenase activity 0
            4,5-dihydroxypyrene dioxygenase activity 0
            4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity 0
            4-hydroxycatechol 1,2-dioxygenase activity 0
            4-hydroxymandelate synthase activity 0
            4-hydroxyphenylpyruvate dioxygenase activity 1
            5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity 0
            5,6-dimethylbenzimidazole synthase activity 0
            5-aminosalicylate dioxygenase activity 0
            7,8-dihydroxy benzo(a)pyrene dioxygenase activity 0
            7,8-dihydroxykynurenate 8,8a-dioxygenase activity 0
            9,10-dihydroxybenzo(a)pyrene dioxygenase activity 0
            9-cis-10'-apo-beta-carotenal cleavage oxygenase activity 0
            9-cis-beta-carotene 9',10'-cleavage oxygenase activity 0
            acetylacetone-cleaving enzyme activity 0
            acireductone dioxygenase (Ni2+-requiring) activity 0
            acireductone dioxygenase [iron(II)-requiring] activity 1
            all-trans-8'-apo-beta-carotenal 15,15'-oxygenase 0
            all-trans-beta-apo-10'-carotenal cleavage oxygenase activity 0
            arachidonate 12(R)-lipoxygenase activity 0
            arachidonate 12(S)-lipoxygenase activity 3
            arachidonate 15-lipoxygenase activity 3
            arachidonate 5-lipoxygenase activity 2
            arachidonate 8(R)-lipoxygenase activity 1
            arachidonate 8(S)-lipoxygenase activity 1
            benzo(a)pyrene 11,12-dioxygenase activity 0
            benzo(a)pyrene 4,5-dioxygenase activity 0
            benzo(a)pyrene 7,8-dioxygenase activity 0
            benzo(a)pyrene 9,10-dioxygenase activity 0
            beta,beta-carotene-9',10'-cleaving oxygenase activity 0
            beta-carotene 15,15'-monooxygenase activity 2
            beta-carotene oxygenase activity 0
            biphenyl-2,3-diol 1,2-dioxygenase activity 0
            caffeate 3,4-dioxygenase activity 0
            carbazole 1,9a-dioxygenase activity 0
            carotenoid dioxygenase activity + 1
            catechol dioxygenase activity + 0
            chloridazon-catechol dioxygenase activity 0
            chlorite O2-lyase activity 0
            chlorocatechol 1,2-dioxygenase activity 0
            cysteamine dioxygenase activity 0
            cysteine dioxygenase activity 1
            dihydroxydibenzothiophene dioxygenase activity 0
            dihydroxyfluorene dioxygenase activity + 0
            diphenyl ether 1,2-dioxygenase activity 0
            fatty acid alpha-oxygenase activity 0
            gallate dioxygenase activity 0
            gentisate 1,2-dioxygenase activity 0
            homogentisate 1,2-dioxygenase activity 1
            hydroquinone 1,2-dioxygenase activity 0
            hydroxyquinol 1,2-dioxygenase activity 0
            indole 2,3-dioxygenase activity 0
            indoleamine 2,3-dioxygenase activity 2
            lignostilbene alpha beta-dioxygenase activity 0
            linoleate 11-lipoxygenase activity 0
            linoleate 13S-lipoxygenase activity 3
            linoleate 8R-lipoxygenase 0
            linoleate 8R-lipoxygenase activity 0
            linoleate 9R-lipoxygenase activity 0
            linoleate 9S-lipoxygenase activity 2
            linolenate 9R-lipoxygenase activity 0
            lutein oxygenase activity 0
            p-cumate 2,3-dioxygenase activity 0
            peptide-tryptophan 2,3-dioxygenase activity 0
            phenanthrene dioxygenase activity 0
            phenanthrene-4-carboxylate dioxygenase activity 0
            protocatechuate 3,4-dioxygenase activity 0
            protocatechuate 3,4-dioxygenase type II activity 0
            protocatechuate 4,5-dioxygenase activity 0
            pyrene dioxygenase activity 0
            pyridine-3,4-diol dioxygenase activity 0
            pyrogallol 1,2-oxygenase activity 0
            quercetin 2,3-dioxygenase activity 1
            stizolobate synthase activity 0
            stizolobinate synthase activity 0
            styrene dioxygenase activity 0
            sulfur dioxygenase activity 1
            sulfur oxygenase/reductase activity 0
            tetrachlorobenzene dioxygenase activity 0
            tryptophan 2,3-dioxygenase activity 3
            violaxanthin oxygenase activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.