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ONTOLOGY REPORT - ANNOTATIONS


Term:2-oxoglutarate-dependent dioxygenase activity
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Accession:GO:0016706 term browser browse the term
Definition:Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
Synonyms:exact_synonym: 2-oxoglutarate dioxygenase activity;   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
 alt_id: GO:0010302
 xref: EC:1.14.11;   Reactome:R-HSA-1234164 "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)";   reactome:R-HSA-6783455 "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)"


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2-oxoglutarate-dependent dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alkbh1 alkB homolog 1, histone H2A dioxygenase JBrowse link 6 111,456,096 111,476,829 RGD:1624291
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase JBrowse link 12 48,257,575 48,262,244 RGD:1624291
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase JBrowse link 3 82,874,242 82,907,467 RGD:1624291
G Alkbh4 alkB homolog 4, lysine demethylase JBrowse link 12 23,568,204 23,574,133 RGD:1624291
G Alkbh5 alkB homolog 5, RNA demethylase JBrowse link 10 46,906,314 46,927,759 RGD:1624291
RGD:1600115
G Alkbh6 alkB homolog 6 JBrowse link 1 88,766,872 88,772,243 RGD:1624291
G Alkbh7 alkB homolog 7 JBrowse link 9 10,045,375 10,047,507 RGD:1624291
G Alkbh8 alkB homolog 8, tRNA methyltransferase JBrowse link 6 18,877,885 18,952,773 RGD:1624291
RGD:13792537
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:1624291
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:1624291
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:1624291
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor JBrowse link 1 264,309,214 264,319,269 RGD:13792537
G Hspbap1 HSPB1 associated protein 1 JBrowse link 11 68,142,684 68,197,783 RGD:13792537
G Jmjd4 jumonji domain containing 4 JBrowse link 10 45,798,964 45,804,188 RGD:1624291
G Jmjd7 jumonji domain containing 7 JBrowse link 3 111,818,150 111,824,211 RGD:13792537
G Kdm7a lysine demethylase 7A JBrowse link 4 66,915,603 66,957,971 RGD:1624291
G Kdm8 lysine demethylase 8 JBrowse link 1 196,838,460 196,854,192 RGD:13792537
G P4htm prolyl 4-hydroxylase, transmembrane JBrowse link 8 117,364,895 117,383,275 RGD:1624291
G Phf8 PHD finger protein 8 JBrowse link X 21,063,487 21,168,750 RGD:1624291
G Riox1 ribosomal oxygenase 1 JBrowse link 6 107,428,508 107,431,126 RGD:1624291
G Trmt9b tRNA methyltransferase 9B (putative) JBrowse link 16 59,316,145 59,368,559 RGD:13792537
G Tyw5 tRNA-yW synthesizing protein 5 JBrowse link 9 64,077,841 64,096,265 RGD:1624291
RGD:13792537
DNA-N1-methyladenine dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase JBrowse link 12 48,257,575 48,262,244 RGD:1624291
RGD:13792537
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase JBrowse link 3 82,874,242 82,907,467 RGD:1600115
RGD:1624291
G Fto FTO, alpha-ketoglutarate dependent dioxygenase JBrowse link 19 16,774,549 17,115,098 RGD:1600115
RGD:13792537
RGD:1624291
gamma-butyrobetaine dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bbox1 gamma-butyrobetaine hydroxylase 1 JBrowse link 3 101,425,684 101,474,848 RGD:632240
RGD:13792537
RGD:1624291
RGD:8554503
RGD:1600115
histone demethylase activity (H3-K36 specific) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kdm2a lysine demethylase 2A JBrowse link 1 219,566,130 219,642,294 RGD:1624291
G Kdm2b lysine demethylase 2B JBrowse link 12 39,021,924 39,161,954 RGD:1624291
G Kdm4a lysine demethylase 4A JBrowse link 5 136,967,650 137,014,402 RGD:1624291
RGD:13792537
G Kdm4b lysine demethylase 4B JBrowse link 9 10,656,035 10,734,127 RGD:1624291
G Kdm4c lysine demethylase 4C JBrowse link 5 90,800,139 91,012,662 RGD:1624291
RGD:13792537
G Kdm7a lysine demethylase 7A JBrowse link 4 66,915,603 66,957,971 RGD:1624291
RGD:1600115
G Kdm8 lysine demethylase 8 JBrowse link 1 196,838,460 196,854,192 RGD:1600115
RGD:13792537
RGD:1624291
G Phf8 PHD finger protein 8 JBrowse link X 21,063,487 21,168,750 RGD:1624291
G Riox1 ribosomal oxygenase 1 JBrowse link 6 107,428,508 107,431,126 RGD:1624291
RGD:13792537
G Riox2 ribosomal oxygenase 2 JBrowse link 11 43,006,190 43,028,722 RGD:13792537
G Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked JBrowse link Y 1,065,274 1,206,127 RGD:1624291
methylcytosine dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alkbh1 alkB homolog 1, histone H2A dioxygenase JBrowse link 6 111,456,096 111,476,829 RGD:1624291
G Tet1 tet methylcytosine dioxygenase 1 JBrowse link 20 27,359,122 27,438,039 RGD:1624291
RGD:13792537
G Tet2 tet methylcytosine dioxygenase 2 JBrowse link 2 238,719,389 238,802,975 RGD:1624291
RGD:13792537
G Tet3 tet methylcytosine dioxygenase 3 JBrowse link 4 115,060,702 115,160,800 RGD:1624291
RGD:13792537
peptide-aspartate beta-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asph aspartate-beta-hydroxylase JBrowse link 5 22,577,680 22,799,333 RGD:13792537
peptidyl-asparagine 3-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor JBrowse link 1 264,309,214 264,319,269 RGD:1624291
RGD:13792537
peptidyl-histidine dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor JBrowse link 1 264,309,214 264,319,269 RGD:1624291
RGD:13792537
peptidyl-lysine 5-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase JBrowse link 10 105,781,752 105,787,803 RGD:1600115
RGD:1624291
peptidyl-proline 3-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 JBrowse link 19 11,425,301 11,451,085 RGD:1624291
peptidyl-proline 4-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07004992.1 RGD:13792537
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:1624291
RGD:13792537
RGD:1600115
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:13602003
RGD:13792537
RGD:1624291
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:1600115
RGD:13792537
RGD:1624291
peptidyl-proline dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07004992.1 RGD:13792537
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:6483365
RGD:13792537
RGD:6483450
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:13792537
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:1624291
RGD:13792537
G Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 JBrowse link 19 11,425,301 11,451,085 RGD:1624291
RGD:13792537
phytanoyl-CoA dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Phyh phytanoyl-CoA 2-hydroxylase JBrowse link 17 77,287,580 77,304,482 RGD:727286
RGD:13792537
RGD:1624291
procollagen-lysine 5-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plod1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 JBrowse link 5 164,720,629 164,747,071 RGD:1599090
RGD:13792537
RGD:1624291
RGD:1600115
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 JBrowse link 8 99,977,334 100,059,736 RGD:1600115
RGD:13792537
RGD:1624291
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 JBrowse link 12 22,716,421 22,726,982 RGD:1600115
RGD:1624291
RGD:13792537
procollagen-proline 3-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G P3h1 prolyl 3-hydroxylase 1 JBrowse link 5 138,279,597 138,294,280 RGD:13792537
RGD:1600115
G P3h2 prolyl 3-hydroxylase 2 JBrowse link 11 78,028,885 78,169,746 RGD:8553392
RGD:13792537
RGD:1600115
RGD:1624291
G P3h3 prolyl 3-hydroxylase 3 JBrowse link 4 157,359,331 157,375,186 RGD:13792537
procollagen-proline 4-dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 JBrowse link 20 28,920,616 28,972,576 RGD:625562
RGD:13792537
RGD:1624291
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 JBrowse link 10 39,435,227 39,464,134 RGD:1624291
RGD:13792537
G P4ha3 prolyl 4-hydroxylase subunit alpha 3 JBrowse link 1 165,295,835 165,330,922 RGD:731224
RGD:1600115
G P4hb prolyl 4-hydroxylase subunit beta JBrowse link 10 109,736,459 109,748,070 RGD:1624291
G P4htm prolyl 4-hydroxylase, transmembrane JBrowse link 8 117,364,895 117,383,275 RGD:13792537
trimethyllysine dioxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tmlhe trimethyllysine hydroxylase, epsilon JBrowse link 20 237,461 285,125 RGD:70558
RGD:1624291

Term paths to the root
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Term Annotations click to browse term
  molecular_function 20216
    catalytic activity 6044
      oxidoreductase activity 856
        dioxygenase activity 81
          2-oxoglutarate-dependent dioxygenase activity 50
            (gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity 0
            (gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity 0
            1-ethyladenine demethylase activity 0
            2'-deoxymugineic-acid 2'-dioxygenase activity 0
            2'-deoxymugineic-acid 3-dioxygenase activity 0
            2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity 0
            2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity 0
            4-chloro-2-methylphenoxyacetate oxygenase activity 0
            4-coumaroyl 2'-hydroxylase activity 0
            5-formylcytosine dioxygenase activity 0
            5-hydroxymethylcytosine dioxygenase activity 0
            6-beta-hydroxyhyoscyamine epoxidase activity 0
            DNA-N1-methyladenine dioxygenase activity 3
            FR-33289 synthase activity 0
            GA20 2,3-desaturase activity 0
            GA5 2,3 epoxidase activity 0
            GA5 3beta-hydroxylase activity 0
            L-gamma-glutamyl-L-propargylglycine hydroxylase activity 0
            N1-methyladenine demethylase activity 0
            N3-methylcytosine demethylase activity 0
            anthocyanidin synthase activity 0
            clavaminate synthase activity 0
            codeine O-demethylase activity 0
            deacetoxycephalosporin-C hydroxylase activity 0
            deoxyuridine 1'-dioxygenase activity 0
            deoxyuridine 2'-dioxygenase activity 0
            desacetoxyvindoline 4-hydroxylase activity 0
            flavone synthase activity 0
            flavonol synthase activity 0
            gamma-butyrobetaine dioxygenase activity 1
            gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin 2-beta-dioxygenase activity + 0
            gibberellin 20-oxidase activity 0
            gibberellin 3-beta-dioxygenase activity 0
            gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming) 0
            gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming) 0
            gibberellin A12,oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A13,oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A17,oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A25 hydroxylase activity 0
            gibberellin A25,oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A28,oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming) 0
            gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity 0
            gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity 0
            gibberellin-44 dioxygenase activity 0
            histone demethylase activity (H3-K36 specific) 11
            hyoscyamine (6S)-dioxygenase activity 0
            hypophosphite dioxygenase activity 0
            hypoxia-inducible factor-asparagine oxygenase activity 0
            leucocyanidin oxygenase activity 0
            methylcytosine dioxygenase activity 4
            mugineic-acid 3-dioxygenase activity 0
            naringenin 3-dioxygenase activity 0
            oripavine 6-O-demethylase activity 0
            peptide-aspartate beta-dioxygenase activity 1
            peptidyl-arginine 3-dioxygenase activity 0
            peptidyl-asparagine 3-dioxygenase activity 1
            peptidyl-histidine dioxygenase activity 1
            peptidyl-lysine 3-dioxygenase activity 0
            peptidyl-lysine 4-dioxygenase activity 0
            peptidyl-lysine 5-dioxygenase activity + 4
            peptidyl-proline dioxygenase activity + 13
            phytanoyl-CoA dioxygenase activity 1
            proline 3-hydroxylase activity 0
            sulfonate dioxygenase activity 0
            tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity 0
            taurine dioxygenase activity 0
            thebaine 6-O-demethylase activity 0
            thebane O-demethylase activity 0
            thymine dioxygenase activity 0
            trimethyllysine dioxygenase activity 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.