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ONTOLOGY REPORT - ANNOTATIONS


Term:acid-amino acid ligase activity
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Accession:GO:0016881 term browser browse the term
Definition:Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
Synonyms:exact_synonym: peptide synthase activity
 xref: EC:6.3.2


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acid-amino acid ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ghdc GH3 domain containing IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:88,672,834...88,677,055
Ensembl chr10:88,672,843...88,677,055
JBrowse link
carnosine synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carns1 carnosine synthase 1 ISO (PMID:20097752), (PMID:24891507)
(MGI:4457482|PMID:20097752), (MGI:5607487|PMID:24891507)
RGD PMID:20097752, PMID:24891507 MGI:4457482, MGI:5607487 NCBI chr 1:219,413,897...219,424,533
Ensembl chr 1:219,414,915...219,422,268
JBrowse link
glutamate-cysteine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit IMP
ISO
IBA
ISS
IDA
MGI:2429419 (MGI:1928560|PMID:11118286), (MGI:2157601|PMID:10966520), (MGI:2447526|PMID:12384496), (MGI:3047441|PMID:15288121), (MGI:3607629|PMID:16081425)
(PMID:11972604), (PMID:16183645), (PMID:8104187), (PMID:9675072), (PMID:9841880)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:8104187, PMID:9675072, PMID:9841880, PMID:10966520, PMID:11118286, PMID:11972604, PMID:12384496, PMID:15288121, PMID:16081425, PMID:16183645, PMID:16183645, PMID:21873635, PMID:12425961 GO_REF:0000024, MGI:1928560, MGI:2157601, MGI:2447526, MGI:3047441, MGI:3607629, RGD:1582661, RGD:13792537, RGD:11049538 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit contributes_to IDA
ISO
IMP
(PMID:16183645) RGD PMID:16183645, PMID:8104188, PMID:16183645 RGD:632762, RGD:1582661 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
glutathione synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gss glutathione synthetase IDA
ISO
IBA
(MGI:81780|PMID:8660701)
PMID:21873635
RGD PMID:8660701, PMID:7862666, PMID:21873635, PMID:10964706 MGI:81780, RGD:69853, RGD:13792537, RGD:1599340 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
phosphopantothenate--cysteine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppcs phosphopantothenoylcysteine synthetase ISO
IBA
(PMID:11923312), (PMID:29754768)
PMID:21873635
RGD PMID:11923312, PMID:29754768, PMID:21873635 RGD:13792537 NCBI chr 5:138,466,298...138,470,108
Ensembl chr 5:138,466,293...138,470,096
JBrowse link
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07036855.1 IEA GO_REF:0000003 UniProt GO_REF:0000003 Ensembl chr  X:4,285,857...4,287,160 JBrowse link
G LOC100910308 multifunctional protein ADE2-like IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:33,968,258...33,977,367
Ensembl chr14:33,968,759...33,977,277
JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:33,563,884...33,580,944
Ensembl chr14:33,563,886...33,580,566
JBrowse link
protein-glutamic acid ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll4 tubulin tyrosine ligase like 4 ISO (MGI:5770179|PMID:26829768) RGD PMID:26829768 MGI:5770179 NCBI chr 9:81,925,363...81,961,882
Ensembl chr 9:81,940,630...81,954,686
JBrowse link
G Ttll6 tubulin tyrosine ligase like 6 ISO (MGI:5770179|PMID:26829768) RGD PMID:26829768 MGI:5770179 NCBI chr10:83,954,221...83,999,542
Ensembl chr10:83,954,279...83,999,710
JBrowse link
protein-glycine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll10 tubulin tyrosine ligase like 10 NOT ISO
ISS
(PMID:19524510)
(MGI:3850271|PMID:19524510)
GO_REF:0000024
RGD
UniProt
PMID:19524510 GO_REF:0000024, MGI:3850271 NCBI chr 5:173,471,020...173,517,783
Ensembl chr 5:173,471,010...173,484,986
JBrowse link
G Ttll3 tubulin tyrosine ligase like 3 ISO (PMID:19524510)
(MGI:3850271|PMID:19524510)
RGD PMID:19524510 MGI:3850271 NCBI chr 4:145,341,059...145,366,614
Ensembl chr 4:145,342,193...145,365,496
JBrowse link
G Ttll8 tubulin tyrosine ligase like 8 ISO (MGI:3850271|PMID:19524510) RGD PMID:19524510 MGI:3850271 NCBI chr 7:129,906,998...129,948,578 JBrowse link
protein-glycine ligase activity, elongating term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll10 tubulin tyrosine ligase like 10 ISS
ISO
GO_REF:0000024
(MGI:3850271|PMID:19524510)
UniProt
RGD
PMID:19524510 GO_REF:0000024, MGI:3850271 NCBI chr 5:173,471,020...173,517,783
Ensembl chr 5:173,471,010...173,484,986
JBrowse link
protein-glycine ligase activity, initiating term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll3 tubulin tyrosine ligase like 3 ISO (MGI:3850271|PMID:19524510) RGD PMID:19524510 MGI:3850271 NCBI chr 4:145,341,059...145,366,614
Ensembl chr 4:145,342,193...145,365,496
JBrowse link
G Ttll8 tubulin tyrosine ligase like 8 ISO (MGI:3850271|PMID:19524510) RGD PMID:19524510 MGI:3850271 NCBI chr 7:129,906,998...129,948,578 JBrowse link
tetrahydrofolylpolyglutamate synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase IDA
IBA
ISO
PMID:21873635
(PMID:25164808), (PMID:3619447)
RGD PMID:3619447, PMID:25164808, PMID:6892914, PMID:21873635 RGD:2315105, RGD:13792537 NCBI chr 3:11,717,667...11,729,694
Ensembl chr 3:11,717,667...11,723,327
JBrowse link
tubulin-glutamic acid ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpgs1 tubulin polyglutamylase complex subunit 1 ISO (MGI:3760183|PMID:17360631) RGD PMID:17360631 MGI:3760183 NCBI chr 7:12,912,251...12,918,173
Ensembl chr 7:12,912,263...12,918,173
JBrowse link
G Ttll1 tubulin tyrosine ligase like 1 IBA
ISO
PMID:21873635
(MGI:5897758|PMID:15890843), (MGI:6269036|PMID:30420556)
RGD PMID:15890843, PMID:30420556, PMID:21873635 MGI:5897758, MGI:6269036, RGD:13792537 NCBI chr 7:124,338,396...124,367,719
Ensembl chr 7:124,338,395...124,367,630
JBrowse link
G Ttll11 tubulin tyrosine ligase like11 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:15,084,244...15,312,312
Ensembl chr 3:15,084,634...15,278,645
JBrowse link
G Ttll13 tubulin tyrosine ligase-like family, member 13 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:142,034,423...142,050,071
Ensembl chr 1:142,034,423...142,050,071
JBrowse link
G Ttll2 tubulin tyrosine ligase like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:53,561,142...53,570,118
Ensembl chr 1:53,561,218...53,563,032
JBrowse link
G Ttll4 tubulin tyrosine ligase like 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:81,925,363...81,961,882
Ensembl chr 9:81,940,630...81,954,686
JBrowse link
G Ttll5 tubulin tyrosine ligase like 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:109,693,915...109,910,479
Ensembl chr 6:109,710,781...109,879,607
JBrowse link
G Ttll6 tubulin tyrosine ligase like 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,954,221...83,999,542
Ensembl chr10:83,954,279...83,999,710
JBrowse link
G Ttll7 tubulin tyrosine ligase like 7 ISO
IBA
(PMID:25959773)
(MGI:3847579|PMID:19152315)
PMID:21873635
RGD PMID:19152315, PMID:25959773, PMID:21873635 MGI:3847579, RGD:13792537 NCBI chr 2:252,779,741...252,854,746
Ensembl chr 2:252,771,017...252,850,495
JBrowse link
G Ttll9 tubulin tyrosine ligase like 9 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:148,426,008...148,485,370
Ensembl chr 3:148,438,939...148,485,360
JBrowse link
tubulin-tyrosine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttl tubulin tyrosine ligase IDA
ISO
IEA
MGI:3584264 (MGI:3584093|PMID:15899979)
(PMID:25908662)
GO_REF:0000107
RGD
Ensembl
PMID:15899979, PMID:25908662, PMID:9108330 GO_REF:0000107, MGI:3584093, RGD:634442 NCBI chr 3:121,596,773...121,626,581
Ensembl chr 3:121,596,791...121,624,048
JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 NOT ISO (PMID:23251473) RGD PMID:23251473 NCBI chr 7:124,472,758...124,491,004
Ensembl chr 7:124,472,758...124,491,004
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6065
      ligase activity 184
        ligase activity, forming carbon-nitrogen bonds 54
          acid-amino acid ligase activity 25
            2,3-dihydroxybenzoate-serine ligase activity 0
            4-aminobenzoate amino acid synthetase activity 0
            4-hydroxybenzoate amino acid synthetase activity 0
            D-alanine-D-alanine ligase activity 0
            D-alanine-alanyl-poly(glycerolphosphate) ligase activity 0
            L-amino-acid alpha-ligase activity 0
            L-propargylglycine--L-glutamate ligase activity 0
            N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity 0
            UDP-N-acetylmuramate-L-alanine ligase activity 0
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity 0
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity 0
            UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity 0
            UDP-N-acetylmuramoylalanine-D-glutamate ligase activity 0
            UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity 0
            UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity 0
            aerobactin synthase activity 0
            aliphatic aldoxime dehydratase activity 0
            amino acid ligation activity by nonribosomal peptide synthase 0
            benzoate amino acid synthetase activity 0
            carnitine-CoA ligase activity 0
            carnosine synthase activity 1
            coenzyme F420-0 gamma-glutamyl ligase activity 0
            coenzyme F420-0:L-glutamate ligase activity 0
            coenzyme F420-1:gamma-L-glutamate ligase activity 0
            coenzyme F420-2 alpha-glutamyl ligase activity 0
            cyanophycin synthetase activity + 0
            cyclo-acetoacetyl-L-tryptophan synthetase activity 0
            dihydrofolate synthase activity 0
            gamma-glutamylhistamine synthase activity 0
            glutamate-cysteine ligase activity 2
            glutathione synthase activity 1
            homocarnosine synthase activity 0
            homoglutathione synthase activity 0
            indole-3-acetic acid amido synthetase activity + 0
            jasmonate-amino synthetase activity 0
            pantoate-beta-alanine ligase activity 0
            phenylacetaldoxime dehydratase activity 0
            phosphopantothenate--cysteine ligase activity 1
            phosphoribosylaminoimidazolesuccinocarboxamide synthase activity 3
            protein-glutamic acid ligase activity + 10
            protein-glycine ligase activity + 3
            tetrahydrofolylpolyglutamate synthase activity 1
            tubulin-tyrosine ligase activity 2
            tyrosine-arginine ligase activity 0
            vanillate amino acid synthetase activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.